ATE304709T1 - Substanzen mit verzweigten linkermolekülen - Google Patents
Substanzen mit verzweigten linkermolekülenInfo
- Publication number
- ATE304709T1 ATE304709T1 AT01985752T AT01985752T ATE304709T1 AT E304709 T1 ATE304709 T1 AT E304709T1 AT 01985752 T AT01985752 T AT 01985752T AT 01985752 T AT01985752 T AT 01985752T AT E304709 T1 ATE304709 T1 AT E304709T1
- Authority
- AT
- Austria
- Prior art keywords
- substances
- linker molecules
- branched linker
- branched linkers
- branched
- Prior art date
Links
- 239000000126 substance Substances 0.000 title 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10048417A DE10048417A1 (de) | 2000-09-29 | 2000-09-29 | Verbindungen mit verzweigtem Linker |
| PCT/EP2001/011118 WO2002027315A2 (en) | 2000-09-29 | 2001-09-26 | Compounds with a branched linker |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE304709T1 true ATE304709T1 (de) | 2005-09-15 |
Family
ID=7658168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01985752T ATE304709T1 (de) | 2000-09-29 | 2001-09-26 | Substanzen mit verzweigten linkermolekülen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040086943A1 (https=) |
| EP (1) | EP1327146B1 (https=) |
| JP (1) | JP3647845B2 (https=) |
| AT (1) | ATE304709T1 (https=) |
| AU (1) | AU2002215904A1 (https=) |
| CA (1) | CA2423916C (https=) |
| DE (2) | DE10048417A1 (https=) |
| DK (1) | DK1327146T3 (https=) |
| ES (1) | ES2248405T3 (https=) |
| WO (1) | WO2002027315A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| CN1434726A (zh) | 2000-06-08 | 2003-08-06 | 拉卓拉药物公司 | 包含高分子量聚环氧乙烷的多价平台分子 |
| EP1392359B2 (en) | 2001-05-11 | 2013-03-13 | Ludwig Institute for Cancer Research Ltd. | Specific binding proteins and uses thereof |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| CA2451974C (en) | 2001-06-21 | 2014-10-14 | Karen L. Fearon | Chimeric immunomodulatory compounds and methods of using the same |
| DE10227599B4 (de) * | 2002-06-20 | 2005-04-28 | Proteome Factory Ag | Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe |
| ES2280829T3 (es) * | 2002-07-19 | 2007-09-16 | Mologen Ag | Constructo de expresion de adn para la expresion de multiples genes. |
| GB0329825D0 (en) * | 2003-12-23 | 2004-01-28 | Celltech R&D Ltd | Biological products |
| DE602005023624D1 (de) * | 2004-07-30 | 2010-10-28 | Advanced Life Science Inst Inc | Sondenkomplex |
| WO2007059760A1 (de) | 2005-11-25 | 2007-05-31 | Mologen Ag | Dna-konstrukte zur spezifischen hemmung der genexpression durch rna-interferenz |
| GB0607479D0 (en) * | 2006-04-13 | 2006-05-24 | Johnson Matthey Plc | Adhesion promoting compound |
| US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
| ES2542152T3 (es) | 2007-03-15 | 2015-07-31 | Ludwig Institute For Cancer Research Ltd. | Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| EP2318051A4 (en) * | 2008-07-14 | 2012-12-26 | Andrew Metters | IN VITRO DIAGNOSTIC MARKERS COMPRISING CARBON NANOPARTICLES AND KITS |
| CN103588801A (zh) * | 2013-12-02 | 2014-02-19 | 天津大港油田圣达科技有限公司 | 一种微量元素井间示踪剂的使用方法 |
| EP3897734A4 (en) * | 2018-12-21 | 2022-12-07 | Seagen Inc. | ADC COMPRISING MULTIPLEX THIOL LINKERS |
| JP7493513B2 (ja) | 2018-12-28 | 2024-05-31 | アボット・ラボラトリーズ | 微粒子上の１分子の直接検出 |
| CN115135680A (zh) * | 2019-12-18 | 2022-09-30 | 标准生物工具加拿大公司 | 用于信号放大的质谱细胞术试剂和方法 |
| CN119775256B (zh) * | 2024-12-31 | 2025-09-19 | 英科新创（苏州）生物科技有限公司 | 吖啶磺酰胺衍生物、制备方法、其应用及试剂盒 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
| US5075447A (en) * | 1984-09-17 | 1991-12-24 | Hoffmann-La Roche Inc. | Ruthenium complexes useful as carriers for immunologically active materials |
| FR2579224B1 (fr) * | 1985-03-25 | 1987-05-22 | Genetica | Procede de preparation microbiologique de la serum-albumine humaine |
| US5750409A (en) * | 1991-11-18 | 1998-05-12 | Boehringer Mannheim Gmbh | Pentacyclic compounds and their use as absorption or fluorescent dyes |
| GB9215780D0 (en) * | 1992-07-24 | 1992-09-09 | Univ London Pharmacy | Peptide compounds |
| DE4310141A1 (de) * | 1993-03-29 | 1994-10-06 | Boehringer Mannheim Gmbh | Homobidentale trifunktionelle Linker |
| GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| AU689626B2 (en) * | 1994-07-25 | 1998-04-02 | Boehringer Mannheim Gmbh | Peptides marked with metal chelates |
| DE59507438D1 (de) * | 1994-07-25 | 2000-01-20 | Roche Diagnostics Gmbh | Hydrophile metallkomplexe |
| FI961349A7 (fi) * | 1994-07-25 | 1996-03-25 | Roche Diagnostics Gmbh | Metallikompleksit, joissa on varautunut linkkeri |
| NZ291155A (en) * | 1994-07-25 | 1997-09-22 | Boehringer Mannheim Gmbh | Production of hapten labelled peptides and their use |
| CA2195753C (en) * | 1994-07-25 | 2008-12-16 | Ursula-Henrike Wienhues | Determination of a specific immunoglobulin using multiple antigens |
| US5718915A (en) * | 1994-10-31 | 1998-02-17 | Burstein Laboratories, Inc. | Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme |
| DE19519973A1 (de) * | 1995-05-31 | 1996-12-05 | Boehringer Mannheim Gmbh | Entstörungsreagenz für die Bestimmung eines Analyten mit einem lumineszenzfähigen Metallkomplex |
| US5714360A (en) * | 1995-11-03 | 1998-02-03 | Bsi Corporation | Photoactivatable water soluble cross-linking agents containing an onium group |
| JP2001505194A (ja) * | 1996-11-05 | 2001-04-17 | ブリストル―マイヤーズ・スクイブ・カンパニー | 分枝ペプチド・リンカー |
| DK1411075T3 (da) * | 1998-03-12 | 2008-10-27 | Nektar Therapeutics Al Corp | Fremgangsmåde til fremstilling af polymerkonjugater |
| DE19811582A1 (de) * | 1998-03-17 | 1999-09-23 | Roche Diagnostics Gmbh | Stabilisierung und Verstärkung von Elektrochemilumineszenz-Signalen |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| DE69915322T2 (de) * | 1998-09-29 | 2005-02-24 | Hewlett-Packard Co.(A Delaware Corporation), Palo Alto | Verfahren und vorrichtung zur herstellung von broschüren |
| GB2413081A (en) * | 2004-04-13 | 2005-10-19 | Sca Hygiene Prod Ab | Absorbant article with folded side flap portions and method of manufacture |
-
2000
- 2000-09-29 DE DE10048417A patent/DE10048417A1/de not_active Withdrawn
-
2001
- 2001-09-26 EP EP01985752A patent/EP1327146B1/en not_active Expired - Lifetime
- 2001-09-26 DK DK01985752T patent/DK1327146T3/da active
- 2001-09-26 AU AU2002215904A patent/AU2002215904A1/en not_active Abandoned
- 2001-09-26 ES ES01985752T patent/ES2248405T3/es not_active Expired - Lifetime
- 2001-09-26 AT AT01985752T patent/ATE304709T1/de active
- 2001-09-26 CA CA002423916A patent/CA2423916C/en not_active Expired - Lifetime
- 2001-09-26 US US10/381,944 patent/US20040086943A1/en not_active Abandoned
- 2001-09-26 JP JP2002530643A patent/JP3647845B2/ja not_active Expired - Lifetime
- 2001-09-26 DE DE60113445T patent/DE60113445T2/de not_active Expired - Lifetime
- 2001-09-26 WO PCT/EP2001/011118 patent/WO2002027315A2/en not_active Ceased
-
2009
- 2009-02-13 US US12/370,886 patent/US20090264618A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP3647845B2 (ja) | 2005-05-18 |
| DE10048417A1 (de) | 2002-04-11 |
| US20040086943A1 (en) | 2004-05-06 |
| DE60113445T2 (de) | 2006-06-29 |
| WO2002027315A3 (en) | 2002-07-11 |
| CA2423916C (en) | 2009-02-03 |
| EP1327146A2 (en) | 2003-07-16 |
| JP2004510160A (ja) | 2004-04-02 |
| DK1327146T3 (da) | 2006-01-23 |
| EP1327146B1 (en) | 2005-09-14 |
| CA2423916A1 (en) | 2002-04-04 |
| ES2248405T3 (es) | 2006-03-16 |
| US20090264618A1 (en) | 2009-10-22 |
| WO2002027315A2 (en) | 2002-04-04 |
| DE60113445D1 (de) | 2005-10-20 |
| AU2002215904A1 (en) | 2002-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE304709T1 (de) | Substanzen mit verzweigten linkermolekülen | |
| CY1120070T1 (el) | Μεθοδοi θεραπευτικης αγωγης με τη χρηση συζευγματων αντισωματος εναντι-erbb-μεϋτανσινοειδους | |
| EP2353611A3 (en) | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease | |
| EA200800657A1 (ru) | Способ приготовления очищенных конъюгатов лекарственных средств | |
| EA200800952A1 (ru) | Конъюгаты антитело-лекарство и способы применения | |
| PT1144459E (pt) | Acidos hialuronicos reticulados e as suas utilizacoes em medicina | |
| MA26886A1 (fr) | Acides malonamiques et leurs derives, utiles comme ligands de recepteurs thyroidiens. | |
| PL374523A1 (pl) | Koniugaty pochodna kalicheamycyny-nośnik | |
| TW200505942A (en) | Antibody molecules having specificity for human IL-1β | |
| CY1114922T1 (el) | Κυτταροτοξικοι παραγοντες οι οποιοι περιλαμβανουν νεα παραγωγα τομαϋμυκινης και τη θεραπευτικη τους χρηση | |
| ATE368054T1 (de) | Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität | |
| DE60042369D1 (de) | Chemisch programmierbare immunität | |
| AU1922902A (en) | Novel means for the diagnosis and therapy of CTCL | |
| WO2004013307A3 (en) | Compounds for targeting hepatocytes | |
| WO2006002895A3 (en) | Conjugates of antibody and duoarmycin derivatives as antitumor agents | |
| SE0003476D0 (sv) | Compounds | |
| DE69921486D1 (de) | Dextran-leptin konjugate, pharmazeutische zusammentsetzungen und verbundene verfahren | |
| DE69840673D1 (de) | Modifizierte polysaccharide mit veränderter biologischer erkennung | |
| ATE507844T1 (de) | Verfahren zur herstellung eines homogenen doxorubicin-transferrin kojugates | |
| DE602005026182D1 (de) | Herstellung von insulinkonjugaten | |
| AU2002360350A1 (en) | Peptides that home to tumor lymphatic vasculature and methods of using same | |
| NO20021429D0 (no) | 1,4-dioksacykloalkan-2-oner og 1,4-dioksacykloalken-2-oner | |
| TR200100651T2 (tr) | İki işlevli antikorlar ve bunların tümör-önleyici amilleri hedeflemede kullanımı | |
| AR023794A1 (es) | Antigeno asociado con tumores | |
| ATE307838T1 (de) | Klebstoffzubereitungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1327146 Country of ref document: EP |