ATE358276T1 - Elektrochemilumineszenz-enzymimmunoassay - Google Patents
Elektrochemilumineszenz-enzymimmunoassayInfo
- Publication number
- ATE358276T1 ATE358276T1 AT96923291T AT96923291T ATE358276T1 AT E358276 T1 ATE358276 T1 AT E358276T1 AT 96923291 T AT96923291 T AT 96923291T AT 96923291 T AT96923291 T AT 96923291T AT E358276 T1 ATE358276 T1 AT E358276T1
- Authority
- AT
- Austria
- Prior art keywords
- electrochemiluminescence
- analyte
- electrochemiluminescent
- molecule
- immunoassays
- Prior art date
Links
- 239000012491 analyte Substances 0.000 abstract 5
- 238000003018 immunoassay Methods 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical group [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 108090000204 Dipeptidase 1 Proteins 0.000 abstract 1
- 102000006635 beta-lactamase Human genes 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 238000011984 electrochemiluminescence immunoassay Methods 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48476695A | 1995-06-07 | 1995-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE358276T1 true ATE358276T1 (de) | 2007-04-15 |
Family
ID=23925520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96923291T ATE358276T1 (de) | 1995-06-07 | 1996-06-06 | Elektrochemilumineszenz-enzymimmunoassay |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6524865B1 (de) |
| EP (1) | EP0871887B1 (de) |
| JP (1) | JP3784072B2 (de) |
| AT (1) | ATE358276T1 (de) |
| AU (1) | AU718767B2 (de) |
| CA (1) | CA2223027A1 (de) |
| DE (1) | DE69637001T2 (de) |
| ES (1) | ES2285713T3 (de) |
| WO (1) | WO1996041175A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866434A (en) * | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
| US5641623A (en) * | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
| KR20000070821A (ko) * | 1997-02-06 | 2000-11-25 | 프란시스 제이 메이어 | 특이적 결합의 전기화학적 검출 |
| AU6115300A (en) * | 1999-07-19 | 2001-02-05 | California Institute Of Technology | Detection of biomolecules by sensitizer-linked substrates |
| WO2006083305A2 (en) | 2004-06-23 | 2006-08-10 | University Of Texas System | Methods and compositions for the detection of biological molecules using a two particle complex |
| US7906276B2 (en) | 2004-06-30 | 2011-03-15 | Kimberly-Clark Worldwide, Inc. | Enzymatic detection techniques |
| US7094528B2 (en) * | 2004-06-30 | 2006-08-22 | Kimberly-Clark Worldwide, Inc. | Magnetic enzyme detection techniques |
| US7521226B2 (en) | 2004-06-30 | 2009-04-21 | Kimberly-Clark Worldwide, Inc. | One-step enzymatic and amine detection technique |
| DE602005026143D1 (de) * | 2004-10-06 | 2011-03-10 | Wellstat Biologics Corp | Erkennung eines erhöhten spiegels von her-2/neu-proteinen in zirkulierenden krebszellen und dessen behandlung |
| US20090145485A1 (en) * | 2005-08-11 | 2009-06-11 | Eksigent Technologies, Llc | Microfluidic methods and apparatuses for fluid mixing and valving |
| KR20080072748A (ko) | 2005-11-29 | 2008-08-06 | 가미다-셀 리미티드 | 줄기세포 귀소 및 생착을 향상시키는 방법 |
| US7820394B2 (en) * | 2005-12-02 | 2010-10-26 | Catassays | Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification |
| EP2008102A4 (de) * | 2006-04-18 | 2009-07-08 | Wellstat Biologics Corp | Detektion von proteinen aus zirkulierenden neoplastischen zellen |
| MX2009011228A (es) * | 2007-04-19 | 2009-11-02 | Wellstat Biologics Corp | Deteccion de niveles elevados de la proteina her-2/neu de celulas cancerosas circulantes no aisladas y tratamiento. |
| JP4887319B2 (ja) | 2008-03-17 | 2012-02-29 | 株式会社日立ハイテクノロジーズ | 自動分析装置、及び光電子増倍管を用いた分析システム |
| WO2009126249A1 (en) * | 2008-04-11 | 2009-10-15 | Board Of Regents Of The University Of Texas System | Method and apparatus for nanoparticle electrogenerated chemiluminescence amplification |
| EP2626693A3 (de) | 2008-05-08 | 2014-10-01 | Board of Regents of the University of Texas System | Nanostrukturierte lumineszente Materialien zur Verwendung in elektrogenerierter Chemolumineszenz |
