ATE28745T1 - Neue komplexbildner, komplexe und komplexsalze. - Google Patents

Neue komplexbildner, komplexe und komplexsalze.

Info

Publication number
ATE28745T1
ATE28745T1 AT84730074T AT84730074T ATE28745T1 AT E28745 T1 ATE28745 T1 AT E28745T1 AT 84730074 T AT84730074 T AT 84730074T AT 84730074 T AT84730074 T AT 84730074T AT E28745 T1 ATE28745 T1 AT E28745T1
Authority
AT
Austria
Prior art keywords
group
represent
complex
numbers
branched chain
Prior art date
Application number
AT84730074T
Other languages
German (de)
English (en)
Inventor
Heinz Dr Gries
Franz-Josef Dr Renneke
Hanns-Joachim Dr Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE28745T1 publication Critical patent/ATE28745T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048—DTPA (diethylenetriamine tetraacetic acid)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT84730074T 1983-07-01 1984-06-28 Neue komplexbildner, komplexe und komplexsalze. ATE28745T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3324235A DE3324235A1 (de) 1983-07-01 1983-07-01 Neue komplexbildner, komplexe und komplexsalze
EP84730074A EP0130934B1 (de) 1983-07-01 1984-06-28 Neue Komplexbildner, Komplexe und Komplexsalze

Publications (1)

Publication Number Publication Date
ATE28745T1 true ATE28745T1 (de) 1987-08-15

Family

ID=6203212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84730074T ATE28745T1 (de) 1983-07-01 1984-06-28 Neue komplexbildner, komplexe und komplexsalze.

Country Status (8)

Country Link
US (2) US5316756A (enExample)
EP (1) EP0130934B1 (enExample)
JP (1) JPS6036452A (enExample)
AT (1) ATE28745T1 (enExample)
CA (1) CA1253514A (enExample)
DE (2) DE3324235A1 (enExample)
DK (1) DK171352B1 (enExample)
IE (1) IE57929B1 (enExample)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8413772D0 (en) * 1984-05-30 1984-07-04 Nyegaard & Co As Chemical compounds
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
DE3508000A1 (de) * 1985-03-04 1986-09-04 Schering AG, Berlin und Bergkamen, 1000 Berlin Ferromagnetische partikel fuer die nmr-diagnostik
JPH07100666B2 (ja) * 1986-04-07 1995-11-01 フランスワ ディエトラン 濃度断層撮影用造影剤
EP0250358A3 (en) * 1986-06-20 1988-10-05 Schering Aktiengesellschaft Novel complex compounds
AU608759B2 (en) * 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
DE3640708C2 (de) * 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB9007965D0 (en) * 1990-04-09 1990-06-06 Nycomed As Compounds
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
HU208947B (en) * 1987-07-16 1994-02-28 Nycomed As Diagnostical compositions and process for producing aminopolycarboxylic acids, their derivatives and metal-kelates
DE3724188C2 (de) * 1987-07-17 1995-05-18 Heinz Dr Gries Metallhaltige Oligosaccharid-Polysulfate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel
GB8801646D0 (en) * 1988-01-26 1988-02-24 Nycomed As Chemical compounds
JPH01240620A (ja) * 1988-03-16 1989-09-26 Miyamoto Kogyosho:Kk ビレット調質方法とビレット調質炉
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
US6039931A (en) * 1989-06-30 2000-03-21 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
CA2065415A1 (en) * 1989-09-05 1991-03-06 Raghavan Rajagopalan Magnetic resonance imaging agents
US5494655A (en) * 1990-03-09 1996-02-27 The Regents Of The University Of California Methods for detecting blood perfusion variations by magnetic resonance imaging
WO1992017215A1 (en) * 1990-03-28 1992-10-15 Nycomed Salutar, Inc. Contrast media
DE4011684A1 (de) 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
GB9007967D0 (en) * 1990-04-09 1990-06-06 Nycomed As Compounds
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5077037A (en) * 1990-08-03 1991-12-31 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
US5908931A (en) * 1990-12-14 1999-06-01 Mallinckrodt Inc. Preorganized hexadentate ligands useful in radiographic imaging agents
GB9027922D0 (en) * 1990-12-21 1991-02-13 Nycomed As Compounds
AU660013B2 (en) * 1991-03-27 1995-06-08 Nycomed Salutar, Inc. Contrast media
EP0594640A4 (en) * 1991-05-23 1998-06-03 Evan C Unger Liposoluble compounds for magnetic resonance imaging
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
GB9208908D0 (en) * 1992-04-24 1992-06-10 Nycomed As Contrast agents
US5439913A (en) 1992-05-12 1995-08-08 Schering Aktiengesellschaft Contraception method using competitive progesterone antagonists and novel compounds useful therein
DE4302287A1 (de) * 1993-01-25 1994-07-28 Schering Ag Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
GB9321595D0 (en) * 1993-10-20 1993-12-08 Nycomed Imaging As Contrast agents
US5571498A (en) * 1994-06-02 1996-11-05 Hemagen/Pfc Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents
US5614170A (en) * 1994-11-30 1997-03-25 Hemagen/Pfc Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
DE19507819A1 (de) * 1995-02-21 1996-08-22 Schering Ag DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
DE19507822B4 (de) * 1995-02-21 2006-07-20 Schering Ag Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
ATE384120T1 (de) * 1999-08-27 2008-02-15 Invitrogen Corp Metallbindende verbindungen und deren verwendung in zusammensetzungen für zellkulturmedien
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US6525234B1 (en) * 2000-11-21 2003-02-25 Exxonmobil Oil Corporation Process for liquid phase aromatics alkylation comprising in-situ catalyst reactivation with polar compounds
US8669236B2 (en) 2005-05-12 2014-03-11 The General Hospital Corporation Biotinylated compositions
FI20065030L (fi) * 2006-01-17 2007-07-18 Wallac Oy Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
EP2890788A1 (en) 2012-08-31 2015-07-08 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
HUP1500076A2 (hu) * 2015-02-25 2016-09-28 Debreceni Egyetem Új helyettesített etilén-diamin-tetraecetsav-bisz(amid) származékok és alkalmazásuk Mn(II)-alapú MRI kontrasztanyag ligandumként
US10568976B2 (en) 2015-11-26 2020-02-25 Debreceni Egyetem 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
US10494379B2 (en) 2015-11-26 2019-12-03 Debreceni Egyetem 6-oxa-3,9,15-triaza-bicyclo[9.3.1]pentadeca-1(14),11(15),12-triene derivatives based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents
EP3380473A1 (en) 2015-11-26 2018-10-03 Debreceni Egyetem New 2, 1 l -diaza-[3.3](2,6)pyridinophane compounds and their application as ligands of essential metal ion based mri contrast agents and 52mn based pet contrast agents
DE102023001815A1 (de) * 2023-05-05 2024-11-07 Siempelkamp Maschinen- Und Anlagenbau Gmbh Verfahren und Vorrichtung (Anlage) zur Herstellung einer Werkstoffplatte, Werkstoffplatte, sowie Verwendung einer Werkstoffplatte

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2673213A (en) * 1952-06-03 1954-03-23 Frederick C Bersworth Polyalkylene polyamino acids
US2854458A (en) * 1954-07-15 1958-09-30 Basf Ag Complex heavy metal salts
US2831885A (en) * 1954-08-13 1958-04-22 Geigy Chem Corp Hydroxyethyl polycarboxymethyl polyamines
US2954458A (en) * 1958-07-17 1960-09-27 Mankouski Charles Holder for welding rods
US3024274A (en) * 1959-03-18 1962-03-06 California Research Corp Amides of cyclic diaminealkylenecarboxylic acids
US3232083A (en) * 1963-12-09 1966-02-01 Rollins Joseph Ashby Lock cylinder plug holder
CH490473A (de) * 1966-11-04 1970-05-15 Basf Ag Verwendung von B-Carbamyl-B-hydroxyäthylaminen als Komplexbildner für die Maskierung von Schwermetallionen bei der Behandlung von Textilmaterialien
GB1374979A (en) * 1970-12-21 1974-11-20 Nat Res Dev 3,5-dioxopiperazine derivatives
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
DE2028219A1 (en) * 1969-06-11 1972-01-20 Stauffer Chemical Co, New York, N Y (V St A ) New derivatives of ethylenediamine tetraa - cetic acid
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
GB1471894A (en) * 1973-12-12 1977-04-27 Wilkinson Sword Ltd Compositions for application to or consumption by the body and containing a compound having a physiological cooling effect
US4022420A (en) * 1975-11-06 1977-05-10 Anacleto Pace Formwork and connecting means apparatus for casting reinforced concrete
DE2650966A1 (de) * 1975-11-14 1977-05-26 Ciba Geigy Ag Gegebenenfalls veraetherte basische methylolverbindungen und deren salze
US4352751A (en) * 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4308249A (en) * 1979-12-13 1981-12-29 G. D. Searle & Co. Radiopharmaceutical complexes of N-(tri-substituted alkyl)-iminodiacetic acids
US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4454106A (en) * 1982-06-07 1984-06-12 Gansow Otto A Use of metal chelate conjugated monoclonal antibodies
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4687659A (en) * 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4859451A (en) * 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4933441A (en) * 1987-01-27 1990-06-12 Gibby Wendell A Contrast enhancing agents for magnetic resonance images
US5078986A (en) * 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent

Also Published As

Publication number Publication date
DK320884A (da) 1985-01-02
EP0130934A1 (de) 1985-01-09
JPH0380148B2 (enExample) 1991-12-24
IE841683L (en) 1985-01-01
US5316756A (en) 1994-05-31
US5419894A (en) 1995-05-30
DK171352B1 (da) 1996-09-16
DE3465191D1 (en) 1987-09-10
EP0130934B1 (de) 1987-08-05
DE3324235A1 (de) 1985-01-10
IE57929B1 (en) 1993-05-19
CA1253514A (en) 1989-05-02
DK320884D0 (da) 1984-06-29
JPS6036452A (ja) 1985-02-25

Similar Documents

Publication Publication Date Title
ATE28745T1 (de) Neue komplexbildner, komplexe und komplexsalze.
FR2311098A1 (fr) Alliage resistant a l'usure
ZA803251B (en) Pyroglutamic acid derivatives and analogs
NO871990L (no) Quinolinkarboksylsyre-derivater.
RO81146B (ro) Compozitie herbicida
KR830001872A (ko) 펩타이드 및 그의 제조방법
MY101352A (en) New benzamides.
SE8500573D0 (sv) Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
FR2358141A1 (fr) Nouveaux anesthesiques locaux
ES8500259A1 (es) "un metodo para preparar derivados de 3-metilflavona".
FR2359131A1 (fr) Agents cardiovasculaires a base de thiazoles
DE3563051D1 (de) Tetrahydroquinolin-1-yl-carbonyl-imidazole derivatives
FR2355500A1 (fr) Composition antimicrobienne a base de 1-acyloxy-2-imidazolyl-1-phenylethanes
DE69012359D1 (de) Arbeitsmittel für eine thermodynamische Einrichtung.
FR2364204A1 (fr) Nouveaux metaaminophenols et compositions tinctoriales les contenant
FR2359150A1 (fr) Derives etain-triorganiques d'oxydes d'hydroxydiazenium utiles comme fongicides
SE8206377D0 (sv) Nya kelatbildande biskinolinforeningar
BR8504196A (pt) Composto,processo para sua preparacao,composicoes praguicidas,aplicacao e processo para combater insetos
GB1504016A (en) Fungicidal agents
FR2367766A1 (fr) Intermediaire pour la pre
CS226883A2 (en) Fungicidni prostredek a zpusob vyroby jehoucinne latky
FR2362827A1 (fr) Nouveaux diurethanes utiles comme herbicides
FR2361337A1 (fr) Nouveaux o-amino-alcoxycycloalcanes utiles comme vasodilatateurs
ATE2747T1 (de) Neue derivate des 9-chlorprednisolons, ihre herstellung und verwendung.
RO83938B (ro) COMPOZITIE ERBICIDA CU DURATA PRELUNGITA îN SOL

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee