ATE284403T1 - Triazolopyridazinderivate als liganden für gaba- rezeptoren - Google Patents

Triazolopyridazinderivate als liganden für gaba- rezeptoren

Info

Publication number
ATE284403T1
ATE284403T1 AT00900748T AT00900748T ATE284403T1 AT E284403 T1 ATE284403 T1 AT E284403T1 AT 00900748 T AT00900748 T AT 00900748T AT 00900748 T AT00900748 T AT 00900748T AT E284403 T1 ATE284403 T1 AT E284403T1
Authority
AT
Austria
Prior art keywords
ligands
gaba receptors
triazolopyridazine derivatives
derivatives
substituted
Prior art date
Application number
AT00900748T
Other languages
German (de)
English (en)
Inventor
William Robert Carling
Piniero Jose Luis Castro
Richard Thomas Lewis
Kevin William Moore
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9901743.6A external-priority patent/GB9901743D0/en
Priority claimed from GBGB9901744.4A external-priority patent/GB9901744D0/en
Priority claimed from GBGB9912429.9A external-priority patent/GB9912429D0/en
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE284403T1 publication Critical patent/ATE284403T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00900748T 1999-01-27 2000-01-19 Triazolopyridazinderivate als liganden für gaba- rezeptoren ATE284403T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9901743.6A GB9901743D0 (en) 1999-01-27 1999-01-27 Therapeutic agents
GBGB9901744.4A GB9901744D0 (en) 1999-01-27 1999-01-27 Therapeutic agents
GBGB9912429.9A GB9912429D0 (en) 1999-05-27 1999-05-27 Therapeutic agents
PCT/GB2000/000183 WO2000044752A1 (en) 1999-01-27 2000-01-19 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (1)

Publication Number Publication Date
ATE284403T1 true ATE284403T1 (de) 2004-12-15

Family

ID=27269629

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900748T ATE284403T1 (de) 1999-01-27 2000-01-19 Triazolopyridazinderivate als liganden für gaba- rezeptoren

Country Status (9)

Country Link
US (2) US6500828B1 (enExample)
EP (1) EP1149102B1 (enExample)
JP (1) JP2002535407A (enExample)
AT (1) ATE284403T1 (enExample)
AU (1) AU772947B2 (enExample)
CA (1) CA2359008C (enExample)
DE (1) DE60016566T2 (enExample)
ES (1) ES2232416T3 (enExample)
WO (1) WO2000044752A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
WO2002083675A2 (en) 2001-04-10 2002-10-24 Merck Sharp & Dohme Limited Inhibitors of akt activity
US6958334B2 (en) 2001-04-10 2005-10-25 Merck & Co., Inc. Inhibitors of Akt activity
WO2002083139A1 (en) 2001-04-10 2002-10-24 Merck & Co., Inc. Inhibitors of akt activity
DE60315876T2 (de) * 2002-11-28 2008-05-21 Neurosearch A/S Verfahren zum screening für verbindungen mit sedativer oder anxiolytischer potenz
WO2006061428A2 (en) * 2004-12-10 2006-06-15 Universität Zürich Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7998971B2 (en) 2006-09-08 2011-08-16 Braincells Inc. Combinations containing a 4-acylaminopyridine derivative
CN102176826B (zh) * 2008-08-29 2014-08-20 康瑟特制药公司 取代的三唑并哒嗪衍生物
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (en) 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
WO2011047315A1 (en) 2009-10-15 2011-04-21 Concert Pharmaceuticals, Inc. Subsitituted benzimidazoles
US20150158870A1 (en) * 2012-05-11 2015-06-11 Concert Pharmaceuticals Inc. Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
US20150119398A1 (en) * 2012-05-11 2015-04-30 Concert Pharmaceuticals Inc. Form 2 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
WO2013170243A1 (en) * 2012-05-11 2013-11-14 Concert Pharmaceuticals, Inc. Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
WO2015095549A1 (en) * 2013-12-18 2015-06-25 Concert Pharmaceuticals, Inc. Dosage regimen for gabaa receptor subtype selective drug
JP7353663B2 (ja) 2018-09-13 2023-10-02 サニオナ エー／エス Ｇａｂａａ受容体リガンド
EP4511025A1 (en) * 2022-04-20 2025-02-26 Engrail Therapeutics, Inc. GABAa RECEPTOR MODULATOR SALTS, PARTICLES, AND USES THEREOF
CN115837022B (zh) * 2023-02-20 2023-04-25 中山大学附属第八医院（深圳福田） 1,2,4三唑并4,3-b哒嗪衍生物在制备抗衰老药物中的应用
WO2025141131A1 (en) 2023-12-27 2025-07-03 Saniona A/S A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU2899A (sh) * 1996-07-25 2000-03-21 Merck Sharp & Dohme Limited Supstituisani triazolo-piridazin derivati kao ligandi za gaba receptore

Also Published As

Publication number Publication date
ES2232416T3 (es) 2005-06-01
CA2359008C (en) 2008-05-20
WO2000044752A1 (en) 2000-08-03
AU772947B2 (en) 2004-05-13
EP1149102B1 (en) 2004-12-08
DE60016566T2 (de) 2005-12-15
US6500828B1 (en) 2002-12-31
JP2002535407A (ja) 2002-10-22
US20030158203A1 (en) 2003-08-21
EP1149102A1 (en) 2001-10-31
CA2359008A1 (en) 2000-08-03
AU3066900A (en) 2000-08-18
DE60016566D1 (de) 2005-01-13

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties