ATE335090T1 - Verfahren zur herstellung von 3- 2- ä(methylsulfonyl)oxyüethoxyö-4-(triphenylmethox )-1-butanol methane sulfonat - Google Patents
Verfahren zur herstellung von 3- 2- ä(methylsulfonyl)oxyüethoxyö-4-(triphenylmethox )-1-butanol methane sulfonatInfo
- Publication number
- ATE335090T1 ATE335090T1 AT01994173T AT01994173T ATE335090T1 AT E335090 T1 ATE335090 T1 AT E335090T1 AT 01994173 T AT01994173 T AT 01994173T AT 01994173 T AT01994173 T AT 01994173T AT E335090 T1 ATE335090 T1 AT E335090T1
- Authority
- AT
- Austria
- Prior art keywords
- methylsulfonyl
- alcohol
- methane sulfonate
- producing
- isomer
- Prior art date
Links
- -1 METHYLSULFONYL Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 abstract 2
- BEIIPJGHIJEDMT-SANMLTNESA-N [(3s)-3-(2-methylsulfonyloxyethoxy)-4-trityloxybutyl] methanesulfonate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(OC[C@H](CCOS(C)(=O)=O)OCCOS(=O)(=O)C)C1=CC=CC=C1 BEIIPJGHIJEDMT-SANMLTNESA-N 0.000 abstract 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N alpha-ketodiacetal Natural products O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- 150000002009 diols Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 1
- JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D309/22—Radicals substituted by oxygen atoms
- C07D309/24—Methylol radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/718,711 US6300106B1 (en) | 2000-11-22 | 2000-11-22 | Method of preparing 3-[2-{(Methylsulfonyl)oxy}-ethoxy ]-4-(triphenylmethoxy)-1-butanol, methane sulfonate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335090T1 true ATE335090T1 (de) | 2006-08-15 |
Family
ID=24887178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01994173T ATE335090T1 (de) | 2000-11-22 | 2001-10-30 | Verfahren zur herstellung von 3- 2- ä(methylsulfonyl)oxyüethoxyö-4-(triphenylmethox )-1-butanol methane sulfonat |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6300106B1 (de) |
| EP (1) | EP1341927B1 (de) |
| JP (2) | JP4133328B2 (de) |
| CN (1) | CN1276978C (de) |
| AT (1) | ATE335090T1 (de) |
| CA (1) | CA2429775A1 (de) |
| DE (1) | DE60121994T2 (de) |
| DK (1) | DK1341927T3 (de) |
| ES (1) | ES2267857T3 (de) |
| PT (1) | PT1341927E (de) |
| WO (1) | WO2002059342A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2181999A1 (de) | 2008-11-03 | 2010-05-05 | Zentiva, A.S. | Verfahren zur Herstellung von Ruboxistaurin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2655341B1 (fr) * | 1989-12-01 | 1992-02-21 | Rhone Poulenc Sante | Derives dihydropyranniques, leurs procedes de preparation et leur utilisation. |
| UA61897C2 (en) * | 1995-11-20 | 2003-12-15 | Lilly Co Eli | Protein kinase c inhibitors, methods for synthesis, pharmaceutical formulations and methods for treating microvascular diabetic complications |
| DK0776899T3 (da) | 1995-11-20 | 2000-07-10 | Lilly Co Eli | Mellemprodukter og deres anvendelse til fremstilling af N,N'-forbundne bisindolylmaleimider |
| US5721272A (en) * | 1996-11-18 | 1998-02-24 | Eli Lilly And Company | Intermediates and their use to prepare N,N'-bridged bisindolylmaleimides |
-
2000
- 2000-11-22 US US09/718,711 patent/US6300106B1/en not_active Expired - Fee Related
-
2001
- 2001-10-30 PT PT01994173T patent/PT1341927E/pt unknown
- 2001-10-30 JP JP2002559825A patent/JP4133328B2/ja not_active Expired - Fee Related
- 2001-10-30 CN CNB018207529A patent/CN1276978C/zh not_active Expired - Fee Related
- 2001-10-30 DE DE60121994T patent/DE60121994T2/de not_active Expired - Fee Related
- 2001-10-30 DK DK01994173T patent/DK1341927T3/da active
- 2001-10-30 AT AT01994173T patent/ATE335090T1/de not_active IP Right Cessation
- 2001-10-30 EP EP01994173A patent/EP1341927B1/de not_active Expired - Lifetime
- 2001-10-30 WO PCT/US2001/047187 patent/WO2002059342A1/en not_active Ceased
- 2001-10-30 CA CA002429775A patent/CA2429775A1/en not_active Abandoned
- 2001-10-30 ES ES01994173T patent/ES2267857T3/es not_active Expired - Lifetime
-
2008
- 2008-04-23 JP JP2008112946A patent/JP2008263985A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE60121994T2 (de) | 2007-03-15 |
| WO2002059342A1 (en) | 2002-08-01 |
| JP2008263985A (ja) | 2008-11-06 |
| EP1341927B1 (de) | 2006-08-02 |
| EP1341927A1 (de) | 2003-09-10 |
| DK1341927T3 (da) | 2006-11-13 |
| PT1341927E (pt) | 2006-12-29 |
| DE60121994D1 (de) | 2006-09-14 |
| US6300106B1 (en) | 2001-10-09 |
| JP2006506941A (ja) | 2006-03-02 |
| JP4133328B2 (ja) | 2008-08-13 |
| CN1633504A (zh) | 2005-06-29 |
| CA2429775A1 (en) | 2002-08-01 |
| CN1276978C (zh) | 2006-09-27 |
| ES2267857T3 (es) | 2007-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1341927 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |