ATE314374T1 - Kondensierte thienopyrimidine mit pde v inhibierender wirkung - Google Patents

Kondensierte thienopyrimidine mit pde v inhibierender wirkung

Info

Publication number
ATE314374T1
ATE314374T1 AT99919263T AT99919263T ATE314374T1 AT E314374 T1 ATE314374 T1 AT E314374T1 AT 99919263 T AT99919263 T AT 99919263T AT 99919263 T AT99919263 T AT 99919263T AT E314374 T1 ATE314374 T1 AT E314374T1
Authority
AT
Austria
Prior art keywords
thienopyrimidines
pde
condensed
inhibiting effect
inhibiting
Prior art date
Application number
AT99919263T
Other languages
German (de)
English (en)
Inventor
Rochus Jonas
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE314374T1 publication Critical patent/ATE314374T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99919263T 1998-04-29 1999-04-23 Kondensierte thienopyrimidine mit pde v inhibierender wirkung ATE314374T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819023A DE19819023A1 (de) 1998-04-29 1998-04-29 Thienopyrimidine
PCT/EP1999/002738 WO1999055708A1 (de) 1998-04-29 1999-04-23 Kondensierte thienopyrimidine mit pde v inhibierender wirkung

Publications (1)

Publication Number Publication Date
ATE314374T1 true ATE314374T1 (de) 2006-01-15

Family

ID=7866082

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99919263T ATE314374T1 (de) 1998-04-29 1999-04-23 Kondensierte thienopyrimidine mit pde v inhibierender wirkung

Country Status (26)

Country Link
US (1) US6495557B1 (https=)
EP (1) EP1084125B1 (https=)
JP (1) JP4242561B2 (https=)
KR (1) KR20010042628A (https=)
CN (1) CN1142936C (https=)
AR (1) AR016233A1 (https=)
AT (1) ATE314374T1 (https=)
AU (1) AU743230B2 (https=)
BR (1) BR9910032A (https=)
CA (1) CA2328280C (https=)
CO (1) CO5011050A1 (https=)
CZ (1) CZ291109B6 (https=)
DE (2) DE19819023A1 (https=)
ES (1) ES2255754T3 (https=)
HU (1) HUP0101832A3 (https=)
ID (1) ID27049A (https=)
MY (1) MY121864A (https=)
NO (1) NO20005434L (https=)
PL (1) PL343637A1 (https=)
RU (1) RU2224760C2 (https=)
SK (1) SK15972000A3 (https=)
TR (1) TR200003144T2 (https=)
TW (1) TWI232220B (https=)
UA (1) UA66856C2 (https=)
WO (1) WO1999055708A1 (https=)
ZA (1) ZA200006994B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19928146A1 (de) 1999-06-19 2000-12-21 Merck Patent Gmbh Thienopyrimidine
DE19943815A1 (de) * 1999-09-14 2001-03-15 Merck Patent Gmbh Verwendung von Thienopyrimidinen
DE19944604A1 (de) * 1999-09-17 2001-03-22 Merck Patent Gmbh Aminderivate
WO2001051089A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische zubereitungen enthaltend 2-pyrrolidon als lösungsvermittler
DE10001021A1 (de) * 2000-01-13 2001-07-19 Merck Patent Gmbh Pharmazeutische Zubereitung
DE10010612A1 (de) * 2000-03-03 2001-09-27 Merck Patent Gmbh Verwendung von PDE V-Inhibitoren
DE10017947A1 (de) 2000-04-11 2001-10-25 Merck Patent Gmbh Verfahren zur Herstellung benzo-annelierter Heterocyclen
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
MXPA03005441A (es) * 2000-12-19 2003-09-10 Merck Patent Gmbh Formulacion farmaceutica que contiene tienopirimidinas y antitromboticos, antagonistas de calcio, prostaglandinas o derivados de prostaglandina (2).
DE10064994A1 (de) * 2000-12-23 2002-07-04 Merck Patent Gmbh Sulfamidothienopyrimidine
CZ20032339A3 (cs) * 2001-01-31 2004-09-15 Merck Patent Gmbh Farmaceutický prostředek obsahující parazolo [4,3-d]pyrimidiny a nitráty nebo thienopyrimidiny a nitráty
DE10107261B4 (de) * 2001-02-16 2005-03-10 Merck Patent Gmbh Pharmazeutische Zusammensetzung
DE10148883A1 (de) * 2001-10-04 2003-04-10 Merck Patent Gmbh Pyrimidinderivate
WO2003035653A1 (en) * 2001-10-26 2003-05-01 Nippon Soda Co.,Ltd. Pyridothienopyrimidine compound and salt thereof
JP5070053B2 (ja) * 2004-08-20 2012-11-07 バイエル・ファルマ・アクチェンゲゼルシャフト 新規な複素環
ES2259892B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
ES2259891B1 (es) * 2004-11-30 2007-11-01 Laboratorios Almirall S.A. Nuevos derivados de piridotienopirimidina.
NZ561746A (en) 2005-04-19 2011-09-30 Nycomed Gmbh Roflumilast for the treatment of pulmonary hypertension

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 4−アミノキナゾリン誘導体およびそれを含有する医薬品
PH31122A (en) * 1993-03-31 1998-02-23 Eisai Co Ltd Nitrogen-containing fused-heterocycle compounds.
GB9311920D0 (en) 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
EP0640599B1 (en) 1993-08-26 1998-03-04 Ono Pharmaceutical Co., Ltd. 4-Aminopyrimidine derivatives
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19632423A1 (de) * 1996-08-12 1998-02-19 Merck Patent Gmbh Thienopyrimidine
DE19644228A1 (de) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidine
DE19752952A1 (de) 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidine

Also Published As

Publication number Publication date
AU743230B2 (en) 2002-01-24
HK1037628A1 (en) 2002-02-15
US6495557B1 (en) 2002-12-17
AR016233A1 (es) 2001-06-20
TWI232220B (en) 2005-05-11
EP1084125A1 (de) 2001-03-21
KR20010042628A (ko) 2001-05-25
AU3709899A (en) 1999-11-16
TR200003144T2 (tr) 2001-03-21
HUP0101832A3 (en) 2002-11-28
HUP0101832A2 (hu) 2001-11-28
CN1142936C (zh) 2004-03-24
ES2255754T3 (es) 2006-07-01
CN1298406A (zh) 2001-06-06
PL343637A1 (en) 2001-08-27
NO20005434D0 (no) 2000-10-27
DE59912986D1 (de) 2006-02-02
ID27049A (id) 2001-02-22
RU2224760C2 (ru) 2004-02-27
CO5011050A1 (es) 2001-02-28
CA2328280A1 (en) 1999-11-04
BR9910032A (pt) 2001-10-16
ZA200006994B (en) 2002-05-28
SK15972000A3 (sk) 2001-05-10
CZ291109B6 (cs) 2002-12-11
JP2002513026A (ja) 2002-05-08
CZ20003976A3 (cs) 2001-02-14
EP1084125B1 (de) 2005-12-28
CA2328280C (en) 2009-09-29
WO1999055708A1 (de) 1999-11-04
MY121864A (en) 2006-02-28
UA66856C2 (uk) 2004-06-15
DE19819023A1 (de) 1999-11-04
NO20005434L (no) 2000-10-27
JP4242561B2 (ja) 2009-03-25

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Legal Events

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