ATE321137T1 - Polyketide und ihre herstellung - Google Patents

Polyketide und ihre herstellung

Info

Publication number
ATE321137T1
ATE321137T1 AT99928128T AT99928128T ATE321137T1 AT E321137 T1 ATE321137 T1 AT E321137T1 AT 99928128 T AT99928128 T AT 99928128T AT 99928128 T AT99928128 T AT 99928128T AT E321137 T1 ATE321137 T1 AT E321137T1
Authority
AT
Austria
Prior art keywords
pks
domain
loading
substituted
acyl
Prior art date
Application number
AT99928128T
Other languages
English (en)
Inventor
Peter Francis Leadlay
James Staunton
Jesus Cortes
Hamish Alastair Irvin Mcarthur
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotica Tech Ltd filed Critical Biotica Tech Ltd
Application granted granted Critical
Publication of ATE321137T1 publication Critical patent/ATE321137T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
AT99928128T 1998-06-29 1999-06-29 Polyketide und ihre herstellung ATE321137T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9814006.4A GB9814006D0 (en) 1998-06-29 1998-06-29 Polyketides and their synthesis

Publications (1)

Publication Number Publication Date
ATE321137T1 true ATE321137T1 (de) 2006-04-15

Family

ID=10834580

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99928128T ATE321137T1 (de) 1998-06-29 1999-06-29 Polyketide und ihre herstellung
AT99928126T ATE461289T1 (de) 1998-06-29 1999-06-29 Polyketide-synthese

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99928126T ATE461289T1 (de) 1998-06-29 1999-06-29 Polyketide-synthese

Country Status (23)

Country Link
US (3) US7148045B1 (de)
EP (2) EP1090123B1 (de)
JP (2) JP2002519014A (de)
KR (2) KR20010071684A (de)
CN (2) CN1315956A (de)
AT (2) ATE321137T1 (de)
AU (2) AU763230B2 (de)
BR (2) BR9911710A (de)
CA (2) CA2331764C (de)
CZ (2) CZ20004913A3 (de)
DE (2) DE69930510T2 (de)
ES (1) ES2341403T3 (de)
GB (1) GB9814006D0 (de)
HK (1) HK1034536A1 (de)
HU (2) HUP0105179A2 (de)
ID (2) ID27419A (de)
IL (2) IL140440A0 (de)
MX (2) MXPA00012885A (de)
NZ (2) NZ509600A (de)
PL (2) PL345578A1 (de)
TR (2) TR200003770T2 (de)
WO (2) WO2000000618A2 (de)
YU (2) YU82700A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7630006B2 (en) * 1997-10-09 2009-12-08 Fotonation Ireland Limited Detecting red eye filter and apparatus using meta-data
US7738015B2 (en) * 1997-10-09 2010-06-15 Fotonation Vision Limited Red-eye filter method and apparatus
GB9814622D0 (en) * 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
AU4354900A (en) 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
GB9912563D0 (en) * 1999-05-28 1999-07-28 Biotica Tech Ltd Polyketides and their synthesis
US6524841B1 (en) 1999-10-08 2003-02-25 Kosan Biosciences, Inc. Recombinant megalomicin biosynthetic genes and uses thereof
US7033818B2 (en) 1999-10-08 2006-04-25 Kosan Biosciences, Inc. Recombinant polyketide synthase genes
DK1278881T3 (da) 2000-04-13 2010-05-10 Biotica Tech Ltd Glycosylerede hybrid-produkter og deres fremstilling og anvendelse
MXPA04008071A (es) * 2002-02-19 2004-11-26 Dow Agrosciences Llc Nuevas sintasas de poliquetida que producen espinosina.
EP2277898A3 (de) 2002-07-16 2011-06-01 Biotica Technology Limited Rapamycinähnliche Substanzen
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US8569023B2 (en) 2008-03-28 2013-10-29 The Regents Of The University Of California Producing dicarboxylic acids using polyketide synthases
EP2268828A4 (de) * 2008-04-29 2012-08-01 Univ California Herstellung von biobrennstoffen mithilfe von polyketidsynthasen
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
US8765431B2 (en) * 2009-07-23 2014-07-01 The Regents Of The University Of Michigan Method for enzymatic production of decarboxylated polyketides and fatty acids
US8664186B2 (en) 2009-07-24 2014-03-04 Universite De Lorraine Stambomycin and derivatives, their production and their uses as drugs
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
WO2016057798A1 (en) * 2014-10-08 2016-04-14 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CN106591388A (zh) * 2016-10-13 2017-04-26 中国农业科学院生物技术研究所 具有聚酮类化合物合成功能的基因Dr2091
WO2018153960A1 (en) 2017-02-22 2018-08-30 Immune System Regulation Holding Ab Novel immune stimulating macrolides
JP7100652B2 (ja) 2017-02-22 2022-07-13 アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） 新規免疫刺激マクロライド
EP3635110A2 (de) 2017-06-06 2020-04-15 Zymergen, Inc. Genomische hochdurchsatz-plattform (htp) zur verbesserung von saccharopolyspora spinosa
EP3768277A1 (de) 2018-03-23 2021-01-27 Isr Immune System Regulation Holding Ab (Publ) Kombinationen von makrolidverbindungen und immuncheckpoint-inhibitoren

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
ES2240259T3 (es) * 1993-09-20 2005-10-16 The Leland Stanford Junior University Produccion recombinante de poliquetidos aromaticos.
WO1997002358A1 (en) * 1995-07-06 1997-01-23 The Leland Stanford Junior University Cell-free synthesis of polyketides
CA2259463A1 (en) * 1996-07-05 1998-01-15 Biotica Technology Limited Polyketides and their synthesis
JPH10303641A (ja) * 1997-04-23 1998-11-13 Mitsubishi Electric Corp 発振器及び無線機
NZ500693A (en) * 1997-04-30 2004-01-30 Kosan Biosciences Inc Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.

Also Published As

Publication number Publication date
AU763230B2 (en) 2003-07-17
WO2000000618A2 (en) 2000-01-06
AU4524799A (en) 2000-01-17
ES2341403T3 (es) 2010-06-18
CZ20004912A3 (cs) 2001-08-15
PL345578A1 (en) 2001-12-17
US7198922B2 (en) 2007-04-03
TR200003771T2 (tr) 2001-10-22
DE69930510D1 (de) 2006-05-11
WO2000000500A2 (en) 2000-01-06
EP1090123B1 (de) 2006-03-22
US7148045B1 (en) 2006-12-12
JP4489947B2 (ja) 2010-06-23
PL345575A1 (en) 2001-12-17
ID28285A (id) 2001-05-10
ID27419A (id) 2001-04-05
EP1090123A2 (de) 2001-04-11
IL140440A0 (en) 2002-02-10
MXPA00012885A (es) 2002-07-02
HUP0102945A2 (hu) 2001-12-28
HUP0105179A2 (hu) 2002-05-29
CA2331764A1 (en) 2000-01-06
GB9814006D0 (en) 1998-08-26
NZ509601A (en) 2004-04-30
NZ509600A (en) 2004-03-26
AU4524599A (en) 2000-01-17
DE69930510T2 (de) 2006-12-07
CZ20004913A3 (cs) 2001-11-14
YU82700A (sh) 2003-10-31
WO2000000500A3 (en) 2000-03-16
KR20010071684A (ko) 2001-07-31
KR20010071683A (ko) 2001-07-31
BR9911712A (pt) 2001-03-20
TR200003770T2 (tr) 2001-04-20
HK1034536A1 (en) 2001-10-26
CN1316001A (zh) 2001-10-03
JP2002519014A (ja) 2002-07-02
CA2335523A1 (en) 2000-01-06
EP1091971A2 (de) 2001-04-18
US20050090461A1 (en) 2005-04-28
WO2000000618A3 (en) 2000-04-27
MXPA00012936A (es) 2002-06-21
DE69942149D1 (en) 2010-04-29
YU82500A (sh) 2004-03-12
EP1091971B1 (de) 2010-03-17
CN1315956A (zh) 2001-10-03
IL140438A0 (en) 2002-02-10
JP2002519032A (ja) 2002-07-02
ATE461289T1 (de) 2010-04-15
BR9911710A (pt) 2001-03-20
AU765257B2 (en) 2003-09-11
CA2331764C (en) 2008-03-11
US20060240528A1 (en) 2006-10-26

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