ATE353864T1 - Fluorierung von proteinen und peptiden für positronemissionstomographie - Google Patents
Fluorierung von proteinen und peptiden für positronemissionstomographieInfo
- Publication number
- ATE353864T1 ATE353864T1 AT98946820T AT98946820T ATE353864T1 AT E353864 T1 ATE353864 T1 AT E353864T1 AT 98946820 T AT98946820 T AT 98946820T AT 98946820 T AT98946820 T AT 98946820T AT E353864 T1 ATE353864 T1 AT E353864T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- peptide
- targeted
- tissue
- fluoration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5748597P | 1997-09-03 | 1997-09-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE353864T1 true ATE353864T1 (de) | 2007-03-15 |
Family
ID=22010853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98946820T ATE353864T1 (de) | 1997-09-03 | 1998-09-03 | Fluorierung von proteinen und peptiden für positronemissionstomographie |
Country Status (8)
Country | Link |
---|---|
US (3) | US6187284B1 (de) |
EP (1) | EP1009726B1 (de) |
JP (1) | JP3992923B2 (de) |
AT (1) | ATE353864T1 (de) |
AU (1) | AU9375698A (de) |
CA (1) | CA2302360C (de) |
DE (1) | DE69837095T2 (de) |
WO (1) | WO1999011590A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US7387772B1 (en) * | 1999-06-22 | 2008-06-17 | Immunimedics, Inc. | Chimeric, human and humanized anti-CSAP monoclonal antibodies |
US7074405B1 (en) * | 1998-06-22 | 2006-07-11 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US7138103B2 (en) * | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
US7833528B2 (en) * | 1998-06-22 | 2010-11-16 | Immunomedics, Inc. | Use of multispecific, non-covalent complexes for targeted delivery of therapeutics |
US6998106B1 (en) * | 1998-12-01 | 2006-02-14 | Duke University | Radioconjugation of internalizing antibodies |
DE10121741A1 (de) * | 2001-05-04 | 2002-11-14 | Forschungszentrum Juelich Gmbh | Verfahren zur Synthese trägerarmer ·18·F markierter Verbindungen |
AU2003217349B2 (en) * | 2002-02-06 | 2008-05-22 | The Johns Hopkins University | Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts |
US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
AU2003209886A1 (en) * | 2002-03-14 | 2003-09-22 | Qlt Inc. | Cancer associated araf1 protein kinase and its uses |
GB0206750D0 (en) * | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
US7563433B2 (en) * | 2007-01-11 | 2009-07-21 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
US7993626B2 (en) | 2007-01-11 | 2011-08-09 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
US7597876B2 (en) * | 2007-01-11 | 2009-10-06 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
FR2841558B1 (fr) * | 2002-07-01 | 2004-08-13 | Commissariat Energie Atomique | Peptides marques ayant une affinite pour un phospholipide et utilisations |
FR2841554B1 (fr) * | 2002-07-01 | 2008-01-18 | Commissariat Energie Atomique | Composes de maleimides marques, leur procede de preparation et leur utilisation pour le marquage de macromolecules |
KR20050033067A (ko) * | 2002-08-02 | 2005-04-08 | 말린크로트, 인코포레이티드 | 방사성 라벨된 아미노산 유사체, 그 제조방법 및 용도 |
US9701754B1 (en) | 2002-10-23 | 2017-07-11 | City Of Hope | Covalent disulfide-linked diabodies and uses thereof |
GB0305704D0 (en) * | 2003-03-13 | 2003-04-16 | Amersham Plc | Radiofluorination methods |
US7741524B2 (en) * | 2003-04-22 | 2010-06-22 | Solvay (Societe Anonyme) | Iodinated organic substances of low molecular mass and process for preparing them |
US7776309B2 (en) * | 2003-07-24 | 2010-08-17 | The Queen's Medical Center | Preparation and use of alkylating agents |
WO2005075486A1 (en) * | 2004-02-06 | 2005-08-18 | The University Of Alberta, Simon Fraser University, The University Of Victoria, The University Of British Columbia And Carleton University, Collectively Doing Business Astriumf | Method of synthesizing compounds having a phosphorus-fluorine-18 bond |
KR100808547B1 (ko) | 2005-06-22 | 2008-02-29 | 재단법인서울대학교산학협력재단 | 펩타이드 수용체 영상용 제제로 사용할 수 있는 f-18-플로로벤질리덴하이드라존-니코틴아마이드-펩타이드 유도체 및 펩타이드에 방사성불소를 효율적으로 표지하기 위한 방법 |
US20070048803A1 (en) * | 2005-08-25 | 2007-03-01 | Lee Peter P | Immune profiling of lymph nodes associated with cancer |
US20070092907A1 (en) * | 2005-10-21 | 2007-04-26 | Gambhir Sanjiv S | Methods of screening compound probes |
GB0525949D0 (en) | 2005-12-21 | 2006-02-01 | Hammersmith Imanet Ltd | Pet radiotracers |
EP1996716B1 (de) * | 2006-03-20 | 2011-05-11 | The Regents of the University of California | Manipulierte anti-prostatastammzellenantigen (psca)-antikörper für krebs-targeting |
US8545809B2 (en) | 2007-01-11 | 2013-10-01 | Immunomedics, Inc. | Methods and compositions for improved 18F labeling of proteins, peptides and other molecules |
CN103372221B (zh) * | 2007-01-11 | 2016-08-24 | 免疫医学股份有限公司 | 用于蛋白质、肽和其他分子的改进的f-18标记的方法和组合物 |
US8398956B2 (en) | 2007-01-11 | 2013-03-19 | Immunomedics, Inc. | In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents |
US8889100B2 (en) | 2007-01-11 | 2014-11-18 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
US8709382B2 (en) | 2007-01-11 | 2014-04-29 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
US8153100B2 (en) * | 2007-01-11 | 2012-04-10 | Immunomedics, Inc. | Methods and compositions for F-18 labeling of proteins, peptides and other molecules |
