ATE283271T1 - Porphyrin derivate, ihre verwendung in der photodynamischen therapie und diese enthaltende medizinische geräte - Google Patents

Porphyrin derivate, ihre verwendung in der photodynamischen therapie und diese enthaltende medizinische geräte

Info

Publication number
ATE283271T1
ATE283271T1 AT99943075T AT99943075T ATE283271T1 AT E283271 T1 ATE283271 T1 AT E283271T1 AT 99943075 T AT99943075 T AT 99943075T AT 99943075 T AT99943075 T AT 99943075T AT E283271 T1 ATE283271 T1 AT E283271T1
Authority
AT
Austria
Prior art keywords
medical devices
photodynamic therapy
devices containing
porphyrin derivatives
compound
Prior art date
Application number
AT99943075T
Other languages
English (en)
Inventor
William Guy Love
Michael John Cook
David Andrew Russell
Original Assignee
Destiny Pharma Ltd
Univ East Anglia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9818789.1A external-priority patent/GB9818789D0/en
Priority claimed from GBGB9912971.0A external-priority patent/GB9912971D0/en
Application filed by Destiny Pharma Ltd, Univ East Anglia filed Critical Destiny Pharma Ltd
Application granted granted Critical
Publication of ATE283271T1 publication Critical patent/ATE283271T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99943075T 1998-08-28 1999-08-31 Porphyrin derivate, ihre verwendung in der photodynamischen therapie und diese enthaltende medizinische geräte ATE283271T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9818789.1A GB9818789D0 (en) 1998-08-28 1998-08-28 Medical device
GBGB9912971.0A GB9912971D0 (en) 1999-06-04 1999-06-04 Medical composition
PCT/GB1999/002864 WO2000012512A1 (en) 1998-08-28 1999-08-31 Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them

Publications (1)

Publication Number Publication Date
ATE283271T1 true ATE283271T1 (de) 2004-12-15

Family

ID=26314278

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99943075T ATE283271T1 (de) 1998-08-28 1999-08-31 Porphyrin derivate, ihre verwendung in der photodynamischen therapie und diese enthaltende medizinische geräte

Country Status (9)

