ATE279407T1 - Fsh mimetika zur behandlung von infertilität - Google Patents

Fsh mimetika zur behandlung von infertilität

Info

Publication number
ATE279407T1
ATE279407T1 AT99939686T AT99939686T ATE279407T1 AT E279407 T1 ATE279407 T1 AT E279407T1 AT 99939686 T AT99939686 T AT 99939686T AT 99939686 T AT99939686 T AT 99939686T AT E279407 T1 ATE279407 T1 AT E279407T1
Authority
AT
Austria
Prior art keywords
infertility
treatment
fsh mimetics
fsh
mimetics
Prior art date
Application number
AT99939686T
Other languages
English (en)
Inventor
Tayer Nabil El
Adulla Reddy
David Buckler
Sharad Magar
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE279407T1 publication Critical patent/ATE279407T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
AT99939686T 1998-08-07 1999-08-05 Fsh mimetika zur behandlung von infertilität ATE279407T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9571298P 1998-08-07 1998-08-07
PCT/US1999/017755 WO2000008015A2 (en) 1998-08-07 1999-08-05 Fsh mimetics for the treatment of infertility

Publications (1)

Publication Number Publication Date
ATE279407T1 true ATE279407T1 (de) 2004-10-15

Family

ID=22253270

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03023514T ATE329911T1 (de) 1998-08-07 1999-08-05 Fsh mimetika zur behandlung von infertilität
AT99939686T ATE279407T1 (de) 1998-08-07 1999-08-05 Fsh mimetika zur behandlung von infertilität

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03023514T ATE329911T1 (de) 1998-08-07 1999-08-05 Fsh mimetika zur behandlung von infertilität

Country Status (12)

Country Link
US (3) US6235755B1 (de)
EP (1) EP1102763B1 (de)
JP (1) JP4511042B2 (de)
AR (1) AR021755A1 (de)
AT (2) ATE329911T1 (de)
AU (1) AU772373B2 (de)
CA (1) CA2339018A1 (de)
DE (2) DE69931975T2 (de)
ES (2) ES2228084T3 (de)
IL (1) IL141063A (de)
PT (2) PT1102763E (de)
WO (1) WO2000008015A2 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
WO2000047207A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
DE60120661T2 (de) * 2000-03-27 2007-07-05 Applied Research Systems Ars Holding N.V. Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
DK1268419T3 (da) * 2000-03-27 2006-10-02 Applied Research Systems Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer
GB0010757D0 (en) 2000-05-05 2000-06-28 Astrazeneca Ab Chemical compounds
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
US6900213B2 (en) 2001-01-19 2005-05-31 Pharmacopeia Drug Discovery, Inc. Bisaryl derivatives having FSH modulatory activity
DE60201415T2 (de) * 2001-01-19 2006-02-09 Pharmacopeia, Inc. Bisarylderivate mit fsh rezeptor modulierender aktivität
CZ20032258A3 (cs) 2001-02-23 2004-01-14 Merck & Co., Inc. N-substituované nearylové heterocyklické sloučeniny
JP2005511478A (ja) 2001-04-03 2005-04-28 メルク エンド カムパニー インコーポレーテッド N−置換非アリール複素環アミジル系nmda/nr2b拮抗薬
CN100448874C (zh) * 2001-05-05 2009-01-07 史密斯克莱·比奇曼公司 N-芳酰基环胺
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives
GB0121941D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
EA007030B1 (ru) * 2001-10-22 2006-06-30 Апплайд Резеч Системз Арс Холдинг Н.В. Гонадотропины для фолликулогенеза
AU2003299124A1 (en) 2002-09-20 2004-04-23 Laboratoires Serono Sa Piperazine derivatives and methods of use
CN100386318C (zh) * 2002-12-20 2008-05-07 欧加农股份有限公司 四氢喹啉衍生物及其作为fsh受体调节剂的用途
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
CN100404508C (zh) * 2002-12-20 2008-07-23 欧加农股份有限公司 四氢喹啉衍生物
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
JP2008504012A (ja) * 2004-01-28 2008-02-14 シントニックス・ファーマシューティカルズ・インコーポレーテッド 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Fc(FSH−Fc)融合タンパク質
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
WO2006095922A1 (ja) * 2005-03-10 2006-09-14 Kyoto Pharmaceutical Industries, Ltd. テトラヒドロイソキノリン化合物およびその医薬用途
JP4869336B2 (ja) 2005-05-04 2012-02-08 ナームローゼ・フエンノートチヤツプ・オルガノン ジヒドロピリジン誘導体
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
US7687623B2 (en) 2005-05-12 2010-03-30 Wyeth Llc Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (FSH-R) antagonists
CA2609714A1 (en) 2005-06-09 2006-12-21 Wyeth Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
WO2007136776A2 (en) * 2006-05-17 2007-11-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pyrimidine low molecular weight ligands for modulating hormone receptors
US7935715B2 (en) 2006-07-28 2011-05-03 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2008097561A1 (en) 2007-02-06 2008-08-14 Lixte Biotechology Holdings, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
EP2200439B1 (de) 2007-10-01 2017-03-22 Lixte Biotechnology, Inc. Hdac-hemmer
JP5492092B2 (ja) 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を調節する化合物
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
EP2326629B1 (de) 2008-07-10 2013-10-02 Boehringer Ingelheim International GmbH Den cb2-rezeptor modulierende sulfonverbindungen
US8227473B2 (en) 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2010147612A1 (en) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Methods of modulating cell regulation by inhibiting p53
WO2010014220A1 (en) 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Neuroprotective agents for the prevention and treatment of neurodegenerative diseases
EA201100523A1 (ru) 2008-09-25 2011-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Соединения сульфонила, которые селективно модулируют рецептор св2
WO2010083328A2 (en) * 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
WO2010096371A2 (en) 2009-02-18 2010-08-26 Boehringer Ingelheim International Gmbh Heterocyclic compounds which modulate the cb2 receptor
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme (二氫)咪唑並異〔5,1-a〕喹啉類
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
JP5756800B2 (ja) * 2009-06-16 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体を調節するアゼチジン2−カルボキサミド誘導体
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116515A (en) * 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
US8304551B2 (en) 2009-09-01 2012-11-06 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
EP2480544A1 (de) 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Verbindungen für selektive cb2-rezeptormodulation
US9315454B2 (en) 2010-01-15 2016-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
US8329735B2 (en) 2010-03-05 2012-12-11 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the CB2 receptor
WO2012012307A1 (en) 2010-07-22 2012-01-26 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 rece
ES2796774T3 (es) 2011-07-01 2020-11-30 Merck Patent Gmbh Dihidropirazoles, composiciones farmacéuticas de los mismos y su uso para el tratamiento de trastornos de fertilidad
JP6162694B2 (ja) 2011-07-18 2017-07-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung ベンズアミド類
EP2802575B1 (de) 2012-01-10 2017-12-27 Merck Patent GmbH Benzamidderivate als modulatoren des follikelstimulierenden hormons
RU2014136334A (ru) 2012-02-08 2016-04-10 Мерк Патент Гмбх Дейтерированные тиазолидиноновые аналоги в качестве агонистов рецептора фолликулостимулирующего гормона
EA201591931A1 (ru) 2013-04-09 2016-05-31 Ликсте Байотекнолоджи, Инк. Композиции оксабициклогептанов и оксабициклогептенов
EP2803668A1 (de) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole
US10138233B2 (en) 2013-06-24 2018-11-27 Merck Patent Gmbh Imidazole compounds as modulators of FSHR and uses thereof
ES2849434T3 (es) 2013-06-24 2021-08-18 Merck Patent Gmbh Compuestos de pirazol como moduladores del FRSH y usos de los mismos
US11433047B2 (en) * 2015-10-09 2022-09-06 Neurotheryx Canada Ltd. Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
US10729689B2 (en) * 2017-10-26 2020-08-04 University Of Puerto Rico Carbazole EHop-016 derivatives as anti-cancer and anti-migratory agents
JP2022552735A (ja) 2019-10-25 2022-12-19 ギリアード サイエンシーズ, インコーポレイテッド Glp-1r調節化合物
US11851419B2 (en) 2020-11-20 2023-12-26 Gilead Sciences, Inc. GLP-1R modulating compounds
JP2024514009A (ja) 2021-04-21 2024-03-27 ギリアード サイエンシーズ, インコーポレイテッド カルボキシ-ベンズイミダゾールglp-1r調節化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947569A (en) * 1972-04-12 1976-03-30 American Home Products Corporation Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
JPS5331669A (en) * 1976-09-06 1978-03-25 Kissei Pharmaceut Co Ltd Novel n-acylpiperidinecaroxyanilide derivatives and their preparation
DE3636278A1 (de) * 1986-10-24 1988-05-05 Hoechst Ag Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung
US4800432A (en) * 1986-10-24 1989-01-24 The Grass Valley Group, Inc. Video Difference key generator
US5071823A (en) 1988-10-12 1991-12-10 Mitsubishi Paper Mills Limited Image-receiving sheet for transfer recording
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
SK65094A3 (en) * 1992-09-03 1995-03-08 Boehringer Ingelheim Kg Aminoacid derivatives, process for producing the same and pharmaceutical compositions containing these derivatives
US5455229A (en) * 1992-12-23 1995-10-03 Eli Lilly And Company Method for minimizing and containing ischemic and reperfusion injury
PE45195A1 (es) * 1994-03-03 1996-01-17 Boehringer Ingelheim Kg Derivado de aminoacido, procedimiento para su preparacion y composicion farmaceutica que lo contiene
SI20424A (sl) * 1998-03-05 2001-06-30 Agouron Pharmaceuticals, Inc. Nepeptidna GnRH sredstva

Also Published As

Publication number Publication date
PT1380582E (pt) 2006-08-31
DE69931975T2 (de) 2006-10-05
AR021755A1 (es) 2002-08-07
EP1102763A2 (de) 2001-05-30
US6235755B1 (en) 2001-05-22
US20020147345A1 (en) 2002-10-10
PT1102763E (pt) 2005-01-31
IL141063A (en) 2005-06-19
DE69921147D1 (de) 2004-11-18
ATE329911T1 (de) 2006-07-15
DE69931975D1 (de) 2006-07-27
EP1102763B1 (de) 2004-10-13
IL141063A0 (en) 2002-02-10
ES2261844T3 (es) 2006-11-16
US6423723B1 (en) 2002-07-23
WO2000008015A2 (en) 2000-02-17
ES2228084T3 (es) 2005-04-01
AU772373B2 (en) 2004-04-22
WO2000008015A3 (en) 2000-05-11
CA2339018A1 (en) 2000-02-17
JP2002522433A (ja) 2002-07-23
DE69921147T2 (de) 2005-02-24
AU5393199A (en) 2000-02-28
US6653338B2 (en) 2003-11-25
JP4511042B2 (ja) 2010-07-28

Similar Documents

Publication Publication Date Title
ATE329911T1 (de) Fsh mimetika zur behandlung von infertilität
DE69928542D1 (de) 5ht2-agoniste zur behandlung des glaukoms
DE69936890D1 (de) Vorrichtung zur Behandlung von Ischämie
ATE235236T1 (de) Unsubstituierte polydiallylaminen zur behandlung von hypercholesterolemia
DE59712045D1 (de) Vorrichtung zur behandlung des herzens
DE60136477D1 (de) Retinoide zur behandlung von emphysem
ATE279386T1 (de) Retinoide zur behandlung von emphysem
ATE344661T1 (de) Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen
DE69943089D1 (de) Methode zur behandlung von staphylokokkeninfektionen
ATE347372T1 (de) Vakzine zur behandlung von mycosen
ATE222910T1 (de) Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten
DE60021252D1 (de) Antikonvulsiva zur behandlung von autismus
DE69834937D1 (de) Antibiotika zur behandlung von magengeschwuren
DE69926485D1 (de) Behandlung von durchblasgasen
ATE230741T1 (de) 3-tetrahydropyridin-4-yl-indole zur behandlung von psychotischen störungen
DE59904802D1 (de) Vorrichtung zur Behandlung von Biomolekülen
NO20003481D0 (no) FremgangsmÕte for behandling av COPD
ATE251167T1 (de) Oxazinocarbazole zur behandlung von cns- erkrankungen
DE60124791D1 (de) S-Methyl-Dihydro-Ziprasidone zur Behandlung von psychiatrischen Störungen.
DE69806062D1 (de) Kombinationstherapie zur behandlung von aids
DE69802498T2 (de) Idebenon enthaltendes kombinationspräparat zur alzheimer behandlung
NO20006383D0 (no) Fremgangsmåte for behandling
DE29819334U1 (de) Rinser zur Innenraumbehandlung von Flaschen
DE69908572D1 (de) Behandlung von metallen
DE29720575U1 (de) Vorrichtung zur Aufbereitung von Kühlflüssigkeit

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1102763

Country of ref document: EP

EEFA Change of the company name