PT90364A - Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional - Google Patents

Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional

Info

Publication number
PT90364A
PT90364A PT90364A PT9036489A PT90364A PT 90364 A PT90364 A PT 90364A PT 90364 A PT90364 A PT 90364A PT 9036489 A PT9036489 A PT 9036489A PT 90364 A PT90364 A PT 90364A
Authority
PT
Portugal
Prior art keywords
plaminogenic
activator
tissue
life
extend
Prior art date
Application number
PT90364A
Other languages
English (en)
Inventor
Thomas Michael Reilly
Andrew Tak-Chau Chiu
Robert Madara Knabb
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of PT90364A publication Critical patent/PT90364A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT90364A 1988-04-26 1989-04-24 Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional PT90364A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/186,277 US5225540A (en) 1988-04-26 1988-04-26 Monoclonal antibodies to tissue plasminogen activator (t-pa) which prolong its functional half-life

Publications (1)

Publication Number Publication Date
PT90364A true PT90364A (pt) 1989-11-10

Family

ID=22684316

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90364A PT90364A (pt) 1988-04-26 1989-04-24 Anticorpos monoclonais para o activador de plaminogenio de tecidos (t-pa) que prolongam a sua semi-vida funcional

Country Status (11)

Country Link
US (1) US5225540A (pt)
EP (1) EP0339505A3 (pt)
JP (1) JPH0213395A (pt)
KR (1) KR900015759A (pt)
AU (1) AU3332389A (pt)
DK (1) DK166489A (pt)
FI (1) FI891956A (pt)
IL (1) IL90054A0 (pt)
NO (1) NO891713L (pt)
PT (1) PT90364A (pt)
ZA (1) ZA893088B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04143992A (ja) * 1990-10-04 1992-05-18 Nec Corp 画像メモリのアドレス発生回路
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
RU2401842C2 (ru) * 2004-10-08 2010-10-20 Домантис Лимитед Антагонисты и способы их применения
KR100600039B1 (ko) * 2005-08-19 2006-07-13 최병만 시각장애인용 유도 블록
EP2948167A4 (en) * 2013-01-22 2016-10-19 Univ Tennessee Res Foundation TISSUE CLASMINE ACTIVATOR ANTIBODIES AND METHOD OF USE THEREOF
CN114686442B (zh) * 2020-12-31 2023-11-07 广州万孚生物技术股份有限公司 一种杂交瘤细胞株及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222084A1 (de) * 1982-06-11 1983-12-15 Bayer Ag, 5090 Leverkusen Monoklonale antikoerper
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
JPS61183299A (ja) * 1985-02-08 1986-08-15 Kowa Co 人正常細胞由来の組織型プラスミノ−ゲンアクチベ−タ−に対する新規なモノクロナル抗体およびそれによる精製法ならびに検出法
EP0190711B1 (en) * 1985-02-07 1989-04-26 Kowa Company, Ltd. Monoclonal antibodies to tissue plasminogen activator derived from human normal cells
JPS61221128A (ja) * 1985-03-26 1986-10-01 Snow Brand Milk Prod Co Ltd プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法
JP2635343B2 (ja) * 1986-04-14 1997-07-30 ザ・ジェネラル・ホスピタル・コーポレーション ヘテロ二官能性抗体および利用方法
US4833085A (en) * 1986-08-13 1989-05-23 Monsanto Company Monoclonal antibody specific for human colon fibroblast-derived t-PA
US4891312A (en) * 1986-08-13 1990-01-02 Monsanto Company Monoclonal antibody specific for human colon fibroblast-derived t-PA
US5009888A (en) * 1987-04-13 1991-04-23 Genzyme Corporation Therapeutic enzyme-antibody complexes

Also Published As

Publication number Publication date
NO891713D0 (no) 1989-04-25
ZA893088B (en) 1990-12-28
AU3332389A (en) 1989-11-02
FI891956A (fi) 1989-10-27
DK166489A (da) 1989-10-27
IL90054A0 (en) 1989-12-15
NO891713L (no) 1989-10-27
US5225540A (en) 1993-07-06
DK166489D0 (da) 1989-04-06
EP0339505A2 (en) 1989-11-02
KR900015759A (ko) 1990-11-10
FI891956A0 (fi) 1989-04-25
JPH0213395A (ja) 1990-01-17
EP0339505A3 (en) 1990-05-16

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Legal Events

Date Code Title Description
FC3A Refusal

Effective date: 19940530