ATE312086T1 - Phenoxazinanaloge zur behandlung von amyloidose - Google Patents
Phenoxazinanaloge zur behandlung von amyloidoseInfo
- Publication number
- ATE312086T1 ATE312086T1 AT01122733T AT01122733T ATE312086T1 AT E312086 T1 ATE312086 T1 AT E312086T1 AT 01122733 T AT01122733 T AT 01122733T AT 01122733 T AT01122733 T AT 01122733T AT E312086 T1 ATE312086 T1 AT E312086T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen
- lower alkyl
- amyloidose
- phenoxazine
- analogues
- Prior art date
Links
- TZMSYXZUNZXBOL-UHFFFAOYSA-N 10H-phenoxazine Chemical class C1=CC=C2NC3=CC=CC=C3OC2=C1 TZMSYXZUNZXBOL-UHFFFAOYSA-N 0.000 title 1
- 206010002022 amyloidosis Diseases 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, carboxy Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23696600P | 2000-09-29 | 2000-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312086T1 true ATE312086T1 (de) | 2005-12-15 |
Family
ID=22891762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01122733T ATE312086T1 (de) | 2000-09-29 | 2001-09-21 | Phenoxazinanaloge zur behandlung von amyloidose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20020143012A1 (de) |
| EP (1) | EP1193260B1 (de) |
| JP (1) | JP2002201186A (de) |
| AT (1) | ATE312086T1 (de) |
| BR (1) | BR0104344A (de) |
| CA (1) | CA2357450A1 (de) |
| DE (1) | DE60115569T2 (de) |
| DK (1) | DK1193260T3 (de) |
| ES (1) | ES2253315T3 (de) |
| MX (1) | MXPA01009768A (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004262970B2 (en) * | 2003-08-07 | 2010-03-18 | Merck Sharp & Dohme Limited | Treatment for Alzheimer's disease and related conditions |
| ES2279422T3 (es) * | 2003-08-18 | 2007-08-16 | Novartis Ag | Derivados de 3h-fenoxazina adecuados como agentes formadores de imagenes en la region del infrarrojo proximo, preparacion y uso de los mismos. |
| GB0410238D0 (en) * | 2004-05-07 | 2004-06-09 | Merck Sharp & Dohme | Therapeutic agents |
| WO2008058402A1 (en) * | 2006-11-17 | 2008-05-22 | Queen's University At Kingston | Compounds and methods for treating protein folding disorders |
| WO2014032732A1 (de) | 2012-08-28 | 2014-03-06 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Halogenierte benzoxazine und ihre verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| WO2000076489A2 (en) * | 1999-06-10 | 2000-12-21 | Warner-Lambert Company | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
| CN1156445C (zh) * | 1999-06-10 | 2004-07-07 | 沃尼尔·朗伯公司 | 采用二氢异吲哚衍生物抑制淀粉样蛋白聚集和使淀粉样蛋白沉积成像的方法 |
-
2001
- 2001-09-19 CA CA002357450A patent/CA2357450A1/en not_active Abandoned
- 2001-09-21 EP EP01122733A patent/EP1193260B1/de not_active Expired - Lifetime
- 2001-09-21 ES ES01122733T patent/ES2253315T3/es not_active Expired - Lifetime
- 2001-09-21 DE DE60115569T patent/DE60115569T2/de not_active Expired - Fee Related
- 2001-09-21 AT AT01122733T patent/ATE312086T1/de not_active IP Right Cessation
- 2001-09-21 DK DK01122733T patent/DK1193260T3/da active
- 2001-09-27 US US09/966,534 patent/US20020143012A1/en not_active Abandoned
- 2001-09-27 MX MXPA01009768A patent/MXPA01009768A/es unknown
- 2001-09-28 BR BR0104344-7A patent/BR0104344A/pt not_active IP Right Cessation
- 2001-09-28 JP JP2001301315A patent/JP2002201186A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01009768A (es) | 2004-08-12 |
| CA2357450A1 (en) | 2002-03-29 |
| DE60115569T2 (de) | 2006-08-10 |
| JP2002201186A (ja) | 2002-07-16 |
| EP1193260A1 (de) | 2002-04-03 |
| DK1193260T3 (da) | 2006-04-10 |
| ES2253315T3 (es) | 2006-06-01 |
| BR0104344A (pt) | 2003-03-05 |
| DE60115569D1 (de) | 2006-01-12 |
| US20020143012A1 (en) | 2002-10-03 |
| EP1193260B1 (de) | 2005-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1193260 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |