DK0851920T3 - Varianter af vaskulær endotelcellevækstfaktor, anvendelser af disse samt fremgangsmåder til fremstilling deraf - Google Patents
Varianter af vaskulær endotelcellevækstfaktor, anvendelser af disse samt fremgangsmåder til fremstilling derafInfo
- Publication number
- DK0851920T3 DK0851920T3 DK96929012T DK96929012T DK0851920T3 DK 0851920 T3 DK0851920 T3 DK 0851920T3 DK 96929012 T DK96929012 T DK 96929012T DK 96929012 T DK96929012 T DK 96929012T DK 0851920 T3 DK0851920 T3 DK 0851920T3
- Authority
- DK
- Denmark
- Prior art keywords
- variants
- preparation
- growth factor
- vascular endothelial
- vegf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Vascular Medicine (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US282795P | 1995-08-25 | 1995-08-25 | |
US08/567,200 US6020473A (en) | 1995-08-25 | 1995-12-05 | Nucleic acids encoding variants of vascular endothelial cell growth factor |
US08/691,794 US6057428A (en) | 1995-08-25 | 1996-08-02 | Variants of vascular endothelial cell growth factor |
PCT/US1996/013621 WO1997008313A1 (en) | 1995-08-25 | 1996-08-23 | Variants of vascular endothelial cell growth factor, their uses, and processes for their production |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0851920T3 true DK0851920T3 (da) | 2008-09-22 |
Family
ID=26670933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96929012T DK0851920T3 (da) | 1995-08-25 | 1996-08-23 | Varianter af vaskulær endotelcellevækstfaktor, anvendelser af disse samt fremgangsmåder til fremstilling deraf |
Country Status (10)
Country | Link |
---|---|
US (4) | US6020473A (da) |
EP (1) | EP0851920B1 (da) |
JP (1) | JP3456706B2 (da) |
AT (1) | ATE399203T1 (da) |
AU (1) | AU6857296A (da) |
CA (1) | CA2230144C (da) |
DE (1) | DE69637570D1 (da) |
DK (1) | DK0851920T3 (da) |
ES (1) | ES2309990T3 (da) |
WO (1) | WO1997008313A1 (da) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020473A (en) * | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
US7005505B1 (en) * | 1995-08-25 | 2006-02-28 | Genentech, Inc. | Variants of vascular endothelial cell growth factor |
US20040072722A1 (en) | 2002-10-10 | 2004-04-15 | Kornblith Paul L. | Methods for assessing efficacy of chemotherapeutic agents |
US5728541A (en) * | 1996-07-12 | 1998-03-17 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
US20040023375A1 (en) * | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
US6416967B2 (en) * | 1996-07-12 | 2002-07-09 | Precision Therapeutics, Inc. | Method of using multicellular particulates to analyze malignant or hyperproliferative tissue |
US6750044B1 (en) * | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
US6485942B1 (en) * | 1997-02-14 | 2002-11-26 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having altered pharmacological properties, and recombinant methods of production |
US6777534B1 (en) | 1997-12-09 | 2004-08-17 | Children's Medical Center Corporation | Peptide antagonists of vascular endothelial growth factor |
AU1906099A (en) * | 1997-12-09 | 1999-06-28 | Children's Medical Center Corporation | Peptide antagonists of vascular endothelial growth factor |
US6635421B1 (en) | 1997-12-09 | 2003-10-21 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
AU767662B2 (en) | 1998-02-06 | 2003-11-20 | Collateral Therapeutics, Inc. | Variants of the angiogenic factor vascular endothelial cell growth factor: VEGF |
AU2004202596B2 (en) * | 1999-04-16 | 2007-06-14 | Genentech, Inc. | Vascular endothelial cell growth factor variants and uses thereof |
US7090834B1 (en) * | 1999-04-16 | 2006-08-15 | Genentech, Inc. | Vascular endothelial cell growth factor variants and uses thereof |
ES2265931T3 (es) * | 1999-04-16 | 2007-03-01 | Genentech, Inc. | Variantes del factor de crecimiento celular endotelial vascular (vegf) y sus usos. |
US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
BR0010017A (pt) | 1999-04-28 | 2002-06-11 | Univ Texas | Composições e processos para o tratamento de câncer por inibição seletiva de vegf |
CA2373822A1 (en) | 1999-05-20 | 2000-11-30 | Scios Inc. | Vascular endothelial growth factor variants |
AR025984A1 (es) * | 1999-10-07 | 2002-12-26 | Maxygen Aps | Polipeptidos oligomericos de cadena simple |
US7078382B1 (en) * | 1999-11-02 | 2006-07-18 | Genentech, Inc. | Modulation of eNOS activity and therapeutic uses thereof |
CA2385665A1 (en) * | 1999-11-02 | 2001-05-10 | Genentech, Inc. | Modulation of enos activity and therapeutic uses thereof |
AU2000230635A1 (en) * | 2000-01-20 | 2001-07-31 | North Bristol Nhs Trust | Vegf148 isoform, a truncated splice variant of vegf. vegf heterodimers and therapeutical uses thereof |
US7355019B2 (en) * | 2000-06-06 | 2008-04-08 | Sibtech, Inc. | Cysteine-containing peptide tag for site-specific conjugation of proteins |
CA2417508A1 (en) * | 2000-07-26 | 2002-01-31 | Ludwig Institute For Cancer Research | Glycosylated vegf-b and method for increasing the amount of soluble vegf-b |
KR100419972B1 (ko) * | 2000-09-09 | 2004-03-03 | 굿젠 주식회사 | 링커 염기서열로 연결된 인간 vegf의 돌연변이형동형이합체 유전자, 이를 포함하는 발현벡터, 이의형질전환체 및 단백질 |
US20020151489A1 (en) * | 2000-10-02 | 2002-10-17 | St. Elizabeth's Medical Center Of Boston, Inc. | Use of lymphangiogenic agents to treat lymphatic disorders |
WO2002081520A2 (en) * | 2001-04-06 | 2002-10-17 | Maxygen Holdings Ltd. | Single chain dimeric polypeptides derived from the vegf family |
CA2449687A1 (en) * | 2001-06-08 | 2002-12-19 | Dnavec Research Inc. | Vascular regeneration therapy |
DK1399484T3 (da) * | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
JP2005500045A (ja) * | 2001-07-12 | 2005-01-06 | ルードビッヒ、インスティテュート、フォー、キャンサー、リサーチ | リンパ管内皮細胞材料および方法 |
CN1332978C (zh) * | 2001-09-12 | 2007-08-22 | 北京市肿瘤防治研究所 | 作为VEGF受体Flt-1拮抗剂的肽 |
US20040086888A1 (en) * | 2001-10-18 | 2004-05-06 | Kornblith Paul L | Method for tandem genomic/proteomic analysis of proliferating cells |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
WO2004065621A1 (en) * | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP1342783A1 (de) * | 2002-03-08 | 2003-09-10 | Eming, Sabine, A.,Dr. med. | Proteolyseresistenter aktiver VEGF |
JP5111729B2 (ja) * | 2002-06-05 | 2013-01-09 | ジェネンテック, インコーポレイテッド | 肝成長及び肝保護のための組成物と方法 |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
DE60305919T2 (de) * | 2002-06-28 | 2007-01-18 | Domantis Limited, Cambridge | Dual-specifische liganden mit erhöhter halbwertszeit |
US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
CA2511910A1 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
EP2526960A1 (en) | 2003-03-12 | 2012-11-28 | Genentech, Inc. | Use of BV8 and/or EG-VEGF to promote hematopoiesis |
JP2005110508A (ja) * | 2003-10-02 | 2005-04-28 | Nec Soft Ltd | 血管内皮増殖因子受容体2型に対する特異的結合性を有するヘビ毒由来血管内皮増殖因子様タンパク質と用途 |
CN1304427C (zh) * | 2004-06-08 | 2007-03-14 | 成都康弘生物科技有限公司 | 抑制血管新生的融合蛋白质及其用途 |
WO2005121176A1 (fr) | 2004-06-08 | 2005-12-22 | Chengdu Kanghong Biotechnologies Co. Ltd | Proteine chimerique inhibitrice d'angiogenese et utilisation associee |
WO2005121316A1 (en) * | 2004-06-11 | 2005-12-22 | Bernard O'brien Institute Of Microsurgery | Tissue material and muscle derived matrix |
CN101031655A (zh) | 2004-07-26 | 2007-09-05 | 陶氏环球技术公司 | 通过株工程改进蛋白表达的方法 |
JP2008513356A (ja) * | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
US7597884B2 (en) * | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
WO2007028146A2 (en) * | 2005-09-01 | 2007-03-08 | Precision Therapeutics, Inc. | Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics |
TW200732347A (en) * | 2005-10-06 | 2007-09-01 | Trophogen Inc | VEGF analogs and methods of use |
UA96139C2 (uk) | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
TW200730539A (en) * | 2005-12-01 | 2007-08-16 | Domantis Ltd | Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1 |
EP2015768A1 (en) * | 2006-03-27 | 2009-01-21 | Genentech, Inc. | Methods for treating kidney disorders |
DK2069798T3 (da) * | 2006-10-04 | 2014-06-16 | Genentech Inc | Elisa til vegf |
AU2013221919B2 (en) * | 2006-10-04 | 2016-04-14 | Genentech, Inc. | ELISA for VEGF |
US20080260820A1 (en) * | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
WO2008134461A2 (en) | 2007-04-27 | 2008-11-06 | Dow Global Technologies, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
NZ580530A (en) * | 2007-06-06 | 2012-04-27 | Domantis Ltd | Anti vegf polypeptides, antibody variable domains and antagonists |
WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
US8741839B2 (en) * | 2009-01-18 | 2014-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Polypeptides targeting vascular endothelial growth factor receptor-2 and αvβ3 integrin |
CA2803792A1 (en) | 2010-07-09 | 2012-01-12 | Genentech, Inc. | Anti-neuropilin antibodies and methods of use |
NZ707016A (en) | 2012-07-30 | 2017-08-25 | Trophogen Inc | Glycoprotein hormone long-acting superagonists |
US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
JP2017502079A (ja) | 2013-11-05 | 2017-01-19 | トロフォジェン インコーポレイテッド | 糖タンパク質ホルモン長時間作用性スーパーアゴニスト |
JP2018507181A (ja) * | 2015-01-16 | 2018-03-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Vegf変異体ポリペプチド組成物 |
EP3216458A1 (en) | 2016-03-07 | 2017-09-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Modified vascular endothelial growth factor a (vegf-a) and its medical use |
US11110063B2 (en) | 2017-08-25 | 2021-09-07 | MAIA Pharmaceuticals, Inc. | Storage stable sincalide formulations |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3691016A (en) * | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
CA1023287A (en) * | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4195128A (en) * | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
US4330440A (en) * | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) * | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
US4229537A (en) * | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
US4399216A (en) * | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
ZA811368B (en) * | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
NZ201918A (en) * | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
HUT35524A (en) * | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
DE3413608A1 (de) * | 1984-04-11 | 1985-10-24 | Hoechst Ag, 6230 Frankfurt | Implantierbare zubereitungen von regulatorischen peptiden mit gesteuerter freisetzung und verfahren zu ihrer herstellung |
FI86885C (fi) * | 1984-04-20 | 1992-10-26 | Genentech Inc | Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill |
JPS63502716A (ja) * | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
EP0266032A1 (en) * | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
US5332671A (en) * | 1989-05-12 | 1994-07-26 | Genetech, Inc. | Production of vascular endothelial cell growth factor and DNA encoding same |
US5219739A (en) * | 1989-07-27 | 1993-06-15 | Scios Nova Inc. | DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121 |
EP0506477B1 (en) * | 1991-03-28 | 1999-06-23 | Merck & Co. Inc. | Vascular endothelial cell growth factor C subunit |
DE9104598U1 (de) | 1991-04-16 | 1992-10-01 | Natec Reich, Summer GmbH & Co KG, 8996 Opfenbach | Schälmaschine |
US5607918A (en) * | 1995-03-01 | 1997-03-04 | Ludwig Institute For Cancer Research | Vascular endothelial growth factor-B and DNA coding therefor |
US6020473A (en) * | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
US6750044B1 (en) * | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
ES2265931T3 (es) * | 1999-04-16 | 2007-03-01 | Genentech, Inc. | Variantes del factor de crecimiento celular endotelial vascular (vegf) y sus usos. |
US7090834B1 (en) * | 1999-04-16 | 2006-08-15 | Genentech, Inc. | Vascular endothelial cell growth factor variants and uses thereof |
-
1995
- 1995-12-05 US US08/567,200 patent/US6020473A/en not_active Expired - Lifetime
-
1996
- 1996-08-02 US US08/691,794 patent/US6057428A/en not_active Expired - Lifetime
- 1996-08-23 JP JP51044797A patent/JP3456706B2/ja not_active Expired - Lifetime
- 1996-08-23 AU AU68572/96A patent/AU6857296A/en not_active Abandoned
- 1996-08-23 DK DK96929012T patent/DK0851920T3/da active
- 1996-08-23 DE DE69637570T patent/DE69637570D1/de not_active Expired - Lifetime
- 1996-08-23 EP EP96929012A patent/EP0851920B1/en not_active Expired - Lifetime
- 1996-08-23 AT AT96929012T patent/ATE399203T1/de not_active IP Right Cessation
- 1996-08-23 WO PCT/US1996/013621 patent/WO1997008313A1/en active Application Filing
- 1996-08-23 ES ES96929012T patent/ES2309990T3/es not_active Expired - Lifetime
- 1996-08-23 CA CA2230144A patent/CA2230144C/en not_active Expired - Lifetime
-
2005
- 2005-06-03 US US11/145,494 patent/US7427596B2/en not_active Expired - Fee Related
-
2006
- 2006-09-28 US US11/536,471 patent/US20070082847A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20060024785A1 (en) | 2006-02-02 |
US7427596B2 (en) | 2008-09-23 |
ATE399203T1 (de) | 2008-07-15 |
WO1997008313A1 (en) | 1997-03-06 |
AU6857296A (en) | 1997-03-19 |
EP0851920B1 (en) | 2008-06-25 |
US6020473A (en) | 2000-02-01 |
CA2230144C (en) | 2013-02-12 |
JPH10511557A (ja) | 1998-11-10 |
CA2230144A1 (en) | 1997-03-06 |
US20070082847A1 (en) | 2007-04-12 |
DE69637570D1 (de) | 2008-08-07 |
ES2309990T3 (es) | 2008-12-16 |
EP0851920A1 (en) | 1998-07-08 |
JP3456706B2 (ja) | 2003-10-14 |
US6057428A (en) | 2000-05-02 |
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