ATE428928T1 - Verfahren zur einführung von heterologischen zellen in fische - Google Patents

Verfahren zur einführung von heterologischen zellen in fische

Info

Publication number
ATE428928T1
ATE428928T1 AT07008609T AT07008609T ATE428928T1 AT E428928 T1 ATE428928 T1 AT E428928T1 AT 07008609 T AT07008609 T AT 07008609T AT 07008609 T AT07008609 T AT 07008609T AT E428928 T1 ATE428928 T1 AT E428928T1
Authority
AT
Austria
Prior art keywords
cells
fish
methods
useful
introducing
Prior art date
Application number
AT07008609T
Other languages
English (en)
Inventor
George Serbedzija
Patricia Mcgrath
Original Assignee
Phylonix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phylonix Pharmaceuticals Inc filed Critical Phylonix Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE428928T1 publication Critical patent/ATE428928T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/4603—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from fish

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
AT07008609T 1998-12-01 1999-11-30 Verfahren zur einführung von heterologischen zellen in fische ATE428928T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11046498P 1998-12-01 1998-12-01

Publications (1)

Publication Number Publication Date
ATE428928T1 true ATE428928T1 (de) 2009-05-15

Family

ID=22333153

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99965950T ATE361469T1 (de) 1998-12-01 1999-11-30 Methoden zur introduktion heterologer zellen in fische
AT07008609T ATE428928T1 (de) 1998-12-01 1999-11-30 Verfahren zur einführung von heterologischen zellen in fische

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99965950T ATE361469T1 (de) 1998-12-01 1999-11-30 Methoden zur introduktion heterologer zellen in fische

Country Status (9)

Country Link
US (4) US6761876B2 (de)
EP (1) EP1135531B1 (de)
JP (1) JP4522587B2 (de)
AT (2) ATE361469T1 (de)
AU (1) AU776246B2 (de)
CA (1) CA2352568A1 (de)
DE (2) DE69935999T2 (de)
ES (2) ES2325285T3 (de)
WO (1) WO2000032822A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2325285T3 (es) 1998-12-01 2009-08-31 Phylonix Pharmaceuticals Inc. Metodos para introducir celulas heterologas en peces.
CA2494310A1 (en) * 2002-08-01 2004-02-12 Immunomedics, Inc. Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof
GB0228093D0 (en) * 2002-12-02 2003-01-08 Daniolabs Ltd Disease models and uses thereof
US20070044168A1 (en) * 2005-07-12 2007-02-22 Northwestern University Transplantable tumor model
CA2778090C (en) 2009-10-07 2018-03-13 Kerecis Ehf Decellularized fish skin scaffold material
JP5875010B2 (ja) * 2012-10-24 2016-03-02 国立大学法人三重大学 異種細胞移植モデル動物の作製方法
WO2014083555A1 (en) * 2012-12-02 2014-06-05 Biomedcore Inc. Accelerated prediction of cancer progression and response to treatment
KR101508356B1 (ko) 2013-05-06 2015-04-06 광주과학기술원 제브라피시 인간 종양 이종이식 모델을 이용한 항암제 스크리닝 방법
US10543287B2 (en) 2013-07-10 2020-01-28 The General Hospital Corporation Immune-compromised zebrafish
EP3597740B1 (de) 2014-11-06 2022-03-23 DuPont US Holding, LLC Peptidvermittelte freisetzung von rna-geführter endonuklease in zellen
WO2016106295A1 (en) * 2014-12-22 2016-06-30 Dana-Farber Cancer Institute, Inc. In vivo methods for identifying cancer-associated immunotherapy targets
JP6622007B2 (ja) * 2015-05-29 2019-12-18 オリンパス株式会社 細胞評価方法
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
US20180362961A1 (en) 2015-12-11 2018-12-20 Danisco Us Inc. Methods and compositions for enhanced nuclease-mediated genome modification and reduced off-target site effects
WO2017105991A1 (en) 2015-12-18 2017-06-22 Danisco Us Inc. Methods and compositions for t-rna based guide rna expression
CN108967358A (zh) * 2018-05-31 2018-12-11 上海交通大学医学院附属瑞金医院 一种斑马鱼fl肿瘤模型的构建方法及其应用
CN112452362B (zh) * 2020-09-25 2021-09-21 中山大学 一种无泵固定斑马鱼微流体芯片系统及其制备方法与应用

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JPS5399992A (en) 1977-02-10 1978-08-31 Hitachi Ltd Water quality fluctuation detector
ZA793568B (en) 1978-07-26 1981-02-25 Duphar Int Res Algicidal composition
GB2080948B (en) 1980-08-04 1983-09-21 Euratom Apparatus and method for measuring the toxicity of pollutants to aquatic living organisms
US4816392A (en) 1984-10-02 1989-03-28 Research Corporation Of The University Of Hawaii Rapid stick test for detection of ciguatoxin and other polyether toxins from tissues
US5510099A (en) 1987-05-01 1996-04-23 Stratagene Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
DE3801476A1 (de) 1988-01-20 1989-08-03 Henkel Kgaa Zusammensetzungen zur befreiung festgesetzter bohrgestaenge
US5190920A (en) 1990-09-24 1993-03-02 W. R. Grace & Co.-Conn. Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity
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DE4401868C1 (de) 1994-01-22 1995-02-16 Lobbe Xenex Gmbh Mikrobielles Verfahren zum Nachweis von Schadstoffen
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ES2325285T3 (es) 1998-12-01 2009-08-31 Phylonix Pharmaceuticals Inc. Metodos para introducir celulas heterologas en peces.

Also Published As

Publication number Publication date
EP1135531A4 (de) 2005-03-09
US6761876B2 (en) 2004-07-13
AU776246B2 (en) 2004-09-02
DE69935999D1 (de) 2007-06-14
AU2161200A (en) 2000-06-19
DE69935999T2 (de) 2008-01-10
JP4522587B2 (ja) 2010-08-11
US7408095B2 (en) 2008-08-05
US20110286973A1 (en) 2011-11-24
WO2000032822A1 (en) 2000-06-08
US7838726B2 (en) 2010-11-23
EP1135531B1 (de) 2007-05-02
CA2352568A1 (en) 2000-06-08
JP2002531104A (ja) 2002-09-24
US20070130632A1 (en) 2007-06-07
DE69940753D1 (de) 2009-05-28
ES2286908T3 (es) 2007-12-01
ATE361469T1 (de) 2007-05-15
US20020061291A1 (en) 2002-05-23
EP1135531A1 (de) 2001-09-26
US20040185431A1 (en) 2004-09-23
ES2325285T3 (es) 2009-08-31

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