ATE334681T1 - Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck - Google Patents
Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruckInfo
- Publication number
- ATE334681T1 ATE334681T1 AT03788945T AT03788945T ATE334681T1 AT E334681 T1 ATE334681 T1 AT E334681T1 AT 03788945 T AT03788945 T AT 03788945T AT 03788945 T AT03788945 T AT 03788945T AT E334681 T1 ATE334681 T1 AT E334681T1
- Authority
- AT
- Austria
- Prior art keywords
- increased
- treatment
- increatic
- pressure
- pteridine derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2003/003096 WO2005037286A1 (en) | 2003-03-25 | 2003-03-25 | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE334681T1 true ATE334681T1 (de) | 2006-08-15 |
Family
ID=33040875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03788945T ATE334681T1 (de) | 2003-03-25 | 2003-10-08 | Verwendung von pteridinderivaten für die behandlung von erhöhtem hirndruck |
Country Status (14)
Country | Link |
---|---|
US (3) | US8222238B2 (de) |
EP (1) | EP1605947B1 (de) |
JP (1) | JP4630669B2 (de) |
KR (1) | KR101103888B1 (de) |
CN (1) | CN1758913B (de) |
AT (1) | ATE334681T1 (de) |
AU (1) | AU2003293607B2 (de) |
CA (1) | CA2519919C (de) |
DE (1) | DE60307327T2 (de) |
ES (1) | ES2270151T3 (de) |
MX (1) | MXPA05009491A (de) |
PL (1) | PL213123B1 (de) |
RU (1) | RU2348410C2 (de) |
WO (2) | WO2005037286A1 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005037286A1 (en) | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
EP2224927B1 (de) * | 2008-01-03 | 2014-08-20 | BioMarin Pharmaceutical Inc. | Pterin-analogon zur behandlung eines auf bh4 ansprechenden zustands |
DK2926805T3 (en) * | 2014-03-31 | 2016-07-25 | Vasopharm Gmbh | Solid pharmaceutical compositions comprising biopterine derivatives and uses of such compositions |
CA3235704A1 (en) | 2021-12-03 | 2023-06-08 | Verinos Operations Gmbh | Methods of treating patients suffering from brain injury and methods of increasing the value of the extended glasgow outcome scale of patients suffering from brain injury |
TW202406555A (zh) | 2022-05-06 | 2024-02-16 | 德商veriNOS運營有限公司 | 治療患有與增加的麩胺酸水平相關的疾病狀況或病症的患者的方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9203323A (es) | 1991-07-11 | 1994-07-29 | Hoechst Ag | El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales. |
US5266594A (en) * | 1992-05-12 | 1993-11-30 | Dawson Valina L | Inhibitors of nitric oxide synthase and use thereof to prevent glutamate neurotoxicity |
WO1994014780A1 (en) * | 1992-12-18 | 1994-07-07 | The Wellcome Foundation Limited | Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors |
US5527822A (en) | 1993-12-29 | 1996-06-18 | Forest Laboratories, Inc. | Method of treatment of traumatic brain injury |
DE4418097A1 (de) | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
DE4418096A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Pteridin-Derivaten als Hemmstoffe der NO-Synthase |
GB9500691D0 (en) | 1995-01-13 | 1995-03-08 | Smithkline Beecham Plc | Compounds |
GB9509156D0 (en) | 1995-05-05 | 1995-06-28 | Sandoz Ltd | Organic compounds |
WO1997021711A1 (de) | 1995-12-12 | 1997-06-19 | Lonza Ag | Verfahren zur herstellung von 4-aminopteridinderivaten |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
KR100650962B1 (ko) * | 1996-08-30 | 2007-07-18 | 다이이치 아스비오파마 가부시키가이샤 | 질소산화물합성효소(nos)의기능저하에의해유발되는질환의예방또는치료제 |
WO1998028257A1 (fr) | 1996-12-24 | 1998-07-02 | Chugai Seiyaku Kabushiki Kaisha | Derives d'amine aromatiques ayant une action inhibitrice a l'egard des nos |
JP4346113B2 (ja) | 1997-02-21 | 2009-10-21 | バイエル・アクチエンゲゼルシヤフト | アリールスルホンアミド及びそれらの類似体並びに神経変性疾患の治療におけるそれらの使用 |
DE19740785A1 (de) | 1997-02-21 | 1998-08-27 | Bayer Ag | Arylsulfonamide und Analoga |
US5922713A (en) | 1997-06-26 | 1999-07-13 | Werner; Ernst | Inhibition of nitric oxide synthase |
DE59703603D1 (de) | 1997-10-06 | 2001-06-28 | Ernst Werner | Pteridinderivate als NO Synthase-Hemmer |
DE19754573A1 (de) | 1997-12-09 | 1999-06-10 | Bayer Ag | Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma |
DE19801646A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
HN1998000027A (es) | 1998-08-19 | 1999-06-02 | Bayer Ip Gmbh | Arilsulfonamidas y analagos |
JP2002533464A (ja) * | 1998-12-28 | 2002-10-08 | カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント | プテリジン誘導体の免疫抑制作用 |
US6255280B1 (en) | 1999-04-08 | 2001-07-03 | University Of Kentucky Research Foundation | Protection against traumatic brain injury |
DE19944767A1 (de) | 1999-09-17 | 2001-03-29 | Vasopharm Biotech Gmbh & Co Kg | N-substituierte 4-Aminopteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AU2928901A (en) * | 2000-01-07 | 2001-07-24 | Rice Creek Medical, L.L.C. | Non-invasive method and apparatus for monitoring intracranial pressure |
DE10109866A1 (de) | 2001-03-01 | 2002-09-05 | Abbott Gmbh & Co Kg | Triazolverbindungen und deren Verwendung zur Prophylaxe und Therapie neurodegenerativer Erkrankungen, Hirntrauma und zerebraler Ischämie |
EP1419388B1 (de) * | 2001-08-20 | 2009-10-07 | Biosite Incorporated | Diagnostische marker für schlaganfall und hirntrauma sowie verfahren zur verwendung davon |
WO2005037286A1 (en) | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
-
2003
- 2003-03-25 WO PCT/EP2003/003096 patent/WO2005037286A1/en unknown
- 2003-10-08 CA CA002519919A patent/CA2519919C/en not_active Expired - Lifetime
- 2003-10-08 EP EP03788945A patent/EP1605947B1/de not_active Expired - Lifetime
- 2003-10-08 AU AU2003293607A patent/AU2003293607B2/en not_active Expired
- 2003-10-08 DE DE60307327T patent/DE60307327T2/de not_active Expired - Lifetime
- 2003-10-08 MX MXPA05009491A patent/MXPA05009491A/es active IP Right Grant
- 2003-10-08 PL PL378633A patent/PL213123B1/pl unknown
- 2003-10-08 AT AT03788945T patent/ATE334681T1/de active
- 2003-10-08 US US10/549,200 patent/US8222238B2/en not_active Expired - Lifetime
- 2003-10-08 RU RU2005128956/15A patent/RU2348410C2/ru active
- 2003-10-08 CN CN2003801102110A patent/CN1758913B/zh not_active Expired - Lifetime
- 2003-10-08 ES ES03788945T patent/ES2270151T3/es not_active Expired - Lifetime
- 2003-10-08 KR KR1020057017933A patent/KR101103888B1/ko active IP Right Grant
- 2003-10-08 JP JP2004569858A patent/JP4630669B2/ja not_active Expired - Lifetime
- 2003-10-08 WO PCT/EP2003/011138 patent/WO2004084906A1/en active IP Right Grant
-
2012
- 2012-07-13 US US13/548,295 patent/US9422289B2/en not_active Expired - Lifetime
-
2013
- 2013-01-10 US US13/738,102 patent/US9382252B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2270151T3 (es) | 2007-04-01 |
KR101103888B1 (ko) | 2012-01-12 |
US8222238B2 (en) | 2012-07-17 |
AU2003293607A1 (en) | 2004-10-18 |
AU2003293607B2 (en) | 2009-12-03 |
WO2005037286A1 (en) | 2005-04-28 |
US9422289B2 (en) | 2016-08-23 |
JP2006514965A (ja) | 2006-05-18 |
KR20060002861A (ko) | 2006-01-09 |
US20130131071A1 (en) | 2013-05-23 |
JP4630669B2 (ja) | 2011-02-09 |
DE60307327D1 (de) | 2006-09-14 |
PL213123B1 (pl) | 2013-01-31 |
CA2519919A1 (en) | 2004-10-07 |
PL378633A1 (pl) | 2006-05-15 |
CN1758913B (zh) | 2010-04-28 |
US20130184281A1 (en) | 2013-07-18 |
EP1605947B1 (de) | 2006-08-02 |
US9382252B2 (en) | 2016-07-05 |
DE60307327T2 (de) | 2007-10-25 |
US20070032498A1 (en) | 2007-02-08 |
RU2005128956A (ru) | 2006-04-27 |
CN1758913A (zh) | 2006-04-12 |
WO2004084906A1 (en) | 2004-10-07 |
MXPA05009491A (es) | 2006-02-22 |
CA2519919C (en) | 2009-09-08 |
RU2348410C2 (ru) | 2009-03-10 |
EP1605947A1 (de) | 2005-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
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