DE10048417A1 - Verbindungen mit verzweigtem Linker - Google Patents

Verbindungen mit verzweigtem Linker

Info

Publication number
DE10048417A1
DE10048417A1 DE10048417A DE10048417A DE10048417A1 DE 10048417 A1 DE10048417 A1 DE 10048417A1 DE 10048417 A DE10048417 A DE 10048417A DE 10048417 A DE10048417 A DE 10048417A DE 10048417 A1 DE10048417 A1 DE 10048417A1
Authority
DE
Germany
Prior art keywords
group
linker
use according
groups
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10048417A
Other languages
German (de)
English (en)
Inventor
Herbert Andres
Eva Hoess
Hans-Peter Josel
Rupert Herrmann
Herbert Von Der Eltz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Priority to DE10048417A priority Critical patent/DE10048417A1/de
Priority to US10/381,941 priority patent/US7897404B2/en
Priority to DE60116146T priority patent/DE60116146T2/de
Priority to CA002423916A priority patent/CA2423916C/en
Priority to EP05023387A priority patent/EP1625857A3/en
Priority to CA2420768A priority patent/CA2420768C/en
Priority to PCT/EP2001/011101 priority patent/WO2002027317A2/en
Priority to PCT/EP2001/011118 priority patent/WO2002027315A2/en
Priority to EP01969773A priority patent/EP1364208B1/en
Priority to EP01985752A priority patent/EP1327146B1/en
Priority to ES01985752T priority patent/ES2248405T3/es
Priority to DK01985752T priority patent/DK1327146T3/da
Priority to AU2001289923A priority patent/AU2001289923A1/en
Priority to AT01969773T priority patent/ATE313796T1/de
Priority to US10/381,944 priority patent/US20040086943A1/en
Priority to DE60113445T priority patent/DE60113445T2/de
Priority to JP2002530643A priority patent/JP3647845B2/ja
Priority to AT01985752T priority patent/ATE304709T1/de
Priority to ES01969773T priority patent/ES2254489T3/es
Priority to AU2002215904A priority patent/AU2002215904A1/en
Priority to JP2002530645A priority patent/JP3836429B2/ja
Publication of DE10048417A1 publication Critical patent/DE10048417A1/de
Priority to US12/370,886 priority patent/US20090264618A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE10048417A 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker Withdrawn DE10048417A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE10048417A DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker
US10/381,941 US7897404B2 (en) 2000-09-29 2001-08-26 Conjugates of defined stoichiometry
DK01985752T DK1327146T3 (da) 2000-09-29 2001-09-26 Forbindelse med et forgrenet linkermolekyle
AT01969773T ATE313796T1 (de) 2000-09-29 2001-09-26 Konjugate definierter stöchiometrie
EP05023387A EP1625857A3 (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry
CA2420768A CA2420768C (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry
PCT/EP2001/011101 WO2002027317A2 (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry
PCT/EP2001/011118 WO2002027315A2 (en) 2000-09-29 2001-09-26 Compounds with a branched linker
EP01969773A EP1364208B1 (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry
EP01985752A EP1327146B1 (en) 2000-09-29 2001-09-26 Compounds with a branched linker
ES01985752T ES2248405T3 (es) 2000-09-29 2001-09-26 Compuestos con un engarce ramificado.
DE60116146T DE60116146T2 (de) 2000-09-29 2001-09-26 Konjugate definierter stöchiometrie
AU2001289923A AU2001289923A1 (en) 2000-09-29 2001-09-26 Conjugates of defined stoichiometry
CA002423916A CA2423916C (en) 2000-09-29 2001-09-26 Compounds with a branched linker
US10/381,944 US20040086943A1 (en) 2000-09-29 2001-09-26 Compounds with a branched linker
DE60113445T DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen
JP2002530643A JP3647845B2 (ja) 2000-09-29 2001-09-26 分枝リンカーを有する化合物
AT01985752T ATE304709T1 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen
ES01969773T ES2254489T3 (es) 2000-09-29 2001-09-26 Conjugados de estequiometria definida.
AU2002215904A AU2002215904A1 (en) 2000-09-29 2001-09-26 Compounds with a branched linker
JP2002530645A JP3836429B2 (ja) 2000-09-29 2001-09-26 規定した化学量論の結合体
US12/370,886 US20090264618A1 (en) 2000-09-29 2009-02-13 Compounds With a Branched Linker

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10048417A DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker

Publications (1)

Publication Number Publication Date
DE10048417A1 true DE10048417A1 (de) 2002-04-11

Family

ID=7658168

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10048417A Withdrawn DE10048417A1 (de) 2000-09-29 2000-09-29 Verbindungen mit verzweigtem Linker
DE60113445T Expired - Lifetime DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60113445T Expired - Lifetime DE60113445T2 (de) 2000-09-29 2001-09-26 Substanzen mit verzweigten linkermolekülen

Country Status (10)

Country Link
US (2) US20040086943A1 (https=)
EP (1) EP1327146B1 (https=)
JP (1) JP3647845B2 (https=)
AT (1) ATE304709T1 (https=)
AU (1) AU2002215904A1 (https=)
CA (1) CA2423916C (https=)
DE (2) DE10048417A1 (https=)
DK (1) DK1327146T3 (https=)
ES (1) ES2248405T3 (https=)
WO (1) WO2002027315A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016786A3 (de) * 2002-07-19 2004-06-03 Mologen Ag Dna-expressionskonstrukt zur multiplen genexpression
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
US9012620B2 (en) 2005-11-25 2015-04-21 Mologen Ag DNA constructs for specific inhibition of gene expression by RNA interference

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KR100361933B1 (ko) 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US6858210B1 (en) 1998-06-09 2005-02-22 La Jolla Pharmaceutical Co. Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
WO2001093914A2 (en) 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
AU2002311919B8 (en) 2001-05-11 2007-03-22 Ludwig Institute For Cancer Research Ltd Specific binding proteins and uses thereof
EP2423335B1 (en) 2001-06-21 2014-05-14 Dynavax Technologies Corporation Chimeric immunomodulatory compounds and methods of using the same
GB0329825D0 (en) * 2003-12-23 2004-01-28 Celltech R&D Ltd Biological products
JP4920415B2 (ja) * 2004-07-30 2012-04-18 株式会社先端生命科学研究所 プローブ複合体
GB0607479D0 (en) * 2006-04-13 2006-05-24 Johnson Matthey Plc Adhesion promoting compound
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
US20110177619A1 (en) * 2008-07-14 2011-07-21 Andrew Metters In vitro diagnostic markers comprising carbon nanoparticles and kits
CN103588801A (zh) * 2013-12-02 2014-02-19 天津大港油田圣达科技有限公司 一种微量元素井间示踪剂的使用方法
AU2019403552A1 (en) * 2018-12-21 2021-06-17 Seagen Inc. ADCs with thiol multiplex linkers
US12061200B2 (en) 2018-12-28 2024-08-13 Abbott Laboratories Direct detection of single molecules on microparticles
CA3162257A1 (en) * 2019-12-18 2021-06-24 Bedilu ALLO Mass cytometry reagents and methods for signal amplification
CN119775256B (zh) * 2024-12-31 2025-09-19 英科新创（苏州）生物科技有限公司 吖啶磺酰胺衍生物、制备方法、其应用及试剂盒

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US5750409A (en) * 1991-11-18 1998-05-12 Boehringer Mannheim Gmbh Pentacyclic compounds and their use as absorption or fluorescent dyes
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DE59511054D1 (de) * 1994-07-25 2006-08-10 Roche Diagnostics Gmbh Bestimmung von spezifischem immunglobulin unter verwendung multipler antigene
CN1114106C (zh) * 1994-07-25 2003-07-09 罗切诊断学有限公司 金属螯合物标记的肽及其制备方法
US5958783A (en) * 1994-07-25 1999-09-28 Roche Diagnostics Gmbh Metal complexes with a charged linker
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US5718915A (en) * 1994-10-31 1998-02-17 Burstein Laboratories, Inc. Antiviral liposome having coupled target-binding moiety and hydrolytic enzyme
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JP4078032B2 (ja) * 1998-03-12 2008-04-23 ネクター セラピューティックス エイエル，コーポレイション 近位の反応性基を持つポリ（エチレングリコール）誘導体
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US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
CN1178800C (zh) * 1998-09-29 2004-12-08 惠普公司 加工小册子的方法和设备
GB2413081A (en) * 2004-04-13 2005-10-19 Sca Hygiene Prod Ab Absorbant article with folded side flap portions and method of manufacture

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10227599B4 (de) * 2002-06-20 2005-04-28 Proteome Factory Ag Verfahren und Reagenz zur spezifischen Identifizierung und Quantifizierung von einem oder mehreren Proteinen in einer Probe
WO2004016786A3 (de) * 2002-07-19 2004-06-03 Mologen Ag Dna-expressionskonstrukt zur multiplen genexpression
US9012620B2 (en) 2005-11-25 2015-04-21 Mologen Ag DNA constructs for specific inhibition of gene expression by RNA interference

Also Published As

Publication number Publication date
WO2002027315A2 (en) 2002-04-04
DE60113445D1 (de) 2005-10-20
DK1327146T3 (da) 2006-01-23
ES2248405T3 (es) 2006-03-16
EP1327146A2 (en) 2003-07-16
EP1327146B1 (en) 2005-09-14
AU2002215904A1 (en) 2002-04-08
ATE304709T1 (de) 2005-09-15
JP3647845B2 (ja) 2005-05-18
WO2002027315A3 (en) 2002-07-11
CA2423916A1 (en) 2002-04-04
US20040086943A1 (en) 2004-05-06
JP2004510160A (ja) 2004-04-02
DE60113445T2 (de) 2006-06-29
US20090264618A1 (en) 2009-10-22
CA2423916C (en) 2009-02-03

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination