ATE360625T1 - Aminoalkoxybenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltenden zusammensetzungen - Google Patents
Aminoalkoxybenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltenden zusammensetzungenInfo
- Publication number
- ATE360625T1 ATE360625T1 AT01965342T AT01965342T ATE360625T1 AT E360625 T1 ATE360625 T1 AT E360625T1 AT 01965342 T AT01965342 T AT 01965342T AT 01965342 T AT01965342 T AT 01965342T AT E360625 T1 ATE360625 T1 AT E360625T1
- Authority
- AT
- Austria
- Prior art keywords
- aminoalkoxybenzoyl
- benzofuranes
- benzothiophenes
- production
- compositions contained
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010833A FR2813308B1 (fr) | 2000-08-23 | 2000-08-23 | Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360625T1 true ATE360625T1 (de) | 2007-05-15 |
Family
ID=8853673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01965342T ATE360625T1 (de) | 2000-08-23 | 2001-08-23 | Aminoalkoxybenzoyl-benzofurane oder benzothiophene, verfahren zu ihrer herstellung und die enthaltenden zusammensetzungen |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7148240B2 (de) |
| EP (1) | EP1315710B1 (de) |
| JP (1) | JP5140226B2 (de) |
| KR (1) | KR20030023769A (de) |
| CN (1) | CN1471520A (de) |
| AT (1) | ATE360625T1 (de) |
| AU (1) | AU2001286003A1 (de) |
| BG (1) | BG107554A (de) |
| BR (1) | BR0113347A (de) |
| CA (1) | CA2415852A1 (de) |
| CZ (1) | CZ2003525A3 (de) |
| DE (1) | DE60128112T2 (de) |
| EA (1) | EA005825B1 (de) |
| FR (1) | FR2813308B1 (de) |
| HU (1) | HUP0302961A3 (de) |
| IL (1) | IL153959A0 (de) |
| IS (1) | IS6675A (de) |
| MA (1) | MA26942A1 (de) |
| MX (1) | MXPA03001536A (de) |
| NO (1) | NO20030802L (de) |
| NZ (1) | NZ523724A (de) |
| OA (1) | OA12360A (de) |
| PL (1) | PL362131A1 (de) |
| SK (1) | SK2122003A3 (de) |
| WO (1) | WO2002016340A1 (de) |
| ZA (1) | ZA200300922B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10129119B4 (de) * | 2001-06-16 | 2007-10-04 | Schwarz Pharma Ag | Kristalline Salze von Benzoylbenzofuran-Derivaten, insbesondere von[2-(4-{1-[2-((S)-sec.-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]-methanoyl}-2,6-diiod-phenoxy)-ethyl]-diethylamino und [2-(4-{1-[(3-Methyl-2-(S)-Butoxycarbonylmethyl)-benzofuran-3-carbonyl]- methanoyl}-2,6-diiodphenoxy)-ethyl]-diethylamino, deren Verwendung und Herstellung sowie diese Salze enthaltende Arzneimittel |
| NZ570014A (en) | 2006-02-03 | 2011-04-29 | Bionomics Ltd | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| FR2958290B1 (fr) | 2010-03-30 | 2012-10-19 | Sanofi Aventis | Procede de preparation de derives de sulfonamido-benzofurane |
| HUP1000330A2 (en) | 2010-06-18 | 2011-12-28 | Sanofi Sa | Process for the preparation of dronedarone and the novel intermediates |
| AU2011202542A1 (en) | 2010-07-14 | 2012-02-02 | Indian Institute Of Science | Benzothiophene carboxamide compounds, composition and applications thereof |
| FR2963006B1 (fr) | 2010-07-21 | 2013-03-15 | Sanofi Aventis | Procede de preparation de derives de nitro-benzofurane |
| HUP1100167A2 (en) | 2011-03-29 | 2012-11-28 | Sanofi Sa | Process for preparation of dronedarone by mesylation |
| HUP1100165A2 (en) | 2011-03-29 | 2012-12-28 | Sanofi Sa | Process for preparation of dronedarone by n-butylation |
| FR2983198B1 (fr) | 2011-11-29 | 2013-11-15 | Sanofi Sa | Procede de preparation de derives de 5-amino-benzoyl-benzofurane |
| EP2617718A1 (de) | 2012-01-20 | 2013-07-24 | Sanofi | Verfahren zur Herstellung von Dronedaron unter Verwendung von Dibutylaminopropanolreagenz |
| US9221778B2 (en) | 2012-02-13 | 2015-12-29 | Sanofi | Process for preparation of dronedarone by removal of hydroxyl group |
| WO2013121234A1 (en) | 2012-02-14 | 2013-08-22 | Sanofi | Process for the preparation of dronedarone by oxidation of a sulphenyl group |
| US9382223B2 (en) | 2012-02-22 | 2016-07-05 | Sanofi | Process for preparation of dronedarone by oxidation of a hydroxyl group |
| WO2013178337A1 (en) | 2012-05-31 | 2013-12-05 | Sanofi | Process for preparation of dronedarone by grignard reaction |
| CN114736181B (zh) * | 2022-04-28 | 2024-03-08 | 河南大学 | 可见光介导的酰基化苯并呋喃衍生物的合成方法 |
| CN117209483B (zh) * | 2022-10-28 | 2025-10-10 | 扬州中宝药业股份有限公司 | 苯并呋喃类衍生物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3248401A (en) * | 1966-04-26 | Diethylaminoe hoxybenzoyl benzofurans | ||
| US4024273A (en) * | 1974-06-20 | 1977-05-17 | Smithkline Corporation | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity |
| US4806663A (en) * | 1987-04-06 | 1989-02-21 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4851554A (en) * | 1987-04-06 | 1989-07-25 | University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzofuran derivatives |
| US4831054A (en) * | 1988-04-18 | 1989-05-16 | Taro Pharmaceuticals, Ltd. | 2-Alkyl-3-benzoylbenzofurans useful for treating cardiac arrhythmia |
| AT391316B (de) * | 1988-09-15 | 1990-09-25 | Ebewe Arzneimittel | Neue thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US5364880A (en) * | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| FR2735365B1 (fr) * | 1995-06-14 | 1997-09-05 | Sanofi Sa | Utilisation d'un antagoniste de l'angiotensine ii et d'un derive du benzofurane pour la preparation d'un medicament utile dans le traitement des affections cardiovasculaires |
| JPH10130258A (ja) * | 1996-10-10 | 1998-05-19 | Eli Lilly & Co | ベンゾ［ｂ］チオフェン化合物、中間体、製剤、および方法 |
-
2000
- 2000-08-23 FR FR0010833A patent/FR2813308B1/fr not_active Expired - Fee Related
-
2001
- 2001-08-23 AU AU2001286003A patent/AU2001286003A1/en not_active Abandoned
- 2001-08-23 JP JP2002521441A patent/JP5140226B2/ja not_active Expired - Fee Related
- 2001-08-23 BR BR0113347-0A patent/BR0113347A/pt not_active IP Right Cessation
- 2001-08-23 CZ CZ2003525A patent/CZ2003525A3/cs unknown
- 2001-08-23 NZ NZ523724A patent/NZ523724A/en unknown
- 2001-08-23 CN CNA018177662A patent/CN1471520A/zh active Pending
- 2001-08-23 WO PCT/FR2001/002657 patent/WO2002016340A1/fr not_active Ceased
- 2001-08-23 DE DE60128112T patent/DE60128112T2/de not_active Expired - Lifetime
- 2001-08-23 SK SK212-2003A patent/SK2122003A3/sk unknown
- 2001-08-23 MX MXPA03001536A patent/MXPA03001536A/es unknown
- 2001-08-23 HU HU0302961A patent/HUP0302961A3/hu unknown
- 2001-08-23 EP EP01965342A patent/EP1315710B1/de not_active Expired - Lifetime
- 2001-08-23 US US10/362,138 patent/US7148240B2/en not_active Expired - Lifetime
- 2001-08-23 CA CA002415852A patent/CA2415852A1/fr not_active Abandoned
- 2001-08-23 KR KR10-2003-7002620A patent/KR20030023769A/ko not_active Withdrawn
- 2001-08-23 AT AT01965342T patent/ATE360625T1/de not_active IP Right Cessation
- 2001-08-23 OA OA1200300036A patent/OA12360A/fr unknown
- 2001-08-23 EA EA200300066A patent/EA005825B1/ru not_active IP Right Cessation
- 2001-08-23 PL PL01362131A patent/PL362131A1/xx not_active Application Discontinuation
- 2001-08-23 IL IL15395901A patent/IL153959A0/xx unknown
-
2003
- 2003-01-13 IS IS6675A patent/IS6675A/is unknown
- 2003-02-03 ZA ZA200300922A patent/ZA200300922B/en unknown
- 2003-02-13 BG BG107554A patent/BG107554A/bg unknown
- 2003-02-17 MA MA27041A patent/MA26942A1/fr unknown
- 2003-02-20 NO NO20030802A patent/NO20030802L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1471520A (zh) | 2004-01-28 |
| DE60128112T2 (de) | 2007-12-27 |
| HUP0302961A2 (hu) | 2003-12-29 |
| ZA200300922B (en) | 2004-06-22 |
| KR20030023769A (ko) | 2003-03-19 |
| OA12360A (fr) | 2006-05-16 |
| EA005825B1 (ru) | 2005-06-30 |
| SK2122003A3 (en) | 2003-09-11 |
| US20040010011A1 (en) | 2004-01-15 |
| MA26942A1 (fr) | 2004-12-20 |
| BR0113347A (pt) | 2004-02-10 |
| NZ523724A (en) | 2005-02-25 |
| BG107554A (bg) | 2003-11-28 |
| PL362131A1 (en) | 2004-10-18 |
| US7148240B2 (en) | 2006-12-12 |
| WO2002016340A8 (fr) | 2003-07-03 |
| JP2004506728A (ja) | 2004-03-04 |
| FR2813308B1 (fr) | 2005-07-01 |
| EP1315710B1 (de) | 2007-04-25 |
| JP5140226B2 (ja) | 2013-02-06 |
| DE60128112D1 (de) | 2007-06-06 |
| MXPA03001536A (es) | 2004-05-04 |
| AU2001286003A1 (en) | 2002-03-04 |
| CA2415852A1 (fr) | 2002-02-28 |
| IL153959A0 (en) | 2003-07-31 |
| EA200300066A1 (ru) | 2003-08-28 |
| WO2002016340A1 (fr) | 2002-02-28 |
| FR2813308A1 (fr) | 2002-03-01 |
| EP1315710A1 (de) | 2003-06-04 |
| HUP0302961A3 (en) | 2005-02-28 |
| NO20030802L (no) | 2003-04-23 |
| CZ2003525A3 (cs) | 2003-06-18 |
| IS6675A (is) | 2003-01-13 |
| NO20030802D0 (no) | 2003-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |