ATE277012T1 - Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stress - Google Patents
Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stressInfo
- Publication number
- ATE277012T1 ATE277012T1 AT99945671T AT99945671T ATE277012T1 AT E277012 T1 ATE277012 T1 AT E277012T1 AT 99945671 T AT99945671 T AT 99945671T AT 99945671 T AT99945671 T AT 99945671T AT E277012 T1 ATE277012 T1 AT E277012T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- donor
- stress
- piperidine
- nitrogen oxide
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title abstract 7
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 1
- -1 superoxide ion Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002840 nitric oxide donor Substances 0.000 abstract 2
- 206010048554 Endothelial dysfunction Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 230000008694 endothelial dysfunction Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000036542 oxidative stress Effects 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801398.0A GB9801398D0 (en) | 1998-01-22 | 1998-01-22 | Chemical compounds |
| PCT/GB1999/000231 WO1999037616A1 (en) | 1998-01-22 | 1999-01-22 | Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277012T1 true ATE277012T1 (de) | 2004-10-15 |
Family
ID=10825732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99945671T ATE277012T1 (de) | 1998-01-22 | 1999-01-22 | Piperidin- und pyrrolidin-derivate enthaltend ein stickstoffoxid donor zur behandlung von stress |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6448267B1 (https=) |
| EP (1) | EP1124801B1 (https=) |
| JP (1) | JP2002501049A (https=) |
| AT (1) | ATE277012T1 (https=) |
| AU (1) | AU4120699A (https=) |
| CA (1) | CA2318208C (https=) |
| DE (1) | DE69920496T2 (https=) |
| GB (1) | GB9801398D0 (https=) |
| WO (1) | WO1999037616A1 (https=) |
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| US6043252A (en) | 1997-05-05 | 2000-03-28 | Icos Corporation | Carboline derivatives |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| IT1292377B1 (it) | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
| JP3377731B2 (ja) * | 1997-09-29 | 2003-02-17 | 三菱重工業株式会社 | 高性能水素分離膜 |
| WO1999040787A1 (en) | 1998-02-13 | 1999-08-19 | Medinox, Inc. | Modified pharmacologically active agents and improved therapeutic methods employing same |
| IN188837B (https=) | 1998-05-22 | 2002-11-09 | Torrent Pharmaceuticals Ltd | |
| US6265420B1 (en) | 1998-06-23 | 2001-07-24 | Medinox, Inc. | Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide |
| US6093743A (en) | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
| AU1025899A (en) | 1998-09-16 | 2000-04-03 | Icos Corporation | Carboline derivatives as cgmp phosphodiesterase inhibitors |
| ATE276241T1 (de) | 1998-11-25 | 2004-10-15 | Yissum Res Dev Co | Antioxidationsmittel |
| JP2002542147A (ja) | 1998-12-14 | 2002-12-10 | セレジィ ファーマシューティカルス， インコーポレイテッド | 肛門直腸障害の処置のための組成物および方法 |
| GB2349385A (en) | 1999-04-30 | 2000-11-01 | Teijin Ltd | Organic nitrates and nitrites useful against heart disease |
| US6417207B1 (en) | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
| ES2313900T3 (es) | 1999-07-28 | 2009-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Nicotina en angiogenesis y vasculogenesis terapeutica. |
| SE9903985D0 (sv) | 1999-11-03 | 1999-11-03 | Aga Ab | Use of nitric oxide |
-
1998
- 1998-01-22 GB GBGB9801398.0A patent/GB9801398D0/en not_active Ceased
-
1999
- 1999-01-22 WO PCT/GB1999/000231 patent/WO1999037616A1/en not_active Ceased
- 1999-01-22 AU AU41206/99A patent/AU4120699A/en not_active Abandoned
- 1999-01-22 JP JP2000528540A patent/JP2002501049A/ja active Pending
- 1999-01-22 AT AT99945671T patent/ATE277012T1/de not_active IP Right Cessation
- 1999-01-22 DE DE69920496T patent/DE69920496T2/de not_active Expired - Lifetime
- 1999-01-22 EP EP99945671A patent/EP1124801B1/en not_active Expired - Lifetime
- 1999-01-22 US US09/600,711 patent/US6448267B1/en not_active Expired - Lifetime
- 1999-01-22 CA CA002318208A patent/CA2318208C/en not_active Expired - Fee Related
-
2002
- 2002-03-06 US US10/093,251 patent/US6455542B1/en not_active Expired - Lifetime
- 2002-07-25 US US10/205,997 patent/US6759430B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6448267B1 (en) | 2002-09-10 |
| US20030069429A1 (en) | 2003-04-10 |
| AU4120699A (en) | 1999-08-09 |
| WO1999037616A1 (en) | 1999-07-29 |
| US6759430B2 (en) | 2004-07-06 |
| GB9801398D0 (en) | 1998-03-18 |
| EP1124801A1 (en) | 2001-08-22 |
| US20020091266A1 (en) | 2002-07-11 |
| DE69920496D1 (de) | 2004-10-28 |
| CA2318208C (en) | 2009-09-29 |
| JP2002501049A (ja) | 2002-01-15 |
| CA2318208A1 (en) | 1999-07-29 |
| DE69920496T2 (de) | 2005-08-25 |
| US6455542B1 (en) | 2002-09-24 |
| EP1124801B1 (en) | 2004-09-22 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |