ATE297467T1 - Für die regulation und reifung von urease notwendige helicobakter pylori-gene und ihre nutzung - Google Patents

Für die regulation und reifung von urease notwendige helicobakter pylori-gene und ihre nutzung

Info

Publication number
ATE297467T1
ATE297467T1 AT92922373T AT92922373T ATE297467T1 AT E297467 T1 ATE297467 T1 AT E297467T1 AT 92922373 T AT92922373 T AT 92922373T AT 92922373 T AT92922373 T AT 92922373T AT E297467 T1 ATE297467 T1 AT E297467T1
Authority
AT
Austria
Prior art keywords
pct
urease
maturation
regulation
polypeptides
Prior art date
Application number
AT92922373T
Other languages
English (en)
Inventor
Agnes Labigne
Valerie Cussac
Richard Ferrero
Original Assignee
Pasteur Institut
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Inst Nat Sante Rech Med filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE297467T1 publication Critical patent/ATE297467T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT92922373T 1991-10-03 1992-10-02 Für die regulation und reifung von urease notwendige helicobakter pylori-gene und ihre nutzung ATE297467T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9112198A FR2682122B1 (fr) 1991-10-03 1991-10-03 Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
PCT/FR1992/000921 WO1993007273A1 (fr) 1991-10-03 1992-10-02 Genes d'helicobacter pylori necessaires pour la regulation et la maturation de l'urease et leur utilisation

Publications (1)

Publication Number Publication Date
ATE297467T1 true ATE297467T1 (de) 2005-06-15

Family

ID=9417566

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92922373T ATE297467T1 (de) 1991-10-03 1992-10-02 Für die regulation und reifung von urease notwendige helicobakter pylori-gene und ihre nutzung

Country Status (10)

Country Link
US (3) US5986051A (de)
EP (1) EP0610322B1 (de)
JP (3) JPH07500010A (de)
AT (1) ATE297467T1 (de)
CA (1) CA2120527C (de)
DE (1) DE69233522T2 (de)
ES (1) ES2243920T3 (de)
FR (1) FR2682122B1 (de)
SG (1) SG52561A1 (de)
WO (1) WO1993007273A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
US5866375A (en) * 1991-10-31 1999-02-02 Chiron S.P.A. Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
WO1994006474A1 (en) * 1992-09-16 1994-03-31 Galagen Inc. ANTIBODY TREATMENT OF $i(HELICOBACTER PYLORI)
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
WO1995014093A1 (en) * 1993-05-19 1995-05-26 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides
ATE244578T1 (de) * 1993-07-27 2003-07-15 Csl Ltd Behandlung eines durch helicobakter verursachten gastroduodenalen krankheit
KR19990007828A (ko) * 1995-04-21 1999-01-25 피터 터비 헬리코박터 감염 방어 항원
TR199701538T1 (xx) * 1995-06-07 1998-03-21 Astra Aktiebolag Helibakter pilor'un n�kleik asit ve amino asit sekanslar�.
FR2736360B1 (fr) 1995-07-04 1997-09-05 Pasteur Institut Clonage et caracterisation du gene fiba de h.pylori, production de souches aflagellees
GB2307987A (en) * 1995-12-06 1997-06-11 Univ Manchester Epitopes of the urease of Helicobacter pylori as dignostic agents; pharmaceuticals comprising such epitopes or the antibodies thereto
EP0835928A1 (de) * 1996-10-11 1998-04-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Helicobacter Pylori Lebendimpfstoff
US6248551B1 (en) * 1997-03-28 2001-06-19 Institut Pasteur Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
JP3430853B2 (ja) 1997-04-11 2003-07-28 株式会社ゲン・コーポレーション 胃炎、胃潰瘍および十二指腸潰瘍の予防剤並びに治療剤
US6190667B1 (en) * 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
EP1173560A1 (de) 1999-04-30 2002-01-23 Hybrigenics S.A. Ansammlung von prokaryotischen dna für two-hybrid systeme helicobacter pylori protein-protein-wechselwirkungen und verwendung davon
ATE535600T1 (de) 2002-04-05 2011-12-15 Pasteur Institut Identifizierung der virulenz-assoziierten region rd1, die die entwicklung von verbesserten impstoffen mit m. microti ermöglicht
US20050009037A1 (en) * 2002-08-16 2005-01-13 Yung-Fu Chang Helicobacter bizzozeronii outer membrane protein encoding gene and its use in diagnostic and treatment methods
US20040142343A1 (en) * 2002-08-16 2004-07-22 Yung-Fu Chang Helicobacter bizzozeronii urease genes and their uses in diagnostic and treatment methods
CA2517899A1 (en) 2003-03-06 2004-09-16 Children's Hospital, Inc. Genes of an otitis media isolate of nontypeable haemophilus influenzae
CA2541765A1 (en) 2003-10-10 2004-10-01 Promega Corporation Luciferase biosensor
JP2008509168A (ja) 2004-08-13 2008-03-27 マーシャル，バリー，ジェー． 細菌デリバリシステム
US8029777B2 (en) 2004-08-13 2011-10-04 Marshall Barry J Helicobacter system and uses thereof
EP2327768B1 (de) 2006-04-03 2015-09-09 Promega Corporation Permutierte und nichtpermutierte Luciferase-Biosensoren
ATE542903T1 (de) 2008-05-19 2012-02-15 Promega Corp Luciferase-biosensoren für camp
US9290794B2 (en) 2010-05-11 2016-03-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
US8735559B2 (en) 2010-05-11 2014-05-27 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
AU2012225146A1 (en) * 2011-03-09 2013-09-26 Ondek Pty Ltd Gene expression and eradication system in Helicobacter pylori
CN104962541A (zh) * 2015-03-31 2015-10-07 芜湖康卫生物科技有限公司 口服重组幽门螺杆菌疫苗的纯化工艺
CN109536628B (zh) * 2019-01-21 2020-10-13 北京大学第三医院（北京大学第三临床医学院） 一种胃幽门螺杆菌特异性分子标记及检测试剂盒
CN113652494A (zh) * 2021-09-30 2021-11-16 山西康健恩生物科技有限公司 一种检测幽门螺杆菌的探针、引物组和试剂盒

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785086A (en) * 1985-01-17 1988-11-15 Integrated Genetics, Inc. Test for Campylobacter
DE3686362T2 (de) * 1985-06-13 1993-02-11 Marshall Barry James Verfahren zur behandlung von magen-darmstoerungen.
US5459041A (en) * 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
US5498528A (en) * 1994-06-10 1996-03-12 King; Wing Detection of helicobacter pylori
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
ATE433325T1 (de) * 1995-04-28 2009-06-15 Merieux Oravax Snc Multimerer, rekombinanter urease impfstoff
AR003125A1 (es) * 1995-06-01 1998-07-08 Astra Ab Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la
EP0745674B1 (de) * 1995-06-02 2006-07-05 Eisai Co., Ltd. Helicobacter Polypeptide, deren Herstellung und Verwendung
WO1996040893A1 (en) * 1995-06-07 1996-12-19 Astra Aktiebolag Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics

Also Published As

Publication number Publication date
JPH07500010A (ja) 1995-01-05
DE69233522T2 (de) 2006-03-16
WO1993007273A1 (fr) 1993-04-15
US5986051A (en) 1999-11-16
FR2682122A1 (fr) 1993-04-09
US6271017B1 (en) 2001-08-07
EP0610322B1 (de) 2005-06-08
FR2682122B1 (fr) 1995-06-09
DE69233522D1 (de) 2005-07-14
EP0610322A1 (de) 1994-08-17
SG52561A1 (en) 1998-09-28
ES2243920T3 (es) 2005-12-01
US6027878A (en) 2000-02-22
CA2120527A1 (fr) 1993-04-15
JP2004121216A (ja) 2004-04-22
JP2002315589A (ja) 2002-10-29
CA2120527C (fr) 2008-12-02
JP3581352B2 (ja) 2004-10-27

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