AR018099A1 - Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion - Google Patents
Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresionInfo
- Publication number
- AR018099A1 AR018099A1 ARP990100696A ARP990100696A AR018099A1 AR 018099 A1 AR018099 A1 AR 018099A1 AR P990100696 A ARP990100696 A AR P990100696A AR P990100696 A ARP990100696 A AR P990100696A AR 018099 A1 AR018099 A1 AR 018099A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- expression
- type
- hydroxysteroid dehydrogenase
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se provee un tipo novedoso de 17beta-hidroxiesteroide dehidrogenasa del tipo 5. Métodos de utilizacion de la secuencia de genes o porciones de las mismaspara sondas o para producir fragmentos de ADN sentido o antisentido que perturben la expresion, oARN antisentido. El método de bloqueo de la síntesis de la17beta-HSD tipo 5 comprendelos pasos de: introducir un oligonucleotido seleccionado del grupo formado por TTTAGCTTTACACACTGCTGTT (SEQ ID No. 30),TCCAAAGCTTTACTTCTCGG (SEQ ID No. 31), GATGAAAAGTGGACCA (SEQ ID No. 32), ATCTGTTGGTGAAAGTTC (SEQ ID No. 33), TCCAGCTGCCTGCGGT (SEQ ID No. 34), CTTGTACTTGAGTCCTG(SEQ ID No. 35), CTCCGGTTGAAATACGGA (SEQ ID No. 36), CATCGTTTGTCTCGTTGAGA (SEQ ID No. 37), TCACTGTTAAAATAGTGGAGAT (SEQ ID No. 38), y ATCTGAATATGGATAAT (SEQ IDNo. 39) en las células. Un método para interferir la expresion de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 comprende la etapa de administrar ácidosnucleicos substancialmente idénticos a por lo menos 15 nucleotidos consecutivos de la SEQ ID No. 1, o un complemento del mismo. El método para interferir laexpresion de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 segun la reinvindicacion 1, comprende la etapa de administrar ácidos nucleicossubstancialmente idénticos a por lo menos 15 nucleotidos consecutivos de la SEQ ID No. 1, o un complemento del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/532,896 US6124115A (en) | 1995-09-22 | 1995-09-22 | Production and use of isolated type 5 17β-hydroxysteroid dehydrogenase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018099A1 true AR018099A1 (es) | 2001-10-31 |
Family
ID=24123646
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104447A AR011501A1 (es) | 1995-09-22 | 1996-09-20 | Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i |
| ARP990100696A AR018099A1 (es) | 1995-09-22 | 1999-02-23 | Metodo de bloqueo de sintesis de la 17beta-hidroxiesteroide dehidrogenasa del tipo 5 y metodo para interferir su expresion |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104447A AR011501A1 (es) | 1995-09-22 | 1996-09-20 | Una secuencia de nucleotidos aislada que codifica la 17 beta- hidroxiesteroide dehidrogenasa de tipo 5; vector de expresion recombinante;celula huesped recombinante; secuencia de oligonucleotidos; un fragmento de adn cromosomico; metodo para producir la 17 beta-hsd de tipo 5; metodo para i |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6124115A (es) |
| EP (1) | EP0856048A1 (es) |
| JP (1) | JPH11511329A (es) |
| AR (2) | AR011501A1 (es) |
| AU (1) | AU6867896A (es) |
| CA (1) | CA2232500A1 (es) |
| IL (1) | IL119200A0 (es) |
| NZ (1) | NZ316441A (es) |
| WO (1) | WO1997011162A1 (es) |
| ZA (1) | ZA967920B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9908592A (pt) * | 1998-03-11 | 2001-04-24 | Endorech Inc | Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit |
| BR0008188A (pt) * | 1999-01-21 | 2002-02-13 | Metamorphix Inc | Inibidores de fator de diferenciação de crescimento e usos para os mesmos |
| FR2798386B1 (fr) * | 1999-09-10 | 2003-04-25 | Didier Raoult | Oligonucleotides monocatenaires, sondes, amorces et procede de detection des spirochetes |
| CN1303927A (zh) | 1999-10-22 | 2001-07-18 | 上海博容基因开发有限公司 | 一种新的多肽——类固醇脱氢酶34和编码这种多肽的多核苷酸 |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| AU2002259147A1 (en) | 2001-05-08 | 2002-11-18 | Schering Corporation | Use of neurokinin receptor antagonists to treat androgen-dependent diseases |
| BR0212378A (pt) | 2001-09-06 | 2004-10-19 | Schering Corp | Inibidores de 17beta-hidroxiesteróide desidrogenase tipo 3 para o tratamento de doenças dependentes de androgênio |
| CA2463626C (en) | 2001-10-17 | 2011-05-24 | Schering Corporation | Piperidine- and piperazineacetamines as 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| AU2002360637B2 (en) * | 2001-12-17 | 2007-08-30 | Metabolex, Inc. | Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia |
| ES2345146T3 (es) | 2002-11-18 | 2010-09-16 | Schering Corporation | Inhibidores de 17beta-hidroxiesteroides deshidrogenasa de tipo 3 para el tratamiento de enfermedades dependientes de androgenos. |
| US7053091B2 (en) | 2002-12-17 | 2006-05-30 | Schering Corporation | 17 β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| US8088758B2 (en) * | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| CA2551737C (en) | 2004-01-07 | 2009-11-10 | Endorecherche, Inc. | Helix 12 directed steroidal pharmaceutical products |
| US20060073099A1 (en) * | 2004-10-01 | 2006-04-06 | Frincke James M | Treatment screening methods |
| GB0513702D0 (en) | 2005-07-04 | 2005-08-10 | Sterix Ltd | Compound |
| WO2007127965A1 (en) * | 2006-04-28 | 2007-11-08 | Mayo Foundation For Medical Education And Research | Treating glaucoma, cardiovascular diseases, and renal diseases |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
| CN111454919B (zh) * | 2020-03-31 | 2022-08-26 | 天津大学 | 17β-羟基类固醇羟化酶3突变酶及编码基因及工程菌 |
-
1995
- 1995-09-22 US US08/532,896 patent/US6124115A/en not_active Expired - Fee Related
-
1996
- 1996-09-04 IL IL11920096A patent/IL119200A0/xx unknown
- 1996-09-12 WO PCT/CA1996/000605 patent/WO1997011162A1/en not_active Application Discontinuation
- 1996-09-12 AU AU68678/96A patent/AU6867896A/en not_active Abandoned
- 1996-09-12 NZ NZ316441A patent/NZ316441A/en unknown
- 1996-09-12 JP JP9512257A patent/JPH11511329A/ja active Pending
- 1996-09-12 CA CA002232500A patent/CA2232500A1/en not_active Abandoned
- 1996-09-12 EP EP96929153A patent/EP0856048A1/en not_active Withdrawn
- 1996-09-19 ZA ZA9607920A patent/ZA967920B/xx unknown
- 1996-09-20 AR ARP960104447A patent/AR011501A1/es not_active Application Discontinuation
-
1999
- 1999-02-23 AR ARP990100696A patent/AR018099A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2232500A1 (en) | 1997-03-27 |
| EP0856048A1 (en) | 1998-08-05 |
| AU6867896A (en) | 1997-04-09 |
| US6124115A (en) | 2000-09-26 |
| NZ316441A (en) | 2000-02-28 |
| IL119200A0 (en) | 1996-12-05 |
| WO1997011162A1 (en) | 1997-03-27 |
| ZA967920B (en) | 1998-03-19 |
| AR011501A1 (es) | 2000-08-30 |
| JPH11511329A (ja) | 1999-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |