ATE384737T1 - Verfahren zur reinigung von rekombinanten proteinen, welche wachstumshormon antagonisten sind, mittels wässriger zweiphasen-extraktion - Google Patents
Verfahren zur reinigung von rekombinanten proteinen, welche wachstumshormon antagonisten sind, mittels wässriger zweiphasen-extraktionInfo
- Publication number
- ATE384737T1 ATE384737T1 AT00928866T AT00928866T ATE384737T1 AT E384737 T1 ATE384737 T1 AT E384737T1 AT 00928866 T AT00928866 T AT 00928866T AT 00928866 T AT00928866 T AT 00928866T AT E384737 T1 ATE384737 T1 AT E384737T1
- Authority
- AT
- Austria
- Prior art keywords
- growth hormone
- phase extraction
- aqueous
- recombinant proteins
- hormone antagonists
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229940122853 Growth hormone antagonist Drugs 0.000 title abstract 2
- 238000000605 extraction Methods 0.000 title abstract 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 102000002265 Human Growth Hormone Human genes 0.000 abstract 1
- 108010000521 Human Growth Hormone Proteins 0.000 abstract 1
- 239000000854 Human Growth Hormone Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/307,549 US6437101B1 (en) | 1999-05-07 | 1999-05-07 | Methods for protein purification using aqueous two-phase extraction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE384737T1 true ATE384737T1 (de) | 2008-02-15 |
Family
ID=23190235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00928866T ATE384737T1 (de) | 1999-05-07 | 2000-05-04 | Verfahren zur reinigung von rekombinanten proteinen, welche wachstumshormon antagonisten sind, mittels wässriger zweiphasen-extraktion |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6437101B1 (de) |
| EP (1) | EP1194445B1 (de) |
| JP (1) | JP2002544139A (de) |
| AT (1) | ATE384737T1 (de) |
| AU (1) | AU777974B2 (de) |
| BR (1) | BR0010707A (de) |
| CA (1) | CA2372513A1 (de) |
| DE (1) | DE60037886T2 (de) |
| ES (1) | ES2303507T3 (de) |
| IL (1) | IL146381A0 (de) |
| MX (1) | MXPA01011356A (de) |
| NZ (1) | NZ515381A (de) |
| WO (1) | WO2000068260A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6966992B2 (en) * | 2001-03-19 | 2005-11-22 | Akzo Nobel Nv | Method of purification of molecules using unbranched terminal alkyldiols |
| CA2496687A1 (en) * | 2002-09-18 | 2004-04-01 | Centre Hospitalier De L'universite De Montreal (Chum) | Ghrh analogues |
| DE502004005503D1 (de) * | 2004-06-25 | 2007-12-27 | Kuehni Ag | Verfahren zur Extraktion von biologischem Material |
| DE602005009827D1 (de) * | 2004-06-29 | 2008-10-30 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| US20070048786A1 (en) * | 2005-09-01 | 2007-03-01 | Arnon Chait | Systems and methods for fractionation of protein mixtures |
| US20080070230A1 (en) * | 2006-06-12 | 2008-03-20 | Wyeth | Methods for reducing or preventing liquid-liquid phase separation in high concentration protein solutions |
| KR100836171B1 (ko) * | 2007-01-19 | 2008-06-09 | 인하대학교 산학협력단 | 분배 향상 물질이 접합된 생물물질을 이용한 수성이상계추출법에서의 친화성 분리 방법 |
| DE102008013490A1 (de) | 2008-03-10 | 2009-09-17 | Bayer Technology Services Gmbh | Verfahren zur Reinigung therapeutischer Proteine |
| CN102224160A (zh) * | 2008-11-25 | 2011-10-19 | 通用电气健康护理生物科学股份公司 | 用于纯化治疗蛋白的水性两相萃取加强的沉淀方法 |
| DE102011001743A1 (de) * | 2011-04-01 | 2012-10-04 | Technische Universität Dortmund | Verfahren zur Trennung/Reinigung von Biomolekühlen |
| CN102662015B (zh) * | 2012-04-12 | 2013-11-20 | 湖南师范大学 | 基于无机盐促相变分离纳米金的生物样品的净化方法 |
| US20130310554A1 (en) * | 2012-05-18 | 2013-11-21 | Hong Kong Baptist University | Aqueous Diphase Solvent System for Preparing High-Purity Polysaccharides |
| CN111249531B (zh) * | 2020-01-19 | 2022-03-22 | 巴斯特医药科技（常州）有限公司 | 一种高活性植物酶制备胶原蛋白支架的方法 |
| CN114957494A (zh) * | 2021-02-23 | 2022-08-30 | 江苏农牧科技职业学院 | 一种采用双水相萃取黄精多糖中蛋白质的工艺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK144731C (da) | 1976-07-30 | 1982-10-18 | Nordisk Insulinlab | Fremgangsmaade til isolering af proteinhormoner stammende fra humant hypofysevaev |
| JPS5815989A (ja) * | 1981-06-12 | 1983-01-29 | Sanki Eng Kk | 生理活性蛋白質の精製方法 |
| DE3908422A1 (de) * | 1989-03-15 | 1990-09-20 | Forschungszentrum Juelich Gmbh | Verfahren zur extraktion von proteinen aus waessrigen biomassesuspensionen |
| US5139943A (en) * | 1989-06-13 | 1992-08-18 | Genencor International, Inc. | Processes for the recovery of microbially produced chymosin |
| US5151358A (en) | 1989-06-13 | 1992-09-29 | Genencor International, Inc. | Processes for the recovery of naturally produced chymosin |
| US5182369A (en) | 1990-02-28 | 1993-01-26 | Monsanto Company | Method for purifying somatotropin monomers |
| US5328841A (en) * | 1990-10-05 | 1994-07-12 | Genencor International, Inc. | Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol |
| SE9003534D0 (sv) * | 1990-11-06 | 1990-11-06 | Kabigen Ab | A method for isolating and purifying peptides and proteins |
| US5407810A (en) | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
| US5734024A (en) * | 1996-04-19 | 1998-03-31 | Boris Y. Zaslavsky | Method for determining the biological activity of recombinant human growth hormone |
| GB0205898D0 (en) * | 2002-03-13 | 2002-04-24 | Pharmacia Ab | Treatment of type I diabetes mellitus |
-
1999
- 1999-05-07 US US09/307,549 patent/US6437101B1/en not_active Expired - Lifetime
-
2000
- 2000-05-04 JP JP2000616234A patent/JP2002544139A/ja not_active Withdrawn
- 2000-05-04 BR BR0010707-7A patent/BR0010707A/pt not_active IP Right Cessation
- 2000-05-04 WO PCT/US2000/012320 patent/WO2000068260A1/en active Search and Examination
- 2000-05-04 ES ES00928866T patent/ES2303507T3/es not_active Expired - Lifetime
- 2000-05-04 EP EP00928866A patent/EP1194445B1/de not_active Expired - Lifetime
- 2000-05-04 NZ NZ515381A patent/NZ515381A/en unknown
- 2000-05-04 AU AU47036/00A patent/AU777974B2/en not_active Ceased
- 2000-05-04 AT AT00928866T patent/ATE384737T1/de not_active IP Right Cessation
- 2000-05-04 DE DE60037886T patent/DE60037886T2/de not_active Expired - Fee Related
- 2000-05-04 MX MXPA01011356A patent/MXPA01011356A/es active IP Right Grant
- 2000-05-04 IL IL14638100A patent/IL146381A0/xx unknown
- 2000-05-04 CA CA002372513A patent/CA2372513A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01011356A (es) | 2003-08-20 |
| WO2000068260A1 (en) | 2000-11-16 |
| DE60037886D1 (de) | 2008-03-13 |
| IL146381A0 (en) | 2002-07-25 |
| AU777974B2 (en) | 2004-11-04 |
| US6437101B1 (en) | 2002-08-20 |
| BR0010707A (pt) | 2002-06-04 |
| EP1194445B1 (de) | 2008-01-23 |
| ES2303507T3 (es) | 2008-08-16 |
| EP1194445A4 (de) | 2002-10-09 |
| AU4703600A (en) | 2000-11-21 |
| JP2002544139A (ja) | 2002-12-24 |
| CA2372513A1 (en) | 2000-11-16 |
| EP1194445A1 (de) | 2002-04-10 |
| NZ515381A (en) | 2003-10-31 |
| DE60037886T2 (de) | 2009-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |