HUP0300761A2 - Eljárás amorf atorvasztatin-kalcium előállítására - Google Patents
Eljárás amorf atorvasztatin-kalcium előállításáraInfo
- Publication number
- HUP0300761A2 HUP0300761A2 HU0300761A HUP0300761A HUP0300761A2 HU P0300761 A2 HUP0300761 A2 HU P0300761A2 HU 0300761 A HU0300761 A HU 0300761A HU P0300761 A HUP0300761 A HU P0300761A HU P0300761 A2 HUP0300761 A2 HU P0300761A2
- Authority
- HU
- Hungary
- Prior art keywords
- water
- amorphous atorvastatin
- production
- atorvastatin calcium
- salt
- Prior art date
Links
- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 title abstract 3
- 229960001770 atorvastatin calcium Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- WAYQDINDUJAOHV-WCCKRBBISA-N (2s)-2,5-diaminopentanoic acid;hydrate Chemical compound O.NCCC[C@H](N)C(O)=O WAYQDINDUJAOHV-WCCKRBBISA-N 0.000 abstract 1
- BJGBAZAEWKCPHZ-MQSFZEHASA-N (3r,5r)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1.C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 BJGBAZAEWKCPHZ-MQSFZEHASA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya új eljárás amorf atorvasztatin-kalciumelőállítására, olyan módon, hogy az atorvasztatinsav bázikusaminosavval képzett sóját - melyet az (I) általános képlet mutat be;és ahol a képletben R jelentése lizinből, argininből vagy ornitinbőlszármazó csoport - víz és valamilyen vízzel korlátlanul elegyedőszerves oldószer elegyében oldják, az oldathoz valamilyen vízbenoldódó kalciumsó vizes oldatát adják, majd a kapott nagy tisztaságú,egységesen amorf atorvasztatin-kalciumot szűréssel izolálják. Ó
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0300761A HU227041B1 (en) | 2003-03-24 | 2003-03-24 | Process for the synthesis of amorphous atorvastatin calcium |
| US10/550,415 US20070066835A1 (en) | 2003-03-24 | 2004-03-23 | Process for the synthesis of amorphous atorvastain calcium |
| PCT/HU2004/000026 WO2004085391A1 (en) | 2003-03-24 | 2004-03-23 | Process for the synthesis of amorphous atorvastatin calcium |
| EP04722598A EP1608618A1 (en) | 2003-03-24 | 2004-03-23 | Process for the synthesis of amorphous atorvastatin calcium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0300761A HU227041B1 (en) | 2003-03-24 | 2003-03-24 | Process for the synthesis of amorphous atorvastatin calcium |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HU0300761D0 HU0300761D0 (en) | 2003-06-28 |
| HUP0300761A2 true HUP0300761A2 (hu) | 2005-01-28 |
| HUP0300761A3 HUP0300761A3 (en) | 2005-03-29 |
| HU227041B1 HU227041B1 (en) | 2010-05-28 |
Family
ID=89981242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300761A HU227041B1 (en) | 2003-03-24 | 2003-03-24 | Process for the synthesis of amorphous atorvastatin calcium |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070066835A1 (hu) |
| EP (1) | EP1608618A1 (hu) |
| HU (1) | HU227041B1 (hu) |
| WO (1) | WO2004085391A1 (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI120344B (fi) | 2004-03-17 | 2009-09-30 | Ranbaxy Lab Ltd | Menetelmä amorfisessa muodossa olevan atorvastatiinikalsiumin valmistamiseksi |
| BRPI0513396A (pt) * | 2004-07-16 | 2008-05-06 | Lek Pharmaceuticals | produtos de degradação oxidativa de atorvastatina de cálcio |
| ES2272206T1 (es) * | 2004-10-18 | 2007-05-01 | Teva Pharmaceutical Industries Ltd. | Procedimiento para la preparacion de la atorvastatina hemicalcica amorfa por disolucion de la sal en un disolvente organico que es una mezcla de un alcohol, y una cetona y/o un ester y eliminacion del disolvente. |
| ES2263370B1 (es) * | 2005-02-16 | 2007-12-01 | Ercros Industrial, S.A. | Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion. |
| CA2613875C (en) * | 2005-07-04 | 2018-09-25 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
| ES2270722B1 (es) * | 2005-09-15 | 2008-03-01 | Ercros Industrial, S.A. | Procedimiento para la obtencion de atorvastatina calcica amorfa. |
| CN100406438C (zh) * | 2006-06-30 | 2008-07-30 | 浙江新东港药业股份有限公司 | 一种无定型阿伐他汀钙的制备方法 |
| EP2182925A2 (en) * | 2007-07-27 | 2010-05-12 | Cipla Limited | Pharmaceutical compositions and process for making them |
| EP2075246A1 (en) | 2007-12-27 | 2009-07-01 | M. J. Institute of Research | A process for preparation of amorphous form of atorvastatin hemi-calcium salt |
| HUP1000299A2 (hu) | 2010-06-08 | 2012-02-28 | Nanoform Cardiovascular Therapeutics Ltd | Nanostrukturált Atorvastatint, gyógyszerészetileg elfogadott sóit és kokristályait tartalmazó készítmény és eljárás elõállításukra |
| CN102424663B (zh) * | 2010-12-03 | 2013-08-14 | 天津滨江药物研发有限公司 | 一种阿托伐他汀氨基酸盐及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| EP0913177A1 (de) * | 1997-11-03 | 1999-05-06 | Roche Diagnostics GmbH | Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung |
| HU226640B1 (en) * | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
| SI20425A (sl) * | 1999-12-10 | 2001-06-30 | LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. | Priprava amorfnega atorvastatina |
| HUP0201083A2 (hu) * | 2002-03-28 | 2004-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új atorvastatinsók és az azokat tartalmazó gyógyszerkészítmények |
-
2003
- 2003-03-24 HU HU0300761A patent/HU227041B1/hu unknown
-
2004
- 2004-03-23 EP EP04722598A patent/EP1608618A1/en not_active Withdrawn
- 2004-03-23 US US10/550,415 patent/US20070066835A1/en not_active Abandoned
- 2004-03-23 WO PCT/HU2004/000026 patent/WO2004085391A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004085391A1 (en) | 2004-10-07 |
| US20070066835A1 (en) | 2007-03-22 |
| HU227041B1 (en) | 2010-05-28 |
| HUP0300761A3 (en) | 2005-03-29 |
| WO2004085391B1 (en) | 2004-11-18 |
| EP1608618A1 (en) | 2005-12-28 |
| HU0300761D0 (en) | 2003-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: RICHTER GEDEON NYRT., HU Free format text: FORMER OWNER(S): RICHTER GEDEON VEGYESZETI GYAR RT., HU |