DK1165478T3 - Fremgangsmåde til syntetisering af sevofluran og et mellemprodukt deraf - Google Patents
Fremgangsmåde til syntetisering af sevofluran og et mellemprodukt derafInfo
- Publication number
- DK1165478T3 DK1165478T3 DK00918331T DK00918331T DK1165478T3 DK 1165478 T3 DK1165478 T3 DK 1165478T3 DK 00918331 T DK00918331 T DK 00918331T DK 00918331 T DK00918331 T DK 00918331T DK 1165478 T3 DK1165478 T3 DK 1165478T3
- Authority
- DK
- Denmark
- Prior art keywords
- sevochlorane
- produce
- synthesizing
- fluoromethyl
- synthesizing sevoflurane
- Prior art date
Links
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 title 1
- 229960002078 sevoflurane Drugs 0.000 title 1
- OOKYWAXNZYBZER-UHFFFAOYSA-N 3-amino-3-(4-ethoxy-3-methoxyphenyl)propanoic acid Chemical compound CCOC1=CC=C(C(N)CC(O)=O)C=C1OC OOKYWAXNZYBZER-UHFFFAOYSA-N 0.000 abstract 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 abstract 1
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical compound C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- 229910001515 alkali metal fluoride Inorganic materials 0.000 abstract 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- General Preparation And Processing Of Foods (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/280,794 US6100434A (en) | 1999-03-26 | 1999-03-26 | Method for synthesizing sevoflurane and an intermediate thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1165478T3 true DK1165478T3 (da) | 2005-11-07 |
Family
ID=23074683
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00918331T DK1165478T3 (da) | 1999-03-26 | 2000-03-24 | Fremgangsmåde til syntetisering af sevofluran og et mellemprodukt deraf |
Country Status (11)
Country | Link |
---|---|
US (1) | US6100434A (da) |
EP (1) | EP1165478B1 (da) |
JP (1) | JP2002540179A (da) |
AT (1) | ATE299486T1 (da) |
AU (1) | AU773249B2 (da) |
CA (1) | CA2366673A1 (da) |
DE (1) | DE60021258T2 (da) |
DK (1) | DK1165478T3 (da) |
ES (1) | ES2246842T3 (da) |
PT (1) | PT1165478E (da) |
WO (1) | WO2000058251A1 (da) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271422B1 (en) * | 2000-06-01 | 2001-08-07 | Abbott Laboratories | Method for fluoromethylation of alcohols via halogenative decarboxylation |
US6245949B1 (en) * | 2000-06-01 | 2001-06-12 | Abbott Laboratories | Synthetic method for the fluoromethylation of alcohols |
CA2512384C (en) * | 2003-01-14 | 2013-03-19 | Baxter International Inc. | Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis |
ES2402145T3 (es) * | 2004-11-17 | 2013-04-29 | Piramal Critical Care, Inc. | Procedimiento para la preparación de sevoflurano |
JP5244109B2 (ja) * | 2006-09-29 | 2013-07-24 | クリスタリア プロデュトス キミコス ファーマシューティコス リミターダ | クロロメチル2,2,2―トリフロオロ−1−(トリフルオロメチル)エチルエーテルの製造方法 |
WO2008037040A2 (en) | 2006-09-29 | 2008-04-03 | Cristália Produtos Químicos Farmacêuticos Ltda. | Process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether |
JP5163064B2 (ja) * | 2007-11-13 | 2013-03-13 | ダイキン工業株式会社 | 新規カルボン酸エステル、その用途及びその製造方法 |
US7732647B2 (en) * | 2007-12-27 | 2010-06-08 | Halocarbon Products Corporation | Process for the purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) |
CN101314560B (zh) * | 2008-07-02 | 2011-06-15 | 鲁南制药集团股份有限公司 | 七氟烷的合成方法 |
WO2010079057A1 (en) * | 2008-12-18 | 2010-07-15 | Shell Internationale Research Maatschappij B.V. | Multi stage process for producing hydrocarbons from syngas |
WO2010096959A1 (zh) * | 2009-02-25 | 2010-09-02 | 江苏恒瑞医药股份有限公司 | 制备氯甲基-1,1,1,3,3,3-六氟异丙基醚的方法 |
JP2013501750A (ja) | 2009-08-10 | 2013-01-17 | ゾルファイ フルーオル ゲゼルシャフト ミット ベシュレンクテル ハフツング | セボフルランの製造方法 |
US20130317251A1 (en) | 2011-02-10 | 2013-11-28 | Solvay Sa | Process for the manufacture of fluoromethoxymalonic acid derivatives |
US8729313B2 (en) | 2011-08-15 | 2014-05-20 | Baxter International Inc. | Process for the manufacturing of sevoflurane |
EP2626341A1 (en) | 2012-02-10 | 2013-08-14 | Solvay Sa | Manufacture of hexafluoroisopropanol |
CN103804151A (zh) * | 2012-11-07 | 2014-05-21 | 东莞市长安东阳光铝业研发有限公司 | 一种七氟醚的制备方法 |
AU2017222392A1 (en) | 2016-02-23 | 2018-08-23 | Sagetech Medical Equipment Limited | Improvements to the manufacture and remanufacture of volatile anaesthetic agents using supercritical fluids |
CN108689808B (zh) * | 2017-04-06 | 2021-11-16 | 江苏恒瑞医药股份有限公司 | 一种氯甲基六氟异丙醚的制备方法 |
CN108727166B (zh) * | 2017-04-17 | 2021-06-29 | 江苏恒瑞医药股份有限公司 | 一种氯甲基六氟异丙醚的精制方法 |
CN107698430B (zh) * | 2017-11-01 | 2021-01-08 | 华东医药(西安)博华制药有限公司 | 一种七氟烷反应液的后处理方法 |
CN110105178A (zh) * | 2019-05-17 | 2019-08-09 | 华东医药(西安)博华制药有限公司 | 一种合成七氟烷中间体的方法 |
CN114057546A (zh) * | 2021-05-07 | 2022-02-18 | 安徽伟祥新材料有限公司 | 一种3-氟-1-丙醇的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2992276A (en) * | 1959-05-20 | 1961-07-11 | Du Pont | Process for preparing polyfluoro alkyl compounds |
US3476860A (en) * | 1966-12-08 | 1969-11-04 | Air Reduction | Halomethyl fluoroisopropyl ethers as anesthetic agents |
GB1250928A (da) * | 1968-10-28 | 1971-10-27 | ||
US3689571A (en) * | 1970-07-31 | 1972-09-05 | Baxter Laboratories Inc | Fluorinated ether |
US3683092A (en) * | 1970-07-31 | 1972-08-08 | Baxter Laboratories Inc | Method of anesthesia |
US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
US4874901A (en) * | 1988-05-06 | 1989-10-17 | Boc, Inc. | Process for the production of polyfluorinated ethers |
ES2169345T5 (es) * | 1996-02-21 | 2005-05-01 | Central Glass Company, Limited | Procedimiento de preparacion de eter de fluorometilo 1,1,1,3,3,3-hexafluoroisopropilico. |
US5969193A (en) * | 1997-08-18 | 1999-10-19 | Medeva Pharmaceuticals Pa, Inc. | Method for the preparation of sevoflurane |
US5886239A (en) * | 1997-11-21 | 1999-03-23 | Baxter International Inc. | Method of preparing monofluoromethyl ethers |
-
1999
- 1999-03-26 US US09/280,794 patent/US6100434A/en not_active Expired - Lifetime
-
2000
- 2000-03-24 EP EP00918331A patent/EP1165478B1/en not_active Expired - Lifetime
- 2000-03-24 AU AU39160/00A patent/AU773249B2/en not_active Ceased
- 2000-03-24 PT PT00918331T patent/PT1165478E/pt unknown
- 2000-03-24 DE DE60021258T patent/DE60021258T2/de not_active Expired - Fee Related
- 2000-03-24 CA CA002366673A patent/CA2366673A1/en not_active Abandoned
- 2000-03-24 ES ES00918331T patent/ES2246842T3/es not_active Expired - Lifetime
- 2000-03-24 AT AT00918331T patent/ATE299486T1/de not_active IP Right Cessation
- 2000-03-24 DK DK00918331T patent/DK1165478T3/da active
- 2000-03-24 WO PCT/US2000/007801 patent/WO2000058251A1/en active IP Right Grant
- 2000-03-24 JP JP2000607957A patent/JP2002540179A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1165478B1 (en) | 2005-07-13 |
US6100434A (en) | 2000-08-08 |
AU773249B2 (en) | 2004-05-20 |
CA2366673A1 (en) | 2000-10-05 |
EP1165478A1 (en) | 2002-01-02 |
PT1165478E (pt) | 2005-11-30 |
ATE299486T1 (de) | 2005-07-15 |
AU3916000A (en) | 2000-10-16 |
DE60021258D1 (de) | 2005-08-18 |
ES2246842T3 (es) | 2006-03-01 |
DE60021258T2 (de) | 2006-04-20 |
JP2002540179A (ja) | 2002-11-26 |
WO2000058251A1 (en) | 2000-10-05 |
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