ATE39487T1 - Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE39487T1 ATE39487T1 AT82303576T AT82303576T ATE39487T1 AT E39487 T1 ATE39487 T1 AT E39487T1 AT 82303576 T AT82303576 T AT 82303576T AT 82303576 T AT82303576 T AT 82303576T AT E39487 T1 ATE39487 T1 AT E39487T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- manufacture
- processes
- pharmaceutical compositions
- lactone
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical class C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000235389 Absidia Species 0.000 abstract 1
- 241000293029 Absidia caerulea Species 0.000 abstract 1
- 241000235555 Cunninghamella Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000736854 Syncephalastrum Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Transplanting Machines (AREA)
- Switches With Compound Operations (AREA)
- Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56114038A JPS5815968A (ja) | 1981-07-21 | 1981-07-21 | Ｍｌ−２３６ｂ誘導体およびその製法 |
| EP82303576A EP0070649B1 (en) | 1981-07-21 | 1982-07-08 | Ml-236b derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE39487T1 true ATE39487T1 (de) | 1989-01-15 |
Family
ID=14627469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82303576T ATE39487T1 (de) | 1981-07-21 | 1982-07-08 | Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4447626A (forum.php) |
| EP (1) | EP0070649B1 (forum.php) |
| JP (1) | JPS5815968A (forum.php) |
| KR (1) | KR880001354B1 (forum.php) |
| AT (1) | ATE39487T1 (forum.php) |
| AU (1) | AU547968B2 (forum.php) |
| CA (1) | CA1185199A (forum.php) |
| DE (1) | DE3279304D1 (forum.php) |
| DK (1) | DK159397C (forum.php) |
| ES (1) | ES514185A0 (forum.php) |
| FI (1) | FI75186C (forum.php) |
| IE (1) | IE54747B1 (forum.php) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| USRE33033E (en) * | 1985-07-05 | 1989-08-22 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US4841074A (en) * | 1987-12-11 | 1989-06-20 | Merck & Co., Inc. | Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors |
| JP2792600B2 (ja) * | 1989-04-14 | 1998-09-03 | 旭電化工業株式会社 | メバロン酸生産菌 |
| ATE135352T1 (de) * | 1989-06-09 | 1996-03-15 | Merck & Co Inc | 3-keto-hmg-coa reduktase-inhibitoren |
| KR100186758B1 (ko) | 1996-08-09 | 1999-04-01 | 영진약품공업 주식회사 | 프라바스타틴(pravastatin)전구체의제조방법 |
| IN191580B (forum.php) * | 1999-12-17 | 2003-12-06 | Ranbaxy Lab Ltd |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (forum.php) * | 1974-06-07 | 1981-03-18 | ||
| DK149080C (da) * | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
-
1981
- 1981-07-21 JP JP56114038A patent/JPS5815968A/ja active Granted
-
1982
- 1982-07-07 US US06/395,968 patent/US4447626A/en not_active Expired - Lifetime
- 1982-07-08 EP EP82303576A patent/EP0070649B1/en not_active Expired
- 1982-07-08 AT AT82303576T patent/ATE39487T1/de not_active IP Right Cessation
- 1982-07-08 DE DE8282303576T patent/DE3279304D1/de not_active Expired
- 1982-07-09 CA CA000406984A patent/CA1185199A/en not_active Expired
- 1982-07-12 AU AU85926/82A patent/AU547968B2/en not_active Expired
- 1982-07-20 DK DK325782A patent/DK159397C/da not_active IP Right Cessation
- 1982-07-20 IE IE1738/82A patent/IE54747B1/en not_active IP Right Cessation
- 1982-07-20 FI FI822567A patent/FI75186C/fi not_active IP Right Cessation
- 1982-07-20 ES ES514185A patent/ES514185A0/es active Granted
- 1982-07-21 KR KR8203252A patent/KR880001354B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK159397C (da) | 1991-03-25 |
| KR840000519A (ko) | 1984-02-25 |
| AU8592682A (en) | 1983-01-27 |
| KR880001354B1 (ko) | 1988-07-28 |
| US4447626A (en) | 1984-05-08 |
| FI822567L (fi) | 1983-01-22 |
| DK325782A (da) | 1983-01-22 |
| ES8308358A1 (es) | 1983-08-16 |
| IE54747B1 (en) | 1990-01-31 |
| DK159397B (da) | 1990-10-08 |
| EP0070649A2 (en) | 1983-01-26 |
| CA1185199A (en) | 1985-04-09 |
| JPS6355502B2 (forum.php) | 1988-11-02 |
| EP0070649B1 (en) | 1988-12-28 |
| IE821738L (en) | 1983-01-21 |
| EP0070649A3 (en) | 1984-04-04 |
| DE3279304D1 (en) | 1989-02-02 |
| AU547968B2 (en) | 1985-11-14 |
| ES514185A0 (es) | 1983-08-16 |
| FI822567A0 (fi) | 1982-07-20 |
| JPS5815968A (ja) | 1983-01-29 |
| FI75186B (fi) | 1988-01-29 |
| FI75186C (fi) | 1988-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |