ATE278021T1 - Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon - Google Patents
Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davonInfo
- Publication number
- ATE278021T1 ATE278021T1 AT99965565T AT99965565T ATE278021T1 AT E278021 T1 ATE278021 T1 AT E278021T1 AT 99965565 T AT99965565 T AT 99965565T AT 99965565 T AT99965565 T AT 99965565T AT E278021 T1 ATE278021 T1 AT E278021T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- bacterial strains
- recombinant bacterial
- natural nucleosides
- modified analogues
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1998MI002792A IT1304500B1 (it) | 1998-12-23 | 1998-12-23 | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
PCT/EP1999/010416 WO2000039307A2 (en) | 1998-12-23 | 1999-12-23 | Recombinant bacterial strains for the production of natural nucleosides and modified analogues thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE278021T1 true ATE278021T1 (de) | 2004-10-15 |
Family
ID=11381317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99965565T ATE278021T1 (de) | 1998-12-23 | 1999-12-23 | Rekombinante bakterienstämme zur herstellung von natürlichen nucleosiden, sowie von modifizierten analogen davon |
Country Status (9)
Country | Link |
---|---|
US (2) | US6911341B2 (de) |
EP (1) | EP1141328B1 (de) |
JP (1) | JP2002533126A (de) |
AT (1) | ATE278021T1 (de) |
AU (1) | AU2103000A (de) |
DE (1) | DE69920749T2 (de) |
ES (1) | ES2229807T3 (de) |
IT (1) | IT1304500B1 (de) |
WO (1) | WO2000039307A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1304500B1 (it) * | 1998-12-23 | 2001-03-19 | Norpharma Spa | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
US7037718B2 (en) * | 2001-10-26 | 2006-05-02 | Cornell Research Foundation, Inc. | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
US7488598B2 (en) | 2001-10-26 | 2009-02-10 | Cornell Center For Technology Enterprise And Commercialization | Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof |
ES2235638B1 (es) * | 2003-12-17 | 2006-10-16 | Cellerix, S.L. | Nuevo vector retroviral de alto titulo y metodos de transduccion. |
ES2343741T3 (es) * | 2006-03-15 | 2010-08-09 | Explora Laboratories Sa | Un proceso para la inmovilizacion de celulas en una resina. |
EP2338985A1 (de) * | 2009-12-22 | 2011-06-29 | Institut Univ. de Ciència i Tecnologia, s.a. | Wärmebeständige Biokatalysatorkombination zur Nukleotidsynthese |
JP2016198075A (ja) * | 2015-04-14 | 2016-12-01 | プラズミア バイオテック,エス.エル. | シトシンヌクレオシドアナログの酵素産生 |
CN113969299B (zh) * | 2021-10-17 | 2023-10-20 | 拓新药业集团股份有限公司 | 一种生物转化合成尿苷的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1573777A (en) * | 1977-11-03 | 1980-08-28 | Wellcome Found | 9-d-arabinonucleosides and an enzymatic process for their preparation |
HU185928B (en) * | 1980-04-23 | 1985-04-28 | Wellcome Found | Process for preparing 4-substituted-1beta-d-ribofuranosyl-1h-imidazo/4,5-c/pyridines |
US4347315A (en) * | 1980-04-25 | 1982-08-31 | Burroughs Wellcome Co. | Synthesis of ribosides using bacterial phosphorylase |
US4835104A (en) | 1987-06-16 | 1989-05-30 | Ajinomoto Co., Inc., Patent & Licensing Department | Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides |
JP2619710B2 (ja) * | 1989-02-27 | 1997-06-11 | 日本製紙 株式会社 | 2′,3′−ジデオキシプリンヌクレオシド類の製造方法 |
EP0423641A3 (en) * | 1989-10-18 | 1992-01-15 | Nippon Mining Company Limited | Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha |
JPH06253854A (ja) * | 1993-02-26 | 1994-09-13 | Yamasa Shoyu Co Ltd | 組換えdna手法によるヌクレオシド・ホスホリラーゼの製造法 |
JP4304727B2 (ja) * | 1996-11-21 | 2009-07-29 | 味の素株式会社 | ヌクレオシド−5’−燐酸エステルの製造法 |
US6229001B1 (en) * | 1997-01-03 | 2001-05-08 | Southern Research Institute | Mycobacterium fol a gene that encodes for the enzyme dihydrofolate reductase |
JPH10286097A (ja) * | 1997-04-15 | 1998-10-27 | Yamasa Shoyu Co Ltd | プリンアラビノシドの酵素的製造法 |
JP3799784B2 (ja) | 1997-11-14 | 2006-07-19 | 味の素株式会社 | 2,6−ジアミノプリン−2’−デオキシリボシドおよび2’−デオキシグアノシンの製造法 |
IT1304500B1 (it) * | 1998-12-23 | 2001-03-19 | Norpharma Spa | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
-
1998
- 1998-12-23 IT IT1998MI002792A patent/IT1304500B1/it active
-
1999
- 1999-12-23 AU AU21030/00A patent/AU2103000A/en not_active Abandoned
- 1999-12-23 JP JP2000591198A patent/JP2002533126A/ja active Pending
- 1999-12-23 DE DE69920749T patent/DE69920749T2/de not_active Expired - Lifetime
- 1999-12-23 EP EP99965565A patent/EP1141328B1/de not_active Expired - Lifetime
- 1999-12-23 WO PCT/EP1999/010416 patent/WO2000039307A2/en active IP Right Grant
- 1999-12-23 ES ES99965565T patent/ES2229807T3/es not_active Expired - Lifetime
- 1999-12-23 AT AT99965565T patent/ATE278021T1/de not_active IP Right Cessation
-
2001
- 2001-06-25 US US09/891,865 patent/US6911341B2/en not_active Expired - Fee Related
-
2005
- 2005-01-14 US US11/036,497 patent/US7781189B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000039307A3 (en) | 2000-11-09 |
AU2103000A (en) | 2000-07-31 |
US20030059870A1 (en) | 2003-03-27 |
IT1304500B1 (it) | 2001-03-19 |
EP1141328B1 (de) | 2004-09-29 |
JP2002533126A (ja) | 2002-10-08 |
DE69920749T2 (de) | 2006-03-02 |
US7781189B2 (en) | 2010-08-24 |
DE69920749D1 (de) | 2004-11-04 |
US20050142645A1 (en) | 2005-06-30 |
WO2000039307A2 (en) | 2000-07-06 |
US6911341B2 (en) | 2005-06-28 |
ES2229807T3 (es) | 2005-04-16 |
EP1141328A2 (de) | 2001-10-10 |
ITMI982792A1 (it) | 2000-06-23 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |