ATE282043T1 - Neue aminopropylphosphinsäuren - Google Patents

Neue aminopropylphosphinsäuren

Info

Publication number
ATE282043T1
ATE282043T1 AT00983634T AT00983634T ATE282043T1 AT E282043 T1 ATE282043 T1 AT E282043T1 AT 00983634 T AT00983634 T AT 00983634T AT 00983634 T AT00983634 T AT 00983634T AT E282043 T1 ATE282043 T1 AT E282043T1
Authority
AT
Austria
Prior art keywords
aminopropyl
new
phosphic
acids
phosphic acids
Prior art date
Application number
AT00983634T
Other languages
German (de)
English (en)
Inventor
Thomas Elebring
Peter Guzzo
Marianne Swanson
Unge Sverker Von
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0003640A external-priority patent/SE0003640D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE282043T1 publication Critical patent/ATE282043T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT00983634T 1999-12-09 2000-12-04 Neue aminopropylphosphinsäuren ATE282043T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9904508A SE9904508D0 (sv) 1999-12-09 1999-12-09 New compounds
SE0003640A SE0003640D0 (sv) 2000-10-09 2000-10-09 New compounds
PCT/SE2000/002426 WO2001042252A1 (en) 1999-12-09 2000-12-04 New aminopropylphosphinic acids

Publications (1)

Publication Number Publication Date
ATE282043T1 true ATE282043T1 (de) 2004-11-15

Family

ID=26655259

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00983634T ATE282043T1 (de) 1999-12-09 2000-12-04 Neue aminopropylphosphinsäuren

Country Status (33)

Country Link
US (5) US6576626B2 (enExample)
EP (2) EP1484333A1 (enExample)
JP (2) JP3914435B2 (enExample)
KR (1) KR100689144B1 (enExample)
CN (1) CN1198832C (enExample)
AR (1) AR030541A1 (enExample)
AT (1) ATE282043T1 (enExample)
AU (1) AU780459B2 (enExample)
BR (1) BR0016253A (enExample)
CA (1) CA2397583C (enExample)
CZ (1) CZ20021983A3 (enExample)
DE (1) DE60015796T2 (enExample)
DK (1) DK1240172T3 (enExample)
EE (1) EE05067B1 (enExample)
ES (1) ES2230174T3 (enExample)
HK (1) HK1048321B (enExample)
HU (1) HUP0300301A3 (enExample)
IL (2) IL149840A0 (enExample)
IS (1) IS2231B (enExample)
MX (1) MXPA02005536A (enExample)
MY (1) MY125414A (enExample)
NO (1) NO329595B1 (enExample)
NZ (1) NZ519376A (enExample)
PL (1) PL201789B1 (enExample)
PT (1) PT1240172E (enExample)
RU (1) RU2260595C2 (enExample)
SE (1) SE9904508D0 (enExample)
SI (1) SI1240172T1 (enExample)
SK (1) SK286904B6 (enExample)
TW (1) TWI228510B (enExample)
UA (1) UA71649C2 (enExample)
WO (1) WO2001042252A1 (enExample)
ZA (1) ZA200204127B (enExample)

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SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
BR0206980A (pt) * 2001-02-05 2004-07-06 Michael Albert Kamm Uso de um modulador do tÈnus do músculo liso
AR033779A1 (es) * 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
SE0402462D0 (sv) * 2004-10-08 2004-10-08 Astrazeneca Ab New process
US7566738B2 (en) 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
US7494985B2 (en) 2004-11-03 2009-02-24 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use
US20060160777A1 (en) * 2004-12-27 2006-07-20 Anders Lehmann New use of GABAbeta receptor agonists
AU2006327317B2 (en) 2005-12-23 2010-11-25 Astrazeneca Ab GABA-B receptor modulators
AU2006327315A1 (en) 2005-12-23 2007-06-28 Astrazeneca Ab Imidazole derivatives for the treatment of gastrointestinal disorders
WO2008033572A1 (en) 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US8026384B2 (en) * 2007-05-04 2011-09-27 Astrazeneca Ab Process for the synthesis of alkyl phosphinic acids by initiation of an amine and an amineoxide
CN101743011A (zh) * 2007-07-25 2010-06-16 阿斯利康(瑞典)有限公司 (3-氨基-2-氟丙基)次膦酸用于治疗非糜烂性反流病的用途
PE20091176A1 (es) * 2007-12-21 2009-09-03 Astrazeneca Ab Nueva forma cristalina c del acido (2r)-(3-amino-2-fluoropropil)fosfinico
EP2235027A4 (en) * 2007-12-21 2011-06-22 Astrazeneca Ab NEW CRYSTALLINE FORM OF (2R) - (3-AMINO-2-FLUOROPROPYL) PHOSPHINIC ACID
WO2009082344A1 (en) * 2007-12-21 2009-07-02 Astrazeneca Ab Novel process for making (2r)-(3-amino-2-fluoropropyl)phosphinic acid form a
WO2009145716A1 (en) * 2008-05-28 2009-12-03 Astrazeneca Ab New pharmaceutical formulation useful in gerd therapy
ES2432386T3 (es) 2008-11-05 2013-12-03 Clariant Finance (Bvi) Limited Procedimiento para la preparación de ácidos, ésteres y sales dialquilfosfínicos mono-carboxi-funcionalizados por medio de alcoholes alílicos/acroleínas y su uso
DE102008056341A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
ES2525550T3 (es) 2008-11-07 2014-12-26 Clariant Finance (Bvi) Limited Procedimiento para la preparación de ácidos, ésteres y sales dialquilfosfínicos mediante derivados del ácido acrílico y su uso
JP5743219B2 (ja) 2008-11-11 2015-07-01 クラリアント・ファイナンス・（ビーブイアイ）・リミテッド アリル化合物を用いる、モノアリル官能性ジアルキルホスフィン酸、それらの塩およびエステルの製造方法およびそれらの使用
DE102008060035A1 (de) * 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
DE102008063627A1 (de) * 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
CN103724372B (zh) 2008-12-18 2017-03-01 科莱恩金融(Bvi)有限公司 亚乙基二烷基次膦酸、亚乙基二烷基次膦酸酯和亚乙基二烷基次膦酸盐的用途
DE102008064003A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders

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US5281747A (en) 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5567840A (en) 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5006560A (en) 1989-12-20 1991-04-09 Schering Corporation Use of GABA-B selective agonists as anti-tussive agents
IL98502A (en) * 1990-06-22 1998-04-05 Ciba Geigy Ag Aminoalkane phosphinic acid derivatives, process for their preparation and pharmaceutical compositions containing them
FR2663934B1 (fr) 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
FR2722192A1 (fr) 1994-07-06 1996-01-12 Adir Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9420784D0 (en) 1994-10-14 1994-11-30 Glaxo Group Ltd Medicaments
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
SE9904507D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds

Also Published As

Publication number Publication date
IL149840A0 (en) 2002-11-10
CA2397583A1 (en) 2001-06-14
US6841698B2 (en) 2005-01-11
EP1240172B1 (en) 2004-11-10
KR100689144B1 (ko) 2007-03-08
NZ519376A (en) 2003-11-28
HK1048321A1 (en) 2003-03-28
HUP0300301A3 (en) 2008-12-29
PL201789B1 (pl) 2009-05-29
SE9904508D0 (sv) 1999-12-09
UA71649C2 (en) 2004-12-15
AU780459B2 (en) 2005-03-24
US20030220303A1 (en) 2003-11-27
JP3914435B2 (ja) 2007-05-16
EP1240172A1 (en) 2002-09-18
RU2002113909A (ru) 2004-01-10
CA2397583C (en) 2010-11-09
IS2231B (is) 2007-04-15
US6576626B2 (en) 2003-06-10
NO20022728D0 (no) 2002-06-07
US20050137414A1 (en) 2005-06-23
CZ20021983A3 (cs) 2002-11-13
JP2006306885A (ja) 2006-11-09
WO2001042252A1 (en) 2001-06-14
EE200200286A (et) 2003-08-15
NO20022728L (no) 2002-08-07
DK1240172T3 (da) 2005-02-14
MY125414A (en) 2006-07-31
US20080146836A1 (en) 2008-06-19
RU2260595C2 (ru) 2005-09-20
NO329595B1 (no) 2010-11-22
SK7642002A3 (en) 2002-12-03
DE60015796D1 (de) 2004-12-16
US7807658B2 (en) 2010-10-05
ZA200204127B (en) 2003-08-25
HK1048321B (en) 2005-09-30
SK286904B6 (sk) 2009-07-06
BR0016253A (pt) 2002-08-27
IL149840A (en) 2006-04-10
JP2003516407A (ja) 2003-05-13
US7034176B2 (en) 2006-04-25
EP1484333A1 (en) 2004-12-08
SI1240172T1 (en) 2005-02-28
CN1409716A (zh) 2003-04-09
DE60015796T2 (de) 2005-11-03
TWI228510B (en) 2005-03-01
AR030541A1 (es) 2003-08-27
EE05067B1 (et) 2008-08-15
ES2230174T3 (es) 2005-05-01
MXPA02005536A (es) 2004-09-10
CN1198832C (zh) 2005-04-27
AU2036401A (en) 2001-06-18
HK1053125A1 (en) 2003-10-10
PL364795A1 (en) 2004-12-13
PT1240172E (pt) 2005-02-28
KR20020060992A (ko) 2002-07-19
US20020156053A1 (en) 2002-10-24
US20070021393A1 (en) 2007-01-25
HUP0300301A2 (hu) 2003-06-28
IS6408A (is) 2002-06-06

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