DE68918447D1 - Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen. - Google Patents

Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen.

Info

Publication number
DE68918447D1
DE68918447D1 DE68918447T DE68918447T DE68918447D1 DE 68918447 D1 DE68918447 D1 DE 68918447D1 DE 68918447 T DE68918447 T DE 68918447T DE 68918447 T DE68918447 T DE 68918447T DE 68918447 D1 DE68918447 D1 DE 68918447D1
Authority
DE
Germany
Prior art keywords
antibody
radionucleid
sulfhydryl
compositions made
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918447T
Other languages
English (en)
Other versions
DE68918447T2 (de
Inventor
Richard Dean
Raymond Boutin
Robert Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of DE68918447D1 publication Critical patent/DE68918447D1/de
Application granted granted Critical
Publication of DE68918447T2 publication Critical patent/DE68918447T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Near-Field Transmission Systems (AREA)
DE68918447T 1988-06-15 1989-06-14 Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen. Expired - Fee Related DE68918447T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/207,261 US5218128A (en) 1988-06-15 1988-06-15 Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
PCT/US1989/002634 WO1989012625A1 (en) 1988-06-15 1989-06-14 Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom

Publications (2)

Publication Number Publication Date
DE68918447D1 true DE68918447D1 (de) 1994-10-27
DE68918447T2 DE68918447T2 (de) 1995-03-16

Family

ID=22769819

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918447T Expired - Fee Related DE68918447T2 (de) 1988-06-15 1989-06-14 Bifunktionelle kuppler und daraus hergestellte mit radionukleid markierte zusammensetzungen.

Country Status (7)

Country Link
US (1) US5218128A (de)
EP (1) EP0420934B1 (de)
JP (1) JPH03505097A (de)
AT (1) ATE111893T1 (de)
CA (1) CA1340665C (de)
DE (1) DE68918447T2 (de)
WO (1) WO1989012625A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075099A (en) * 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
EP0593452A1 (de) * 1989-11-30 1994-04-27 Mallinckrodt Medical, Inc. Verfahren zur herstellung eines mit metallradionuklid markierten proteins
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
CA2101942C (en) * 1991-02-08 2001-01-30 Richard T. Dean Technetium-99m labeled polypeptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2141739A1 (en) * 1993-05-03 1994-11-10 Alfons M. Verbruggen Method for preparing a metal-radionuclide-labelled protein
US5980861A (en) * 1996-03-12 1999-11-09 University Of Massachusetts Chelator compositions and methods of synthesis thereof
US5886142A (en) * 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
KR102355113B1 (ko) 2014-03-28 2022-01-24 린텍 가부시키가이샤 보호막 형성용 필름 및 보호막이 형성된 반도체 칩의 제조 방법
JPWO2022224968A1 (de) * 2021-04-19 2022-10-27

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024464B1 (de) * 1979-08-29 1982-05-12 Nihon Medi-Physics Co., Ltd. 2-Oxopropionaldehyd-bis(thiosemicarbazon)-Derivate und ihre Herstellung und Verwendung
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
GB2109407B (en) * 1981-10-27 1985-12-18 Hybritech Inc Tumour imaging with radiolabelled monoclonal antibodies
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4668503A (en) * 1982-07-26 1987-05-26 Trustees Of University Of Massachusetts Process for labeling amines with 99m Tc
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4732864A (en) * 1983-10-06 1988-03-22 E. I. Du Pont De Nemours And Company Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
US4670545A (en) * 1984-05-11 1987-06-02 University Patents, Inc. Chelating agents for technetium-99M
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
NO167124C (no) * 1985-04-03 1991-10-09 Du Pont Merck Pharma Fremgangsmaate for fremstilling av et spormerket konjugat av metallthionein og biologisk aktivt molekyl.
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
DE3762624D1 (de) * 1986-05-28 1990-06-13 Mallinckrodt Inc Technetiumchelate fuer die bestimmung der nierenfunktion.
EP0284071B1 (de) * 1987-03-26 1994-06-08 Neorx Corporation Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie

Also Published As

Publication number Publication date
EP0420934A1 (de) 1991-04-10
JPH03505097A (ja) 1991-11-07
CA1340665C (en) 1999-07-20
EP0420934B1 (de) 1994-09-21
US5218128A (en) 1993-06-08
ATE111893T1 (de) 1994-10-15
WO1989012625A1 (en) 1989-12-28
DE68918447T2 (de) 1995-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee