ATE333312T1 - Verfahren zur herstellung von feinkörnigen medizinischen substanzen - Google Patents

Verfahren zur herstellung von feinkörnigen medizinischen substanzen

Info

Publication number
ATE333312T1
ATE333312T1 AT00951767T AT00951767T ATE333312T1 AT E333312 T1 ATE333312 T1 AT E333312T1 AT 00951767 T AT00951767 T AT 00951767T AT 00951767 T AT00951767 T AT 00951767T AT E333312 T1 ATE333312 T1 AT E333312T1
Authority
AT
Austria
Prior art keywords
medicament
streams
solvent
stream
solution
Prior art date
Application number
AT00951767T
Other languages
English (en)
Inventor
Dominique Begon
Pfefer Guillaume
Michael Kohl
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10859471&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE333312(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of ATE333312T1 publication Critical patent/ATE333312T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/916—Turbulent flow, i.e. every point of the flow moves in a random direction and intermixes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
AT00951767T 1999-08-19 2000-08-18 Verfahren zur herstellung von feinkörnigen medizinischen substanzen ATE333312T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9919693.3A GB9919693D0 (en) 1999-08-19 1999-08-19 Process

Publications (1)

Publication Number Publication Date
ATE333312T1 true ATE333312T1 (de) 2006-08-15

Family

ID=10859471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00951767T ATE333312T1 (de) 1999-08-19 2000-08-18 Verfahren zur herstellung von feinkörnigen medizinischen substanzen

Country Status (13)

Country Link
US (2) US20030049321A1 (de)
EP (1) EP1214129B1 (de)
JP (1) JP4870300B2 (de)
AT (1) ATE333312T1 (de)
AU (1) AU781834B2 (de)
CA (1) CA2376269A1 (de)
DE (1) DE60029457T2 (de)
DK (1) DK1214129T3 (de)
ES (1) ES2269167T3 (de)
GB (1) GB9919693D0 (de)
IL (2) IL148140A0 (de)
PT (1) PT1214129E (de)
WO (1) WO2001014036A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10119718A1 (de) 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
SG126676A1 (en) * 2001-05-09 2007-01-30 Nanomaterials Tech Pte Ltd Process for the controlled production of organic particles
DE10124952A1 (de) * 2001-05-21 2002-12-12 Bayer Ag Verfahren zur Herstellung von Nanodispersionen
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
CA2458889C (en) * 2001-08-29 2011-06-21 Dow Global Technologies Inc. A process for preparing crystalline drug particles by means of precipitation
US20040187770A1 (en) * 2001-10-17 2004-09-30 Calabrese Richard V. Rotor-stator apparatus and process for the formation of particles
DE10214031A1 (de) * 2002-03-27 2004-02-19 Pharmatech Gmbh Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation
WO2004034943A2 (en) * 2002-10-17 2004-04-29 Boehringer Ingelheim Pharma Gmbh & Co.Kg Process and reactor for the manufacture of powders of inhalable medicaments
GB0300339D0 (en) * 2003-01-08 2003-02-05 Bradford Particle Design Ltd Particle formation
EP1603652B1 (de) * 2003-03-04 2009-07-01 Five Star Technologies, Inc. Verfahren zur kristallisation unter verwendung von hydrodynamischer kavitation
WO2006096906A1 (en) * 2005-03-18 2006-09-21 Nanomaterials Technology Pte Ltd Inhalable drug
JP2009502969A (ja) * 2005-07-28 2009-01-29 アイエスピー インヴェストメンツ インコーポレイテッド 非晶質エファビレンツ及びその製造
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
US20080152717A1 (en) * 2006-12-14 2008-06-26 Isp Investments, Inc. Amorphous valsartan and the production thereof
WO2008080037A2 (en) * 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
US10189957B2 (en) * 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
US20080181961A1 (en) * 2007-01-26 2008-07-31 Isp Investments, Inc. Amorphous oxcarbazepine and the production thereof
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
CN101918123B (zh) * 2007-12-07 2013-12-18 X喷雾微粒公司 生产微粒的方法与装置
DE102008037025C5 (de) * 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
ES2359708B1 (es) * 2009-11-16 2012-03-30 Ferrer Internacional S.A. Procedimiento de preparación de la (11beta,16alfa)-9-fluoro-11-hidroxi-16,17-[1-metil-etilidenebis(oxi)]-21-[1-oxo-[4-(nitrooximetil)benzoxi]]preña-1,4-dien-3,20-diona.
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
ES2694102T3 (es) * 2013-01-07 2018-12-18 Nicox Ophthalmics, Inc. Forma C polimórfica de triamcinolona acetónido
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
TWI884404B (zh) * 2022-12-30 2025-05-21 永信藥品工業股份有限公司 無菌眼用注射劑的製造方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US741756A (en) * 1903-03-02 1903-10-20 Werner P Arntz Journal-bearing.
US2334812A (en) * 1940-02-23 1943-11-23 Du Pont Process for the preparation of organic pigments
GB741756A (en) * 1953-02-24 1955-12-14 Secr Defence Brit Method for producing fine crystals of controlled particle size
US3299001A (en) * 1964-07-27 1967-01-17 Gen Dynamics Corp Isolation and purification of phosphonitrilic chloride adducts
US3622496A (en) * 1969-12-04 1971-11-23 Exxon Research Engineering Co Low-pour dewaxing process utilizing dual solvents
US3895111A (en) * 1973-06-27 1975-07-15 American Cyanamid Co Asthma treatment by inhalation of micronized N,N-diethyl-4-methyl-1-piperazinecarboxamide pamoate
GB2121203B (en) * 1982-04-06 1985-10-16 Canon Kk Making toner particles
US4567912A (en) * 1984-07-30 1986-02-04 Acheson Industries, Inc. Multiple spray nozzles
US4767074A (en) * 1984-09-17 1988-08-30 Bower Glenister B Dispensing holder
US4663433A (en) * 1985-12-23 1987-05-05 General Electric Company Separation of cyclic oligomeric carbonate from high molecular weight polycarbonate
JPS62289257A (ja) * 1986-06-09 1987-12-16 Ikeuchi:Kk 超微霧噴射ノズル
US4915302A (en) * 1988-03-30 1990-04-10 Kraus Robert A Device for making artificial snow
US4952224A (en) * 1989-04-17 1990-08-28 Canadian Oxygen Limited Method and apparatus for cryogenic crystallization of fats
US5011293A (en) * 1989-10-12 1991-04-30 The United States Of America As Represented By The Secretary Of The Army Emulsifier mixing cell
JP3282731B2 (ja) * 1990-06-15 2002-05-20 メルク エンド カムパニー インコーポレーテッド 結晶の構造および大きさを改良する結晶化方法
US5074671A (en) * 1990-11-13 1991-12-24 Dew Engineering And Development Limited Mixing apparatus
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
ATE161742T1 (de) * 1992-10-06 1998-01-15 Merck & Co Inc Kristallisationsvorrichtung mit zwei strahlen
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
US5716642A (en) * 1995-01-10 1998-02-10 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB9905512D0 (en) * 1999-03-10 1999-05-05 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
DK1214129T3 (da) 2006-09-25
JP2003527323A (ja) 2003-09-16
AU781834B2 (en) 2005-06-16
HK1046873A1 (en) 2003-01-30
PT1214129E (pt) 2006-10-31
US20030049321A1 (en) 2003-03-13
DE60029457T2 (de) 2007-07-19
GB9919693D0 (en) 1999-10-20
EP1214129B1 (de) 2006-07-19
IL148140A0 (en) 2002-09-12
US20050214228A1 (en) 2005-09-29
DE60029457D1 (de) 2006-08-31
ES2269167T3 (es) 2007-04-01
EP1214129A1 (de) 2002-06-19
IL148140A (en) 2006-04-10
AU6461500A (en) 2001-03-19
CA2376269A1 (en) 2001-03-01
WO2001014036A1 (en) 2001-03-01
JP4870300B2 (ja) 2012-02-08

Similar Documents

Publication Publication Date Title
ATE333312T1 (de) Verfahren zur herstellung von feinkörnigen medizinischen substanzen
ATE381963T1 (de) Verfahren zur herstellung von gereinigten partikeln
ATE232754T1 (de) Verfahren und vorrichtung zur herstellung von partikeln
DE69629949D1 (de) Aktivierte verbindungen und verfahren zur herstellung und reiningung
DE60201127D1 (de) Apparat und methode zur bildung von mikro- und submikropartikeln
ATE472373T1 (de) Vorrichtung zur zentrifugalen trennung und verfahren zur trennung von flüssigkeitsbestandteilen
ATE471203T1 (de) Verfahren und vorrichtung zur grösssenabhängigen trennung von mikro- und nanopartikeln
ATE264931T1 (de) Vorrichtung und verfahren zum spinnen von materialien
ATE226563T1 (de) Aufbereitung von flugaschen durch ausbrennen von kohlenstoff in einem trockenen sprudel-wirbelbett
ATE251896T1 (de) Granulat-präparate mit kontinuierlicher freisetzung und verfahren zur herstellung
ATE336231T1 (de) Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung
ATE375207T1 (de) Vorrichtung und verfahren zur herstellung von stationären mehrkomponentenflüssigkeits- kapillarströmen und kapseln in mikrometer- und nanometergrösse
DE69426934D1 (de) Verfahren zur konditionierung von substanzen
DE69124276D1 (de) Verfahren zur Herstellung eines mit Sauerstoff angereicherten Produktstroms
DE69833819D1 (de) Vorrichtung zur Herstellung von feinen Schneeteilchen mittels eines flüssigen Kohlendioxidstroms
IL207348A0 (en) Circular dna molecules, processes for their preparation, pharmaceutical compositions comprising them, and use thereof in the manufacture of medicinal products for producing recombinant proteins in vivo
DE69835230D1 (de) Verfahren zur herstellung von nordamerikanischen ginseng fraktionen, enthaltende produkte, und verwendung als immunmodulatoren
ATE306314T1 (de) Verfahren zur herstellung von partiklen unter verwendung einer überkritischen flüssigkeit
MXPA04003718A (es) Procesamiento de fluidos supercriticos: preparacion de microparticulas de proteina y su estabilizacion.
DE3781504D1 (de) Verfahren und vorrichtung zum mischen von gasen und fluessigkeiten.
DE69325393D1 (de) Pharmazeutische zusammensetzungen und verfahren unter verwendung von isobutyramid zur behandlung von betaglobinerkrankungen
DE69806020D1 (de) Verfahren und apparat zur herstellung von vesikeln
TW201325685A (zh) 一種以模擬移動床分離不同分子量高分子之方法
DE69407996D1 (de) Vorrichtung und verfahren zur herstellung eines agglomerierten materials
DE59813246D1 (de) Vorrichtung zum mischen und anschliessendem versprühen von flüssigkeiten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1214129

Country of ref document: EP