ATE335200T1 - Diagnose von zellenproliferation sowie screeningverfahren für deren modulatore - Google Patents

Diagnose von zellenproliferation sowie screeningverfahren für deren modulatore

Info

Publication number
ATE335200T1
ATE335200T1 AT00973914T AT00973914T ATE335200T1 AT E335200 T1 ATE335200 T1 AT E335200T1 AT 00973914 T AT00973914 T AT 00973914T AT 00973914 T AT00973914 T AT 00973914T AT E335200 T1 ATE335200 T1 AT E335200T1
Authority
AT
Austria
Prior art keywords
diagnosis
modulators
cell proliferation
screening procedures
methods
Prior art date
Application number
AT00973914T
Other languages
English (en)
Inventor
Kenneth W Wood
Jeffrey T Finer
Christophe Beraud
John Mak
Roman Sakowicz
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Application granted granted Critical
Publication of ATE335200T1 publication Critical patent/ATE335200T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00973914T 1999-10-27 2000-10-26 Diagnose von zellenproliferation sowie screeningverfahren für deren modulatore ATE335200T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/428,156 US6617115B1 (en) 1999-10-27 1999-10-27 Methods of screening for modulators of cell proliferation

Publications (1)

Publication Number Publication Date
ATE335200T1 true ATE335200T1 (de) 2006-08-15

Family

ID=23697770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973914T ATE335200T1 (de) 1999-10-27 2000-10-26 Diagnose von zellenproliferation sowie screeningverfahren für deren modulatore

Country Status (8)

Country Link
US (5) US6617115B1 (de)
EP (2) EP1726954A3 (de)
AT (1) ATE335200T1 (de)
AU (1) AU1236101A (de)
CA (1) CA2387804A1 (de)
DE (1) DE60029812T2 (de)
ES (1) ES2269196T3 (de)
WO (1) WO2001031335A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
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ATE342257T1 (de) 1999-08-27 2006-11-15 Chemocentryx Inc Heterozyclische verbindungen und verfahren zur modulierung von cxcr3 funktion
US6617115B1 (en) * 1999-10-27 2003-09-09 Cytokinetics, Inc. Methods of screening for modulators of cell proliferation
US6638754B1 (en) * 2000-11-28 2003-10-28 Cytokinetics, Inc. Motor proteins and methods for their use
EP1351671A1 (de) * 2001-01-19 2003-10-15 Cytokinetics, Inc. Triphenylmethanderivate als kinesinhemmer
US6900214B2 (en) 2001-03-29 2005-05-31 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
US6809102B2 (en) 2001-03-29 2004-10-26 Bristol-Myers Squibb Company Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
GB0108143D0 (en) * 2001-03-31 2001-05-23 Univ Dundee High-throughput screen
US9274101B2 (en) * 2001-04-20 2016-03-01 Biolog, Inc. Methods and kits for obtaining a metabolic profile of living animal cells
PT1454903E (pt) * 2001-12-11 2010-11-09 Kyowa Hakko Kirin Co Ltd Derivados de tiadiazolina para tratamento do cancro
US20060134767A1 (en) * 2002-07-08 2006-06-22 Buser-Doepner Carolyn A Mitotic kinesin binding site
US8032346B1 (en) 2002-08-28 2011-10-04 Rigel Pharmaceuticals, Inc. System and method for high-content oncology assay
US7970549B1 (en) 2002-08-28 2011-06-28 Rigel Pharmaceuticals Inc. System and method for high-content oncology assay
AU2003277069A1 (en) * 2002-09-30 2004-04-23 Ciphergen Biosystems, Inc. Apparatus and method for expression and capture of biomolecules and complexes on adsorbent surfaces
AU2003301442A1 (en) * 2002-10-17 2004-05-04 Cytokinetics, Inc. MODIFIED NUCLEOTIDE SEQUENCE ENCODING C. ALBICANS Kip3 KINESIN PROTEIN
KR101096948B1 (ko) 2003-04-18 2011-12-20 후지필름 홀딩스 가부시끼가이샤 Ｍ기 키네신 저해제
US20070134660A1 (en) * 2003-05-30 2007-06-14 Rosetta Inpharmatics Llc Methods for identifying modulators of kinesin activity
CA2528433A1 (en) * 2003-06-10 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Thiadiazoline derivative
US20070087984A1 (en) * 2003-09-04 2007-04-19 Xiuyuan Hu Method of identifying agents that inhibit the growth of cancer cells
CA2539651A1 (en) * 2003-09-22 2005-04-07 Rosetta Inpharmatics Llc Synthetic lethal screen using rna interference
WO2005035512A1 (ja) * 2003-10-10 2005-04-21 Kyowa Hakko Kogyo Co., Ltd. チアジアゾリン誘導体
EP1694281A4 (de) * 2003-12-19 2008-12-24 Smithkline Beecham Corp Biphenyl-verbindungen und verfahren
US20050152940A1 (en) * 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
EP1737979B9 (de) * 2004-03-23 2011-09-21 Oncotherapy Science, Inc. Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs
US7618981B2 (en) 2004-05-06 2009-11-17 Cytokinetics, Inc. Imidazopyridinyl-benzamide anti-cancer agents
KR101347830B1 (ko) 2004-05-23 2014-01-07 에이치엠아이, 인코포레이티드 테라뮤틴 조절물질
US20100093767A1 (en) * 2004-12-03 2010-04-15 Takeda San Diego, Inc. Mitotic Kinase Inhibitors
KR20070114822A (ko) * 2005-03-22 2007-12-04 교와 핫꼬 고교 가부시끼가이샤 조혈기 종양 치료제
CN101193878A (zh) * 2005-03-22 2008-06-04 协和发酵工业株式会社 实体肿瘤治疗剂
JPWO2006137490A1 (ja) * 2005-06-24 2009-01-22 協和発酵キリン株式会社 再狭窄治療剤
DE102006002065B4 (de) * 2006-01-16 2007-11-29 Infineon Technologies Austria Ag Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
EP2112509A1 (de) * 2008-03-25 2009-10-28 4Sc Ag Centrosomen-Assay
WO2011009523A1 (en) 2009-07-24 2011-01-27 Merck Patent Gmbh Eg5 as biomarker in rare thoracic cancer
US20130210733A1 (en) 2010-06-17 2013-08-15 Cytokinetics, Inc. Methods of treating lung disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU689840B2 (en) 1994-01-05 1998-04-09 Board Of Trustees Of The University Of Illinois, The Association of kinesin with sensitivity to chemotherapeutic drugs
JP2002500190A (ja) * 1998-01-08 2002-01-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 海洋海綿から誘導されるキネシンモーターモジュレーター
AU5322399A (en) 1998-07-27 2000-02-21 President And Fellows Of Harvard College Method of high-throughput screening of molecules and compounds for their effectson biological and chemical processes
AU4367700A (en) 1999-04-20 2000-11-02 Cytokinetics, Inc. Human kinesins and methods of producing and purifying human kinesins
US6410254B1 (en) * 1999-05-18 2002-06-25 Cytokinetics Compositions and assays utilizing ADP or phosphate for detecting protein modulators
DE19935303A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonukleotide zur Inhibierung der Expression von humanem eg5
US6617115B1 (en) * 1999-10-27 2003-09-09 Cytokinetics, Inc. Methods of screening for modulators of cell proliferation

Also Published As

Publication number Publication date
US6437115B1 (en) 2002-08-20
EP1726954A3 (de) 2007-06-13
EP1224460A2 (de) 2002-07-24
DE60029812D1 (de) 2006-09-14
WO2001031335A9 (en) 2002-08-15
EP1726954A2 (de) 2006-11-29
CA2387804A1 (en) 2001-05-03
US20100261160A1 (en) 2010-10-14
DE60029812T2 (de) 2007-03-29
ES2269196T3 (es) 2007-04-01
US6617115B1 (en) 2003-09-09
WO2001031335A3 (en) 2001-11-01
US20040214249A1 (en) 2004-10-28
AU1236101A (en) 2001-05-08
US6414121B1 (en) 2002-07-02
EP1224460B1 (de) 2006-08-02
WO2001031335A2 (en) 2001-05-03

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