| JP5209705B2 (ja) | 2008-05-08 | 2013-06-12 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP5124498B2 (ja) | 2009-01-30 | 2013-01-23 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP6043629B2 (ja) * | 2011-01-07 | 2016-12-14 | 中外製薬株式会社 | 抗体の物性を改善させる方法 |
| US9689021B2 (en) * | 2011-10-14 | 2017-06-27 | Université de Liège | Method for measuring beta-lactam antibiotics |
| US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
| US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
| US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
| CN105102612B (zh) | 2012-12-06 | 2020-11-17 | 恩立夫克治疗有限责任公司 | 治疗性凋亡细胞制剂、其制备方法以及其用途 |
| EP3258269B1 (de) * | 2015-02-10 | 2019-06-05 | Shenzhen New Industries Biomedical Engineering Co. Ltd. | Reagenzienkit für den nachweis von lipoproteinassoziierter phospholipase a2 und herstellungsverfahren sowie anwendung für reagenzienkit |
| CN117491623A (zh) | 2015-08-20 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 使用聚乙二醇化分析物特异性结合剂的基于颗粒的免疫测定法 |
| JP7065781B2 (ja) | 2016-03-07 | 2022-05-12 | エフ.ホフマン-ラ ロシュ アーゲー | 抗p53抗体の検出 |
| WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
| CN106645111A (zh) * | 2017-03-01 | 2017-05-10 | 桂林理工大学 | 一种电化学发光快速检测抗生素ZwittermicinA浓度的方法 |
| EP3781600A1 (de) | 2018-04-18 | 2021-02-24 | F. Hoffmann-La Roche AG | Neuartige anti-thymidinkinase-antikörper |
| JP7577647B2 (ja) | 2018-08-31 | 2024-11-05 | エフ. ホフマン-ラ ロシュ アーゲー | Dlbclについての予後指標におけるチミジンキナーゼ(tk-1) |
| WO2020146497A1 (en) * | 2019-01-09 | 2020-07-16 | The Regents Of The University Of California | An electrochemiluminescence elisa for ps129-a-synuclein |
| CN109839501B (zh) * | 2019-01-30 | 2022-04-08 | 东南大学 | 一种测定循环肿瘤细胞的电致化学发光免疫传感器及其制备方法与应用 |
| CN114144674A (zh) | 2019-07-22 | 2022-03-04 | 豪夫迈·罗氏有限公司 | P物质作为用于子宫内膜异位症的非侵入性诊断的血液生物标志物 |
| WO2021013784A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis |
| BR112022001140A2 (pt) | 2019-07-22 | 2022-03-15 | Hoffmann La Roche | Métodos para avaliar se um paciente tem endometriose ou está em risco de desenvolver endometriose, selecionar um paciente para terapia e monitorar um paciente que sofre de endometriose ou que está sendo tratado para endometriose |
| KR20220016210A (ko) | 2019-07-22 | 2022-02-08 | 에프. 호프만-라 로슈 아게 | 자궁내막증의 비-침습적 진단용 혈액 생물표지자로써 s100a9 |
| EP4004555A1 (de) | 2019-07-22 | 2022-06-01 | F. Hoffmann-La Roche AG | S100a6 als blutbiomarker zur nichtinvasiven diagnose von endometriose |
| EP4058459A1 (de) | 2019-11-15 | 2022-09-21 | F. Hoffmann-La Roche AG | Derivatisierung von beta-lactam-antibiotika für massspec-messungen in patientenproben |
| JP2023547505A (ja) | 2020-11-02 | 2023-11-10 | エフ. ホフマン-ラ ロシュ アーゲー | SARS-CoV-2ヌクレオカプシド抗体 |
| CN112964768A (zh) * | 2021-03-23 | 2021-06-15 | 海南微氪生物科技股份有限公司 | 一种Bst DNA聚合酶电致化学发光测定方法 |
| WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
| WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
| JP7727015B2 (ja) | 2021-05-17 | 2025-08-20 | エフ. ホフマン-ラ ロシュ アーゲー | 腺筋症の非侵襲的診断のための血液バイオマーカーとしてのsFRP4 |
| WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
| WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
| CN119404103A (zh) | 2022-06-23 | 2025-02-07 | 豪夫迈·罗氏有限公司 | 用于诊断子宫内膜异位症及用于对子宫内膜异位症的分期进行分类的方法 |
| CN119604768A (zh) | 2022-07-22 | 2025-03-11 | 豪夫迈·罗氏有限公司 | 白三烯a4水解酶(lta4h)作为(血液)生物标志物用于诊断多囊卵巢综合征 |
| EP4558825A1 (de) | 2022-07-22 | 2025-05-28 | F. Hoffmann-La Roche AG | Meteorin-ähnliches protein (metrnl) als (blut) biomarker zur diagnose des polyzystischen ovarialsyndroms |
| WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
| WO2025017135A1 (en) | 2023-07-20 | 2025-01-23 | F. Hoffmann-La Roche Ag | Screening methods for antibody compositions |
| WO2025026908A1 (en) | 2023-07-28 | 2025-02-06 | Roche Diagnostics Gmbh | Serum epha1 as biomarker for endometriosis |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4293310A (en) * | 1980-03-14 | 1981-10-06 | University Of Pittsburgh | Photoelectrochemical immunoassay |
| US4818709A (en) * | 1983-01-21 | 1989-04-04 | Primus Frederick J | CEA-family antigens, Anti-CEA antibodies and CEA immunoassay |
| GB8305324D0 (en) | 1983-02-25 | 1983-03-30 | Unilever Plc | Microbiological test processes |
| US4470459A (en) | 1983-05-09 | 1984-09-11 | Halliburton Company | Apparatus and method for controlled temperature heating of volumes of hydrocarbonaceous materials in earth formations |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4877725A (en) * | 1985-04-01 | 1989-10-31 | New York Blood Center, Inc. | Immunoassays for antibodies which bind to the acquired immunodeficiency virus |
| US5147806A (en) | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
| ATE127923T1 (de) * | 1986-04-30 | 1995-09-15 | Igen Inc | Elektrochemilumineszenz-testverfahren. |
| US4931223A (en) * | 1986-07-24 | 1990-06-05 | Tropix, Inc. | Methods of using chemiluminescent 1,2-dioxetanes |
| DE3855535T2 (de) * | 1987-11-04 | 1997-01-16 | Igen Inc | Elektrochemilumineszente rhenium-fraktionen und verfahren |
| US5061445A (en) | 1988-11-03 | 1991-10-29 | Igen, Inc. | Apparatus for conducting measurements of electrochemiluminescent phenomena |
| US5296191A (en) | 1988-11-03 | 1994-03-22 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| US5247243A (en) | 1988-11-03 | 1993-09-21 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| US5068808A (en) | 1988-11-22 | 1991-11-26 | Reality Imaging Corporation | Imager and process |
| US4978613A (en) * | 1989-01-17 | 1990-12-18 | Abbott Laboratories | Beta-lactamase assay employing chromogenic precipitating substrates |
| US5187068A (en) * | 1989-06-09 | 1993-02-16 | Nicolae Luca | Method for determination of lipid moiety and apolipoprotein expressed epitope immunoreactivity on intact lipoprotein |
| US5264346A (en) | 1991-06-03 | 1993-11-23 | Chen Kirk C S | Colorimetric method for beta-lactamase assay and its applications |
| US6030773A (en) * | 1992-07-08 | 2000-02-29 | Agnello; Vincent | Chemiluminescent assay for DSDNA antibodies |
| US5527710A (en) * | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
| US5641623A (en) * | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
| FR2729759A1 (fr) * | 1995-01-19 | 1996-07-26 | Pasteur Sanofi Diagnostics | Procede de dosage ultrasensible de la troponine i cardiaque |
-
1996
- 1996-06-06 EP EP96923291A patent/EP0871887B1/de not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/010119 patent/WO1996041175A1/en not_active Ceased
- 1996-06-06 JP JP50221497A patent/JP3784072B2/ja not_active Expired - Fee Related
- 1996-06-06 AU AU63844/96A patent/AU718767B2/en not_active Ceased
- 1996-06-06 CA CA002223027A patent/CA2223027A1/en not_active Abandoned
- 1996-06-06 AT AT96923291T patent/ATE358276T1/de not_active IP Right Cessation
- 1996-06-06 DE DE69637001T patent/DE69637001T2/de not_active Expired - Fee Related
- 1996-06-06 ES ES96923291T patent/ES2285713T3/es not_active Expired - Lifetime
-
1997
- 1997-09-11 US US08/928,075 patent/US6524865B1/en not_active Expired - Fee Related
-
2002
- 2002-09-04 US US10/234,874 patent/US7018802B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11507726A (ja) | 1999-07-06 |
| DE69637001D1 (de) | 2007-05-10 |
| CA2223027A1 (en) | 1996-12-19 |
| WO1996041175A1 (en) | 1996-12-19 |
| EP0871887A4 (de) | 2000-04-26 |
| JP3784072B2 (ja) | 2006-06-07 |
| EP0871887B1 (de) | 2007-03-28 |
| US6524865B1 (en) | 2003-02-25 |
| US20040096918A1 (en) | 2004-05-20 |
| AU718767B2 (en) | 2000-04-20 |
| US7018802B2 (en) | 2006-03-28 |
| AU6384496A (en) | 1996-12-30 |
| ES2285713T3 (es) | 2007-11-16 |
| EP0871887A1 (de) | 1998-10-21 |
| DE69637001T2 (de) | 2007-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |