ATE362482T1 - Rgd-sequenzen enthaltende peptido-mimetische verbindungen als integrin inhibitioren - Google Patents

Rgd-sequenzen enthaltende peptido-mimetische verbindungen als integrin inhibitioren

Info

Publication number
ATE362482T1
ATE362482T1 AT00830535T AT00830535T ATE362482T1 AT E362482 T1 ATE362482 T1 AT E362482T1 AT 00830535 T AT00830535 T AT 00830535T AT 00830535 T AT00830535 T AT 00830535T AT E362482 T1 ATE362482 T1 AT E362482T1
Authority
AT
Austria
Prior art keywords
peptido
compounds containing
integrin inhibitors
mimetic compounds
rgd sequences
Prior art date
Application number
AT00830535T
Other languages
English (en)
Inventor
Carlo Scolastico
Giuseppe Giannini
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE362482T1 publication Critical patent/ATE362482T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00830535T 1999-08-04 2000-07-27 Rgd-sequenzen enthaltende peptido-mimetische verbindungen als integrin inhibitioren ATE362482T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/366,198 US6235877B1 (en) 1999-08-04 1999-08-04 Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors

Publications (1)

Publication Number Publication Date
ATE362482T1 true ATE362482T1 (de) 2007-06-15

Family

ID=23442047

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00830535T ATE362482T1 (de) 1999-08-04 2000-07-27 Rgd-sequenzen enthaltende peptido-mimetische verbindungen als integrin inhibitioren

Country Status (10)

Country Link
US (2) US6235877B1 (de)
EP (1) EP1077218B1 (de)
JP (1) JP2001089499A (de)
KR (2) KR20010049974A (de)
AT (1) ATE362482T1 (de)
DE (1) DE60034849T2 (de)
DK (1) DK1077218T3 (de)
ES (1) ES2284469T3 (de)
PT (1) PT1077218E (de)
SI (1) SI1077218T1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
EP2292251A1 (de) * 2001-04-24 2011-03-09 Merck Patent GmbH Kombinationstherapie mit Anti-angiogenen Mitteln und TNF-alpha
AU2003213682C1 (en) * 2002-03-04 2008-06-12 Medimmune, Inc. Methods of preventing or treating disorders by administering an integrin alphavbeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate
JP2005533001A (ja) * 2002-03-04 2005-11-04 メディミューン，インコーポレーテッド インテグリンαｖβ３アンタゴニストを他の物質と併用投与する癌の予防または治療方法
ITRM20020370A1 (it) * 2002-07-09 2004-01-09 Sigma Tau Ind Farmaceuti Composto peptido-mimetico contenente la sequenza rgd utile come inibitore delle integrine.
GB2395480A (en) * 2002-11-19 2004-05-26 Sigma Tau Ind Farmaceuti Pyrrolo[1,2-a]pyridine & pyrrolo[1,2-a]azepine scaffolds useful for the synthesis of compounds with biological activity
WO2004066956A2 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
ITMI20031476A1 (it) * 2003-07-18 2005-01-19 Univ Degli Studi Milano Composti peptido-mimetici a struttura azabicicloalcanica comprendenti la sequenza rgd
ITMI20032102A1 (it) * 2003-10-30 2005-04-30 Univ Degli Studi Milano Composti peptidomimetici, procedimento stereoselettivo per la loro preparazione, loro uso come intermedi di sintesi di derivati biologicamente attivi.
EA200700225A1 (ru) * 2004-07-12 2008-02-28 Айдан Фармасьютикалз, Инк. Аналоги тетрапептида
ATE490976T1 (de) * 2004-10-30 2010-12-15 Univ Pais Vasco B-lactam-rgd-cyclopeptide mit gamma-(g-)wendungen
JP5588172B2 (ja) * 2006-09-25 2014-09-10 フォルシュングフェアブント ベルリン エー．ファウ． プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途
US7709370B2 (en) * 2007-09-20 2010-05-04 International Business Machines Corporation Spin-on antireflective coating for integration of patternable dielectric materials and interconnect structures
US8084862B2 (en) 2007-09-20 2011-12-27 International Business Machines Corporation Interconnect structures with patternable low-k dielectrics and method of fabricating same
US8618663B2 (en) 2007-09-20 2013-12-31 International Business Machines Corporation Patternable dielectric film structure with improved lithography and method of fabricating same
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
EP2457593A1 (de) * 2010-11-08 2012-05-30 Lykera Biomed S.A. Zyklische RGD-Peptide von Aminosäuren auf Basis von Thiazolen oder Oxazolen als selektive Antagonisten des Alpha-v beta-3-Integrins
US9339329B2 (en) 2012-09-17 2016-05-17 The Regents Of The University Of California Bladder denervation for treating overactive bladder
US11332498B2 (en) 2017-03-17 2022-05-17 Technische Universitat Munchen Ligands for integrin αVβ8, synthesis and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69126871T2 (de) 1990-04-06 1998-03-12 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
DE69226077T2 (de) 1991-04-05 1998-12-03 Genentech Inc PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa
DE69432983T2 (de) 1993-06-11 2004-04-29 Merrell Pharmaceuticals Inc., Cincinnati Trifunktionelle antithrombin-und antiplättchenpeptide
ATE195949T1 (de) 1993-06-18 2000-09-15 Jolla Cancer Res Found Verfahren und zusammensetzungen zur behandlung der thrombose
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US5770565A (en) 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
AU2958195A (en) * 1994-06-29 1996-01-25 Texas Biotechnology Corporation Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
US5767071A (en) 1995-06-07 1998-06-16 Ixsys Incorporated Sevenmer cyclic peptide inhibitors of diseases involving αv β3
IT1277405B1 (it) * 1995-08-01 1997-11-10 Menarini Farma Ind Derivati di lattami biciclici come inibitori della trombina
CA2227265C (en) 1995-08-14 2012-01-03 The Scripps Research Institute Methods and compositions useful for inhibition of .alpha.v.beta.5 mediated angiogenesis
US5817750A (en) 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
DE19653036A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptidderivate
WO1998056408A2 (en) 1997-06-10 1998-12-17 Regents Of The University Of Minnesota Inhibitors of microbial adherence or invasion as therapeutic agents and broad-spectrum enhancers of antibiotic therapy

Also Published As

Publication number Publication date
JP2001089499A (ja) 2001-04-03
KR20070104314A (ko) 2007-10-25
ES2284469T3 (es) 2007-11-16
EP1077218B1 (de) 2007-05-16
US6235877B1 (en) 2001-05-22
EP1077218A2 (de) 2001-02-21
DE60034849D1 (de) 2007-06-28
DK1077218T3 (da) 2007-09-24
DE60034849T2 (de) 2008-01-17
PT1077218E (pt) 2007-08-08
US20010001309A1 (en) 2001-05-17
SI1077218T1 (sl) 2007-08-31
EP1077218A3 (de) 2001-12-19
US6437094B2 (en) 2002-08-20
KR20010049974A (ko) 2001-06-15

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