TR200102502T2 - Trombin reseptör modülatörleri olarak yararlı sübstitüe edilmiş heterosiklik açil-tripeptidler. - Google Patents

Trombin reseptör modülatörleri olarak yararlı sübstitüe edilmiş heterosiklik açil-tripeptidler.

Info

Publication number
TR200102502T2
TR200102502T2 TR2001/02502T TR200102502T TR200102502T2 TR 200102502 T2 TR200102502 T2 TR 200102502T2 TR 2001/02502 T TR2001/02502 T TR 2001/02502T TR 200102502 T TR200102502 T TR 200102502T TR 200102502 T2 TR200102502 T2 TR 200102502T2
Authority
TR
Turkey
Prior art keywords
substituted heterocyclic
receptor modulators
thrombin receptor
heterocyclic acyl
tripeptides
Prior art date
Application number
TR2001/02502T
Other languages
English (en)
Inventor
F. Mccomsey David
E. Maryanoff Bruce
J. Hawkins Michael
Original Assignee
Ortho-Mcneil Pharmaceutical. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical. Inc. filed Critical Ortho-Mcneil Pharmaceutical. Inc.
Publication of TR200102502T2 publication Critical patent/TR200102502T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu bulus, trombin reseptör modülatörleri olarak yararli olan sübstitüe edilmis heterosiklik açil-tripeptidler, bunlarin yara iyilestirilmesinde ve trombosit agregasyonunun önlenmesinde kullanimi ile ilgilidir.Ayrica bu bulusa ait sübstitüe edilmis heteroksiklik açil-tripeptidleri ihtiva eden farmasötik terkipler ve trombin reseptörünün araciligi ile olusan durumlari tedavi etmek için yöntemler de açiklanmistir.
TR2001/02502T 1998-12-14 1999-11-19 Trombin reseptör modülatörleri olarak yararlı sübstitüe edilmiş heterosiklik açil-tripeptidler. TR200102502T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11231398P 1998-12-14 1998-12-14
US44432799A 1999-11-19 1999-11-19

Publications (1)

Publication Number Publication Date
TR200102502T2 true TR200102502T2 (tr) 2002-05-21

Family

ID=26809819

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02502T TR200102502T2 (tr) 1998-12-14 1999-11-19 Trombin reseptör modülatörleri olarak yararlı sübstitüe edilmiş heterosiklik açil-tripeptidler.

Country Status (13)

Country Link
US (2) US6747127B1 (tr)
EP (1) EP1140985A1 (tr)
CN (1) CN1342164A (tr)
AU (1) AU771844B2 (tr)
BR (1) BR9916811A (tr)
CA (1) CA2355818A1 (tr)
CZ (1) CZ20012136A3 (tr)
HU (1) HUP0104588A3 (tr)
NO (1) NO20012939L (tr)
PL (1) PL348504A1 (tr)
TR (1) TR200102502T2 (tr)
WO (1) WO2000035942A1 (tr)
YU (1) YU42401A (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20060293231A1 (en) * 2004-07-30 2006-12-28 Regina Landesberg Method for enhancing bone formation
US20060159663A1 (en) * 2004-07-30 2006-07-20 Lu Helen H Growth factor encapsulation system for enhancing bone formation
US8097582B2 (en) 2006-05-09 2012-01-17 Neobiotics Ab Peptide derivatives useful as antimicrobial agents and for treating wounds
US8466180B2 (en) 2006-09-11 2013-06-18 Syngenta Crop Protection Llc Insecticidal compounds
CN101747410B (zh) * 2008-11-28 2013-03-13 北京大学 具镇痛活性的氨基酰酪氨酰色氨酸三肽及制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60888A (en) 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
GB9019558D0 (en) 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
EP0503203A1 (en) 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
US5391705A (en) 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
HU221974B1 (hu) 1992-06-04 2003-03-28 Merrell Dow Pharmaceuticals Inc. Eljárás trombingátló hatású fluortartalmú peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US5696231A (en) 1994-12-21 1997-12-09 Corvas International, Inc. N-substituted glycine derivatives as enzyme inhibitors
US6069232A (en) 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US6017890A (en) 1998-02-19 2000-01-25 Ortho-Mcneil Pharmaceutical, Inc. Azole peptidomimetics as thrombin receptor antagonists
DE69902887T2 (de) * 1998-02-19 2003-08-07 Ortho Mcneil Pharm Inc Azole peptidomimetische verbindungen als thrombin rezeptor antagoniste

Also Published As

Publication number Publication date
EP1140985A1 (en) 2001-10-10
AU1825600A (en) 2000-07-03
NO20012939D0 (no) 2001-06-14
HUP0104588A3 (en) 2002-05-28
US20040063903A1 (en) 2004-04-01
CA2355818A1 (en) 2000-06-22
NO20012939L (no) 2001-08-09
AU771844B2 (en) 2004-04-01
YU42401A (sh) 2003-12-31
WO2000035942A1 (en) 2000-06-22
US6747127B1 (en) 2004-06-08
PL348504A1 (en) 2002-05-20
BR9916811A (pt) 2002-01-15
HUP0104588A2 (hu) 2002-04-29
CN1342164A (zh) 2002-03-27
US7312306B2 (en) 2007-12-25
CZ20012136A3 (cs) 2002-02-13

Similar Documents

Publication Publication Date Title
TR200102401T2 (tr) C-21 Değiştirilmiş epotilonlar.
TR200102029T2 (tr) 1-Heterosiklil ikameli diarilaminler.
TR200100267T2 (tr) İkameli anilid bileşimleri ve yöntemler.
DE50306232D1 (de) Ampholytisches copolymer und dessen verwendung
ATE411082T1 (de) Neue verwendung von kurzkettigen carbonsäuren
DE69813898D1 (de) Substituierte porphyrinen
PT1140944E (pt) Derivados de epotilona e sua utilizacao como agentes antitumorais
PT1214936E (pt) Utilizacao de derivados de tiazolidina ou pirrolidina de aminoacidos como agentes anti-hiperglicemicos
ATE445386T1 (de) Polymerische parfümpartikel
TR200102773T2 (tr) Alkoksisilan yapısal birimleri olan poliüretan eriyikleri
DE60141950D1 (de) Vernetzte, nicht von pilzen kommende lipase enthaltende zusammensetzung und methoden zu deren verwendung
TR200100149T2 (tr) Dual anjiyotensin endotelin alıcı antagonistleri olarak bifenil-sülfonamitler
DE60237851D1 (de) Modifiziertes Propylenpolymer, dieses enthaltende Zusammensetzung und deren Verwendung
PT1083903E (pt) Indenopirrolocarbazoles em ponte
TR199800679T2 (tr) Kiral metil fenil oksazolidinon.
DE69720062D1 (de) Integrin antagonisten
DE69900080D1 (de) Wasser-in-Öl Zusammensetzung mit verlaufsveränderlicher Schergeschwindigkeit
TR200100462T2 (tr) Muskarinik agonistleri ve antagonistleri
EE03619B1 (et) Süsivesik-modifitseeritud tsütostaatikumid
DE60041418D1 (de) Zusammensetzung für hydrogele, hydrogel und dessen verwendung
TR200201459T2 (tr) Okzkarbazepin içeren süspansiyon
TR199800967T2 (tr) Sulu silikat bilesikleri
TR200102041T2 (tr) Progesteron reseptör bağlama aktif maddeleri olarak ikameli 2-arilimino heterosaykıllar
TR200102502T2 (tr) Trombin reseptör modülatörleri olarak yararlı sübstitüe edilmiş heterosiklik açil-tripeptidler.
EA200100854A1 (ru) Кальций-литические соединения