AR011501A1 - Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i - Google Patents
Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para iInfo
- Publication number
- AR011501A1 AR011501A1 ARP960104447A AR10444796A AR011501A1 AR 011501 A1 AR011501 A1 AR 011501A1 AR P960104447 A ARP960104447 A AR P960104447A AR 10444796 A AR10444796 A AR 10444796A AR 011501 A1 AR011501 A1 AR 011501A1
- Authority
- AR
- Argentina
- Prior art keywords
- beta
- recombinant
- type
- nucleotide sequence
- isolated nucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se provee un tipo novedoso de 17 beta-hidroxiesteroide dehidrogenasa del tipo 5. Una secuencia de nucleotidos aislada que codifica la 17 beta-eroide dehidrogenasa del tipo 5, siendo dicha secuencia suficientemente homologa con la SEC ID Ns 1 o uncomplemento de la misma, como para hibridizar bajocondiciones restrictivas a la region de codificacion de la SEQ ID Ns 1, o un complemento de la misma, codificando dicha secuencia una enzima que cataliza laconversion de progesterona a20a-hidroxip rogesterona y la conversion de 4- androstenediona a testosterona. Se describen métodos para la produccion de laenzima y para utilizar a la enzima con el objeto de identificar compuestos potenciales que inhiban o alteren laactividad de las enzimas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/532,896 US6124115A (en) | 1995-09-22 | 1995-09-22 | Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR011501A1 true AR011501A1 (es) | 2000-08-30 |
Family
ID=24123646
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104447A AR011501A1 (es) | 1995-09-22 | 1996-09-20 | Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i |
| ARP990100696A AR018099A1 (es) | 1995-09-22 | 1999-02-23 | Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100696A AR018099A1 (es) | 1995-09-22 | 1999-02-23 | Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6124115A (es) |
| EP (1) | EP0856048A1 (es) |
| JP (1) | JPH11511329A (es) |
| AR (2) | AR011501A1 (es) |
| AU (1) | AU6867896A (es) |
| CA (1) | CA2232500A1 (es) |
| IL (1) | IL119200A0 (es) |
| NZ (1) | NZ316441A (es) |
| WO (1) | WO1997011162A1 (es) |
| ZA (1) | ZA967920B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429104A (zh) * | 1998-03-11 | 2003-07-09 | 内部研究股份有限公司 | 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法 |
| JP2003517580A (ja) * | 1999-01-21 | 2003-05-27 | メタモーフイクス・インコーポレーテツド | 増殖分化因子インヒビター及びそれらの用途 |
| FR2798386B1 (fr) * | 1999-09-10 | 2003-04-25 | Didier Raoult | Oligonucleotides monocatenaires, sondes, amorces et procede de detection des spirochetes |
| CN1303927A (zh) * | 1999-10-22 | 2001-07-18 | 上海博容基因开发有限公司 | 一种新的多肽——类固醇脱氢酶34和编码这种多肽的多核苷酸 |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| AU2002259147A1 (en) | 2001-05-08 | 2002-11-18 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| CN1551878B (zh) | 2001-09-06 | 2011-08-10 | 先灵公司 | 用于治疗雄激素依赖性疾病的3型17β-羟基类固醇脱氢酶抑制剂 |
| EP1436281B1 (en) | 2001-10-17 | 2010-06-16 | Schering Corporation | Piperidine- and piperazineacetamides as 17beta hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| US7510851B2 (en) | 2001-12-17 | 2009-03-31 | Metabolex, Inc. | Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia |
| CN100374421C (zh) | 2002-11-18 | 2008-03-12 | 先灵公司 | 用于治疗雄激素依赖性疾病的3型17β-羟基类固醇脱氢酶抑制剂 |
| MXPA05006485A (es) | 2002-12-17 | 2005-08-26 | Schering Corp | Inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades dependientes de androgeno. |
| US8088758B2 (en) * | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| KR20130124576A (ko) | 2004-01-07 | 2013-11-14 | 앙도르쉐르슈 인코포레이티드 | 헬릭스 12 배향형 스테로이드계 약학 제품 |
| US20060073099A1 (en) * | 2004-10-01 | 2006-04-06 | Frincke James M | Treatment screening methods |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| WO2007127965A1 (en) * | 2006-04-28 | 2007-11-08 | Mayo Foundation For Medical Education And Research | Treating glaucoma, cardiovascular diseases, and renal diseases |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
| CN111454919B (zh) * | 2020-03-31 | 2022-08-26 | 天津大学 | 17β-羟基类固醇羟化酶3突变酶及编码基因及工程菌 |
-
1995
- 1995-09-22 US US08/532,896 patent/US6124115A/en not_active Expired - Fee Related
-
1996
- 1996-09-04 IL IL11920096A patent/IL119200A0/xx unknown
- 1996-09-12 WO PCT/CA1996/000605 patent/WO1997011162A1/en not_active Application Discontinuation
- 1996-09-12 JP JP9512257A patent/JPH11511329A/ja active Pending
- 1996-09-12 CA CA002232500A patent/CA2232500A1/en not_active Abandoned
- 1996-09-12 AU AU68678/96A patent/AU6867896A/en not_active Abandoned
- 1996-09-12 EP EP96929153A patent/EP0856048A1/en not_active Withdrawn
- 1996-09-12 NZ NZ316441A patent/NZ316441A/en unknown
- 1996-09-19 ZA ZA9607920A patent/ZA967920B/xx unknown
- 1996-09-20 AR ARP960104447A patent/AR011501A1/es not_active Application Discontinuation
-
1999
- 1999-02-23 AR ARP990100696A patent/AR018099A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0856048A1 (en) | 1998-08-05 |
| NZ316441A (en) | 2000-02-28 |
| IL119200A0 (en) | 1996-12-05 |
| WO1997011162A1 (en) | 1997-03-27 |
| AR018099A1 (es) | 2001-10-31 |
| AU6867896A (en) | 1997-04-09 |
| CA2232500A1 (en) | 1997-03-27 |
| ZA967920B (en) | 1998-03-19 |
| US6124115A (en) | 2000-09-26 |
| JPH11511329A (ja) | 1999-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |