ATE334119T1 - Geldanamycinderivate zur krebsbehandlung - Google Patents
Geldanamycinderivate zur krebsbehandlungInfo
- Publication number
- ATE334119T1 ATE334119T1 AT02757908T AT02757908T ATE334119T1 AT E334119 T1 ATE334119 T1 AT E334119T1 AT 02757908 T AT02757908 T AT 02757908T AT 02757908 T AT02757908 T AT 02757908T AT E334119 T1 ATE334119 T1 AT E334119T1
- Authority
- AT
- Austria
- Prior art keywords
- anamycin
- money
- derivatives
- cancer treatment
- host
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28007801P | 2001-03-30 | 2001-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE334119T1 true ATE334119T1 (de) | 2006-08-15 |
Family
ID=23071560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02757908T ATE334119T1 (de) | 2001-03-30 | 2002-03-28 | Geldanamycinderivate zur krebsbehandlung |
Country Status (19)
Country | Link |
---|---|
US (1) | US6890917B2 (de) |
EP (1) | EP1373215B1 (de) |
JP (1) | JP4213472B2 (de) |
KR (1) | KR100831133B1 (de) |
CN (1) | CN1262542C (de) |
AT (1) | ATE334119T1 (de) |
AU (1) | AU2002307020B2 (de) |
CA (1) | CA2430692C (de) |
CY (1) | CY1107484T1 (de) |
DE (1) | DE60213386T2 (de) |
DK (1) | DK1373215T3 (de) |
ES (1) | ES2268068T3 (de) |
IL (2) | IL156122A0 (de) |
MX (1) | MXPA03007856A (de) |
NZ (1) | NZ526133A (de) |
PT (1) | PT1373215E (de) |
SI (1) | SI21369A (de) |
WO (1) | WO2002079167A1 (de) |
ZA (1) | ZA200304178B (de) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US20060148776A1 (en) * | 2003-03-13 | 2006-07-06 | Conforma Therapeutics Corporation | Drug formulations having long and medium chain triglycerides |
US20050020534A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites |
US20050020556A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes |
US20050054589A1 (en) * | 2003-05-30 | 2005-03-10 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics |
US7691838B2 (en) * | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
US20050054625A1 (en) * | 2003-05-30 | 2005-03-10 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors |
US20050026893A1 (en) * | 2003-05-30 | 2005-02-03 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants |
US20050020557A1 (en) * | 2003-05-30 | 2005-01-27 | Kosan Biosciences, Inc. | Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors |
WO2005009345A2 (en) | 2003-06-13 | 2005-02-03 | Kosan Biosciences, Inc. | 2-desmethyl ansamycin compounds |
US6875863B1 (en) | 2003-11-12 | 2005-04-05 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
EP1682514A4 (de) * | 2003-11-12 | 2008-07-16 | Kosan Biosciences Inc | 11- o-methylgeldanamycinverbindungen |
US6855705B1 (en) | 2003-11-12 | 2005-02-15 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
US6887993B1 (en) | 2003-11-12 | 2005-05-03 | Kosan Biosciences, Inc. | 11-O-methylgeldanamycin compounds |
WO2005063714A1 (en) | 2003-12-23 | 2005-07-14 | Infinity Pharmaceuticals, Inc | Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
US20060019941A1 (en) * | 2003-12-23 | 2006-01-26 | Infinity Pharmaceuticals, Inc. | Analogs of benzoquinone-containing ansamycins and methods of use thereof |
US20050256097A1 (en) * | 2004-05-11 | 2005-11-17 | Kosan Biosciences, Inc. | Pharmaceutical solution formulations containing 17-AAG |
US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
US20060067953A1 (en) * | 2004-09-29 | 2006-03-30 | Conforma Therapeutics Corporation | Oral pharmaceutical formulations and methods for producing and using same |
EP1863769A4 (de) * | 2005-03-11 | 2009-03-18 | Univ Colorado | Hsp90-inhibitoren, verfahren zu deren herstellung und deren anwendungen |
JP2008539273A (ja) * | 2005-04-29 | 2008-11-13 | コーザン バイオサイエンシス インコーポレイテッド | 17−aag又は17−ag又はどちらかのプロドラッグをプロテアソーム阻害剤と組み合わせて使用する多発性骨髄腫の治療方法 |
US20100279994A1 (en) * | 2005-06-21 | 2010-11-04 | Inifinity Discovery, Inc. | Ansamycin Formulations and Methods of Use Thereof |
WO2007059116A2 (en) * | 2005-11-14 | 2007-05-24 | Abraxis Bioscience, Inc. | Geldanamycin derivatives and pharmaceutical compositions thereof |
US7648976B2 (en) * | 2005-11-23 | 2010-01-19 | Bristol-Myers Squibb Company | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
US20090042847A1 (en) * | 2005-11-23 | 2009-02-12 | Kosan Biosciences Incorporated | 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations |
US20070167422A1 (en) * | 2006-01-18 | 2007-07-19 | Yu Kwok S | Pharmaceutical compositions comprising 17-allylamino-17-demethoxygeldanamycin |
WO2007098229A2 (en) * | 2006-02-21 | 2007-08-30 | Michigan State University | Geldanamycin derivatives and method of use thereof |
CN100519536C (zh) * | 2006-03-21 | 2009-07-29 | 中国医学科学院医药生物技术研究所 | 一组连有核苷碱基的格尔德霉素衍生物 |
US20070293451A1 (en) * | 2006-05-02 | 2007-12-20 | University Of Pittsburgh | Regulation ao ApoB by Hsp110 proteins and related compositions and methods |
KR100796637B1 (ko) * | 2006-09-29 | 2008-01-22 | 한국생명공학연구원 | 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제 |
CN100500668C (zh) * | 2006-12-19 | 2009-06-17 | 中国人民解放军军事医学科学院毒物药物研究所 | 格尔德霉素衍生物及其制备方法和制备药物的用途 |
US7855192B2 (en) * | 2007-01-26 | 2010-12-21 | Kosan Biosciences, Inc. | Macrolactams by engineered biosynthesis |
WO2008118601A2 (en) * | 2007-02-27 | 2008-10-02 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Radiolabeled affibody molecules |
US20100111943A1 (en) * | 2007-03-22 | 2010-05-06 | Medical College Of Georgia Research Institute, Inc | Compositions and methods for inhibiting cancer metastasis |
CN101677991A (zh) * | 2007-04-12 | 2010-03-24 | 英菲尼蒂发现公司 | 氢醌安莎霉素制剂 |
WO2009026548A1 (en) | 2007-08-23 | 2009-02-26 | The Regents Of The University Of Colorado | Hsp90 inhibitors with modified toxicity |
WO2009036092A2 (en) | 2007-09-10 | 2009-03-19 | University Of Massachusetts | Mitochondria-targeted anti-tumor agents |
US20090186039A1 (en) * | 2008-01-18 | 2009-07-23 | Jang Sung-Key | Novel use of grp 94 in virus infection |
US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
KR20110090925A (ko) | 2008-10-15 | 2011-08-10 | 인피니티 파마슈티컬스, 인코포레이티드 | 안사마이신 하이드로퀴논 조성물 |
DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
JPWO2011040421A1 (ja) | 2009-09-29 | 2013-02-28 | 武田薬品工業株式会社 | スクリーニング方法 |
CN102030764B (zh) * | 2010-11-12 | 2012-07-04 | 中国医学科学院医药生物技术研究所 | 4,5双氢噻嗪酮格尔德霉素及其制备方法 |
WO2012082765A2 (en) | 2010-12-16 | 2012-06-21 | The United State Of America. As Represented By The Secretary Department Of Health And Human Services | Methods for decreasing body weight and treating diabetes |
CN102603635B (zh) * | 2011-01-21 | 2016-08-03 | 杭州华东医药集团生物工程研究所有限公司 | 格尔德霉素衍生物及其制备方法和用途 |
US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
US9603829B2 (en) | 2011-11-14 | 2017-03-28 | The Regents Of The University Of Colorado, A Body Corporate | HSP90 inhibitors with modified toxicity |
CN102552150B (zh) * | 2012-03-02 | 2013-10-30 | 首都医科大学 | 一种格尔德霉素脂质体的制备及应用 |
WO2018160772A1 (en) | 2017-02-28 | 2018-09-07 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Method of treating obesity, insulin resistance, non-alcoholic fatty liver disease including non-alcoholic steatohepatitis |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55111469A (en) | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
JPS55111470A (en) | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
JPS55111419A (en) | 1979-02-20 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Antitumorigenic agent |
CA2166320A1 (en) * | 1993-06-29 | 1995-01-12 | Randall James Gallaschun | Ansamycin derivatives as antioncogene and anticancer agents |
JPH09502614A (ja) * | 1993-09-14 | 1997-03-18 | メルク エンド カンパニー インコーポレーテッド | 新規ヒト蛋白質チロシンホスファターゼをコードするcDNA |
US5932566A (en) * | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
WO1996034525A1 (en) * | 1995-05-02 | 1996-11-07 | The Regents Of The University Of California | Inducement of thermotolerance with benzoquinonoid ansamycins |
US5958892A (en) * | 1996-07-30 | 1999-09-28 | Board Of Regents, The University Of Texas System | 2-methoxyestradiol-induced apoptosis in cancer cells |
US5948814A (en) * | 1997-02-20 | 1999-09-07 | The Curators Of The University Of Missouri | Genistein for the treatment of cystic fibrosis |
US5952175A (en) * | 1997-10-09 | 1999-09-14 | Incyte Pharmaceuticals, Inc. | DNA encoding a human progesterone receptor complex p23-like protein |
US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
-
2002
- 2002-03-28 DE DE60213386T patent/DE60213386T2/de not_active Expired - Lifetime
- 2002-03-28 IL IL15612202A patent/IL156122A0/xx unknown
- 2002-03-28 DK DK02757908T patent/DK1373215T3/da active
- 2002-03-28 ES ES02757908T patent/ES2268068T3/es not_active Expired - Lifetime
- 2002-03-28 EP EP02757908A patent/EP1373215B1/de not_active Expired - Lifetime
- 2002-03-28 AU AU2002307020A patent/AU2002307020B2/en not_active Expired
- 2002-03-28 JP JP2002577794A patent/JP4213472B2/ja not_active Expired - Lifetime
- 2002-03-28 PT PT02757908T patent/PT1373215E/pt unknown
- 2002-03-28 AT AT02757908T patent/ATE334119T1/de active
- 2002-03-28 CN CNB028034651A patent/CN1262542C/zh not_active Expired - Lifetime
- 2002-03-28 KR KR1020037008551A patent/KR100831133B1/ko active IP Right Grant
- 2002-03-28 NZ NZ526133A patent/NZ526133A/en not_active IP Right Cessation
- 2002-03-28 MX MXPA03007856A patent/MXPA03007856A/es active IP Right Grant
- 2002-03-28 CA CA2430692A patent/CA2430692C/en not_active Expired - Lifetime
- 2002-03-28 US US10/432,581 patent/US6890917B2/en not_active Expired - Lifetime
- 2002-03-28 WO PCT/US2002/010097 patent/WO2002079167A1/en active IP Right Grant
- 2002-03-28 SI SI200220013A patent/SI21369A/sl not_active IP Right Cessation
-
2003
- 2003-05-26 IL IL156122A patent/IL156122A/en unknown
- 2003-05-29 ZA ZA200304178A patent/ZA200304178B/en unknown
-
2006
- 2006-09-12 CY CY20061101299T patent/CY1107484T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2430692C (en) | 2011-05-31 |
IL156122A (en) | 2010-11-30 |
CN1262542C (zh) | 2006-07-05 |
NZ526133A (en) | 2005-08-26 |
CA2430692A1 (en) | 2002-10-10 |
MXPA03007856A (es) | 2003-12-04 |
KR20040023581A (ko) | 2004-03-18 |
IL156122A0 (en) | 2003-12-23 |
PT1373215E (pt) | 2006-12-29 |
DE60213386D1 (de) | 2006-09-07 |
SI21369A (sl) | 2004-06-30 |
DK1373215T3 (da) | 2006-11-13 |
US20040053909A1 (en) | 2004-03-18 |
ES2268068T3 (es) | 2007-03-16 |
DE60213386T2 (de) | 2006-11-23 |
EP1373215B1 (de) | 2006-07-26 |
JP4213472B2 (ja) | 2009-01-21 |
CY1107484T1 (el) | 2013-03-13 |
JP2004519514A (ja) | 2004-07-02 |
AU2002307020B2 (en) | 2007-06-28 |
ZA200304178B (en) | 2004-02-17 |
KR100831133B1 (ko) | 2008-05-20 |
WO2002079167A1 (en) | 2002-10-10 |
CN1484639A (zh) | 2004-03-24 |
EP1373215A1 (de) | 2004-01-02 |
US6890917B2 (en) | 2005-05-10 |
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Legal Events
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