ATE315578T1 - Neuriturin und verwandte wachstumsfaktoren - Google Patents

Neuriturin und verwandte wachstumsfaktoren

Info

Publication number
ATE315578T1
ATE315578T1 AT96932163T AT96932163T ATE315578T1 AT E315578 T1 ATE315578 T1 AT E315578T1 AT 96932163 T AT96932163 T AT 96932163T AT 96932163 T AT96932163 T AT 96932163T AT E315578 T1 ATE315578 T1 AT E315578T1
Authority
AT
Austria
Prior art keywords
methods
neurturin
growth factors
vectors
human
Prior art date
Application number
AT96932163T
Other languages
English (en)
Inventor
Eugene M Johnson Jr
Jeffrey D Milbrandt
Paul T Kotzbauer
Patricia A Lampe
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of ATE315578T1 publication Critical patent/ATE315578T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
AT96932163T 1995-08-28 1996-08-27 Neuriturin und verwandte wachstumsfaktoren ATE315578T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/519,777 US5739307A (en) 1995-08-28 1995-08-28 Polynucleotide encoding neurturin neurotrophic factor

Publications (1)

Publication Number Publication Date
ATE315578T1 true ATE315578T1 (de) 2006-02-15

Family

ID=24069730

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96932163T ATE315578T1 (de) 1995-08-28 1996-08-27 Neuriturin und verwandte wachstumsfaktoren

Country Status (12)

Country Link
US (6) US5739307A (de)
EP (1) EP0787142B1 (de)
JP (1) JP4222629B2 (de)
AT (1) ATE315578T1 (de)
AU (1) AU714107B2 (de)
CA (1) CA2194172C (de)
DE (1) DE69635738T2 (de)
DK (1) DK0787142T3 (de)
IL (1) IL122774A0 (de)
MX (1) MX9800277A (de)
NZ (3) NZ332921A (de)
WO (1) WO1997008196A1 (de)

Families Citing this family (55)

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US6743628B1 (en) * 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
WO1997033911A1 (en) 1996-03-14 1997-09-18 Washington University Persephin and related growth factors
US6222022B1 (en) 1996-03-14 2001-04-24 Washington University Persephin and related growth factors
US7015316B1 (en) * 1996-03-14 2006-03-21 Washington University Polynucleotides encoding human persephin and related growth factors
CN1268639C (zh) * 1996-11-15 2006-08-09 基因技术股份有限公司 神经营养蛋白的纯化
EP0983296A4 (de) * 1997-04-17 2002-11-06 Univ Washington Rezeptoren für tgf beta related neurotrophic factors
US7723473B2 (en) * 1997-06-19 2010-05-25 St. Louis University Peptide antagonists of TGF-beta family members and therapeutic uses thereof
SI1005358T1 (en) * 1997-07-30 2003-06-30 Amgen Inc. Use of a neurturin protein product for preventing and treating hearing loss
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
HU226073B1 (en) * 1998-07-14 2008-04-28 Janssen Pharmaceutica Nv Neurotrophic growth factor
US7067473B1 (en) * 1998-07-14 2006-06-27 Janssen Pharmaceutica N.V. Neurotrophic growth factor
US6268352B1 (en) * 1998-09-02 2001-07-31 The Regents Of The University Of California Promoters of neural regeneration
US20020002269A1 (en) 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
DE69939484D1 (de) * 1998-10-28 2008-10-16 Cornell Res Foundation Inc Methoden zur regulierung der angiogenese und vaskuläre integrität mittels trk rezeptor liganden bdnf, nt-3 und nt-4
WO2000066612A1 (en) 1999-05-04 2000-11-09 Strakan Limited Androgen glycosides and androgenic activity thereof
EP1179067B1 (de) * 1999-05-17 2006-12-13 BIOPHARM Gesellschaft zur biotechnologischen Entwicklung und zum Vertrieb von Pharmaka mbH Neuroprotektive eigenschaften von gdf-15, ein mitglied der tgf-beta superfamilie
US7592433B1 (en) * 1999-11-05 2009-09-22 The University Of Queensland; Hexima Limited Polynucleotides encoding cyclotide-like structures
US6866851B1 (en) 1999-12-28 2005-03-15 Washington University GFRα1-RET specific agonists and methods therefor
GB0024550D0 (de) 2000-10-06 2000-11-22 Oxford Biomedica Ltd
US7442370B2 (en) 2001-02-01 2008-10-28 Biogen Idec Ma Inc. Polymer conjugates of mutated neublastin
US7276580B2 (en) 2001-03-12 2007-10-02 Biogen Idec Ma Inc. Neurotrophic factors
EP1395279B1 (de) 2001-03-28 2011-10-05 Biogen Idec MA Inc. Verwendung von neublastin-polypeptide zur behandlung von neuropathischen schmerzen
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US20050222070A1 (en) * 2002-05-29 2005-10-06 Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung Pancreas-specific proteins
EP2275118A3 (de) 2002-05-29 2011-10-19 DeveloGen Aktiengesellschaft Pankreas spezifische proteine
KR100795840B1 (ko) * 2002-08-08 2008-01-17 베일러 칼리지 오브 메디신 Ｔ세포의 분리 및 식별
ES2328640T3 (es) 2003-04-18 2009-11-16 Biogen Idec Ma Inc. Neublastina conjugada con un polimero glicosilada.
WO2004104172A2 (en) * 2003-05-15 2004-12-02 Bioarray Solutions, Ltd. Hybridization-mediated analysis of polymorphisms
WO2004108760A2 (en) 2003-06-10 2004-12-16 Nsgene A/S Improved secretion of neublastin
WO2005026382A1 (en) * 2003-09-12 2005-03-24 Stemcell Technologies Inc. Neural colony forming assay
US7598059B2 (en) 2003-10-02 2009-10-06 Biogen Idec Ma Inc. Neublastin expression constructs
BRPI0415563A (pt) 2003-10-20 2007-01-02 Nsgene As método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional
ATE435026T1 (de) * 2003-11-27 2009-07-15 Develogen Ag Verfahren zur prävention und behandlung von diabetes mit neurturin
CN101123978B (zh) 2004-08-19 2012-12-12 比奥根艾迪克Ma公司 神经胚素变体
PT1786454E (pt) 2004-08-19 2010-08-18 Biogen Idec Inc Variantes de neublastina
TWI501774B (zh) 2006-02-27 2015-10-01 Biogen Idec Inc 神經性病症之治療
CA2651328A1 (en) * 2006-05-05 2007-11-15 Opexa Therapeutics T-cell vaccine
EP1872790A1 (de) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft Neue Zusammensetzung zur Erhöhung der Bioverfügbarkeit von Neurturin
TWI445544B (zh) 2007-05-01 2014-07-21 Biogen Idec Inc 增進血管形成之組合物及方法
WO2009029656A1 (en) 2007-08-27 2009-03-05 Auxagen, Inc. METHODS FOR INHIBITING TGF-β
MX2010004899A (es) * 2007-11-05 2010-09-07 Develogen Ag Conjugados de neurturina novedosos para uso farmaceutico.
US8487006B2 (en) 2008-09-16 2013-07-16 Auxagen, Inc. Method of enhancing TGF-β signalling
US9127083B2 (en) 2009-10-30 2015-09-08 Ntf Therapeutics, Inc. Neurturin molecules
EP2774935B8 (de) * 2009-10-30 2017-06-21 NTF Therapeutics, Inc. Verbesserte Neurturinmoleküle
US8445432B2 (en) 2009-10-30 2013-05-21 Ntf Therapeutics Inc Neurturin molecules
US8564522B2 (en) * 2010-03-31 2013-10-22 Apple Inc. Reduced-power communications within an electronic display
JP5726299B2 (ja) * 2010-06-14 2015-05-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 細胞透過性ペプチドおよびその使用
EP2394665A1 (de) * 2010-06-14 2011-12-14 F. Hoffmann-La Roche AG Zellenpenetrierende Peptide und Verwendungen davon
US9869272B1 (en) 2011-04-20 2018-01-16 Martin A. Stuart Performance of a transcritical or supercritical CO2 Rankin cycle engine
EP2594295A1 (de) 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nervenimplantat basierend auf einem kompaktierten, zellhaltigen Biomaterial
JP7056932B2 (ja) 2015-08-25 2022-04-19 ヒスタイド アクツィエンゲゼルシャフト 組織形成誘導用化合物及びその使用
EP3341397A2 (de) * 2015-08-25 2018-07-04 Histide AG Verbindungen zur induzierung von gewebebildung und verwendungen davon
EP3442559B1 (de) * 2016-04-13 2024-05-01 Chondropeptix B.V. Bmp-7 abgeleitete peptide zur verwendung in der behandlung oder prevention von osteoarthritis

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011914A (en) * 1989-01-05 1991-04-30 Collins Franklin D Purified ciliary neurotrophic factor
US5141856A (en) * 1989-01-05 1992-08-25 Synergen, Inc. Expression of purified ciliary neurotrophic factor
US5260417A (en) * 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5436104A (en) 1991-06-29 1995-07-25 Kao Corporation Method of forming fixed images using heated belt
CA2119463C (en) * 1991-09-20 2003-09-16 Leu-Fen H. Lin Glial cell line-derived neutrophic factor
CA2170751A1 (en) * 1993-09-01 1995-03-09 Timothy J. Cunningham Neuron regulatory factor for promoting neuron survival
WO1995017203A1 (en) * 1993-12-22 1995-06-29 The University Of Medicine And Dentistry Of New Jersey Novel nucleic acid sequences isolated from glial cells
US5759775A (en) * 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
WO1997033911A1 (en) * 1996-03-14 1997-09-18 Washington University Persephin and related growth factors

Also Published As

Publication number Publication date
JP4222629B2 (ja) 2009-02-12
DK0787142T3 (da) 2006-05-29
CA2194172C (en) 2012-07-10
NZ332922A (en) 1999-07-29
NZ332921A (en) 2001-03-30
US5843914A (en) 1998-12-01
US6090778A (en) 2000-07-18
US5739307A (en) 1998-04-14
WO1997008196A1 (en) 1997-03-06
DE69635738T2 (de) 2006-08-31
CA2194172A1 (en) 1997-03-01
US5747655A (en) 1998-05-05
DE69635738D1 (de) 2006-04-06
US7015311B1 (en) 2006-03-21
IL122774A0 (en) 1998-08-16
MX9800277A (es) 1998-09-30
EP0787142B1 (de) 2006-01-11
EP0787142A4 (de) 1999-04-07
JPH11512928A (ja) 1999-11-09
US5817622A (en) 1998-10-06
NZ318939A (en) 1999-01-28
AU714107B2 (en) 1999-12-16
AU7105496A (en) 1997-03-19
EP0787142A1 (de) 1997-08-06

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