ATE111893T1 - Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen. - Google Patents

Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen.

Info

Publication number
ATE111893T1
ATE111893T1 AT89908036T AT89908036T ATE111893T1 AT E111893 T1 ATE111893 T1 AT E111893T1 AT 89908036 T AT89908036 T AT 89908036T AT 89908036 T AT89908036 T AT 89908036T AT E111893 T1 ATE111893 T1 AT E111893T1
Authority
AT
Austria
Prior art keywords
radionucide
compositions made
antibody
sulfhydryl
bifunctional
Prior art date
Application number
AT89908036T
Other languages
English (en)
Inventor
Richard T Dean
Raymond H Boutin
Robert W Weber
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Application granted granted Critical
Publication of ATE111893T1 publication Critical patent/ATE111893T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Near-Field Transmission Systems (AREA)
AT89908036T 1988-06-15 1989-06-14 Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen. ATE111893T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/207,261 US5218128A (en) 1988-06-15 1988-06-15 Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom

Publications (1)

Publication Number Publication Date
ATE111893T1 true ATE111893T1 (de) 1994-10-15

Family

ID=22769819

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89908036T ATE111893T1 (de) 1988-06-15 1989-06-14 Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen.

Country Status (7)

Country Link
US (1) US5218128A (de)
EP (1) EP0420934B1 (de)
JP (1) JPH03505097A (de)
AT (1) ATE111893T1 (de)
CA (1) CA1340665C (de)
DE (1) DE68918447T2 (de)
WO (1) WO1989012625A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
JPH05504763A (ja) * 1989-11-30 1993-07-22 マリンクロッド・メディカル・インコーポレイテッド 金属放射性核種でラベル付けされたタンパク質の調製方法
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
WO1992013572A1 (en) * 1991-02-08 1992-08-20 Diatech, Inc. TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
WO1994025488A1 (en) * 1993-05-03 1994-11-10 Mallinckrodt Medical, Inc. Method for preparing a metal-radionuclide-labelled protein
US5980861A (en) * 1996-03-12 1999-11-09 University Of Massachusetts Chelator compositions and methods of synthesis thereof
US5886142A (en) * 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
CN106030763B (zh) 2014-03-28 2019-06-28 琳得科株式会社 保护膜形成用膜及带保护膜的半导体芯片的制造方法
JPWO2022224968A1 (de) * 2021-04-19 2022-10-27

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3060377D1 (en) * 1979-08-29 1982-07-01 Nihon Mediphysics Co Ltd 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
FR2515046B1 (fr) * 1981-10-27 1985-11-29 Hybritech Inc Anticorps monoclonaux marques par un radionucleide et leur application a la visualisation d'une tumeur
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
NO167124C (no) * 1985-04-03 1991-10-09 Du Pont Merck Pharma Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl.
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
ES2017088B3 (es) * 1986-05-28 1991-01-01 Mallinckrodt Inc (A Missouri Corporation) Quelatos de tecnecio a utilizar para determinar la funcion renal.
ATE106898T1 (de) * 1987-03-26 1994-06-15 Neorx Corp Metall-radionuklid-markierte proteine und glykoproteine zur diagnose und therapie.

Also Published As

Publication number Publication date
EP0420934B1 (de) 1994-09-21
JPH03505097A (ja) 1991-11-07
US5218128A (en) 1993-06-08
DE68918447D1 (de) 1994-10-27
DE68918447T2 (de) 1995-03-16
EP0420934A1 (de) 1991-04-10
CA1340665C (en) 1999-07-20
WO1989012625A1 (en) 1989-12-28

Similar Documents

Publication Publication Date Title
ATE111893T1 (de) Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen.
DE3588210T2 (de) Biologisch nützliche Konjugate
DE69837095D1 (de) Fluorierung von proteinen und peptiden für positronemissionstomographie
NO158250C (no) Leddarm-mekanisme.
DE68914244T2 (de) Monoklonaler Antikörper.
NO890115D0 (no) Antigen-antistoff-konjugat.
NO924279D0 (no) Lyofilisert, monoklonalt antistoffpreparat
DE3854502D1 (de) Gegen hiv-antigene spezifischer monoklonaler antikörper.
DE69231495T2 (de) Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungen
DE69115104T2 (de) Composition comprising at least two different antibodies or fragments thereof.
DE3888604T2 (de) Monoklonale Antikörper gegen Antithrombinbindende Substanz und seine Verwendungen.
DK21586A (da) Antigener og antistoffer samt praeparater indeholdende disse
PT90364A (pt) Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional
NO883603L (no) Humane monoklonale antistoffer og profylaktiske og terapeutiske midler mot infektioese sykdommer inneholdende disse som effektiv bestanddel.
NO890116L (no) Monoklonale antistoffer.
NO167813C (no) Fremgangsmaate for fremstilling av carboxylgruppeholdige polyamider, og anvendelse av disse som lakkbindemiddel.
DE68912772T2 (de) Monoklonaler antikörper gegen entero-viren.
TR199701513A3 (tr) Monoklonal antikor hazirlama yöntemi, monoklonal antikor, farmasötik bir bilesim ve bir teshis miyari.
DE3668978D1 (de) Rohrgelenkhebel.
NL190789C (nl) Voegafdichting bij een tunnel.
DE68916088T2 (de) Anti-CPBII-monoklonaler Antikörper.
NO903788D0 (no) Monoklonalt antistoff mot protein c.
NO882518L (no) Fremgangsmaater ved forbedret binding til antistoff, antistoff-fragmenter, hormoner og andre bindingsmidler, og konjugater derav.
DK34393D0 (da) Humant foetalt antigen 1 (fa1), anvendelse af fa1 og anti-fa1 specifikke antistoffer som biologiske principper og immunoreagenser samt kvantitive teknikker baseret herpaa
NO885392D0 (no) Humant tumor-assosiert antigen.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties