ATE359280T1 - Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit - Google Patents

Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit

Info

Publication number
ATE359280T1
ATE359280T1 AT01910155T AT01910155T ATE359280T1 AT E359280 T1 ATE359280 T1 AT E359280T1 AT 01910155 T AT01910155 T AT 01910155T AT 01910155 T AT01910155 T AT 01910155T AT E359280 T1 ATE359280 T1 AT E359280T1
Authority
AT
Austria
Prior art keywords
starting materials
supercritical liquid
producing taxol
taxol
liquid
Prior art date
Application number
AT01910155T
Other languages
English (en)
Inventor
Jin Woong Kim
Young Hae Choi
Ki Pung Yoo
Min Jeong Noh
Joo Hee Han
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Application granted granted Critical
Publication of ATE359280T1 publication Critical patent/ATE359280T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01910155T 2000-02-25 2001-02-24 Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit ATE359280T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020000009255A KR100666652B1 (ko) 2000-02-25 2000-02-25 식물 원료로부터 초임계 유체를 이용하여 탁솔을 제조하는방법

Publications (1)

Publication Number Publication Date
ATE359280T1 true ATE359280T1 (de) 2007-05-15

Family

ID=19649887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01910155T ATE359280T1 (de) 2000-02-25 2001-02-24 Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit

Country Status (8)

Country Link
US (1) US6503396B2 (de)
EP (1) EP1261596B1 (de)
KR (1) KR100666652B1 (de)
CN (1) CN1205197C (de)
AT (1) ATE359280T1 (de)
AU (1) AU2001237736A1 (de)
DE (1) DE60127820T2 (de)
WO (1) WO2001062753A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6648609B2 (en) * 2002-04-05 2003-11-18 Berger Instruments, Inc. Pump as a pressure source for supercritical fluid chromatography involving pressure regulators and a precision orifice
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
CA2559077A1 (en) * 2004-03-16 2005-09-22 Universite Laval Process for extraction of diterpenes and triterpenes from biomaterial
US7169307B2 (en) * 2004-09-02 2007-01-30 Jian Liu Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
US20060074254A1 (en) * 2004-09-30 2006-04-06 Zisheng Zhang Process for extracting taxanes
EP1792542A1 (de) * 2005-12-02 2007-06-06 SCF Technologies A/S Verfahren zur Hestellung eines einen verringerten Inhalt an Spezies enthaltenden vorbereiteten Lebensmittels
WO2007092827A2 (en) * 2006-02-08 2007-08-16 Waters Investments Limited Improved separation method
EP1818328A1 (de) * 2006-02-10 2007-08-15 6570763 Canada Inc. Chromatographisches Verfahren zur Isolierung und Reinigung von Taxanderivaten
JP5060791B2 (ja) * 2007-01-26 2012-10-31 独立行政法人森林総合研究所 木材の乾燥方法、木材への薬剤浸透方法及び乾燥装置
US8215922B2 (en) 2008-06-24 2012-07-10 Aurora Sfc Systems, Inc. Compressible fluid pumping system for dynamically compensating compressible fluids over large pressure ranges
US9163618B2 (en) 2008-06-24 2015-10-20 Agilent Technologies, Inc. Automated conversion between SFC and HPLC
US8419936B2 (en) 2010-03-23 2013-04-16 Agilent Technologies, Inc. Low noise back pressure regulator for supercritical fluid chromatography
US8293111B2 (en) * 2010-05-17 2012-10-23 Uti Limited Partnership Apparatus, system, and method for chromatography using a water stationary phase
WO2012035117A1 (en) * 2010-09-15 2012-03-22 Basf Plant Science Company Gmbh Extraction device and method for extracting ingredients from a biological sample
WO2012071385A1 (en) 2010-11-23 2012-05-31 Lexington Pharmaceutical Laboratories, Llc Low temperature chlorination of carbohydrates
CN102649776A (zh) * 2011-02-25 2012-08-29 苏州宝泽堂医药科技有限公司 一种高乌甲素的制备方法
DK2646452T3 (da) 2011-10-14 2016-06-20 Lexington Pharmaceutical Laboratories Llc Chlorering af carbohydrater og carbohydratderivater
CN103030673B (zh) * 2012-12-31 2015-07-22 浙江大学宁波理工学院 一种从南方红豆杉叶中提取杨梅素-3-o-芸香糖的方法
US9745269B2 (en) 2013-03-15 2017-08-29 Cba Pharma, Inc. Supercritical fluid extraction of bis-benzyl isoquinolines
CN104059034A (zh) * 2014-06-06 2014-09-24 庞作仁 超声波逆流无毒提取紫杉醇的生产系统及工艺
US10857482B1 (en) * 2016-12-07 2020-12-08 Rien Havens Botanical super heated processing equipment
CN110305079A (zh) * 2019-06-12 2019-10-08 苏州岚云医药科技有限公司 一种抗癌药物超临界流体萃取提纯法
US12023601B2 (en) * 2019-09-09 2024-07-02 Alden Botanica LLC Carbon dioxide extraction processes, devices, methods, and systems
WO2021051094A1 (en) * 2019-09-13 2021-03-18 Dalrada Health Products Plant oil extraction device
CN112979594B (zh) * 2021-02-26 2021-12-14 南通科鑫超临界设备有限公司 一种穿心莲内酯超临界萃取工艺
CN113896695B (zh) * 2021-05-26 2023-12-01 四川杉宝生物科技有限公司 从曼地亚红豆杉中同时提取三尖杉宁碱和紫杉醇的方法
CN113831306A (zh) * 2021-09-30 2021-12-24 王强 一种超临界co2流体萃取法提取紫杉醇的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683063A (en) * 1985-05-08 1987-07-28 Vitamins, Inc. Method for carrying out extractions in subterranean well
US4898673A (en) * 1987-07-11 1990-02-06 Vitamins, Inc. Dynamic supercritical fluid extraction system
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
EP0580759B1 (de) * 1991-04-19 1999-05-26 The University Of Mississippi Verfahren und zubereitungen zur isolierung von taxanen
CA2072400C (en) * 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
KR0133947B1 (ko) 1992-09-15 1998-04-22 윤종용 음성채널절환장치
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5854064A (en) * 1996-07-31 1998-12-29 Aphios Corporation Methods for fractionation of biologically-derived materials
KR0132275B1 (ko) * 1994-04-14 1998-04-17 한동근 탁솔의 향류 초임계 추출 및 정제방법과 그의 장치
KR100278917B1 (ko) 1994-11-21 2001-01-15 김영환 반도체 소자의 콘택 마스크 제조방법
US5654448A (en) * 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
KR100208656B1 (ko) * 1996-11-19 1999-07-15 변상요 초임계유체를 이용한 추출과 정제의 온라인 연속공정에 의한 탁솔의 제조장치
CN1099899C (zh) 1997-12-31 2003-01-29 孙传经 生产型超临界二氧化碳制备色谱及其用途
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US6291241B1 (en) * 1999-03-29 2001-09-18 Trevor Percival Castor Methods for making Hypericum fractions and St. John's Wort products

