ATE392473T1 - Leptin-rezeptor db, für diesen kodierende nukleinsäuren und anwendungen desselben - Google Patents
Leptin-rezeptor db, für diesen kodierende nukleinsäuren und anwendungen desselbenInfo
- Publication number
- ATE392473T1 ATE392473T1 AT97905602T AT97905602T ATE392473T1 AT E392473 T1 ATE392473 T1 AT E392473T1 AT 97905602 T AT97905602 T AT 97905602T AT 97905602 T AT97905602 T AT 97905602T AT E392473 T1 ATE392473 T1 AT E392473T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- leptin
- nucleic acids
- applications
- leptin receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/586,594 US7084252B1 (en) | 1996-01-16 | 1996-01-16 | DB, the receptor for leptin |
US08/599,974 US7063958B1 (en) | 1996-01-16 | 1996-02-14 | Nucleic acids db, the receptor for leptin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE392473T1 true ATE392473T1 (de) | 2008-05-15 |
Family
ID=27079758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97905602T ATE392473T1 (de) | 1996-01-16 | 1997-01-16 | Leptin-rezeptor db, für diesen kodierende nukleinsäuren und anwendungen desselben |
Country Status (12)
Country | Link |
---|---|
US (1) | US7063958B1 (de) |
EP (1) | EP0879286B1 (de) |
JP (1) | JP4285771B2 (de) |
AT (1) | ATE392473T1 (de) |
AU (1) | AU2244797A (de) |
CA (1) | CA2243446A1 (de) |
DE (1) | DE69738637T2 (de) |
ES (1) | ES2306456T3 (de) |
IL (3) | IL125353A (de) |
MX (1) | MX9805814A (de) |
NZ (1) | NZ511840A (de) |
WO (1) | WO1997026335A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6310034B1 (en) | 1993-05-21 | 2001-10-30 | Ut-Battelle, Llc | Agouti polypeptide compositions |
US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
US6287782B1 (en) * | 1995-11-27 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Methods of using the Ob receptor to identify therapeutic compounds |
US6620413B1 (en) | 1995-12-27 | 2003-09-16 | Genentech, Inc. | OB protein-polymer chimeras |
ES2244990T3 (es) * | 1996-01-04 | 2005-12-16 | Amgen Inc. | Receptor de la proteina ob y composiciones y metodos relacionados. |
US20050019325A1 (en) | 1996-01-08 | 2005-01-27 | Carter Paul J. | WSX receptor agonist antibodies |
US7074397B1 (en) | 1996-01-08 | 2006-07-11 | Genentech, Inc. | Method for enhancing proliferation or differentiation of a cell using ob protein |
US6541604B1 (en) | 1996-01-08 | 2003-04-01 | Genentech, Inc. | Leptin receptor having a WSX motif |
US6281346B1 (en) * | 1996-03-22 | 2001-08-28 | Merck & Co., Inc. | Rat ob-receptors and nucleotides encoding them |
WO1997046587A2 (en) * | 1996-06-07 | 1997-12-11 | Eli Lilly And Company | Ob PROTEIN BINDING PROTEIN |
WO1998006752A1 (en) * | 1996-08-16 | 1998-02-19 | The Rockefeller University | A leptin binding protein and its use in methods for diagnosing and treating abnormalities of the endogenous leptin pathway |
HUP9904023A3 (en) | 1996-09-20 | 2002-01-28 | Hoechst Ag | Use of leptin antagonists for treating insulin resistance in type ii diabetes |
EP0948595A4 (de) | 1996-12-02 | 2002-11-06 | Merck & Co Inc | Mutierte ob-rezeptoren und nukleotide, welche fuer diese kodieren |
WO1998057177A1 (en) * | 1997-06-09 | 1998-12-17 | Regeneron Pharmaceuticals, Inc. | Assay systems for leptin-enhancing agents |
US6770444B2 (en) | 1998-07-16 | 2004-08-03 | Synaptic Pharmaceutical Corporation | Methods of identifying or screening for agents that binds the Ob-Re |
CA2335107C (en) | 1998-07-28 | 2010-01-19 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Leptin-mediated gene-induction |
US6777388B1 (en) | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
EP1191945A4 (de) * | 1999-06-11 | 2003-04-23 | Baylor College Medicine | Verfahren und zusammensetzungen zur kontrolle der knochenbildung mittels modulation der leptin-aktivität |
AU767068B2 (en) * | 1999-06-11 | 2003-10-30 | Baylor College Of Medicine | Methods and compositions for control of bone formation via modulation of leptin activity |
JP4756813B2 (ja) | 2000-05-22 | 2011-08-24 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | レセプターを用いた相互作用の捕捉法 |
US7235629B2 (en) * | 2000-11-14 | 2007-06-26 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Functional fragment of the leptin receptor |
ES2294048T3 (es) * | 2000-11-14 | 2008-04-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Fragmento funcional de receptor de leptina. |
US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
AU2002315165A1 (en) * | 2001-06-14 | 2003-01-02 | Genelink, Inc. | Kits and methods for assessing leptin-mediated lipid matabolism |
CA2585549A1 (en) | 2004-11-18 | 2006-05-26 | Vib Vzw | Novel type leptin receptor antagonist |
UA127678C2 (uk) | 2016-11-08 | 2023-11-29 | Редженерон Фармасьютікалс, Інк. | Виділене антитіло, яке зв'язується з лептиновим рецептором людини |
MX2020010547A (es) | 2018-04-06 | 2020-11-06 | Regeneron Pharma | Anticuerpo agonista del receptor de leptina para usarse en el tratamiento de una disfuncion metabolica o hipoleptinemia. |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990014092A1 (en) | 1989-05-18 | 1990-11-29 | Cell Genesys, Inc. | Single-strand site-directed modification of mammalian genes in vivo |
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
WO1991006666A1 (en) | 1989-11-06 | 1991-05-16 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
AU645294B2 (en) | 1989-12-22 | 1994-01-13 | Merck Serono Sa | Endogenous gene expression modification with regulatory element |
KR100246529B1 (ko) | 1990-12-14 | 2000-04-01 | 스티븐 에이. 서윈. 엠.디. | 수용체 관련된 신호 변환 경로를 위한 키메라 사슬 |
AU5098193A (en) * | 1992-09-01 | 1994-03-29 | Berlex Laboratories, Inc. | Glycolation of glycosylated macromolecules |
IL107378A (en) * | 1993-10-24 | 2005-05-17 | Yeda Res & Dev | SOLUBLE INTERFERON alpha-RECEPTOR, ITS PREPARATION AND USE |
US5912123A (en) | 1994-09-14 | 1999-06-15 | Progenitor, Inc. | Detection of the leptin receptor in reproductive organs and methods for regulating reproductive biology |
US5643748A (en) * | 1994-09-14 | 1997-07-01 | Progenitor, Inc. | HU-B1.219, a novel human hematopoietin receptor |
CA2218529A1 (en) * | 1995-05-08 | 1996-11-14 | Chiron Corporation | Nucleic acids for treating obesity |
AUPN564195A0 (en) | 1995-09-26 | 1995-10-19 | Walter And Eliza Hall Institute Of Medical Research, The | A novel haemopoietin receptor and genetic sequences encoding same |
US6506877B1 (en) * | 1995-11-27 | 2003-01-14 | Millennium Pharmaceuticals, Inc. | Ob receptor |
US6482927B1 (en) * | 1995-11-27 | 2002-11-19 | Millennium Pharmaceuticals, Inc. | Chimeric proteins comprising the extracellular domain of murine Ob receptor |
ES2244990T3 (es) | 1996-01-04 | 2005-12-16 | Amgen Inc. | Receptor de la proteina ob y composiciones y metodos relacionados. |
US20020193571A1 (en) * | 1996-01-08 | 2002-12-19 | Paul J. Carter | Wsx receptor agonist antibodies |
AU1833197A (en) | 1996-01-18 | 1997-08-11 | Progenitor, Inc. | Detection of a leptin receptor variant and methods for regulating obesity |
EP0922052A4 (de) | 1996-02-22 | 2001-08-01 | Merck & Co Inc | Ratten-spezifische ob-rezeptoren und nukleotide, welche für diese kodieren |
WO1997040380A1 (en) | 1996-04-22 | 1997-10-30 | Merck & Co., Inc. | Leptin assay |
AU2408397A (en) | 1996-04-30 | 1997-11-19 | Otsuka Pharmaceutical Co., Ltd. | Ob protein receptor genes and use of the same |
JP2000512486A (ja) | 1996-05-06 | 2000-09-26 | メルク エンド カンパニー インコーポレーテッド | Obレセプターイソ型及びそれらをコードする核酸 |
-
1996
- 1996-02-14 US US08/599,974 patent/US7063958B1/en not_active Expired - Fee Related
-
1997
- 1997-01-16 DE DE69738637T patent/DE69738637T2/de not_active Expired - Lifetime
- 1997-01-16 AU AU22447/97A patent/AU2244797A/en not_active Abandoned
- 1997-01-16 CA CA002243446A patent/CA2243446A1/en not_active Abandoned
- 1997-01-16 ES ES97905602T patent/ES2306456T3/es not_active Expired - Lifetime
- 1997-01-16 IL IL125353A patent/IL125353A/en not_active IP Right Cessation
- 1997-01-16 AT AT97905602T patent/ATE392473T1/de not_active IP Right Cessation
- 1997-01-16 WO PCT/US1997/001010 patent/WO1997026335A1/en active Application Filing
- 1997-01-16 JP JP52629697A patent/JP4285771B2/ja not_active Expired - Fee Related
- 1997-01-16 EP EP97905602A patent/EP0879286B1/de not_active Expired - Lifetime
- 1997-01-16 NZ NZ511840A patent/NZ511840A/en not_active IP Right Cessation
-
1998
- 1998-07-16 MX MX9805814A patent/MX9805814A/es not_active IP Right Cessation
-
2008
- 2008-12-15 IL IL195948A patent/IL195948A/en not_active IP Right Cessation
-
2010
- 2010-10-14 IL IL208750A patent/IL208750A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL125353A (en) | 2009-07-20 |
EP0879286A1 (de) | 1998-11-25 |
IL195948A (en) | 2010-12-30 |
JP4285771B2 (ja) | 2009-06-24 |
CA2243446A1 (en) | 1997-07-24 |
EP0879286B1 (de) | 2008-04-16 |
ES2306456T3 (es) | 2008-11-01 |
IL208750A0 (en) | 2010-12-30 |
MX9805814A (es) | 1998-12-31 |
AU2244797A (en) | 1997-08-11 |
US7063958B1 (en) | 2006-06-20 |
IL125353A0 (en) | 1999-03-12 |
DE69738637T2 (de) | 2009-05-28 |
NZ511840A (en) | 2005-02-25 |
DE69738637D1 (de) | 2008-05-29 |
JP2000504938A (ja) | 2000-04-25 |
WO1997026335A1 (en) | 1997-07-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |