EE05067B1 - Aminoproplfosfiinhapped ning nende kasutamine meditsiinis - Google Patents

Aminoproplfosfiinhapped ning nende kasutamine meditsiinis

Info

Publication number
EE05067B1
EE05067B1 EEP200200286A EEP200200286A EE05067B1 EE 05067 B1 EE05067 B1 EE 05067B1 EE P200200286 A EEP200200286 A EE P200200286A EE P200200286 A EEP200200286 A EE P200200286A EE 05067 B1 EE05067 B1 EE 05067B1
Authority
EE
Estonia
Prior art keywords
aminopropphosphinic
medicine
acids
aminopropphosphinic acids
Prior art date
Application number
EEP200200286A
Other languages
English (en)
Inventor
Elebring Thomas
Guzzo Peter
Swanson Marianne
Von Unge Sverker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0003640A external-priority patent/SE0003640D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200200286A publication Critical patent/EE200200286A/et
Publication of EE05067B1 publication Critical patent/EE05067B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP200200286A 1999-12-09 2000-12-04 Aminoproplfosfiinhapped ning nende kasutamine meditsiinis EE05067B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9904508A SE9904508D0 (sv) 1999-12-09 1999-12-09 New compounds
SE0003640A SE0003640D0 (sv) 2000-10-09 2000-10-09 New compounds
PCT/SE2000/002426 WO2001042252A1 (en) 1999-12-09 2000-12-04 New aminopropylphosphinic acids

Publications (2)

Publication Number Publication Date
EE200200286A EE200200286A (et) 2003-08-15
EE05067B1 true EE05067B1 (et) 2008-08-15

Family

ID=26655259

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200286A EE05067B1 (et) 1999-12-09 2000-12-04 Aminoproplfosfiinhapped ning nende kasutamine meditsiinis

Country Status (33)

Country Link
US (5) US6576626B2 (et)
EP (2) EP1484333A1 (et)
JP (2) JP3914435B2 (et)
KR (1) KR100689144B1 (et)
CN (1) CN1198832C (et)
AR (1) AR030541A1 (et)
AT (1) ATE282043T1 (et)
AU (1) AU780459B2 (et)
BR (1) BR0016253A (et)
CA (1) CA2397583C (et)
CZ (1) CZ20021983A3 (et)
DE (1) DE60015796T2 (et)
DK (1) DK1240172T3 (et)
EE (1) EE05067B1 (et)
ES (1) ES2230174T3 (et)
HK (2) HK1048321B (et)
HU (1) HUP0300301A3 (et)
IL (2) IL149840A0 (et)
IS (1) IS2231B (et)
MX (1) MXPA02005536A (et)
MY (1) MY125414A (et)
NO (1) NO329595B1 (et)
NZ (1) NZ519376A (et)
PL (1) PL201789B1 (et)
PT (1) PT1240172E (et)
RU (1) RU2260595C2 (et)
SE (1) SE9904508D0 (et)
SI (1) SI1240172T1 (et)
SK (1) SK286904B6 (et)
TW (1) TWI228510B (et)
UA (1) UA71649C2 (et)
WO (1) WO2001042252A1 (et)
ZA (1) ZA200204127B (et)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
EP1357905A2 (en) * 2001-02-05 2003-11-05 Michael Albert Kamm A treatment of oesophageal motility disorders and gastro-oesophageal reflux disease
AR033779A1 (es) * 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0401653D0 (sv) 2004-06-24 2004-06-24 Astrazeneca Ab New compounds
SE0402462D0 (sv) * 2004-10-08 2004-10-08 Astrazeneca Ab New process
US7566738B2 (en) 2004-11-03 2009-07-28 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) * 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US20060160777A1 (en) * 2004-12-27 2006-07-20 Anders Lehmann New use of GABAbeta receptor agonists
EP1968947A1 (en) 2005-12-23 2008-09-17 AstraZeneca AB Gaba-b receptor modulators
KR20080091452A (ko) 2005-12-23 2008-10-13 아스트라제네카 아베 위장 장애의 치료를 위한 이미다졸 유도체
US7585996B2 (en) 2006-09-15 2009-09-08 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
ES2373255T3 (es) * 2007-05-04 2012-02-01 Astrazeneca Ab Proceso para s�?ntesis de �?cidos alquilfosf�?nicos mediante iniciación de una amina y un aminóxido.
CN101743011A (zh) * 2007-07-25 2010-06-16 阿斯利康(瑞典)有限公司 (3-氨基-2-氟丙基)次膦酸用于治疗非糜烂性反流病的用途
US20110054216A1 (en) * 2007-12-21 2011-03-03 Hassan Abbasi Novel process for making (2r)-(3-amino-2-fluoropropyl)phosphinic acid form a
WO2009082348A1 (en) * 2007-12-21 2009-07-02 Astrazeneca Ab Novel crystalline form c of (2r)-(3-amino-2-fluoropropyl)phosphinic acid
US20110034420A1 (en) * 2007-12-21 2011-02-10 Ida Hoyer Novel crystalline form b of (2r)-(3-amino-2-fluoropropyl)phosphinic acid
WO2009145716A1 (en) * 2008-05-28 2009-12-03 Astrazeneca Ab New pharmaceutical formulation useful in gerd therapy
EP2346885B1 (de) 2008-11-05 2013-08-28 Clariant International Ltd. Verfahren zur herstellung von monocarboxyfunktionaslisierten dialkylphosphinsäuren, -estern und -salzen mittels allylalkoholen/acroleinen und ihre verwendung
DE102008056341A1 (de) 2008-11-07 2010-05-12 Clariant International Limited Verfahren zur Herstellung von monoaminofunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Acrylnitrilen und ihre Verwendung
JP5570518B2 (ja) 2008-11-07 2014-08-13 クラリアント・ファイナンス・（ビーブイアイ）・リミテッド アクリル酸誘導体を用いたジアルキルホスフィン酸、−エステル及び−塩の製造方法及びそれらの使用
JP5743219B2 (ja) 2008-11-11 2015-07-01 クラリアント・ファイナンス・（ビーブイアイ）・リミテッド アリル化合物を用いる、モノアリル官能性ジアルキルホスフィン酸、それらの塩およびエステルの製造方法およびそれらの使用
DE102008060035A1 (de) * 2008-12-02 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-hydroxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylester einer Carbonsäure und ihre Verwendung
DE102008060535A1 (de) 2008-12-04 2010-06-10 Clariant International Limited Verfahren zur Herstellung von mono-carboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Vinylether und ihre Verwendung
WO2010069545A2 (de) 2008-12-18 2010-06-24 Clariant International Ltd Verfahren zur herstellung von ethylendialkylphosphinsäuren, -estern und -salzen mittels acetylen und ihre verwendung
DE102008063642A1 (de) 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monocarboxyfunktionalisierten Dialkylphosphinsäuren, -estern und -salzen mittels Alkylenoxiden und ihre Verwendung
DE102008063627A1 (de) * 2008-12-18 2010-06-24 Clariant International Limited Verfahren zur Herstellung von monohydroxyfunktionalisierten Dialkylphosphinsäuren,-estern und -salzen mittels Ethylenoxid und ihre Verwendung
DE102008063668A1 (de) 2008-12-18 2010-07-01 Clariant International Limited Verfahren zur Herstellung von Alkylphosponsäuren, -estern und -salzen mittels Oxidation von Alkylphosphonigsäuren und ihre Verwendung
DE102008064003A1 (de) 2008-12-19 2010-06-24 Clariant International Limited Verfahren zur Herstellung von mono-funktionalisierten Dialkylphosphinsäuren, -estern und -salzen und ihre Verwendung
WO2011113904A1 (en) 2010-03-17 2011-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration
US20120016021A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders

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CH449046A (de) 1963-07-09 1967-12-31 Ciba Geigy Verfahren zur Herstellung neuer Aminosäuren
GB8425872D0 (en) * 1984-10-12 1984-11-21 Ciba Geigy Ag Chemical compounds
EP0250572A1 (en) 1986-01-03 1988-01-07 The University Of Melbourne Gastro-oesophageal reflux composition
US4740332A (en) * 1986-05-12 1988-04-26 E. R. Squibb & Sons, Inc. Process for preparing phosphonous acids
GB8820266D0 (en) 1988-08-26 1988-09-28 Smith Kline French Lab Compounds
GB8911017D0 (en) 1989-05-13 1989-06-28 Ciba Geigy Ag Substituted aminoalkylphosphinic acids
US5281747A (en) 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5567840A (en) 1989-05-13 1996-10-22 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5006560A (en) 1989-12-20 1991-04-09 Schering Corporation Use of GABA-B selective agonists as anti-tussive agents
IL98502A (en) * 1990-06-22 1998-04-05 Ciba Geigy Ag History of Aminoalkene Phosphine Acid, Process for Their Preparation and Pharmaceutical Preparations Containing Them
FR2663934B1 (fr) 1990-06-27 1994-06-03 Adir Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.
GB9125615D0 (en) * 1991-12-02 1992-01-29 Wyeth John & Brother Ltd Amines
AU662404B2 (en) * 1992-05-08 1995-08-31 Novartis Ag Novel N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids
FR2722192A1 (fr) 1994-07-06 1996-01-12 Adir Nouveaux derives de l'acide 4-amino butyrique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9420784D0 (en) 1994-10-14 1994-11-30 Glaxo Group Ltd Medicaments
SE9603408D0 (sv) * 1996-09-18 1996-09-18 Astra Ab Medical use
SE9904508D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) * 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
SE9904507D0 (sv) * 1999-12-09 1999-12-09 Astra Ab New compounds

Also Published As

Publication number Publication date
IS2231B (is) 2007-04-15
JP2003516407A (ja) 2003-05-13
US6576626B2 (en) 2003-06-10
DE60015796T2 (de) 2005-11-03
US7034176B2 (en) 2006-04-25
WO2001042252A1 (en) 2001-06-14
SK286904B6 (sk) 2009-07-06
US7807658B2 (en) 2010-10-05
CZ20021983A3 (cs) 2002-11-13
PL364795A1 (en) 2004-12-13
AR030541A1 (es) 2003-08-27
NO329595B1 (no) 2010-11-22
IL149840A0 (en) 2002-11-10
IL149840A (en) 2006-04-10
US20080146836A1 (en) 2008-06-19
PL201789B1 (pl) 2009-05-29
US20020156053A1 (en) 2002-10-24
MXPA02005536A (es) 2004-09-10
DK1240172T3 (da) 2005-02-14
EP1240172A1 (en) 2002-09-18
NO20022728L (no) 2002-08-07
NO20022728D0 (no) 2002-06-07
US20030220303A1 (en) 2003-11-27
HK1053125A1 (en) 2003-10-10
HUP0300301A2 (hu) 2003-06-28
HUP0300301A3 (en) 2008-12-29
AU2036401A (en) 2001-06-18
JP3914435B2 (ja) 2007-05-16
CA2397583A1 (en) 2001-06-14
AU780459B2 (en) 2005-03-24
IS6408A (is) 2002-06-06
US6841698B2 (en) 2005-01-11
RU2002113909A (ru) 2004-01-10
US20050137414A1 (en) 2005-06-23
ES2230174T3 (es) 2005-05-01
UA71649C2 (en) 2004-12-15
US20070021393A1 (en) 2007-01-25
EP1240172B1 (en) 2004-11-10
EE200200286A (et) 2003-08-15
HK1048321A1 (en) 2003-03-28
CA2397583C (en) 2010-11-09
SK7642002A3 (en) 2002-12-03
ZA200204127B (en) 2003-08-25
TWI228510B (en) 2005-03-01
JP2006306885A (ja) 2006-11-09
DE60015796D1 (de) 2004-12-16
KR100689144B1 (ko) 2007-03-08
KR20020060992A (ko) 2002-07-19
BR0016253A (pt) 2002-08-27
MY125414A (en) 2006-07-31
EP1484333A1 (en) 2004-12-08
ATE282043T1 (de) 2004-11-15
HK1048321B (zh) 2005-09-30
SE9904508D0 (sv) 1999-12-09
CN1409716A (zh) 2003-04-09
NZ519376A (en) 2003-11-28
SI1240172T1 (en) 2005-02-28
RU2260595C2 (ru) 2005-09-20
CN1198832C (zh) 2005-04-27
PT1240172E (pt) 2005-02-28

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Legal Events

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KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20111204