ATE325880T1 - Herstellung eines rekombinanten proteins in prokaryotischen wirtszellen durch kodonsoptimisierung - Google Patents
Herstellung eines rekombinanten proteins in prokaryotischen wirtszellen durch kodonsoptimisierungInfo
- Publication number
- ATE325880T1 ATE325880T1 AT01955373T AT01955373T ATE325880T1 AT E325880 T1 ATE325880 T1 AT E325880T1 AT 01955373 T AT01955373 T AT 01955373T AT 01955373 T AT01955373 T AT 01955373T AT E325880 T1 ATE325880 T1 AT E325880T1
- Authority
- AT
- Austria
- Prior art keywords
- host cells
- prokaryotic host
- production
- recombinant protein
- codon optimization
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000005457 optimization Methods 0.000 title 1
- 108020004705 Codon Proteins 0.000 abstract 2
- 108020004566 Transfer RNA Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10037111A DE10037111A1 (de) | 2000-07-27 | 2000-07-27 | Herstellung eines rekombinanten Proteins in einer prokaryontischen Wirtszelle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE325880T1 true ATE325880T1 (de) | 2006-06-15 |
Family
ID=7650734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01955373T ATE325880T1 (de) | 2000-07-27 | 2001-07-21 | Herstellung eines rekombinanten proteins in prokaryotischen wirtszellen durch kodonsoptimisierung |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1307569B1 (de) |
| JP (1) | JP5044085B2 (de) |
| CN (2) | CN1444655A (de) |
| AT (1) | ATE325880T1 (de) |
| AU (1) | AU2001277554A1 (de) |
| CA (1) | CA2414978C (de) |
| DE (2) | DE10037111A1 (de) |
| DK (1) | DK1307569T3 (de) |
| ES (1) | ES2264700T3 (de) |
| MX (1) | MXPA03000427A (de) |
| WO (1) | WO2002010411A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001068835A2 (en) * | 2000-03-13 | 2001-09-20 | Aptagen | Method for modifying a nucleic acid |
| US8551469B2 (en) | 2001-02-28 | 2013-10-08 | Superlab Far East Limited | Treatment of tumors and viral diseases with recombinant interferon alpha |
| JP4124639B2 (ja) | 2002-12-17 | 2008-07-23 | 株式会社日本触媒 | 大腸菌を用いたｓ−ヒドロキシニトリルリアーゼの製造方法 |
| CA2597317C (en) * | 2005-03-09 | 2018-01-02 | Guangwen Wei | Uses of recombinant super-compound interferons |
| EP2021490B1 (de) | 2006-05-30 | 2011-09-07 | Pfenex, Inc. | Anthrax-Impfstoff |
| JP4886654B2 (ja) * | 2007-10-29 | 2012-02-29 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモンの効率化された製造方法 |
| CN102286101B (zh) * | 2011-08-08 | 2013-05-08 | 常州亚当生物技术有限公司 | 抗VEGF单克隆抗体Fab片段Vasculizumab及其应用 |
| CN104245937B (zh) * | 2012-04-17 | 2021-09-21 | 弗·哈夫曼-拉罗切有限公司 | 使用修饰的核酸表达多肽的方法 |
| CN107723287B (zh) * | 2016-08-12 | 2021-07-06 | 中国科学院天津工业生物技术研究所 | 一种增强丝蛋白生产制备的表达系统 |
| CN108456703B (zh) * | 2017-02-20 | 2022-01-14 | 复旦大学 | 一种异源表达埃博霉素的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU618640B2 (en) * | 1988-11-11 | 1992-01-02 | Boehringer Mannheim Gmbh | Process for the expression of a recombinant gene |
| JPH05284973A (ja) * | 1992-04-13 | 1993-11-02 | Kurita Water Ind Ltd | 組換プラスミドおよびこれをベクターとして用いる異種蛋白質の分泌生産方法 |
| JP3556965B2 (ja) * | 1993-11-08 | 2004-08-25 | 天野エンザイム株式会社 | 糸状菌および酵母で使用可能なポリペプチド分泌発現用プラスミドおよびそれを用いたポリペプチドの製造法 |
| AU6148798A (en) * | 1997-02-07 | 1998-08-26 | Vanderbilt University | Synthetic genes for recombinant mycobacterium proteins |
| AUPP807899A0 (en) * | 1999-01-08 | 1999-02-04 | University Of Queensland, The | Codon utilization |
| JP2000175687A (ja) * | 1998-12-16 | 2000-06-27 | Japan Science & Technology Corp | ネオカルチノスタチン・アポタンパク質合成遺伝子 |
| WO2000044926A1 (en) * | 1999-01-27 | 2000-08-03 | Stratagene | High level expression of a heterologous protein having rare codons |
-
2000
- 2000-07-27 DE DE10037111A patent/DE10037111A1/de not_active Withdrawn
-
2001
- 2001-07-21 DK DK01955373T patent/DK1307569T3/da active
- 2001-07-21 JP JP2002516327A patent/JP5044085B2/ja not_active Expired - Lifetime
- 2001-07-21 AU AU2001277554A patent/AU2001277554A1/en not_active Abandoned
- 2001-07-21 DE DE60119535T patent/DE60119535T2/de not_active Expired - Lifetime
- 2001-07-21 AT AT01955373T patent/ATE325880T1/de active
- 2001-07-21 WO PCT/EP2001/008660 patent/WO2002010411A2/en active IP Right Grant
- 2001-07-21 EP EP01955373A patent/EP1307569B1/de not_active Expired - Lifetime
- 2001-07-21 CN CN01813410A patent/CN1444655A/zh active Pending
- 2001-07-21 CA CA002414978A patent/CA2414978C/en not_active Expired - Lifetime
- 2001-07-21 CN CN2009100035743A patent/CN101525628B/zh not_active Expired - Lifetime
- 2001-07-21 ES ES01955373T patent/ES2264700T3/es not_active Expired - Lifetime
- 2001-07-21 MX MXPA03000427A patent/MXPA03000427A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001277554A1 (en) | 2002-02-13 |
| WO2002010411A2 (en) | 2002-02-07 |
| JP2004504847A (ja) | 2004-02-19 |
| CA2414978C (en) | 2009-02-24 |
| ES2264700T3 (es) | 2007-01-16 |
| CN1444655A (zh) | 2003-09-24 |
| DE60119535D1 (de) | 2006-06-14 |
| CA2414978A1 (en) | 2002-02-07 |
| MXPA03000427A (es) | 2003-10-06 |
| CN101525628B (zh) | 2011-08-24 |
| CN101525628A (zh) | 2009-09-09 |
| JP5044085B2 (ja) | 2012-10-10 |
| EP1307569A2 (de) | 2003-05-07 |
| DE10037111A1 (de) | 2002-02-07 |
| EP1307569B1 (de) | 2006-05-10 |
| DK1307569T3 (da) | 2006-09-04 |
| DE60119535T2 (de) | 2006-09-07 |
| WO2002010411A3 (en) | 2002-07-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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