DE60039240D1 - Neovaskulär gerichtete immunkonjugate - Google Patents
Neovaskulär gerichtete immunkonjugateInfo
- Publication number
- DE60039240D1 DE60039240D1 DE60039240T DE60039240T DE60039240D1 DE 60039240 D1 DE60039240 D1 DE 60039240D1 DE 60039240 T DE60039240 T DE 60039240T DE 60039240 T DE60039240 T DE 60039240T DE 60039240 D1 DE60039240 D1 DE 60039240D1
- Authority
- DE
- Germany
- Prior art keywords
- immunoconjugates
- alanine
- factor vii
- effector domain
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14216199P | 1999-07-01 | 1999-07-01 | |
PCT/US2000/016481 WO2001002439A1 (en) | 1999-07-01 | 2000-06-14 | Neovascular-targeted immunoconjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60039240D1 true DE60039240D1 (de) | 2008-07-31 |
Family
ID=22498780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60039240T Expired - Lifetime DE60039240D1 (de) | 1999-07-01 | 2000-06-14 | Neovaskulär gerichtete immunkonjugate |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1198479B1 (de) |
JP (2) | JP2003504315A (de) |
AT (1) | ATE398633T1 (de) |
AU (1) | AU775621B2 (de) |
CA (1) | CA2377381C (de) |
CY (1) | CY1110394T1 (de) |
DE (1) | DE60039240D1 (de) |
DK (1) | DK1198479T3 (de) |
ES (1) | ES2307517T3 (de) |
PT (1) | PT1198479E (de) |
WO (1) | WO2001002439A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7160540B2 (en) | 2000-06-30 | 2007-01-09 | Regents Of The University Of Minnesota | Methods for detecting activity of clottings factors |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
US6423826B1 (en) | 2000-06-30 | 2002-07-23 | Regents Of The University Of Minnesota | High molecular weight derivatives of vitamin K-dependent polypeptides |
EP1474451A2 (de) | 2002-02-13 | 2004-11-10 | Micromet AG | Deimmunisierte (poly)peptidkonstrukte |
US20060229239A9 (en) * | 2002-03-08 | 2006-10-12 | Mamoru Shoji | Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis |
EP1485476A2 (de) * | 2002-03-12 | 2004-12-15 | Novo Nordisk A/S | Dimerer tf-antagonist |
AU2003242506A1 (en) * | 2002-07-12 | 2004-02-02 | Novo Nordisk A/S | Tf antagonist |
EP1523504A2 (de) * | 2002-07-12 | 2005-04-20 | Novo Nordisk A/S | Gewebe faktorbindende immunokonjugate die faktor viia enthalten |
US7425328B2 (en) | 2003-04-22 | 2008-09-16 | Purdue Pharma L.P. | Tissue factor antibodies and uses thereof |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
AU2004239244C1 (en) | 2003-05-06 | 2015-04-23 | Bioverativ Therapeutics Inc. | Clotting factor-Fc chimeric proteins to treat hemophilia |
AU2012203896B2 (en) * | 2003-05-06 | 2014-09-25 | Bioverativ Therapeutics Inc. | Clotting Factor-Fc Chimeric Proteins to Treat Hemophilia |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
WO2005025623A2 (en) * | 2003-07-28 | 2005-03-24 | Emory University | Ef-24-factor vii conjugates |
CA2546580A1 (en) * | 2003-11-18 | 2005-06-09 | Iconic Therapeutics, Inc. | Homogeneous preparations of chimeric proteins |
JP2009203161A (ja) * | 2006-06-05 | 2009-09-10 | Mebiopharm Co Ltd | リウマチ治療薬 |
WO2012006633A1 (en) * | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Chimeric clotting factors |
EP3402537B1 (de) | 2016-01-15 | 2021-01-06 | Rigshospitalet | Quantitative pet-bildgebung der gewebefaktorexpression mittels 18f-markiertem, durch an der aktiven stelle gehemmten faktor vii |
EP3442554A4 (de) * | 2016-04-14 | 2019-12-04 | Iconic Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von erkrankungen im zusammenhang mit neovaskularisation |
EP3541432A4 (de) | 2016-11-17 | 2020-08-05 | Minerva Imaging ApS | 177-lu-markierter, durch aktive stelle inhibierter faktor vii |
JP7155144B2 (ja) * | 2017-03-14 | 2022-10-18 | オハイオ・ステイト・イノベーション・ファウンデーション | 組織因子標的化IgG3免疫複合体に関連する方法及び組成物 |
WO2019067249A1 (en) * | 2017-09-27 | 2019-04-04 | Ohio State Innovation Foundation | CAR-NK CELL THERAPY AND TISSUE FACTOR TARGETING T-CARD |
WO2021030787A1 (en) * | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5861374A (en) * | 1991-02-28 | 1999-01-19 | Novo Nordisk A/S | Modified Factor VII |
US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
WO1993017715A1 (en) * | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
US5879672A (en) * | 1994-10-07 | 1999-03-09 | Regeneron Pharmaceuticals, Inc. | Tie-2 ligand 1 |
DE69519929T2 (de) * | 1994-07-11 | 2001-05-23 | Univ Texas | Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen |
US6132730A (en) * | 1997-01-22 | 2000-10-17 | Board Of Regents, The University Of Texas System | Combined tissue factor and factor VIIa methods and compositions for coagulation and tumor treatment |
-
2000
- 2000-06-14 DE DE60039240T patent/DE60039240D1/de not_active Expired - Lifetime
- 2000-06-14 AU AU56149/00A patent/AU775621B2/en not_active Expired
- 2000-06-14 JP JP2001508226A patent/JP2003504315A/ja not_active Withdrawn
- 2000-06-14 EP EP00941443A patent/EP1198479B1/de not_active Expired - Lifetime
- 2000-06-14 CA CA2377381A patent/CA2377381C/en not_active Expired - Lifetime
- 2000-06-14 ES ES00941443T patent/ES2307517T3/es not_active Expired - Lifetime
- 2000-06-14 AT AT00941443T patent/ATE398633T1/de active
- 2000-06-14 DK DK00941443T patent/DK1198479T3/da active
- 2000-06-14 WO PCT/US2000/016481 patent/WO2001002439A1/en active IP Right Grant
- 2000-06-14 PT PT00941443T patent/PT1198479E/pt unknown
-
2008
- 2008-09-10 CY CY20081100974T patent/CY1110394T1/el unknown
-
2012
- 2012-09-27 JP JP2012213338A patent/JP5745486B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2377381A1 (en) | 2001-01-11 |
JP2012255032A (ja) | 2012-12-27 |
EP1198479B1 (de) | 2008-06-18 |
EP1198479A4 (de) | 2004-10-20 |
CY1110394T1 (el) | 2015-04-29 |
AU5614900A (en) | 2001-01-22 |
DK1198479T3 (da) | 2008-10-13 |
ES2307517T3 (es) | 2008-12-01 |
AU775621B2 (en) | 2004-08-05 |
PT1198479E (pt) | 2008-08-12 |
CA2377381C (en) | 2013-06-11 |
ATE398633T1 (de) | 2008-07-15 |
JP5745486B2 (ja) | 2015-07-08 |
WO2001002439A1 (en) | 2001-01-11 |
EP1198479A1 (de) | 2002-04-24 |
JP2003504315A (ja) | 2003-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |