ATE312086T1 - Phenoxazinanaloge zur behandlung von amyloidose - Google Patents

Phenoxazinanaloge zur behandlung von amyloidose

Info

Publication number
ATE312086T1
ATE312086T1 AT01122733T AT01122733T ATE312086T1 AT E312086 T1 ATE312086 T1 AT E312086T1 AT 01122733 T AT01122733 T AT 01122733T AT 01122733 T AT01122733 T AT 01122733T AT E312086 T1 ATE312086 T1 AT E312086T1
Authority
AT
Austria
Prior art keywords
hydrogen
lower alkyl
amyloidose
phenoxazine
analogues
Prior art date
Application number
AT01122733T
Other languages
English (en)
Inventor
Corinne Elizab Augelli-Szafran
Yingije Lai
Tomoyuki Yasunaga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE312086T1 publication Critical patent/ATE312086T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01122733T 2000-09-29 2001-09-21 Phenoxazinanaloge zur behandlung von amyloidose ATE312086T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23696600P 2000-09-29 2000-09-29

Publications (1)

Publication Number Publication Date
ATE312086T1 true ATE312086T1 (de) 2005-12-15

Family

ID=22891762

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01122733T ATE312086T1 (de) 2000-09-29 2001-09-21 Phenoxazinanaloge zur behandlung von amyloidose

Country Status (10)

Country Link
US (1) US20020143012A1 (de)
EP (1) EP1193260B1 (de)
JP (1) JP2002201186A (de)
AT (1) ATE312086T1 (de)
BR (1) BR0104344A (de)
CA (1) CA2357450A1 (de)
DE (1) DE60115569T2 (de)
DK (1) DK1193260T3 (de)
ES (1) ES2253315T3 (de)
MX (1) MXPA01009768A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1656141B1 (de) * 2003-08-07 2010-04-14 MERCK SHARP & DOHME LTD. Behandlung von alzheimer-krankheit und verwandten zuständen
DE602004004280T2 (de) * 2003-08-18 2007-06-21 Novartis Ag Als mittel zur nahinfrarotabbildung geeignete 3h-phenoxazinderivate, deren herstellung und verwendung
GB0410238D0 (en) 2004-05-07 2004-06-09 Merck Sharp & Dohme Therapeutic agents
CA2668744C (en) * 2006-11-17 2015-09-15 Queen's University At Kingston Compounds and methods for treating protein folding disorders
WO2014032732A1 (de) * 2012-08-28 2014-03-06 Eberhard Karls Universität Tübingen Medizinische Fakultät Halogenierte benzoxazine und ihre verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) * 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
HUP0201586A2 (en) * 1999-06-10 2002-08-28 Warner Lambert Co Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isoindoline derivatives
AP2002002387A0 (en) * 1999-06-10 2002-03-31 Warner Lambert Co Method of inhibiting amyloid aggregation and imaging amyloid deposits.

Also Published As

Publication number Publication date
JP2002201186A (ja) 2002-07-16
EP1193260A1 (de) 2002-04-03
MXPA01009768A (es) 2004-08-12
DE60115569D1 (de) 2006-01-12
DE60115569T2 (de) 2006-08-10
CA2357450A1 (en) 2002-03-29
DK1193260T3 (da) 2006-04-10
US20020143012A1 (en) 2002-10-03
EP1193260B1 (de) 2005-12-07
ES2253315T3 (es) 2006-06-01
BR0104344A (pt) 2003-03-05

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