ATE398633T1 - Neovaskulär gerichtete immunkonjugate - Google Patents
Neovaskulär gerichtete immunkonjugateInfo
- Publication number
- ATE398633T1 ATE398633T1 AT00941443T AT00941443T ATE398633T1 AT E398633 T1 ATE398633 T1 AT E398633T1 AT 00941443 T AT00941443 T AT 00941443T AT 00941443 T AT00941443 T AT 00941443T AT E398633 T1 ATE398633 T1 AT E398633T1
- Authority
- AT
- Austria
- Prior art keywords
- immunoconjugates
- alanine
- neovascular
- factor vii
- effector domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14216199P | 1999-07-01 | 1999-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE398633T1 true ATE398633T1 (de) | 2008-07-15 |
Family
ID=22498780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00941443T ATE398633T1 (de) | 1999-07-01 | 2000-06-14 | Neovaskulär gerichtete immunkonjugate |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1198479B1 (de) |
JP (2) | JP2003504315A (de) |
AT (1) | ATE398633T1 (de) |
AU (1) | AU775621B2 (de) |
CA (1) | CA2377381C (de) |
CY (1) | CY1110394T1 (de) |
DE (1) | DE60039240D1 (de) |
DK (1) | DK1198479T3 (de) |
ES (1) | ES2307517T3 (de) |
PT (1) | PT1198479E (de) |
WO (1) | WO2001002439A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
AU2003208839A1 (en) * | 2002-02-13 | 2003-09-04 | Micromet Ag | De-immunized (poly)peptide constructs |
AU2003220091B2 (en) * | 2002-03-08 | 2006-02-16 | Emory University | Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis |
JP2005538936A (ja) * | 2002-03-12 | 2005-12-22 | ノボ ノルディスク アクティーゼルスカブ | 二量体のtfアンタゴニスト |
WO2004006962A2 (en) * | 2002-07-12 | 2004-01-22 | Novo Nordisk A/S | A tissue factor binding immunoconjugate comprising factor viia |
WO2004007557A2 (en) * | 2002-07-12 | 2004-01-22 | Novo Nordisk A/S | Tf antagonist |
US7425328B2 (en) | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
DE602004031390D1 (de) * | 2003-05-06 | 2011-03-24 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor VII-Fc chimäre Proteine zur Behandlung von hämostatischen Krankheiten |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
AU2012203896B2 (en) * | 2003-05-06 | 2014-09-25 | Bioverativ Therapeutics Inc. | Clotting Factor-Fc Chimeric Proteins to Treat Hemophilia |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
WO2005025623A2 (en) * | 2003-07-28 | 2005-03-24 | Emory University | Ef-24-factor vii conjugates |
CA2546580A1 (en) * | 2003-11-18 | 2005-06-09 | Iconic Therapeutics, Inc. | Homogeneous preparations of chimeric proteins |
JP2009203161A (ja) * | 2006-06-05 | 2009-09-10 | Mebiopharm Co Ltd | リウマチ治療薬 |
AU2011274423B2 (en) * | 2010-07-09 | 2016-02-11 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
ES2856968T3 (es) | 2016-01-15 | 2021-09-28 | Rigshospitalet | Adquisición de imágenes de TEP cuantitativas de la expresión de factor tisular usando factor VII inhibido en el punto activo y marcado con 18F |
US20190153119A1 (en) * | 2016-04-14 | 2019-05-23 | Iconic Therapeutics, Inc. | Compositions and methods for treating disorders associated with neovascularization |
US20190358351A1 (en) | 2016-11-17 | 2019-11-28 | Minerva Imaging Aps | 177-lu labeled active site inhibited factor vii |
CA3056396A1 (en) * | 2017-03-14 | 2018-09-20 | Ohio State Innovation Foundation | Methods and compositions related to a tissue factor-targeting igg3 immunoconjugates |
CN111263640A (zh) * | 2017-09-27 | 2020-06-09 | 俄亥俄州创新基金会 | 组织因子靶向car-nk和car-t细胞疗法 |
WO2021030787A1 (en) * | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5861374A (en) * | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
ES2193143T3 (es) * | 1992-03-05 | 2003-11-01 | Univ Texas | Uso de inmunoconjugados para la diagnosis y/o terapia de tumores vascularizaos. |
US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
DE69519929T2 (de) * | 1994-07-11 | 2001-05-23 | Univ Texas | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen |
IL130908A0 (en) * | 1997-01-22 | 2001-01-28 | Univ Texas | Tissue-factor (tf) compositions for coagulation and tumor treatment |
-
2000
- 2000-06-14 JP JP2001508226A patent/JP2003504315A/ja not_active Withdrawn
- 2000-06-14 AU AU56149/00A patent/AU775621B2/en not_active Expired
- 2000-06-14 DK DK00941443T patent/DK1198479T3/da active
- 2000-06-14 DE DE60039240T patent/DE60039240D1/de not_active Expired - Lifetime
- 2000-06-14 WO PCT/US2000/016481 patent/WO2001002439A1/en active IP Right Grant
- 2000-06-14 EP EP00941443A patent/EP1198479B1/de not_active Expired - Lifetime
- 2000-06-14 ES ES00941443T patent/ES2307517T3/es not_active Expired - Lifetime
- 2000-06-14 PT PT00941443T patent/PT1198479E/pt unknown
- 2000-06-14 AT AT00941443T patent/ATE398633T1/de active
- 2000-06-14 CA CA2377381A patent/CA2377381C/en not_active Expired - Lifetime
-
2008
- 2008-09-10 CY CY20081100974T patent/CY1110394T1/el unknown
-
2012
- 2012-09-27 JP JP2012213338A patent/JP5745486B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2307517T3 (es) | 2008-12-01 |
WO2001002439A1 (en) | 2001-01-11 |
CY1110394T1 (el) | 2015-04-29 |
EP1198479A4 (de) | 2004-10-20 |
DE60039240D1 (de) | 2008-07-31 |
EP1198479B1 (de) | 2008-06-18 |
JP2003504315A (ja) | 2003-02-04 |
AU775621B2 (en) | 2004-08-05 |
JP5745486B2 (ja) | 2015-07-08 |
JP2012255032A (ja) | 2012-12-27 |
EP1198479A1 (de) | 2002-04-24 |
DK1198479T3 (da) | 2008-10-13 |
AU5614900A (en) | 2001-01-22 |
PT1198479E (pt) | 2008-08-12 |
CA2377381A1 (en) | 2001-01-11 |
CA2377381C (en) | 2013-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1110394T1 (el) | Ανοσοσυζευγματα νεοαγγειακης στοχευσης | |
ES2224099T3 (es) | Inmunotoxinas dirigidas contra antigenos de superficies relacionados con c-erbb-2 (her-2/neu). | |
Govindan et al. | Designing immunoconjugates for cancer therapy | |
ATE347378T1 (de) | Konjugate zur behandlung von entzündungskrankheiten und von assozierter gewebeschädigung | |
SA112330402B1 (ar) | اتحادات جسم مضاد- عقار | |
WO2004032828A3 (en) | Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders | |
HK1155070A1 (en) | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders -cd70 - | |
EP2841103A1 (de) | Dr5-liganden-arzneimittelkonjugate | |
JPH06509563A (ja) | 炎症性関節炎の治療用の表皮細胞成長因子受容体を標的とする分子 | |
DE69530109D1 (de) | Zusammensetzung für behandlung von maligner tumore und ihre metastase | |
Muñoz et al. | In vitro and in vivo effects of an anti-mouse endoglin (CD105)–immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours | |
KR20200135841A (ko) | 고형 종양을 치료하기 위한 튜불린 교란제들을 포함하는 항체 약물 접합체들의 용도 | |
US5690935A (en) | Biotherapy of cancer by targeting TP-3/P80 | |
CA2366713A1 (en) | Antibody and chemokine constructs and their use in the treatment of autoimmune diseases | |
CN116669772A (zh) | Gpc3结合剂、其缀合物以及使用它们的方法 | |
Rathore et al. | Generation of active immunotoxins containing recombinant restrictocin | |
WO2004007557A3 (en) | Tf antagonist | |
WO1990011779A1 (en) | Heteroconjugates | |
Maiti et al. | Tolerogenic conjugates of xenogeneic monoclonal antibodies with monomethoxypolyethylene glycol. I. Induction of long‐lasting tolerance to xenogeneic monoclonal antibodies | |
WO2022268050A1 (zh) | 一种药物组合及其用途 | |
Morgan Jr et al. | Preclinical and clinical evaluation of a monoclonal antibody to a human melanoma-associated antigen | |
Engert et al. | Experimental therapy in Hodgkin's disease | |
Hertler et al. | Immunotoxins in the therapy of leukemias and lymphomas | |
WO1994002174A1 (en) | Immunocomplex | |
陈东泉 et al. | POTENTIAL FOR TARGETING HEPATOMA WITH ANTI-FERRITIN IgG-DAUNOMYCIN IMMUNOCONJUGATE |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1198479 Country of ref document: EP |