Country Link
US (1) US6630128B1 (de)
EP (1) EP1107971B1 (de)
JP (1) JP5008793B2 (de)
AT (1) ATE283271T1 (de)
AU (1) AU765509B2 (de)
CA (1) CA2341507C (de)
DE (1) DE69922216T2 (de)
ES (1) ES2237146T3 (de)
WO (1) WO2000012512A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050255039A1 (en) * 1998-06-26 2005-11-17 Pro Surg, Inc., A California Corporation Gel injection treatment of breast, fibroids & endometrial ablation
US20030017164A1 (en) 2001-07-03 2003-01-23 Mallinckrodt Inc. Dye-azide compounds for dual phototherapy
US6545102B1 (en) * 2001-09-27 2003-04-08 Lumigen, Inc. Polymer-supported photosensitizers
US6962910B2 (en) * 2002-02-01 2005-11-08 Virginia Tech Intellectual Properties, Inc. Supramolecular complexes as photoactivated DNA cleavage agents
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
US7008937B2 (en) * 2003-06-10 2006-03-07 Frontier Scientific, Inc. Porphyrins and metalloporphyrins for inhibiting heme iron uptake
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
ITFI20050092A1 (it) * 2005-05-05 2006-11-06 Molteni & C Derivati ftalocianinici, processo per la loro preparazione, composizioni farmaceutiche che li contengono e loro uso
ITFI20050093A1 (it) * 2005-05-05 2006-11-06 Molteni & C Processo per la preparazione di cloruri di derivati ftalocianinici comprendenti almeno un gruppo ammonio quaternario
WO2007000472A1 (en) * 2005-06-29 2007-01-04 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Self-sterilizing products
WO2007019478A2 (en) * 2005-08-08 2007-02-15 Board Of Regents, The University Of Texas System Drug delivery from implants using self-assembled monolayers - therapeutic sams
CA2662530A1 (en) * 2005-09-30 2007-04-12 Cornova, Inc. Systems and methods for analysis and treatment of a body lumen
GB0602125D0 (en) * 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
US20120075577A1 (en) 2006-03-20 2012-03-29 Ishak Andrew W High performance selective light wavelength filtering providing improved contrast sensitivity
US8882267B2 (en) 2006-03-20 2014-11-11 High Performance Optics, Inc. High energy visible light filter systems with yellowness index values
EP2004197A4 (de) * 2006-03-31 2009-08-19 Univ North Carolina State Mit licht aktivierte antivirale stoffe und vorrichtungen und verfahren zur dekontamination von virus-infizierten umgebungen
US20090187108A1 (en) * 2006-09-29 2009-07-23 Cornova, Inc. Systems and methods for analysis and treatment of a body lumen
AU2007325483B2 (en) * 2006-11-28 2013-08-29 High Performance Optics, Inc. High performance selective light wavelength filtering providing improved contrast sensitivity
JP5290142B2 (ja) * 2007-02-19 2013-09-18 三栄源エフ・エフ・アイ株式会社 新規な糖連結クロリン誘導体
DK2222636T3 (da) 2007-12-21 2013-06-03 Ligand Pharm Inc Selektive androgenreceptormodulatorer (SARMS) og anvendelser deraf
EP2250181A1 (de) * 2008-02-08 2010-11-17 Binyomin A. Cohen Rutheniumverbindungen und zusammensetzungen
EP2253634A4 (de) * 2008-03-11 2012-03-21 Dainippon Printing Co Ltd Flüssiges porphyrinderivat und herstellungsverfahren dafür
EP2432542A4 (de) * 2009-05-20 2013-07-03 Cornova Inc Systeme und verfahren zur analyse und behandlung eines körperlumens
US8203118B2 (en) * 2009-12-11 2012-06-19 Honeywell International, Inc. Ion-trap mass spectrometer driven by a monolithic photodiode array
DE102010001757A1 (de) * 2010-02-10 2011-08-11 Technische Universität Graz Selbstreinigende optische Sensoren
JP5843113B2 (ja) * 2010-09-02 2016-01-13 国立大学法人群馬大学 含ケイ素置換基を導入した化合物、並びにそれを含む一重項酸素発生剤及び癌治療薬
US9126890B2 (en) * 2011-10-20 2015-09-08 International Flavors & Fragrances Inc. Low volatile reactive malodor counteractives and methods of use thereof
US9642916B2 (en) * 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
CA3159715A1 (en) * 2013-03-15 2014-09-18 Edward J. Britt Energy conversion device and method for making and using same
CN104863554A (zh) * 2014-02-26 2015-08-26 中国石油天然气股份有限公司 一种超稠油井调剖剂及应用
CN106620893B (zh) * 2015-07-23 2021-07-30 爱博诺德(北京)医疗科技股份有限公司 用于眼部疾病光治疗的材料
CN106773120A (zh) * 2015-11-25 2017-05-31 鸿富锦精密工业（深圳）有限公司 隐形眼镜镜片材料及隐形眼镜镜片
US11369688B2 (en) 2016-09-15 2022-06-28 The Regents Of The University Of California Hybrid telodendrimers
JP7620321B2 (ja) 2018-08-31 2025-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア シアニンベースをベースとするテロデンドリマー及び癌治療のための使用
KR102179530B1 (ko) * 2018-12-27 2020-11-18 서울대학교산학협력단 광감작제를 포함하는 자기 조립 나노입자 및 이를 포함하는 광역학 치료용 조성물
CN114096522A (zh) 2019-04-19 2022-02-25 利亘制药公司 化合物的晶型和制备化合物的晶型的方法
BR102019014681A2 (pt) * 2019-07-16 2021-01-26 Universidade De São Paulo - Usp processo de obtenção de superfícies poliméricas funcionalizadas com fotossensibilizadores, material polimérico funcionalizado e seu uso
US20210169549A1 (en) * 2019-12-04 2021-06-10 Acclarent, Inc. Photodynamic therapy ablation device
JP6886578B1 (ja) 2020-09-01 2021-06-16 株式会社エム・ティー・スリー 化合物又はその塩、がん治療薬、光増感剤、及び蛍光プローブ組成物
WO2022074014A1 (en) * 2020-10-05 2022-04-14 Biolitec Unternehmensbeteiligungs Ii Ag Tetrapyrrole-based compounds and their formulations for anti-microbial therapy
KR102664860B1 (ko) * 2021-06-22 2024-05-10 주식회사 에스앤지바이오텍 광응답성 위저부 스텐트
KR102605175B1 (ko) * 2021-06-22 2023-11-24 주식회사 에스앤지바이오텍 광응답성 십이지장 스텐트

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4512762A (en) 1982-11-23 1985-04-23 The Beth Israel Hospital Association Method of treatment of atherosclerosis and a balloon catheter for same
GB8429845D0 (en) * 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment
SE8505518D0 (sv) * 1985-11-22 1985-11-22 Swedish Graft Tech Ab Implantationslins, forfarande for framsstellning derav och anordning for att utfora forfarandet
US5051415A (en) 1986-01-02 1991-09-24 The University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
JPS636451A (ja) 1986-06-27 1988-01-12 Terumo Corp 酵素センサ
US4812352A (en) 1986-08-25 1989-03-14 Minnesota Mining And Manufacturing Company Article having surface layer of uniformly oriented, crystalline, organic microstructures
US5171749A (en) 1987-01-20 1992-12-15 University Of British Columbia Wavelength-specific cytotoxic agents
WO1988006175A1 (en) 1987-02-13 1988-08-25 The Secretary Of State For Defence In Her Britanni Substituted phthalocyanines
SU1553537A1 (ru) 1988-03-04 1990-03-30 Сыктывкарский Государственный Университет Им.50-Летия Ссср Способ получени водорастворимых сополимеров металлопорфиринов
GB8805849D0 (en) * 1988-03-11 1988-04-13 Efamol Holdings Porphyrins & cancer treatment
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
SU1684289A1 (ru) 1988-08-16 1991-10-15 Институт Биологической И Медицинской Химии Амн Ссср Способ получени конъюгатов на основе производного сефарозы
JP2575199B2 (ja) 1988-11-25 1997-01-22 株式会社トクヤマ カーボネート共重合体の製造方法
JP2738943B2 (ja) 1988-12-27 1998-04-08 株式会社長野計器製作所 酸素吸脱着剤用高分子錯体
JP2763612B2 (ja) 1989-09-08 1998-06-11 株式会社トクヤマ 重合性基を有するポルフィリン誘導体及びその製造方法
US5543514A (en) 1989-12-21 1996-08-06 Board Of Regents, The University Of Texas System Water-soluble sapphyrins
US5159065A (en) 1989-12-21 1992-10-27 Board Of Regents, The University Of Texas System Sapphyrins, derivatives and syntheses
US5594136A (en) 1989-12-21 1997-01-14 Pharmacyclics, Inc. Texaphyrin solid supports and devices
US5457195A (en) 1989-12-21 1995-10-10 Board Of Regents, The University Of Texas System Sapphyrin derivatives and conjugates
US5053423A (en) 1990-03-22 1991-10-01 Quadra Logic Technologies Inc. Compositions for photodynamic therapy
GB9007408D0 (en) 1990-04-02 1990-05-30 Nycomed As Compositions
CA2082934C (en) 1990-05-15 2003-08-05 Walter B. Dandliker Phthalocyanatopolyethylene glycol, and phthalocyanato saccharides as fluorescent digoxin reagents
DE69132750T2 (de) 1990-05-15 2002-06-20 Hyperion, Inc. Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden
US5622685A (en) 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
DK0485563T3 (da) 1990-05-30 1995-03-20 Deutsches Krebsforsch Polyethersubstituerede antitumormidler
JPH0657307B2 (ja) 1990-06-30 1994-08-03 ユニオン・カーバイド・インダストリアル・ガセズ・テクノロジー・コーポレーション 酸素透過高分子膜
JPH0657308B2 (ja) 1990-08-15 1994-08-03 ユニオン・カーバイド・インダストリアル・ガセズ・テクノロジー・コーポレーション 酸素分離多孔質膜
ATE146508T1 (de) 1990-11-02 1997-01-15 Zeneca Ltd Polysubstituierte phthalocyanine
US5411580A (en) 1991-07-31 1995-05-02 Praxair Technology, Inc. Oxygen-separating porous membranes
JPH05247081A (ja) * 1991-08-05 1993-09-24 Honen Corp 新規なテトラフェニルポルフィン配糖体およびその製造方法
ES2149178T3 (es) * 1991-08-16 2000-11-01 Miles A Galin Implante ocular para la camara anterior refractivo, recubierto con un medicamento.
US5599924A (en) 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5371199B1 (en) 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5783306A (en) 1992-08-14 1998-07-21 Trustees Of The University Of Pennsylvania Hyperpolarizable compounds and devices fabricated therefrom
WO1994004507A1 (en) 1992-08-21 1994-03-03 The Board Of Trustees Of The Leland Stanford Junior University Basket porphyrin oxygen carriers
DE4305523A1 (de) 1993-02-17 1994-08-18 Diagnostikforschung Inst Meso-Tetraphenylporphyrin-Komplexverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
GB9317881D0 (en) 1993-08-27 1993-10-13 Secr Defence Photosensitizers
US5994339A (en) 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
CA2180556C (en) * 1994-01-26 2007-08-07 Mark A. Reiley Improved inflatable device for use in surgical protocol relating to fixation of bone
US5707986A (en) 1994-03-14 1998-01-13 Miller; Joan W. Angiographic method using green porphyrins in primate eyes
WO1995029702A1 (en) 1994-04-28 1995-11-09 Board Of Regents, The University Of Texas System Texaphyrin solid-supports and devices
GB9408746D0 (en) 1994-05-03 1994-06-22 Scotia Holdings Plc Tumour locallising photosensitising compounds
US5697973A (en) 1994-09-19 1997-12-16 Peyman; Gholam A. Intraocular silicone lens
ES2249784T3 (es) 1995-06-07 2006-04-01 Duke University Antioxidantges de oxidantes.
JP2000500741A (ja) 1995-10-25 2000-01-25 イーオーイー，インコーポレイテッド 微小孔性病原体殺傷組成物
GB9524028D0 (en) 1995-11-23 1996-01-24 Secr Defence Substituted porphyrins
US5776138A (en) 1996-01-26 1998-07-07 Allergan Apparatus and methods for IOL insertion
NO304735B1 (no) 1996-02-07 1999-02-08 Singlet Oxygen Technologies As Apparat for aa tilveiebringe en singlettoksygen-aktivert oksygenholdig gasstroem
DE19627164C2 (de) 1996-07-05 1998-09-24 Deutsches Krebsforsch Herstellung polyether-aufweisender Chlorine und Bakteriochlorine, solche Verbindungen und ihre Verwendung
US5716364A (en) 1996-07-10 1998-02-10 Allergan IOL insertion apparatus and method for making and using same
US6043237A (en) 1996-12-10 2000-03-28 Qlt Phototherapeutics, Inc. Use of photodynamic therapy for prevention of secondary cataracts
AU737252B2 (en) * 1997-02-20 2001-08-16 Cook Medical Technologies Llc Coated implantable medical device

Also Published As

Publication number Publication date
ES2237146T3 (es) 2005-07-16
DE69922216D1 (de) 2004-12-30
WO2000012512A1 (en) 2000-03-09
EP1107971A1 (de) 2001-06-20
JP5008793B2 (ja) 2012-08-22
AU765509B2 (en) 2003-09-18
JP2002523509A (ja) 2002-07-30
EP1107971B1 (de) 2004-11-24
AU5636099A (en) 2000-03-21
CA2341507C (en) 2011-05-24
DE69922216T2 (de) 2005-12-01
CA2341507A1 (en) 2000-03-09
US6630128B1 (en) 2003-10-07

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