WO2009032949A2 (en) | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
US8029743B2 (en) * | 2007-09-19 | 2011-10-04 | General Electric Company | Microfluidic device with vertical injection aperture |
US8916570B2 (en) | 2008-03-31 | 2014-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor agonists and antagonists |
US8735407B2 (en) * | 2008-03-31 | 2014-05-27 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Purine derivatives as A3 adenosine receptor-selective agonists |
CA2732320C (en) * | 2008-08-01 | 2017-08-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A3 adenosine receptor antagonists and partial agonists |
US9181253B2 (en) | 2008-08-01 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenosine receptor agonists, partial agonists, and antagonists |
US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
US7927476B2 (en) * | 2008-12-22 | 2011-04-19 | General Electric Company | Injection method for microfluidic chips |
DK3903829T3 (da) | 2009-02-13 | 2023-06-26 | Immunomedics Inc | Immunkonjugater med en intracellulær spaltelig binding |
EP2398504B1 (de) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Verfahren und Kits zur Diagnose von Krebs und Vorhersage des therapeutischen Nutzens |
GB0905438D0 (en) * | 2009-03-30 | 2009-05-13 | Ge Healthcare Ltd | Radiolabelling reagents and methods |
US8834839B2 (en) * | 2009-04-27 | 2014-09-16 | General Electric Company | Labeled molecular imaging agents, methods of making and methods of use |
MX354143B (es) | 2009-12-02 | 2018-02-14 | Imaginab Inc | Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antígeno de membrana específico para próstata de humano (psma) y métodos para su uso. |
AU2010326004B2 (en) * | 2009-12-04 | 2016-04-21 | Immunomedics, Inc. | Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules |
EP2704751B1 (de) | 2011-05-02 | 2019-04-17 | Immunomedics, Inc. | Ultrafiltrationskonzentration ausgewählter allotypen-antikörper für kleinvolumige verabreichung |
US8784774B2 (en) | 2011-09-16 | 2014-07-22 | General Electric Company | Labeled molecular imaging agents and methods of use |
MX2014015205A (es) | 2012-06-14 | 2015-08-14 | Ambrx Inc | Anticuerpos anti-psma conjugados a polipeptidos de ligando de receptor nuclear. |
US8937186B2 (en) | 2012-08-21 | 2015-01-20 | Uop Llc | Acids removal and methane conversion process using a supersonic flow reactor |
EP2774930A1 (de) | 2013-03-07 | 2014-09-10 | Aptenia S.R.L. | Metallocenverbindungen und markierte Moleküle damit für In-vivo-Bildgebung |
US9468692B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
US9468693B2 (en) | 2014-01-23 | 2016-10-18 | General Electric Company | Labeled molecular imaging agents and methods of use |
US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
WO2016130549A1 (en) * | 2015-02-09 | 2016-08-18 | The Trustees Of Princeton University | Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation |
EP3286224A4 (de) | 2015-04-22 | 2018-11-14 | Immunomedics, Inc. | Isolierung, detektion, diagnose und/oder charakterisierung von zirkulierenden trop-2-positiven krebszellen |
KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
BR112018073642A2 (pt) | 2016-05-19 | 2019-02-26 | Bristol-Myers Squibb Company | imunomoduladores para imagiologia tep |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
BR112020023505A2 (pt) | 2018-06-01 | 2021-03-30 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Composições e usos das mesmas para tratamento de doença ou condição |
CN115231995A (zh) * | 2022-06-14 | 2022-10-25 | 上海应用技术大学 | 一种单氟二溴代丙酮衍生物及其制备与应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0932417T3 (da) * | 1996-10-17 | 2003-04-14 | Immunomedics Inc | Non-antigent toxinkonjugat og fusionsprotein af internaliserende receptorsystem |
-
1998
- 1998-09-03 US US09/146,318 patent/US6187284B1/en not_active Expired - Lifetime
- 1998-09-03 WO PCT/US1998/018268 patent/WO1999011590A1/en active IP Right Grant
- 1998-09-03 EP EP98946820A patent/EP1009726B1/de not_active Expired - Lifetime
- 1998-09-03 DE DE69837095T patent/DE69837095T2/de not_active Expired - Lifetime
- 1998-09-03 AT AT98946820T patent/ATE353864T1/de not_active IP Right Cessation
- 1998-09-03 JP JP2000508634A patent/JP3992923B2/ja not_active Expired - Fee Related
- 1998-09-03 AU AU93756/98A patent/AU9375698A/en not_active Abandoned
- 1998-09-03 CA CA002302360A patent/CA2302360C/en not_active Expired - Lifetime
-
2000
- 2000-08-24 US US09/644,706 patent/US6358489B1/en not_active Expired - Lifetime
-
2002
- 2002-02-11 US US10/071,247 patent/US6953567B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69837095D1 (de) | 2007-03-29 |
JP3992923B2 (ja) | 2007-10-17 |
AU9375698A (en) | 1999-03-22 |
US6187284B1 (en) | 2001-02-13 |
CA2302360A1 (en) | 1999-03-11 |
WO1999011590A1 (en) | 1999-03-11 |
EP1009726B1 (de) | 2007-02-14 |
DE69837095T2 (de) | 2007-11-22 |
EP1009726A1 (de) | 2000-06-21 |
US6358489B1 (en) | 2002-03-19 |
US20020119096A1 (en) | 2002-08-29 |
US6953567B2 (en) | 2005-10-11 |
JP2001515843A (ja) | 2001-09-25 |
CA2302360C (en) | 2005-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |