ATE311453T1 - Grf-analoge mit erhöhter biologischer potenz - Google Patents
Grf-analoge mit erhöhter biologischer potenzInfo
- Publication number
- ATE311453T1 ATE311453T1 AT99941349T AT99941349T ATE311453T1 AT E311453 T1 ATE311453 T1 AT E311453T1 AT 99941349 T AT99941349 T AT 99941349T AT 99941349 T AT99941349 T AT 99941349T AT E311453 T1 ATE311453 T1 AT E311453T1
- Authority
- AT
- Austria
- Prior art keywords
- grf
- increased biological
- biological potency
- potency
- present
- Prior art date
Links
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 238000004873 anchoring Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/148,982 US6020311A (en) | 1995-05-26 | 1998-09-08 | GRF analogs with increased biological potency |
US09/389,486 US6458764B1 (en) | 1995-05-26 | 1999-09-03 | GRF analogs with increased biological potency |
PCT/CA1999/000816 WO2000014236A2 (en) | 1998-09-08 | 1999-09-07 | Grf analogs with increased biological potency |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE311453T1 true ATE311453T1 (de) | 2005-12-15 |
Family
ID=26846360
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99941349T ATE311453T1 (de) | 1998-09-08 | 1999-09-07 | Grf-analoge mit erhöhter biologischer potenz |
Country Status (12)
Country | Link |
---|---|
US (2) | US6458764B1 (de) |
EP (1) | EP1109909B1 (de) |
JP (1) | JP2002524472A (de) |
KR (1) | KR100474868B1 (de) |
AT (1) | ATE311453T1 (de) |
AU (1) | AU755852B2 (de) |
BR (1) | BR9913515A (de) |
CA (1) | CA2342070A1 (de) |
DE (2) | DE1109909T1 (de) |
ES (1) | ES2164626T1 (de) |
MX (1) | MXPA01002468A (de) |
WO (1) | WO2000014236A2 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6458764B1 (en) * | 1995-05-26 | 2002-10-01 | Theratechnologies Inc. | GRF analogs with increased biological potency |
WO2002010195A2 (en) * | 2000-08-02 | 2002-02-07 | Theratechnologies Inc. | Modified peptides with increased potency |
CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
JP2006506386A (ja) * | 2002-10-22 | 2006-02-23 | ワラタ ファーマシューティカルズ, インコーポレイテッド | 糖尿病の処置 |
AU2003229222B2 (en) * | 2003-05-29 | 2009-11-12 | Theratechnologies Inc. | GRF analog compositions and their use |
JP5030590B2 (ja) * | 2003-09-02 | 2012-09-19 | イスム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | バクテリアエフェクターとしてのオキサザボロリディン類 |
WO2005037307A1 (en) * | 2003-10-20 | 2005-04-28 | Theratechnologies Inc. | Use of growth hormone releasing factor analogs in treating patients suffering from wasting |
AU2005297366B2 (en) * | 2004-10-20 | 2011-12-08 | Theratechnologies Inc. | GH secretagogues and uses thereof |
ES2336245T3 (es) * | 2005-04-08 | 2010-04-09 | Lonza Ag | Sintesis peptidica de helices alfa sobre resina de peg. |
CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
CA2682174C (en) | 2007-03-28 | 2021-04-06 | President And Fellows Of Harvard College | Stitched polypeptides |
US8980249B2 (en) | 2010-06-03 | 2015-03-17 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
WO2012021876A2 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
CN108929375A (zh) | 2011-10-18 | 2018-12-04 | 爱勒让治疗公司 | 拟肽大环化合物 |
US9079974B2 (en) | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
ES2817877T3 (es) | 2012-02-15 | 2021-04-08 | Aileron Therapeutics Inc | Macrociclos peptidomiméticos |
JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス,インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
US9855312B2 (en) | 2012-12-21 | 2018-01-02 | University Of Miami | GHRH agonists for the treatment of ischemic disorders |
WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
CA2979847A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
WO2023014978A2 (en) * | 2021-08-06 | 2023-02-09 | Rebalance Health, Inc. | Growth hormone-releasing hormone peptides and formulations thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
US5112808A (en) * | 1987-05-11 | 1992-05-12 | American Cyanamid Company | Alkylated hormone-releasing peptides and method of treatig mammals therewith |
JPH06502618A (ja) * | 1990-05-04 | 1994-03-24 | ジ・アドミニストレイターズ・オブ・ザ・テュレイン・エデュケイショナル・ファンド | 新規な合成grf類似物 |
US6458764B1 (en) * | 1995-05-26 | 2002-10-01 | Theratechnologies Inc. | GRF analogs with increased biological potency |
US6020311A (en) * | 1995-05-26 | 2000-02-01 | Theratechnologies, Inc. | GRF analogs with increased biological potency |
PT828758E (pt) * | 1995-05-26 | 2002-02-28 | Theratechnologies Inc | Analogos quimericos de corpo gordo-pro-grf com potencia biologica aumentada |
-
1999
- 1999-09-03 US US09/389,486 patent/US6458764B1/en not_active Expired - Lifetime
- 1999-09-07 BR BR9913515-9A patent/BR9913515A/pt not_active IP Right Cessation
- 1999-09-07 EP EP99941349A patent/EP1109909B1/de not_active Expired - Lifetime
- 1999-09-07 AU AU55007/99A patent/AU755852B2/en not_active Ceased
- 1999-09-07 DE DE1109909T patent/DE1109909T1/de active Pending
- 1999-09-07 AT AT99941349T patent/ATE311453T1/de not_active IP Right Cessation
- 1999-09-07 KR KR10-2001-7002933A patent/KR100474868B1/ko not_active IP Right Cessation
- 1999-09-07 ES ES99941349T patent/ES2164626T1/es active Pending
- 1999-09-07 WO PCT/CA1999/000816 patent/WO2000014236A2/en active IP Right Grant
- 1999-09-07 CA CA002342070A patent/CA2342070A1/en not_active Abandoned
- 1999-09-07 MX MXPA01002468A patent/MXPA01002468A/es unknown
- 1999-09-07 DE DE69928677T patent/DE69928677D1/de not_active Expired - Lifetime
- 1999-09-07 JP JP2000568979A patent/JP2002524472A/ja active Pending
-
2002
- 2002-08-07 US US10/212,883 patent/US20040171534A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20040171534A1 (en) | 2004-09-02 |
WO2000014236A3 (en) | 2000-06-02 |
AU755852B2 (en) | 2002-12-19 |
EP1109909B1 (de) | 2005-11-30 |
JP2002524472A (ja) | 2002-08-06 |
DE69928677D1 (de) | 2006-01-05 |
AU5500799A (en) | 2000-03-27 |
US6458764B1 (en) | 2002-10-01 |
CA2342070A1 (en) | 2000-03-16 |
EP1109909A2 (de) | 2001-06-27 |
KR20010086368A (ko) | 2001-09-10 |
BR9913515A (pt) | 2001-06-05 |
KR100474868B1 (ko) | 2005-03-08 |
MXPA01002468A (es) | 2002-04-24 |
DE1109909T1 (de) | 2002-05-23 |
WO2000014236A2 (en) | 2000-03-16 |
ES2164626T1 (es) | 2002-03-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |