ATE406351T1 - Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren - Google Patents

Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren

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Publication number
ATE406351T1
ATE406351T1 AT05702022T AT05702022T ATE406351T1 AT E406351 T1 ATE406351 T1 AT E406351T1 AT 05702022 T AT05702022 T AT 05702022T AT 05702022 T AT05702022 T AT 05702022T AT E406351 T1 ATE406351 T1 AT E406351T1
Authority
AT
Austria
Prior art keywords
heteroyral
condensed
derivatives
kinase inhibitors
kinase
Prior art date
Application number
AT05702022T
Other languages
German (de)
English (en)
Inventor
Paul Bamborough
Sebastien Andre Campos
Vipulkumar Kantibhai Patel
Stephen Swanson
Ann Louise Walker
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE406351T1 publication Critical patent/ATE406351T1/de

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
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AT05702022T 2004-01-30 2005-01-27 Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren ATE406351T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0402143.2A GB0402143D0 (en) 2004-01-30 2004-01-30 Novel compounds

Publications (1)

Publication Number Publication Date
ATE406351T1 true ATE406351T1 (de) 2008-09-15

Family

ID=31971803

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05702022T ATE406351T1 (de) 2004-01-30 2005-01-27 Kondensierte heteroyralderivate zur verwendung als p38-kinase-inhibitoren

Country Status (8)

Country Link
US (1) US20090023725A1 (enExample)
EP (1) EP1708996B1 (enExample)
JP (1) JP2007519692A (enExample)
AT (1) ATE406351T1 (enExample)
DE (1) DE602005009318D1 (enExample)
ES (1) ES2313283T3 (enExample)
GB (1) GB0402143D0 (enExample)
WO (1) WO2005073189A1 (enExample)

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GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124938D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
ES2295553T3 (es) * 2002-02-12 2008-04-16 Smithkline Beecham Corporation Derivados de nicotinamida utiles como inhibidores de p38.
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CA2655999A1 (en) * 2006-06-28 2008-01-03 Aska Pharmaceutical Co., Ltd. Treating agent of inflammatory bowel disease
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EP1708996A1 (en) 2006-10-11
DE602005009318D1 (de) 2008-10-09
EP1708996B1 (en) 2008-08-27
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