ATE299486T1 - Verfahren zur herstellung von sevofluran und eines zwischenproduktes davon - Google Patents
Verfahren zur herstellung von sevofluran und eines zwischenproduktes davonInfo
- Publication number
- ATE299486T1 ATE299486T1 AT00918331T AT00918331T ATE299486T1 AT E299486 T1 ATE299486 T1 AT E299486T1 AT 00918331 T AT00918331 T AT 00918331T AT 00918331 T AT00918331 T AT 00918331T AT E299486 T1 ATE299486 T1 AT E299486T1
- Authority
- AT
- Austria
- Prior art keywords
- sevochlorane
- produce
- fluoromethyl
- producing sevoflurane
- hexafluoroisopropyl ether
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 title 1
- 229960002078 sevoflurane Drugs 0.000 title 1
- OOKYWAXNZYBZER-UHFFFAOYSA-N 3-amino-3-(4-ethoxy-3-methoxyphenyl)propanoic acid Chemical compound CCOC1=CC=C(C(N)CC(O)=O)C=C1OC OOKYWAXNZYBZER-UHFFFAOYSA-N 0.000 abstract 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 abstract 1
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- 229910001515 alkali metal fluoride Inorganic materials 0.000 abstract 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/280,794 US6100434A (en) | 1999-03-26 | 1999-03-26 | Method for synthesizing sevoflurane and an intermediate thereof |
| PCT/US2000/007801 WO2000058251A1 (en) | 1999-03-26 | 2000-03-24 | Method for synthesizing sevoflurane and an intermediate thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299486T1 true ATE299486T1 (de) | 2005-07-15 |
Family
ID=23074683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00918331T ATE299486T1 (de) | 1999-03-26 | 2000-03-24 | Verfahren zur herstellung von sevofluran und eines zwischenproduktes davon |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6100434A (de) |
| EP (1) | EP1165478B1 (de) |
| JP (1) | JP2002540179A (de) |
| AT (1) | ATE299486T1 (de) |
| AU (1) | AU773249B2 (de) |
| CA (1) | CA2366673A1 (de) |
| DE (1) | DE60021258T2 (de) |
| DK (1) | DK1165478T3 (de) |
| ES (1) | ES2246842T3 (de) |
| PT (1) | PT1165478E (de) |
| WO (1) | WO2000058251A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245949B1 (en) * | 2000-06-01 | 2001-06-12 | Abbott Laboratories | Synthetic method for the fluoromethylation of alcohols |
| US6271422B1 (en) * | 2000-06-01 | 2001-08-07 | Abbott Laboratories | Method for fluoromethylation of alcohols via halogenative decarboxylation |
| CA2512384C (en) * | 2003-01-14 | 2013-03-19 | Baxter International Inc. | Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis |
| EA200701073A1 (ru) * | 2004-11-17 | 2007-12-28 | Минрад Инк. | Способ получения севофлурана |
| WO2008037039A2 (en) * | 2006-09-29 | 2008-04-03 | Cristália Produtos Químicos Farmacêuticos Ltda. | Process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether |
| EP2066609B1 (de) * | 2006-09-29 | 2016-01-06 | Cristália Produtos Químicos Farmacêuticos Ltda. | Verfahren zur herstellung von fluormethyl-2,2,2-trifluor-1-(trifluormethyl)ethylether |
| RU2368597C2 (ru) * | 2007-08-06 | 2009-09-27 | Закрытое акционерное общество Научно-производственное объединение "ПиМ-Инвест" | Двухстадийный способ получения 2-(фторметокси)-1,1,1,3,3,3-гексафторизопропана (севофлурана) |
| JP5163064B2 (ja) | 2007-11-13 | 2013-03-13 | ダイキン工業株式会社 | 新規カルボン酸エステル、その用途及びその製造方法 |
| US7732647B2 (en) | 2007-12-27 | 2010-06-08 | Halocarbon Products Corporation | Process for the purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) |
| CN101314560B (zh) * | 2008-07-02 | 2011-06-15 | 鲁南制药集团股份有限公司 | 七氟烷的合成方法 |
| WO2010079057A1 (en) * | 2008-12-18 | 2010-07-15 | Shell Internationale Research Maatschappij B.V. | Multi stage process for producing hydrocarbons from syngas |
| WO2010096959A1 (zh) * | 2009-02-25 | 2010-09-02 | 江苏恒瑞医药股份有限公司 | 制备氯甲基-1,1,1,3,3,3-六氟异丙基醚的方法 |
| CA2769797A1 (en) | 2009-08-10 | 2011-02-17 | Solvay Fluor Gmbh | Process for the manufacture of sevoflurane |
| WO2012107438A1 (en) | 2011-02-10 | 2012-08-16 | Solvay Sa | Process for the manufacture of fluoromethoxymalonic acid derivatives |
| US8729313B2 (en) * | 2011-08-15 | 2014-05-20 | Baxter International Inc. | Process for the manufacturing of sevoflurane |
| EP2626341A1 (de) | 2012-02-10 | 2013-08-14 | Solvay Sa | Prozess zur Herstellung von Hexafluoroisopropanol |
| CN103804151A (zh) * | 2012-11-07 | 2014-05-21 | 东莞市长安东阳光铝业研发有限公司 | 一种七氟醚的制备方法 |
| JP2019514446A (ja) | 2016-02-23 | 2019-06-06 | セージテック メディカル イクイップメント リミテッドＳａｇｅｔｅｃｈ Ｍｅｄｉｃａｌ Ｅｑｕｉｐｍｅｎｔ Ｌｉｍｉｔｅｄ | 超臨界流体を使用した揮発性麻酔剤の製造及び再生の改善 |
| CN108689808B (zh) * | 2017-04-06 | 2021-11-16 | 江苏恒瑞医药股份有限公司 | 一种氯甲基六氟异丙醚的制备方法 |
| CN108727166B (zh) * | 2017-04-17 | 2021-06-29 | 江苏恒瑞医药股份有限公司 | 一种氯甲基六氟异丙醚的精制方法 |
| CN107698430B (zh) * | 2017-11-01 | 2021-01-08 | 华东医药（西安）博华制药有限公司 | 一种七氟烷反应液的后处理方法 |
| CN110105178A (zh) * | 2019-05-17 | 2019-08-09 | 华东医药（西安）博华制药有限公司 | 一种合成七氟烷中间体的方法 |
| CN114057546A (zh) * | 2021-05-07 | 2022-02-18 | 安徽伟祥新材料有限公司 | 一种3-氟-1-丙醇的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2992276A (en) * | 1959-05-20 | 1961-07-11 | Du Pont | Process for preparing polyfluoro alkyl compounds |
| US3476860A (en) * | 1966-12-08 | 1969-11-04 | Air Reduction | Halomethyl fluoroisopropyl ethers as anesthetic agents |
| GB1250928A (de) * | 1968-10-28 | 1971-10-27 | ||
| US3689571A (en) * | 1970-07-31 | 1972-09-05 | Baxter Laboratories Inc | Fluorinated ether |
| US3683092A (en) * | 1970-07-31 | 1972-08-08 | Baxter Laboratories Inc | Method of anesthesia |
| US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| US4874901A (en) * | 1988-05-06 | 1989-10-17 | Boc, Inc. | Process for the production of polyfluorinated ethers |
| CN1074759C (zh) * | 1996-02-21 | 2001-11-14 | 森陶硝子株式会社 | 氟甲基1,1,1,3,3,3－六氟异丙醚的生产方法 |
| US5969193A (en) * | 1997-08-18 | 1999-10-19 | Medeva Pharmaceuticals Pa, Inc. | Method for the preparation of sevoflurane |
| US5886239A (en) * | 1997-11-21 | 1999-03-23 | Baxter International Inc. | Method of preparing monofluoromethyl ethers |
-
1999
- 1999-03-26 US US09/280,794 patent/US6100434A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 AT AT00918331T patent/ATE299486T1/de not_active IP Right Cessation
- 2000-03-24 WO PCT/US2000/007801 patent/WO2000058251A1/en not_active Ceased
- 2000-03-24 ES ES00918331T patent/ES2246842T3/es not_active Expired - Lifetime
- 2000-03-24 DK DK00918331T patent/DK1165478T3/da active
- 2000-03-24 AU AU39160/00A patent/AU773249B2/en not_active Ceased
- 2000-03-24 CA CA002366673A patent/CA2366673A1/en not_active Abandoned
- 2000-03-24 EP EP00918331A patent/EP1165478B1/de not_active Expired - Lifetime
- 2000-03-24 JP JP2000607957A patent/JP2002540179A/ja active Pending
- 2000-03-24 PT PT00918331T patent/PT1165478E/pt unknown
- 2000-03-24 DE DE60021258T patent/DE60021258T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT1165478E (pt) | 2005-11-30 |
| WO2000058251A1 (en) | 2000-10-05 |
| CA2366673A1 (en) | 2000-10-05 |
| EP1165478A1 (de) | 2002-01-02 |
| DE60021258T2 (de) | 2006-04-20 |
| ES2246842T3 (es) | 2006-03-01 |
| DK1165478T3 (da) | 2005-11-07 |
| JP2002540179A (ja) | 2002-11-26 |
| US6100434A (en) | 2000-08-08 |
| DE60021258D1 (de) | 2005-08-18 |
| AU3916000A (en) | 2000-10-16 |
| EP1165478B1 (de) | 2005-07-13 |
| AU773249B2 (en) | 2004-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1165478 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |