ATE311365T1 - Verfahren zur herstellung der amorphen form von atorvastatin calzium salz - Google Patents
Verfahren zur herstellung der amorphen form von atorvastatin calzium salzInfo
- Publication number
- ATE311365T1 ATE311365T1 AT03727362T AT03727362T ATE311365T1 AT E311365 T1 ATE311365 T1 AT E311365T1 AT 03727362 T AT03727362 T AT 03727362T AT 03727362 T AT03727362 T AT 03727362T AT E311365 T1 ATE311365 T1 AT E311365T1
- Authority
- AT
- Austria
- Prior art keywords
- calcium salt
- atorvastatin calcium
- producing
- amorphic form
- water
- Prior art date
Links
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical class CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000907A ITMI20020907A1 (it) | 2002-04-29 | 2002-04-29 | Processo di preparazione della forma amorfa del sale di calcio della atorvastatina |
| PCT/EP2003/004313 WO2003093233A1 (en) | 2002-04-29 | 2003-04-25 | Process for the preparation of the amorphous form of atorvastatin calcium salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE311365T1 true ATE311365T1 (de) | 2005-12-15 |
Family
ID=11449799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727362T ATE311365T1 (de) | 2002-04-29 | 2003-04-25 | Verfahren zur herstellung der amorphen form von atorvastatin calzium salz |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060128971A1 (de) |
| EP (1) | EP1509500B1 (de) |
| AT (1) | ATE311365T1 (de) |
| AU (1) | AU2003233064A1 (de) |
| CA (1) | CA2483862A1 (de) |
| DE (1) | DE60302571T2 (de) |
| ES (1) | ES2253674T3 (de) |
| IT (1) | ITMI20020907A1 (de) |
| WO (1) | WO2003093233A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0409292A (pt) | 2003-04-11 | 2006-04-11 | Lek Pharmaceuticals | processo para a preparação de sal de cálcio amorfo de atorvastatina |
| HUE029911T2 (en) * | 2004-07-16 | 2017-04-28 | Lek Pharmaceuticals | Products of atorvastatin calcium oxidative degradation |
| WO2006011155A1 (en) * | 2004-07-26 | 2006-02-02 | Apollo International Limited | One pot process for amorphous atorvastain calcium |
| ES2263370B1 (es) * | 2005-02-16 | 2007-12-01 | Ercros Industrial, S.A. | Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion. |
| US20100113802A1 (en) * | 2006-11-02 | 2010-05-06 | Cadila Pharmaceuticals Limited | Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate |
| KR100833439B1 (ko) * | 2007-01-02 | 2008-05-29 | 씨제이제일제당 (주) | 비결정형 아토르바스타틴 칼슘의 개선된 제조방법 |
| EP2075246A1 (de) | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | Verfahren zur Herstellung einer amorphen Form von Atorvastatin-Hemicalcium-Salz |
| US9334266B2 (en) | 2009-09-04 | 2016-05-10 | The University Of Toledo | Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| HRP960313B1 (en) * | 1995-07-17 | 2002-08-31 | Warner Lambert Co | Form iii crystalline (r- (r*, r*)-2- (4-fluorophenyl) -beta-delta-hydroxy-5-(1-methylethyl) -3-phenyl-4- ((phenylamino) carbonyl -1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| WO1997003959A1 (en) * | 1995-07-17 | 1997-02-06 | Warner-Lambert Company | Crystalline [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) |
| HRP960312B1 (en) * | 1995-07-17 | 2001-10-31 | Warner Lambert Co | NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1) |
| US6087511A (en) * | 1996-07-16 | 2000-07-11 | Warner-Lambert Company | Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1) |
| IN191236B (de) * | 1999-05-25 | 2003-10-11 | Ranbaxy Lab Ltd | |
| HU226640B1 (en) * | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
| SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
| SI20814A (sl) * | 2001-01-23 | 2002-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Priprava amorfnega atorvastatina |
| US7563911B2 (en) * | 2001-08-31 | 2009-07-21 | Morepen Laboratories Ltd. | Process for the preparation of amorphous atorvastin calcium salt (2:1) |
-
2002
- 2002-04-29 IT IT2002MI000907A patent/ITMI20020907A1/it unknown
-
2003
- 2003-04-25 US US10/512,895 patent/US20060128971A1/en not_active Abandoned
- 2003-04-25 EP EP03727362A patent/EP1509500B1/de not_active Expired - Lifetime
- 2003-04-25 AU AU2003233064A patent/AU2003233064A1/en not_active Abandoned
- 2003-04-25 AT AT03727362T patent/ATE311365T1/de not_active IP Right Cessation
- 2003-04-25 DE DE60302571T patent/DE60302571T2/de not_active Expired - Fee Related
- 2003-04-25 CA CA002483862A patent/CA2483862A1/en not_active Abandoned
- 2003-04-25 ES ES03727362T patent/ES2253674T3/es not_active Expired - Lifetime
- 2003-04-25 WO PCT/EP2003/004313 patent/WO2003093233A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2253674T3 (es) | 2006-06-01 |
| WO2003093233A1 (en) | 2003-11-13 |
| ITMI20020907A1 (it) | 2003-10-29 |
| US20060128971A1 (en) | 2006-06-15 |
| CA2483862A1 (en) | 2003-11-13 |
| DE60302571D1 (de) | 2006-01-05 |
| ITMI20020907A0 (it) | 2002-04-29 |
| EP1509500B1 (de) | 2005-11-30 |
| AU2003233064A1 (en) | 2003-11-17 |
| EP1509500A1 (de) | 2005-03-02 |
| DE60302571T2 (de) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |