ATE39487T1 - Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents

Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE39487T1
ATE39487T1 AT82303576T AT82303576T ATE39487T1 AT E39487 T1 ATE39487 T1 AT E39487T1 AT 82303576 T AT82303576 T AT 82303576T AT 82303576 T AT82303576 T AT 82303576T AT E39487 T1 ATE39487 T1 AT E39487T1
Authority
AT
Austria
Prior art keywords
derivatives
manufacture
processes
pharmaceutical compositions
lactone
Prior art date
Application number
AT82303576T
Other languages
English (en)
Inventor
Akira Fermentation Re Terahara
Company Limited - -Chom Sankyo
Minoru Analytical And M Tanaka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE39487T1 publication Critical patent/ATE39487T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14Fungi; Culture media therefor
    • C12N1/145Fungal isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/645Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Steering-Linkage Mechanisms And Four-Wheel Steering (AREA)
  • Transplanting Machines (AREA)
  • Switches With Compound Operations (AREA)
  • Peptides Or Proteins (AREA)
AT82303576T 1981-07-21 1982-07-08 Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. ATE39487T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56114038A JPS5815968A (ja) 1981-07-21 1981-07-21 Ml−236b誘導体およびその製法
EP82303576A EP0070649B1 (de) 1981-07-21 1982-07-08 ML-236B-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number Publication Date
ATE39487T1 true ATE39487T1 (de) 1989-01-15

Family

ID=14627469

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82303576T ATE39487T1 (de) 1981-07-21 1982-07-08 Ml-236b-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Country Status (12)

Country Link
US (1) US4447626A (de)
EP (1) EP0070649B1 (de)
JP (1) JPS5815968A (de)
KR (1) KR880001354B1 (de)
AT (1) ATE39487T1 (de)
AU (1) AU547968B2 (de)
CA (1) CA1185199A (de)
DE (1) DE3279304D1 (de)
DK (1) DK159397C (de)
ES (1) ES514185A0 (de)
FI (1) FI75186C (de)
IE (1) IE54747B1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE33033E (en) * 1985-07-05 1989-08-22 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4611081A (en) * 1985-07-05 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors intermediates
US4841074A (en) * 1987-12-11 1989-06-20 Merck & Co., Inc. Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
JP2792600B2 (ja) * 1989-04-14 1998-09-03 旭電化工業株式会社 メバロン酸生産菌
DE69025817T2 (de) * 1989-06-09 1996-11-14 Merck & Co Inc 3-Keto-HMG-CoA Reduktase-Inhibitoren
KR100186758B1 (ko) 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
IN191580B (de) 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (de) * 1974-06-07 1981-03-18
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre

Also Published As

Publication number Publication date
FI75186C (fi) 1988-05-09
ES8308358A1 (es) 1983-08-16
EP0070649B1 (de) 1988-12-28
DK159397C (da) 1991-03-25
EP0070649A2 (de) 1983-01-26
CA1185199A (en) 1985-04-09
AU8592682A (en) 1983-01-27
FI75186B (fi) 1988-01-29
US4447626A (en) 1984-05-08
IE54747B1 (en) 1990-01-31
FI822567L (fi) 1983-01-22
AU547968B2 (en) 1985-11-14
DK325782A (da) 1983-01-22
DK159397B (da) 1990-10-08
JPS5815968A (ja) 1983-01-29
JPS6355502B2 (de) 1988-11-02
KR880001354B1 (ko) 1988-07-28
KR840000519A (ko) 1984-02-25
IE821738L (en) 1983-01-21
ES514185A0 (es) 1983-08-16
EP0070649A3 (en) 1984-04-04
FI822567A0 (fi) 1982-07-20
DE3279304D1 (en) 1989-02-02

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time