IL148140A0 - Process for producing fine medicinal substances - Google Patents

Process for producing fine medicinal substances

Info

Publication number
IL148140A0
IL148140A0 IL14814000A IL14814000A IL148140A0 IL 148140 A0 IL148140 A0 IL 148140A0 IL 14814000 A IL14814000 A IL 14814000A IL 14814000 A IL14814000 A IL 14814000A IL 148140 A0 IL148140 A0 IL 148140A0
Authority
IL
Israel
Prior art keywords
medicament
streams
solvent
stream
solution
Prior art date
Application number
IL14814000A
Other languages
English (en)
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10859471&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL148140(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Publication of IL148140A0 publication Critical patent/IL148140A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0018—Evaporation of components of the mixture to be separated
    • B01D9/0027—Evaporation of components of the mixture to be separated by means of conveying fluid, e.g. spray-crystallisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/23—Mixing by intersecting jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F2025/91—Direction of flow or arrangement of feed and discharge openings
    • B01F2025/916—Turbulent flow, i.e. every point of the flow moves in a random direction and intermixes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Prostheses (AREA)
  • Steroid Compounds (AREA)
IL14814000A 1999-08-19 2000-08-18 Process for producing fine medicinal substances IL148140A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9919693.3A GB9919693D0 (en) 1999-08-19 1999-08-19 Process
PCT/GB2000/003178 WO2001014036A1 (en) 1999-08-19 2000-08-18 Process for producing fine medicinal substances

Publications (1)

Publication Number Publication Date
IL148140A0 true IL148140A0 (en) 2002-09-12

Family

ID=10859471

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14814000A IL148140A0 (en) 1999-08-19 2000-08-18 Process for producing fine medicinal substances
IL148140A IL148140A (en) 1999-08-19 2002-02-13 Process for the production of thin pharmaceuticals

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148140A IL148140A (en) 1999-08-19 2002-02-13 Process for the production of thin pharmaceuticals

Country Status (13)

Country Link
US (2) US20030049321A1 (de)
EP (1) EP1214129B1 (de)
JP (1) JP4870300B2 (de)
AT (1) ATE333312T1 (de)
AU (1) AU781834B2 (de)
CA (1) CA2376269A1 (de)
DE (1) DE60029457T2 (de)
DK (1) DK1214129T3 (de)
ES (1) ES2269167T3 (de)
GB (1) GB9919693D0 (de)
IL (2) IL148140A0 (de)
PT (1) PT1214129E (de)
WO (1) WO2001014036A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
SG126676A1 (en) * 2001-05-09 2007-01-30 Nanomaterials Tech Pte Ltd Process for the controlled production of organic particles
DE10124952A1 (de) * 2001-05-21 2002-12-12 Bayer Ag Verfahren zur Herstellung von Nanodispersionen
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
EP1423096B1 (de) * 2001-08-29 2006-08-16 Dow Global Technologies Inc. Verfahren zur herstellung kristalliner arzneimittelteilchen durch ausfällung
AU2002335080A1 (en) * 2001-10-17 2003-04-28 E.I. Du Pont De Nemours And Company Rotor-stator apparatus and process for the formation of particles
DE10214031A1 (de) * 2002-03-27 2004-02-19 Pharmatech Gmbh Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation
WO2004034943A2 (en) * 2002-10-17 2004-04-29 Boehringer Ingelheim Pharma Gmbh & Co.Kg Process and reactor for the manufacture of powders of inhalable medicaments
GB0300339D0 (en) * 2003-01-08 2003-02-05 Bradford Particle Design Ltd Particle formation
DE602004021781D1 (de) 2003-03-04 2009-08-13 Five Star Technologies Inc Verfahren zur kristallisation unter verwendung von hydrodynamischer kavitation
EP1871344A4 (de) * 2005-03-18 2012-05-02 Nanomaterials Tech Pte Ltd Inhalierbares arzneimittel
CN101272769B (zh) * 2005-07-28 2013-04-24 Isp投资有限公司 生物利用度提高的苯醌类化合物
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
US10189957B2 (en) * 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
GB0705159D0 (en) 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
CA2706684C (en) * 2007-12-07 2016-01-12 Xspray Microparticles Ab Method and arrangement for the production of particles
DE102008037025C5 (de) * 2008-08-08 2016-07-07 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform
ES2359708B1 (es) * 2009-11-16 2012-03-30 Ferrer Internacional S.A. Procedimiento de preparación de la (11beta,16alfa)-9-fluoro-11-hidroxi-16,17-[1-metil-etilidenebis(oxi)]-21-[1-oxo-[4-(nitrooximetil)benzoxi]]preña-1,4-dien-3,20-diona.
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
ES2694102T3 (es) * 2013-01-07 2018-12-18 Nicox Ophthalmics, Inc. Forma C polimórfica de triamcinolona acetónido
GB201402556D0 (en) 2014-02-13 2014-04-02 Crystec Ltd Improvements relating to inhalable particles
TWI884404B (zh) * 2022-12-30 2025-05-21 永信藥品工業股份有限公司 無菌眼用注射劑的製造方法

Family Cites Families (23)

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US741756A (en) * 1903-03-02 1903-10-20 Werner P Arntz Journal-bearing.
US2334812A (en) * 1940-02-23 1943-11-23 Du Pont Process for the preparation of organic pigments
GB741756A (en) * 1953-02-24 1955-12-14 Secr Defence Brit Method for producing fine crystals of controlled particle size
US3299001A (en) * 1964-07-27 1967-01-17 Gen Dynamics Corp Isolation and purification of phosphonitrilic chloride adducts
US3622496A (en) * 1969-12-04 1971-11-23 Exxon Research Engineering Co Low-pour dewaxing process utilizing dual solvents
US3897779A (en) * 1973-06-27 1975-08-05 American Cyanamid Co Triamcinolone acetonide inhalation therapy
GB2121203B (en) * 1982-04-06 1985-10-16 Canon Kk Making toner particles
US4567912A (en) * 1984-07-30 1986-02-04 Acheson Industries, Inc. Multiple spray nozzles
US4767074A (en) * 1984-09-17 1988-08-30 Bower Glenister B Dispensing holder
US4663433A (en) * 1985-12-23 1987-05-05 General Electric Company Separation of cyclic oligomeric carbonate from high molecular weight polycarbonate
JPS62289257A (ja) * 1986-06-09 1987-12-16 Ikeuchi:Kk 超微霧噴射ノズル
US4915302A (en) * 1988-03-30 1990-04-10 Kraus Robert A Device for making artificial snow
US4952224A (en) * 1989-04-17 1990-08-28 Canadian Oxygen Limited Method and apparatus for cryogenic crystallization of fats
US5011293A (en) * 1989-10-12 1991-04-30 The United States Of America As Represented By The Secretary Of The Army Emulsifier mixing cell
CA2044706C (en) * 1990-06-15 2003-02-25 Michael Midler Jr. Crystallization method to improve crystal structure and size
US5074671A (en) * 1990-11-13 1991-12-24 Dew Engineering And Development Limited Mixing apparatus
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
ATE161742T1 (de) * 1992-10-06 1998-01-15 Merck & Co Inc Kristallisationsvorrichtung mit zwei strahlen
US5716642A (en) * 1995-01-10 1998-02-10 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents
US5665331A (en) * 1995-01-10 1997-09-09 Nanosystems L.L.C. Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
GB9905512D0 (en) * 1999-03-10 1999-05-05 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
EP1214129A1 (de) 2002-06-19
DK1214129T3 (da) 2006-09-25
WO2001014036A1 (en) 2001-03-01
AU6461500A (en) 2001-03-19
ATE333312T1 (de) 2006-08-15
US20050214228A1 (en) 2005-09-29
GB9919693D0 (en) 1999-10-20
EP1214129B1 (de) 2006-07-19
DE60029457T2 (de) 2007-07-19
IL148140A (en) 2006-04-10
ES2269167T3 (es) 2007-04-01
JP2003527323A (ja) 2003-09-16
CA2376269A1 (en) 2001-03-01
PT1214129E (pt) 2006-10-31
HK1046873A1 (en) 2003-01-30
DE60029457D1 (de) 2006-08-31
AU781834B2 (en) 2005-06-16
JP4870300B2 (ja) 2012-02-08
US20030049321A1 (en) 2003-03-13

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Legal Events

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