Also Published As

Publication number Publication date
US6503396B2 (en) 2003-01-07
CN1205197C (zh) 2005-06-08
CN1406235A (zh) 2003-03-26
EP1261596A4 (de) 2004-06-30
DE60127820T2 (de) 2007-12-27
EP1261596A1 (de) 2002-12-04
US20020000410A1 (en) 2002-01-03
WO2001062753A1 (en) 2001-08-30
KR100666652B1 (ko) 2007-01-09
DE60127820D1 (de) 2007-05-24
EP1261596B1 (de) 2007-04-11
KR20010084323A (ko) 2001-09-06
AU2001237736A1 (en) 2001-09-03

Similar Documents

Publication Publication Date Title
ATE359280T1 (de) Verfahren und apparatur zur herstellung von taxol aus ausgangsstoffen unter verwendung von superkritischer flüssigkeit
ATE361352T1 (de) Verfahren und vorrichtung zur gleichzeitigen produktion eines erdgases zur verflüssigung und einer flüssigen fraktion aus erdgas
ATE555833T1 (de) Verfahren zur zubereitung von angereicherten cannabinoid-extrakten aus cannabis- pflanzenmaterial
WO2002026371A3 (en) Apparatus and method for preparing microparticles using liquid-liquid extraction
DE69942508D1 (de) Verfahren und vorrichtung zur grösssenabhängigen trennung von mikro- und nanopartikeln
DE60040992D1 (de) Verfahren zur extraktion von furanlipid-derivaten und polyhydroxylierten fettalkoholen der avocado
ATE466065T1 (de) Verfahren zur gewinnung hochangereicherter naturstoff-fraktionen aus palmöl unter verwendung von superkritischen und beinahe superkritischen flüssigmedien
TW200510294A (en) Extraction process for removal of impurities form an aqueous mixture
AU2003238296A1 (en) Purification of n,n-dimethylacetamide
ATE230736T1 (de) Verfahren zum extrahieren und reinigung von paclitaxel aus natürlicher quelle
DE50305512D1 (de) Destillative verfahren zur herstellung von ipda mit einem hohen cis/trans-isomerenverhältnis
ATE400540T1 (de) Verfahren zur herstellung von einem gereinigten hydrofluoralkan
ATE240926T1 (de) Verfahren zur trennung und reinigung eines wässrigen gemisches aus den hauptkomponenten essigsäure und ameisensäure
DE50310209D1 (de) Verfahren zur gewinnung eines aliphatischen dialdehyd-monoacetals
DE60311244D1 (de) Verfahren und automatische extraktion von nucleinsäuren aus komplexen mischungen
ATE285826T1 (de) Lösungsmittelextraktionsverfahren
HUP0204028A2 (en) Chromatographic separation method of paclitaxel and cephalomannin
ATE337073T1 (de) Verfahren zur hochdruck-gastrennung
ATE248185T1 (de) Verfahren zur gewinnung von sterolen aus kohlenwasserstoffextrakten durch verdampfungsfraktionierung
WO2004026430A3 (en) Solvent extraction method and apparatus
DE69515488D1 (de) Vorrichtung und Verfahren zur gleichzeitigen Destillierung und Extraktion
ATE246237T1 (de) Entfernung von kontaminanten aus einem kohlenwasserstoffkomponent oder -fraktion
CN109534979A (zh) 一种6-姜酚的分离纯化方法以及生产方法
KR960010594A (ko) 탁솔의 분리 방법
ATE148443T1 (de) Verfahren zur trennung von enantiomeren aus einer racemischen mischung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties