ATE359090T1 - Monoklonale antikörper spezifisch gegen vegf- rezeptoren und ihre verwendung - Google Patents
Monoklonale antikörper spezifisch gegen vegf- rezeptoren und ihre verwendungInfo
- Publication number
- ATE359090T1 ATE359090T1 AT95911659T AT95911659T ATE359090T1 AT E359090 T1 ATE359090 T1 AT E359090T1 AT 95911659 T AT95911659 T AT 95911659T AT 95911659 T AT95911659 T AT 95911659T AT E359090 T1 ATE359090 T1 AT E359090T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibodies
- antibodies specific
- vegf receptors
- receptor
- vegf
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19604194A | 1994-02-10 | 1994-02-10 | |
US08/326,552 US5840301A (en) | 1994-02-10 | 1994-10-20 | Methods of use of chimerized, humanized, and single chain antibodies specific to VEGF receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE359090T1 true ATE359090T1 (de) | 2007-05-15 |
Family
ID=26891612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95911659T ATE359090T1 (de) | 1994-02-10 | 1995-02-10 | Monoklonale antikörper spezifisch gegen vegf- rezeptoren und ihre verwendung |
Country Status (7)
Country | Link |
---|---|
US (2) | US5840301A (de) |
EP (2) | EP0741748B1 (de) |
AT (1) | ATE359090T1 (de) |
AU (1) | AU1914795A (de) |
CA (1) | CA2185683A1 (de) |
DE (1) | DE69535459T2 (de) |
WO (1) | WO1995021868A1 (de) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030206899A1 (en) * | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US5367057A (en) * | 1991-04-02 | 1994-11-22 | The Trustees Of Princeton University | Tyrosine kinase receptor flk-2 and fragments thereof |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US8211422B2 (en) * | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
US6872699B2 (en) | 1992-11-13 | 2005-03-29 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. | Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
AUPM379394A0 (en) * | 1994-02-10 | 1994-03-03 | Ludwig Institute For Cancer Research | Immunointeractive molecules - i |
US5861499A (en) | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
US6448077B1 (en) * | 1994-02-10 | 2002-09-10 | Imclone Systems, Inc. | Chimeric and humanized monoclonal antibodies specific to VEGF receptors |
IL117645A (en) * | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
US7060808B1 (en) * | 1995-06-07 | 2006-06-13 | Imclone Systems Incorporated | Humanized anti-EGF receptor monoclonal antibody |
EP0848755B2 (de) | 1995-09-08 | 2011-02-09 | Genentech, Inc. | Vegf-verwandtes protein |
US6346398B1 (en) | 1995-10-26 | 2002-02-12 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for the treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor |
US7034009B2 (en) | 1995-10-26 | 2006-04-25 | Sirna Therapeutics, Inc. | Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R) |
US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
WO1997034920A1 (en) * | 1996-03-21 | 1997-09-25 | Sugen, Inc. | Assays for kdr/flk-1 receptor tyrosine kinase inhibitors |
US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
DE19638745C2 (de) * | 1996-09-11 | 2001-05-10 | Schering Ag | Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR) |
WO1999060025A1 (fr) * | 1998-05-20 | 1999-11-25 | Kyowa Hakko Kogyo Co., Ltd. | Anticorps recombines de gene |
US6986890B1 (en) * | 1996-11-21 | 2006-01-17 | Kyowa Hakko Kogyo Co., Ltd. | Anti-human VEGF receptor Flt-1 monoclonal antibody |
JP3746790B2 (ja) * | 1996-11-21 | 2006-02-15 | 協和醗酵工業株式会社 | 抗ヒトVEGF受容体F1t―1モノクローナル抗体 |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
PT973804E (pt) * | 1997-04-07 | 2007-03-30 | Genentech Inc | Anticorpos anti-vegf |
JP2002500879A (ja) * | 1998-01-23 | 2002-01-15 | イムクローン システムズ インコーポレーテッド | 幹細胞の精製ポピュレーション |
AU2299099A (en) * | 1998-02-04 | 1999-08-23 | Kyowa Hakko Kogyo Co. Ltd. | Antibodies against human vegf receptor kdr |
US20030224001A1 (en) * | 1998-03-19 | 2003-12-04 | Goldstein Neil I. | Antibody and antibody fragments for inhibiting the growth of tumors |
ZA200007412B (en) * | 1998-05-15 | 2002-03-12 | Imclone Systems Inc | Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases. |
AU2004200700B2 (en) * | 1998-05-20 | 2006-08-31 | Kyowa Hakko Kirin Co., Ltd. | Gene Recombinant Antibody |
JP3679406B2 (ja) * | 1998-05-20 | 2005-08-03 | 協和醗酵工業株式会社 | 遺伝子組換え抗体 |
US20030175271A1 (en) * | 1998-05-20 | 2003-09-18 | Kyowa Hakko Kogyo Co., Ltd. | VEGF activity inhibitor |
WO1999059636A1 (fr) * | 1998-05-20 | 1999-11-25 | Kyowa Hakko Kogyo Co., Ltd. | Inhibiteurs de l'activite du facteur de croissance endothelial vasculaire (vegf) |
CA2363568A1 (en) * | 1999-03-04 | 2000-09-08 | Kyowa Hakko Kogyo Co., Ltd. | Diagnostic agent and therapeutic agent for leukemia |
US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
US6342219B1 (en) | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
IL146480A0 (en) * | 1999-05-14 | 2002-07-25 | Imclone Systems Inc | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
EP1906184A1 (de) * | 1999-06-17 | 2008-04-02 | Kyowa Hakko Kogyo Co., Ltd. | Diagnosemittel und Therapiemittel für durch Makrophyten und Makrophagen hervorgerufene Krankheiten |
JP2003519670A (ja) * | 2000-01-12 | 2003-06-24 | ライト サイエンシーズ コーポレイション | 眼疾患の新規処置 |
US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
WO2001057067A1 (en) | 2000-02-04 | 2001-08-09 | Supratek Pharma Inc. | Ligand for vascular endothelial growth factor receptor |
US7125542B2 (en) * | 2000-02-10 | 2006-10-24 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
EP1130032A1 (de) * | 2000-02-28 | 2001-09-05 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Einzelkette-Antikörper die den menschlichen vaskulären endothelialen Wachstumsfaktorrezeptor-2 (VEGFR-2/KDR) erkennen |
AU2001243418A1 (en) * | 2000-03-03 | 2001-09-17 | Imclone Systems Incorporated | Ve-cadherin and vegfr-2 antagonists for therapeutic modulation of angiogenesis |
WO2001075109A2 (en) * | 2000-03-31 | 2001-10-11 | Imclone Systems Incorporated | Antagonist antibodies to ve-cadherin without adverse effects on vascular permeability |
AU2001264946A1 (en) * | 2000-05-24 | 2001-12-03 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
EP1311291A4 (de) * | 2000-08-09 | 2007-07-25 | Imclone Systems Inc | Behandlung von hyperproliferativen krankheiten mit antagonisten des epidermalen wachstumsfaktors |
US20030186920A1 (en) * | 2000-10-13 | 2003-10-02 | Sirois Martin G. | Antisense oligonucleotide directed toward mammalian vegf receptor genes and uses thereof |
US20080008704A1 (en) * | 2001-03-16 | 2008-01-10 | Mark Rubin | Methods of treating colorectal cancer with anti-epidermal growth factor antibodies |
AU2002257132A1 (en) | 2001-04-06 | 2002-10-21 | The Trustees Of The University Of Pennsylvania | Erbb interface peptidomimetics and methods of use thereof |
AU2002348477A1 (en) | 2001-05-01 | 2002-12-23 | The General Hospital Corporation | Photoimmunotherapies for cancer using photosensitizer immunoconjugates and combination therapies |
WO2002102972A2 (en) * | 2001-06-20 | 2002-12-27 | Prochon Biotech Ltd. | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
US20040247597A1 (en) * | 2001-06-20 | 2004-12-09 | Peter Carmeliet | Method of treating atherosclerosis and other inflammatory diseases |
WO2003002144A1 (en) * | 2001-06-26 | 2003-01-09 | Imclone Systems Incorporated | Bispecific antibodies that bind to vegf receptors |
JP2005515967A (ja) * | 2001-07-13 | 2005-06-02 | イムクローン システムズ インコーポレイティド | 乳癌を治療するためのvegfr−1抗体 |
WO2003014326A2 (en) * | 2001-08-10 | 2003-02-20 | Imclone Systems Incorporated | Isolation and mobilization of stem cells expressing vegfr-1 |
FR2832154B1 (fr) * | 2001-11-09 | 2007-03-16 | Centre Nat Rech Scient | Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene |
US20030185870A1 (en) | 2001-11-20 | 2003-10-02 | Grinstaff Mark W. | Interfacial biomaterials |
CN101474404A (zh) * | 2002-03-04 | 2009-07-08 | 伊姆克罗尼系统公司 | 用血管内皮生长因子受体拮抗剂抑制肿瘤生长的联合疗法 |
GB0206072D0 (en) * | 2002-03-15 | 2002-04-24 | Astrazeneca Ab | Epitope |
US7402397B2 (en) | 2002-05-21 | 2008-07-22 | Monogram Biosciences, Inc. | Detecting and profiling molecular complexes |
US20040229380A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB heterodimers as biomarkers |
US20040229294A1 (en) * | 2002-05-21 | 2004-11-18 | Po-Ying Chan-Hui | ErbB surface receptor complexes as biomarkers |
US20050186204A1 (en) * | 2002-06-28 | 2005-08-25 | Peter Carmeliet | Use of antibodies against FLT-1 for the treatment of osteoporosis |
EP1622941A2 (de) * | 2003-03-20 | 2006-02-08 | ImClone Systems Incorporated | Methode zur produktion von anti-egfr antikörpern |
WO2008109433A2 (en) | 2007-03-02 | 2008-09-12 | The Cleveland Clinic Foundation | Anti-angiogenic peptides |
JP2007500248A (ja) | 2003-06-09 | 2007-01-11 | ワクサル,サムエル | 細胞外アンタゴニストおよび細胞内アンタゴニストによる受容体チロシンキナーゼの抑制方法 |
KR101471732B1 (ko) | 2003-08-27 | 2014-12-16 | 옵쏘테크 코포레이션 | 안구의 혈관신생성 장애를 치료하기 위한 조합 치료법 |
US7402399B2 (en) * | 2003-10-14 | 2008-07-22 | Monogram Biosciences, Inc. | Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy |
WO2005069906A2 (en) * | 2004-01-16 | 2005-08-04 | Yale University | Methods and compositions relating to vascular endothelial growth factor and th2 mediated inflammatory diseases |
EP2332990A1 (de) * | 2004-03-19 | 2011-06-15 | Imclone LLC | Humaner Anti-Epidermiswachstumsfaktor-Rezeptor-Antikörper |
US20060234210A1 (en) * | 2004-04-14 | 2006-10-19 | Affinergy, Inc. | Filtration device and method for removing selected materials from biological fluids |
EP2377555A3 (de) | 2004-11-18 | 2011-11-23 | Imclone LLC | Antikörper gegen den vaskulären endothelialen Wachstumsfaktorrezeptor-1 |
KR101371773B1 (ko) * | 2005-12-15 | 2014-03-07 | 아스트라제네카 아베 | 암 치료를 위한, 안지오포이에틴-2 길항자와 vegf-a,kdr 및/또는 flt1 길항자의 조합물 |
US20070258976A1 (en) * | 2006-05-04 | 2007-11-08 | Ward Keith W | Combination Therapy for Diseases Involving Angiogenesis |
WO2008093246A2 (en) * | 2007-02-02 | 2008-08-07 | Vegenics Limited | Vegf receptor antagonist for treating organ transplant alloimmunity and arteriosclerosis |
KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
EA034136B1 (ru) | 2007-11-09 | 2020-01-09 | Перигрин Фармасьютикалз, Инк. | Изолированное антитело, которое связывается с vegf, и его применения |
WO2011005377A2 (en) * | 2009-05-27 | 2011-01-13 | Mount Sinai School Of Medicine Of New York University | Compositions and methods comprising vegfr-2 and vegfr-3 antagonists for the treatment of metastatic disease |
JP5934099B2 (ja) * | 2009-10-01 | 2016-06-15 | アメリカ合衆国 | 抗血管内皮増殖因子受容体−2キメラ抗原受容体及び癌の治療のためのその使用 |
EP2538965B1 (de) | 2010-02-25 | 2017-04-12 | Schepens Eye Research Institute | Therapeutische zusammensetzungen zur behandlung des syndroms des trockenen auges |
EP2994758B1 (de) | 2013-05-08 | 2017-12-20 | Opthea Limited | Biomarker für altersbedingte makuladegeneration (amd) |
US10160973B2 (en) | 2015-03-30 | 2018-12-25 | Nissan Chemical Industries, Ltd. | Nucleic acid aptamers binding to vascular endothelial growth factor receptors |
CN106892980B (zh) * | 2017-01-25 | 2020-08-04 | 长春金赛药业有限责任公司 | 抗vegfr2单克隆抗体及其应用 |
US11723955B1 (en) | 2022-05-13 | 2023-08-15 | Allgenesis Biotherapeutics Inc. | VEGFR fusion protein pharmaceutical composition |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
ATE221915T1 (de) * | 1991-02-22 | 2002-08-15 | American Cyanamid Co | Identifizierung eines menschlichen rezeptor- tyrosinkinasegens |
US5185438A (en) * | 1991-04-02 | 1993-02-09 | The Trustees Of Princeton University | Nucleic acids encoding hencatoporetic stem cell receptor flk-2 |
US5270458A (en) * | 1991-04-02 | 1993-12-14 | The Trustees Of Princeton University | Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 |
JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
AU3236793A (en) * | 1991-12-12 | 1993-07-19 | Berlex Laboratories, Inc. | Recombinant and chimeric antibodies to c-erbB-2 |
WO1993021319A1 (en) * | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
CA2085291A1 (en) * | 1992-07-30 | 1994-01-31 | Martin L. Breitman | Novel receptor tyrosine kinase |
DK0666868T4 (da) * | 1992-10-28 | 2006-09-18 | Genentech Inc | Anvendelse af anti-VEGF-antistoffer til behandling af cancer |
CA2148244A1 (en) * | 1992-10-29 | 1994-05-11 | Christopher Richard Parish | Angiogenesis inhibitory antibodies |
CN1173991C (zh) * | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
AUPM379394A0 (en) * | 1994-02-10 | 1994-03-03 | Ludwig Institute For Cancer Research | Immunointeractive molecules - i |
-
1994
- 1994-10-20 US US08/326,552 patent/US5840301A/en not_active Expired - Fee Related
-
1995
- 1995-02-10 DE DE69535459T patent/DE69535459T2/de not_active Expired - Lifetime
- 1995-02-10 AU AU19147/95A patent/AU1914795A/en not_active Abandoned
- 1995-02-10 EP EP95911659A patent/EP0741748B1/de not_active Expired - Lifetime
- 1995-02-10 WO PCT/US1995/001678 patent/WO1995021868A1/en active IP Right Grant
- 1995-02-10 EP EP05002398A patent/EP1602668A1/de not_active Withdrawn
- 1995-02-10 CA CA002185683A patent/CA2185683A1/en not_active Abandoned
- 1995-02-10 AT AT95911659T patent/ATE359090T1/de not_active IP Right Cessation
-
1997
- 1997-06-02 US US08/866,969 patent/US5874542A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1914795A (en) | 1995-08-29 |
EP1602668A1 (de) | 2005-12-07 |
EP0741748B1 (de) | 2007-04-11 |
DE69535459D1 (de) | 2007-05-24 |
WO1995021868A1 (en) | 1995-08-17 |
US5840301A (en) | 1998-11-24 |
DE69535459T2 (de) | 2007-12-13 |
US5874542A (en) | 1999-02-23 |
CA2185683A1 (en) | 1995-08-17 |
EP0741748A1 (de) | 1996-11-13 |
EP0741748A4 (de) | 2000-07-05 |
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