IT1283134B1 - Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare in - Google Patents
Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare inInfo
- Publication number
- IT1283134B1 IT1283134B1 IT96MI001408A ITMI961408A IT1283134B1 IT 1283134 B1 IT1283134 B1 IT 1283134B1 IT 96MI001408 A IT96MI001408 A IT 96MI001408A IT MI961408 A ITMI961408 A IT MI961408A IT 1283134 B1 IT1283134 B1 IT 1283134B1
- Authority
- IT
- Italy
- Prior art keywords
- somatostatins
- synthetic
- body growth
- derivatives
- stimulation
- Prior art date
Links
- 230000021332 multicellular organism growth Effects 0.000 title abstract 3
- 230000000638 stimulation Effects 0.000 title 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- UYCAGRPOUWSBIQ-WOYAITHZSA-N [(1s)-1-carboxy-4-(diaminomethylideneamino)butyl]azanium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound OC(=O)[C@@H]1CCC(=O)N1.OC(=O)[C@@H](N)CCCN=C(N)N UYCAGRPOUWSBIQ-WOYAITHZSA-N 0.000 abstract 1
- -1 arginine Chemical class 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229940075863 arginine pyroglutamate Drugs 0.000 abstract 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI001408A IT1283134B1 (it) | 1996-07-08 | 1996-07-08 | Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare in |
| AU36930/97A AU3693097A (en) | 1996-07-08 | 1997-07-08 | Derivatives of somatostatin, amino acids or oligopeptides and their combination useful for promoting body growth |
| PCT/EP1997/003605 WO1998001474A2 (en) | 1996-07-08 | 1997-07-08 | Derivatives of somatostatin, amino acids or oligopeptides and their combination useful for promoting body growth |
| AT97933655T ATE330971T1 (de) | 1996-07-08 | 1997-07-08 | Polymere somatostatinderivate geeignet zur förderung des körperwachstums |
| DE69736179T DE69736179D1 (de) | 1996-07-08 | 1997-07-08 | Polymere somatostatinderivate geeignet zur förderung des körperwachstums |
| EP97933655A EP0914342B1 (en) | 1996-07-08 | 1997-07-08 | Polymeric somatostatin derivatives useful for promoting body growth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI001408A IT1283134B1 (it) | 1996-07-08 | 1996-07-08 | Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare in |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI961408A0 ITMI961408A0 (it) | 1996-07-08 |
| ITMI961408A1 ITMI961408A1 (it) | 1998-01-08 |
| IT1283134B1 true IT1283134B1 (it) | 1998-04-07 |
Family
ID=11374550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96MI001408A IT1283134B1 (it) | 1996-07-08 | 1996-07-08 | Derivati sintetici e semisintetici di somatostatine utili nella stimolazione della crescita corporea, in particolare in |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0914342B1 (it) |
| AT (1) | ATE330971T1 (it) |
| AU (1) | AU3693097A (it) |
| DE (1) | DE69736179D1 (it) |
| IT (1) | IT1283134B1 (it) |
| WO (1) | WO1998001474A2 (it) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030204063A1 (en) * | 2000-08-02 | 2003-10-30 | Denis Gravel | Modified biological peptides with increased potency |
| ES2351569B8 (es) * | 2009-05-07 | 2012-06-20 | Bcn Peptides S.A. | Ligandos peptídicos de receptores de somatostatina. |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912807A (en) * | 1974-04-18 | 1975-10-14 | American Home Prod | Treatment of diabetes using somatostatin and insulin |
| US3926937A (en) * | 1974-04-18 | 1975-12-16 | American Home Prod | Polymeric somatostatin |
| US4061626A (en) * | 1976-04-29 | 1977-12-06 | Eli Lilly And Company | Somatostatin analogs and intermediates thereto |
| US4505897A (en) * | 1983-04-18 | 1985-03-19 | The Administrators Of The Tulane Educational Fund | Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith |
| US4508711A (en) * | 1983-04-18 | 1985-04-02 | American Cyanamid Company | Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith |
| LU85269A1 (fr) * | 1984-03-26 | 1985-10-14 | Techland S A | Composes nouveaux de somatostatine,procede pour leur synthese,preparation a usage veterinaire contenant lesdits composes et procede pour le traitement d'animaux |
| US5122512A (en) * | 1988-09-12 | 1992-06-16 | Pitman-Moore, Inc. | Swine growth promoting composition |
-
1996
- 1996-07-08 IT IT96MI001408A patent/IT1283134B1/it active IP Right Grant
-
1997
- 1997-07-08 EP EP97933655A patent/EP0914342B1/en not_active Expired - Lifetime
- 1997-07-08 AT AT97933655T patent/ATE330971T1/de not_active IP Right Cessation
- 1997-07-08 WO PCT/EP1997/003605 patent/WO1998001474A2/en active IP Right Grant
- 1997-07-08 AU AU36930/97A patent/AU3693097A/en not_active Abandoned
- 1997-07-08 DE DE69736179T patent/DE69736179D1/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998001474A2 (en) | 1998-01-15 |
| DE69736179D1 (de) | 2006-08-03 |
| EP0914342A2 (en) | 1999-05-12 |
| ATE330971T1 (de) | 2006-07-15 |
| ITMI961408A1 (it) | 1998-01-08 |
| EP0914342B1 (en) | 2006-06-21 |
| AU3693097A (en) | 1998-02-02 |
| ITMI961408A0 (it) | 1996-07-08 |
| WO1998001474A3 (en) | 1998-04-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |