ATE388168T1 - Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungen - Google Patents
Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungenInfo
- Publication number
- ATE388168T1 ATE388168T1 AT02017044T AT02017044T ATE388168T1 AT E388168 T1 ATE388168 T1 AT E388168T1 AT 02017044 T AT02017044 T AT 02017044T AT 02017044 T AT02017044 T AT 02017044T AT E388168 T1 ATE388168 T1 AT E388168T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- antibodies
- therapeutic uses
- inhibitors
- binding
- Prior art date
Links
- 108090001007 Interleukin-8 Proteins 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000010681 interleukin-8 receptors Human genes 0.000 abstract 2
- 108010038415 interleukin-8 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/121,105 US6448379B1 (en) | 1993-09-14 | 1993-09-14 | IL8 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388168T1 true ATE388168T1 (de) | 2008-03-15 |
Family
ID=22394586
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02017044T ATE388168T1 (de) | 1993-09-14 | 1994-09-13 | Antikörper gegen den il-8 rezeptor und deren therapeutische verwendungen |
| AT94929201T ATE229036T1 (de) | 1993-09-14 | 1994-09-13 | Il-8 inhibitoren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94929201T ATE229036T1 (de) | 1993-09-14 | 1994-09-13 | Il-8 inhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6448379B1 (de) |
| EP (3) | EP1932856A3 (de) |
| JP (3) | JPH09502725A (de) |
| AT (2) | ATE388168T1 (de) |
| AU (1) | AU697190B2 (de) |
| CA (1) | CA2171289C (de) |
| DE (2) | DE69435083T2 (de) |
| DK (1) | DK1283217T3 (de) |
| ES (1) | ES2302774T3 (de) |
| PT (1) | PT1283217E (de) |
| WO (1) | WO1995007934A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6283896A (en) * | 1995-06-20 | 1997-01-22 | Chiron Corporation | Interleukin-8 receptor binding compounds |
| AU777766B2 (en) * | 1996-07-05 | 2004-10-28 | Cancer Research Technology Limited | Inhibitors of the interaction between p53 and MDM2 |
| US7083983B2 (en) | 1996-07-05 | 2006-08-01 | Cancer Research Campaign Technology Limited | Inhibitors of the interaction between P53 and MDM2 |
| WO1998006398A1 (en) * | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| AU7127298A (en) * | 1997-04-14 | 1998-11-11 | Emory University | Serine protease inhibitors |
| ES2156534B1 (es) * | 1999-02-03 | 2002-02-01 | Smithkline Beecham Sa | Nuevos inhibidores de la interaccion entre la interleuquina-8 y sus receptores |
| AU2001250412A1 (en) * | 2000-03-31 | 2001-10-08 | Ipf Pharmaceuticals Gmbh | Diagnostic and medicament for analysing the cell surface proteome of tumour and inflammatory cells and for treating tumorous and inflammatory diseases, preferably using specific chemokine receptor analysis and the chemokine receptor-ligand interaction |
| CA2510087C (en) * | 2002-12-16 | 2018-09-04 | Medarex, Inc. | Human monoclonal antibodies against interleukin 8 (il-8) |
| CL2008001071A1 (es) * | 2007-04-17 | 2009-05-22 | Smithkline Beecham Corp | Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades. |
| AR083784A1 (es) | 2010-11-08 | 2013-03-20 | Novartis Ag | Polipeptidos de enlace de los receptores de quimiocina |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| US20150224190A1 (en) | 2012-07-06 | 2015-08-13 | Mohamed Bentires-Alj | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction |
| WO2018067548A1 (en) * | 2016-10-03 | 2018-04-12 | The Children's Medicial Center Corporation | Prevention and treatment of diabetic nephropathy |
| JP2021510697A (ja) | 2018-01-12 | 2021-04-30 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | がん処置のための坑ｉｌ−８抗体及び坑ｐｄ−１抗体を用いる組合せ治療 |
| JP7429427B2 (ja) | 2020-01-31 | 2024-02-08 | 株式会社大都技研 | 抽出装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) * | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| IE913192A1 (en) | 1990-09-12 | 1992-02-25 | Scripps Research Inst | Active site of interleukin-8: polypeptide analogs and¹antibodies |
| JP2866182B2 (ja) | 1990-10-08 | 1999-03-08 | 日本ケミファ株式会社 | エンドセリン受容体 |
| US5856457A (en) * | 1991-03-29 | 1999-01-05 | Genentech, Inc. | Nucleic acids encoding a human IL-8 receptor |
| US5440021A (en) * | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| WO1992018641A1 (en) * | 1991-04-10 | 1992-10-29 | The Trustees Of Boston University | Interleukin-8 receptors and related molecules and methods |
| US5374506A (en) | 1991-09-13 | 1994-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Amino acid sequence for a functional human interleukin-8 receptor |
-
1993
- 1993-09-14 US US08/121,105 patent/US6448379B1/en not_active Expired - Lifetime
-
1994
- 1994-09-13 AT AT02017044T patent/ATE388168T1/de not_active IP Right Cessation
- 1994-09-13 JP JP7509317A patent/JPH09502725A/ja not_active Withdrawn
- 1994-09-13 PT PT02017044T patent/PT1283217E/pt unknown
- 1994-09-13 WO PCT/US1994/010356 patent/WO1995007934A2/en active IP Right Grant
- 1994-09-13 EP EP08000646A patent/EP1932856A3/de not_active Withdrawn
- 1994-09-13 CA CA002171289A patent/CA2171289C/en not_active Expired - Fee Related
- 1994-09-13 ES ES02017044T patent/ES2302774T3/es not_active Expired - Lifetime
- 1994-09-13 DE DE69435083T patent/DE69435083T2/de not_active Expired - Lifetime
- 1994-09-13 DE DE69431843T patent/DE69431843T2/de not_active Expired - Lifetime
- 1994-09-13 AU AU78348/94A patent/AU697190B2/en not_active Ceased
- 1994-09-13 EP EP02017044A patent/EP1283217B1/de not_active Expired - Lifetime
- 1994-09-13 EP EP94929201A patent/EP0719285B1/de not_active Expired - Lifetime
- 1994-09-13 DK DK02017044T patent/DK1283217T3/da active
- 1994-09-13 AT AT94929201T patent/ATE229036T1/de not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/487,795 patent/US6436390B1/en not_active Expired - Lifetime
-
2004
- 2004-09-08 JP JP2004261714A patent/JP4122321B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-14 JP JP2008066818A patent/JP2008169227A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1932856A3 (de) | 2009-09-30 |
| DE69431843T2 (de) | 2003-07-10 |
| ATE229036T1 (de) | 2002-12-15 |
| DE69435083T2 (de) | 2009-03-12 |
| WO1995007934A3 (en) | 1995-04-13 |
| US6436390B1 (en) | 2002-08-20 |
| JP2005023085A (ja) | 2005-01-27 |
| PT1283217E (pt) | 2008-06-11 |
| US6448379B1 (en) | 2002-09-10 |
| DE69431843D1 (de) | 2003-01-23 |
| JP4122321B2 (ja) | 2008-07-23 |
| EP0719285A1 (de) | 1996-07-03 |
| AU697190B2 (en) | 1998-10-01 |
| EP1932856A2 (de) | 2008-06-18 |
| CA2171289C (en) | 2007-04-10 |
| EP0719285B1 (de) | 2002-12-04 |
| ES2302774T3 (es) | 2008-08-01 |
| EP1283217B1 (de) | 2008-03-05 |
| AU7834894A (en) | 1995-04-03 |
| JPH09502725A (ja) | 1997-03-18 |
| JP2008169227A (ja) | 2008-07-24 |
| CA2171289A1 (en) | 1995-03-23 |
| EP1283217A3 (de) | 2003-09-17 |
| DK1283217T3 (da) | 2008-07-07 |
| WO1995007934A2 (en) | 1995-03-23 |
| EP1283217A2 (de) | 2003-02-12 |
| DE69435083D1 (de) | 2008-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1283217 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |